Gene BRK (Mouse)

BRK

Species: Mouse
Alias: BRK, Ptk6
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Src
Subfamily: SRM

Sequence

Name Sequence Type Origin Length Description Download
BRK.AA Protein Sugen 451 None Fasta, JSON
BRK.NA RNA Sugen 2286 None Fasta, JSON
BRK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of BRK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 BRK.AA SH3 11-71 32 7.8e-19 69.81 SMART 1-58 (58) Show / Hide 
Range on Protein: 11-71
Range on HMM: 1-58/58
Sequence Identity: 32% (20 aa)

PKYVGLWDFKARTDEELSFQAGDLLHVTKK-EELWWWATLLDAEGKALAEGYVPHNYLAEKE
|... |.|..|....||||..|| ..|..| .. ||.... .       ||..|.||..|..
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNR----TGQEGWFPSNYVEEID
SH3_1 BRK.AA SH3_1 14-64 33 1.3e-09 35.46 Pfam 1-49 (49) Show / Hide 
Range on Protein: 14-64
Range on HMM: 1-49/49
Sequence Identity: 33% (18 aa)

VGLWDFKARTDEELSFQAGDLLHVTKKEEL--WWWATLLDAEGKALAEGYVPH
| | |..|....||||. || .|| .|..   || . ...       ||..|.
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNT----GQEGWFPS
SH3_2 BRK.AA SH3_2 12-70 22 9.4e-08 30.04 Pfam 1-68 (68) Show / Hide 
Range on Protein: 12-70
Range on HMM: 1-68/68
Sequence Identity: 22% (16 aa)

KYVGLWDFKA-RTDEE-----LSFQAGDLLHVT----KKEELWWWA-TLLDAEGKALAEGYVPHNYLAEK
.|. . |... .  .|     |.|..||...|.    |. . |||. . . ..|..   |..|.....| 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETI-WGGRR-MRGWFPSQWVEEC
SH2 BRK.AA SH2 76-161 39 4.3e-31 110.55 SMART 1-87 (87) Show / Hide 
Range on Protein: 76-161
Range on HMM: 1-87/87
Sequence Identity: 39% (35 aa)

EPWFFGCISRSEAMHRLQAEDNSKGAFLIRVSQKPGADYVLSVRDAQAVRHYRIWKNNEGRLHLNE--AVSFSNLSELVDYHKTQSLS
.||..| |||.|| . |... .  |.||.| |..   |||||||. . |.|||| .|..|. .. |   ..|..| |||..... .|.
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 BRK.AA SH2 78-155 40 3.7e-29 87.44 Pfam 1-81 (81) Show / Hide 
Range on Protein: 78-155
Range on HMM: 1-81/81
Sequence Identity: 40% (33 aa)

WFFGCISRSEAMHRLQAEDNSKGAFLIRVSQ-KPGADYVLSVRDAQ---AVRHYRIWKNNEGRLHLNEAVSFSNLSELVDYH
|..| |||.|| ..|... |  |.||.| |. .||  |.|||||      |.|||| ....| . . . . |..|.|||...
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGD-YTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
Kinase BRK.AA SRM 191-442 78 2.5e-225 754.87 In-house 1-253 (253) Show / Hide 
Range on Protein: 191-442
Range on HMM: 1-253/253
Sequence Identity: 78% (199 aa)

FTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLLRDSDEKALPILELV
||||.|||.||||||.|.|||||||||.|||.||||.|||..|.|||||||||||||..|.||...|||||||||||.||||.|.|||||||||||..|.
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARLVKEDIY-LSHEHNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQMPYP
|||.||||||||||.|||||||||||||||..||||||||||||||.|.||| .||.||.|||||||||....|||.||||||||.||||.|..||.|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMSNHETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKLT
||.|||||...|.|||||||.||||..|||||.||.|||.||||||||.||||
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase BRK.AA Src 191-441 53 5.3e-172 577.72 In-house 1-255 (255) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-255/255
Sequence Identity: 53% (138 aa)

FTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLLR-DSDEKALPILEL
..||.|||.|.||||....|.|...||||...... .... |..|.|.||||||.....|||| . ..|.||.||.| .|.||. |. |.....|.. .|
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQL

VDFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARLVK--EDIY-LSHEHNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQM
.|.| ||||||.||||.|||||||||||||| |||.|||.|||||||.|  .|.|  .|....|.|||||||...|...|||||||||.||.||...|..
IDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYPGMSNHETFLRVDAGYRMPCPLECPPNIHK-LMLSCWSRDPKQRPCFKDLCEKL
|||||.|||.. .|..||||||| .||..... .|| || .||.|||.|. |...|
PYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase BRK.AA Pkinase_Tyr 191-441 46 3.8e-135 458.33 Pfam 1-270 (270) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-270/270
Sequence Identity: 46% (126 aa)

FTLCKKLGAGYFGEVFEALWK-----GQVHVAVKVISRDNLLHQ----HTFQAEIQAMKKL-RHKHILSLYAVAT-AGDP--VYIITELMPKGNLLQLLR
 |. ||||.| ||||... ||     ....||||.. ...  |.      | .|.. ||.| .|..|..||.| |  |.|  .||..|.||.|.||  ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

DS--DEKALPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARLV-KEDIYLSHEHN---VPYKWTAPEALSRGHYSIKSDVW
.   |...|.. .|.... |.|.|| ||||.|.|||||||||.|||||| .|..||||||.. ..| | .. .    .| ||.|||... | ...|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGVLLHEIFSRGQMP-YPGMSNHETFLRV-DAGYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKL
|||||. |||..|..| ||||||.| . .. . |||||||  ||. |..||..||  ||..|| |... |.|
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase BRK.AA TyrKc 191-441 40 3.6e-134 452.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-280/280
Sequence Identity: 40% (117 aa)

FTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKL--RHKHILSLYAVATAG-------DPVYIITELMPKGNLLQLLRDSDE
 || |||| | ||||... ||  . ||||..  |    .  |  |.. |.||  .|..|. ||.|.| .       .|..|..|.||.|.|.. ||.. .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KALPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARLVKED-------IYLSH----EHN--VPYKWTAPEALSRGHYSIKS
| |.  .|..|. |.|.|| ||.|.|.|||||||||.||.||. .|..||||.| ...|        | ..      .  .|..|.|||..  | ...||
K-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWSFGVLLHEIFSRGQMPYPG-----MSNHETFLRVDAGYRMPCPLE--------CPPNIHKLMLSCWSRDPKQRPCFKDLCEKL
|||||||.. |||..||.||||     ||| | . .|..|||||.| .        ||. ....|..|| .||..||.|....|..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase BRK.AA SFK-Src 191-445 50 3e-126 376.35 In-house 1-259 (259) Show / Hide 
Range on Protein: 191-445
Range on HMM: 1-259/259
Sequence Identity: 50% (130 aa)

FTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLLRDSDEKALPILELV
  | ||||.| ||.|.   | ..  ||||   .     .  | .| | ||||||     |||| | | |.|||||||  | ||  |..   ..| .  ||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTL-KPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLV

DFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARLV-KEDI-YLSHEH-NVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQMP
| |.||| || ||| ||..||||||||||| .|| |||||||..| . ..|. |  ||    | ||||||| .   .||||||||||.|. ||   | .|
DMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIP

YPGMSNHETFLRVDA--GYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKLTGIT
||||.| |   .||   |||||||  ||.  .|.|. ||   |  || |  |  ..    
YPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase BRK.AA TK 191-441 24 1.1e-116 392.84 In-house 1-486 (486) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-486/486
Sequence Identity: 24% (120 aa)

