Gene CCK4 (Mouse)
CCK4
Sequence
Protein domains of CCK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| IGc2 | CCK4.AA | IGc2 | 36-100 | 21 | 7.7e-09 | 36.62 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 36-100 Range on HMM: 1-56/56 Sequence Identity: 21% (14 aa) LQGRRALLRCEVEAPDPVHVYWLLNGVPVQDTERRFAQGSSLSFAAVDRLQDSGAFQCVARDNVT ..|. . |.|.... . . |. | |.. ...|.. | . ||| .|.|| .. HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVT-PEDSGYYTCYARNPWG |
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| IG | CCK4.AA | IG | 30-114 | 15 | 0.000627 | 20.3 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 30-114 Range on HMM: 1-58/58 Sequence Identity: 15% (14 aa) PSSQDALQGRRALLRCEVEAPDPVHVYWLLNGVPVQDTERRFAQGSSLSFAAVDRLQDS---GAFQCVARDNVTGEEVRS-TNASFNIK |. . . | .. |.| |. ...|. | . | ...|| | ..|.|. . .. | .. .. PP-VTVKEGETVTLTC-VS-----QIWWY------------------LTI-NV-QPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ |
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| I-set | CCK4.AA | I-set | 24-69 | 25 | 0.181764 | 7.49 | Pfam | 1-47 (92) | Show / Hide |
Range on Protein: 24-69 Range on HMM: 1-47/92 Sequence Identity: 25% (12 aa) IVFIKEPSSQDALQGRRALLRCEVEAPDPVHVYWLLNGVPVQD-TER .|.. |... . | .| . |.|. | | |. .| |.. ..| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDR |
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| V-set | CCK4.AA | V-set | 23-57 | 13 | 3.243811 | 2.57 | Pfam | 1-45 (128) | Show / Hide |
Range on Protein: 23-57 Range on HMM: 1-45/128 Sequence Identity: 13% (6 aa) AIVFIK-EPS----SQDALQGRRALLRCEVE----APDPV-HVYW ... |. . . .| ...|.| . .... ..|| QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYW |
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| I-set | CCK4.AA | I-set | 120-211 | 30 | 3.2e-16 | 57.54 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 120-211 Range on HMM: 1-92/92 Sequence Identity: 30% (29 aa) PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDDQSTHTVSSRE---RNLTLRPASPEHSGLYSCCAHNAFGQACSSQNFTLSV |.....| . .|.| ... |...|.| |. .||.|| ||. | . | .. .. || . . |. .| |.| | | ||.| . ..| | PKFTQKP-KDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEA--ECTAELTV |
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| IGc2 | CCK4.AA | IGc2 | 133-199 | 32 | 4.2e-15 | 57.43 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 133-199 Range on HMM: 1-56/56 Sequence Identity: 32% (22 aa) QPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDDQSTHTVSSRERNLTLRPASPEHSGLYSCCAHNAFG .. ..|||.|. .| | |. .|.. |.||. . ||.....||.||.|.| | |. | HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | CCK4.AA | IG | 127-212 | 18 | 9.2e-10 | 39.68 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 127-212 Range on HMM: 1-58/58 Sequence Identity: 18% (17 aa) ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDDQSTHTVSSRERNLTLRPASPEHS---GLYSCCAHNAFGQACSSQ--NFTLSVA . . .. |||.| . ...|. ||. ...||.| | | | |. . .. ..||.| PP-VTVKEGETVTLTC-VS-----QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ |
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| V-set | CCK4.AA | V-set | 120-211 | 15 | 0.000446 | 15.89 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 120-211 Range on HMM: 1-128/128 Sequence Identity: 15% (20 aa) PVVLKH-PAS----EAEIQPQTQVTLRCHIDGHP----RP-TYQWFR-DGT--------------PLSDDQSTHTVSSRERN------------LTLRPA ..... | . . . |. . |||.|| . .. ...|.| . ...... . . ..| ||.. . QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL SPEHSGLYSCCAHNAFGQACSSQNFTLSV .|..|| | | . | . . .| | QPSDSGTYYCAVWNC-NEDYFGHGTRLTV |
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| I-set | CCK4.AA | I-set | 217-294 | 26 | 2e-08 | 31.13 | Pfam | 1-76 (92) | Show / Hide |
Range on Protein: 217-294 Range on HMM: 1-76/92 Sequence Identity: 26% (22 aa) ARVVLAPQDVVVARNEEAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLR--RAVVFANG----SLLLTQVRPRNAGVYRCI ... |.||.| | | | || . .|||. .| . |... . | .. ..| .| ..| |. .|.|.|. PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKD-GQPLRP-------DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCV |
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| IG | CCK4.AA | IG | 223-312 | 17 | 3.9e-08 | 34.29