FTLCKKLGAGYFG---EVFEALWKGQ--------------------------VHVAVKVISRDNLLHQHTFQA--------------EIQAMKKLR----
 || ||||.| ||   ||....|.|.                          . ||||..  ..  .|  |..              | ..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKHILSLYAVATAG------------DPVYIITELMPKGN----LLQLLRDSDEK--------------------------------------------
 |..|..||.| | |             |..|..|.||.|.    |.. ||....|                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------ALPILELVDFASQVAEGMCYLESQ------NYIHRDLAARNVLVTENNL-----------CKVGDFG---
                               |.  .|. .. |.|.|| ||.|.      |..||||||||.||.|||            ||..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLV--KEDIYLSH------------------------EHNVPYKWTAPEALS---------RGHYSIKSDVWSFGVLLHEIFSRGQMPYPG-M
     ||| .  ..| | ..                           .| .|.|||.|           |....||||||||||..|||..||.||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------HETFLRVDAG--------------YRMPCPLECP--------------PNIHKLMLSCWSRDPKQRPCFKDLCEKL
||         .| . .. .|              .|||.|  ||              . .. ||..||..||..|| |..| |.|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase BRK.AA Frk 191-445 51 4.6e-107 361.98 In-house 1-260 (260) Show / Hide 
Range on Protein: 191-445
Range on HMM: 1-260/260
Sequence Identity: 51% (134 aa)

FTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLLR--DSDEKALPILE
  | ..||.| ||||.| ||  .. |||| . .   .  . | .| | ||||||  ...|||| |  .|.||||||| .| |.. |.  .   . . . .
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTL-KPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQ

LVDFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLAR-LVKEDI--YLSH-EHNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRG
||| | ||| || ||||||||||||||||||| |.| ||. |||||| |.|...  | |. .  .| |||||||    ...|||||||||.|| ||   |
LVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYG

QMPYPGMSNHETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKLTGIT
.|||||| | |    ||.|||||.| .||... ..|| ||  ||..|| |  |  ||    
RMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase BRK.AA Src-Unclassified 191-441 44 6.4e-105 354.88 In-house 1-284 (284) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-284/284
Sequence Identity: 44% (126 aa)

FTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRD--NLLHQHTFQ--------AEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLLRDSD
  | .||| | ||||. . |.| | ||||    .    .    |         .| | |||.||  .  |||| .   | |||||.| .| ||| ||  .
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

EKALPILEL------------VDFASQVAEGMCYLESQNYIHRDLAARNVLVTENN-----LCKVGDFGLA--RLVKEDIYLSHEHN-VPYKWTAPEALS
 . |.| ..            || | ||| || ||||  |.||||||||||. .||     . || |||||  .|. .|.|     .  | ||.|||.  
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

RGHYSIKSDVWSFGVLLHEIFSRGQMPYPGMSNHETFLRVDAGYRMPCP--LECPPNIHK-LMLSCWSRDPKQRPCFKDLCEKL
 |  ||||||||.|.|| ||.  || ||||| | |.   |  ||||| |    || .|   .|. ||  || .|| |  |   .
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase BRK.AA UTK 191-441 35 1.1e-103 350.78 In-house 1-296 (296) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-296/296
Sequence Identity: 35% (105 aa)

FTLCKKLGAGYFGEVFEALWK------GQVHVAVKVIS-RDNLLHQHT----FQAEIQ---AMKKLR-HKHILSLYAVATAGDPVYIITELMPKGNLLQL
  | ..||.| ||||..| ..      ....||||| . ...  ....    |  | .    ||... | ..| |..| |.. | .|.||.|..|.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRDSDEKA------LPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLVTEN-------NLCKVGDFG---LARLVKE--------DIYLSHEHN---
||.. ...      |   .....|...|.|| ||.|....||||||||.||...       ..||..|||   ..|.|.         . |..  ..   
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

VPYKWTAPEALSRG-HYSIKSDVWSFGVLLHEIFSRGQMPYPGMSNHETFLRVDAG--YRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKL
.| .|.|||||  . ....|||||||||...||...|..|||||||......| .|  |||||| .|| .. .||..||  ||  || |.|| ...
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase BRK.AA SrcA 191-441 49 1.1e-103 328.51 In-house 1-250 (250) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-250/250
Sequence Identity: 49% (125 aa)

FTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLLRDSDEKALPILELV
 .| ..|| | ||||.   | |. .||.| . .   .  ..|  | | ||||||  .  ||||    .|.||.|| | || ||  |.| . |.| . .||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTL-KPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSE-EPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLV

DFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARLVKEDIYLSHE-HNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQMPYP
| | |||||| |.|  ||||||| | |.|| || .||. |||||||.... | ..     | |||||||   | . |||||||||.|| |.  .| .|||
DMAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYP

GMSNHETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKL
|| | |    |. ||.|||| .||  .| ||  || .||  || |  |   |
GMNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase BRK.AA Src-Echino1 192-441 45 4.1e-96 325.61 In-house 2-252 (252) Show / Hide 
Range on Protein: 192-441
Range on HMM: 2-252/252
Sequence Identity: 45% (115 aa)

TLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLLRDSDEKALPILELVD
 . ||.| | .|||.. .|.|   |||| .     . .  | ||   |||.||. |. .|||    .|.||.|||| .|||.. |.. . | . . .|.|
RMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKT-MSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

FASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARLVKEDIYLSHE-HNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQMPYPG
   ..| || ||.|.|..||||||||||| . |.||. ||||||....|.| ...   .| |||||||   | . |||||||||.|. |.   |..||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MSNHETFLRVDAGYRMPCPLECPPNIHKL-MLSCWSRDPKQRPCFKDLCEKL
| |.|   .|| ||||| . .||  .... |. || .||.||| |. | . .
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase BRK.AA Abl 191-441 45 4.3e-95 317.71 In-house 1-252 (252) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-252/252
Sequence Identity: 45% (115 aa)

FTLCKKLGAGYFGEVFEALWKG-QVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLLRDSDEKALPILEL
 .. .||| | .|||.|..||  .  |||| .  |. .. | | .|   ||...|. .  |  | |   | ||||| |..||||. ||..|.. || . |
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDT-MEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVL

VDFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARLVKEDIYLSHE-HNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQMPY
.  |.|.| || |||....||||||||| || |... || ||||||..|.|.|  |     | ||||||.|   ..|.||||| ||||| ||   |  ||
LYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPY

PGMSNHETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKL
||.   . . ... ||||  |  |||.. .||. ||  ..  || ||.. ...
PGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase BRK.AA S_TKc 191-445 25 8.7e-54 185.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 191-445
Range on HMM: 1-231/231
Sequence Identity: 25% (67 aa)

FTLCKKLGAGYFGEVFEALWKG-QVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPK--GNLLQLLRDSDE----KA
... .|.| | ||.|. . .|. . .||.|.|.        ... ||| .|| .|..|  || |    | .|...|...   |.|......       . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARLVKEDIYLSHEHNVPYKWTAPEALSRGHYSI-KSDVWSFGVLLHEIFS
.|  .   .. |..... |. |.. |||||   |.|..|    |..||||||..       .   .   . ||| |   .|.  |.|.||.|..| | ..
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

RGQMPYPGMSNHETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCE-----KLTGIT
 |. |.|   .... ...            .|    ..  |. .||..||   .. .     |.    
-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase BRK.AA Pkinase 191-441 23 1.3e-46 165.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-293/293
Sequence Identity: 23% (70 aa)

FTLCKKLGAGYFGEVFEALWKGQVH-VAVKVISRDNLLHQHTFQA----EIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKG----NLLQLLRDSDE
... .|.|.| ||.|... .||  . ||||.|....  ..   ..    ||| ||.|.|..|. || . . .| .|...|....|     |  ... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KAL--PILELVDFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLC----KVGDFGLARLVKEDIYLSHEHNVP---YKWTAPEALS-RGHYSIKSDVW
...  .  |. ... |...|. |. |.. |||||   |.|. .|. .    |..|||||....  .  ..  ...   . . ||| .  . .|. |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGVLLHEIFSRGQMPYPGM-------SNHETFLRVDAGYRMPCPLECP-------------------PNIHKLMLSCWSRDPKQRPCFKDLCEK--L
|.|..|.| .. |. |.||         ..  ... .. .. ..| .|.                   ..  ... .|. .|||.|| ......   .
SCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF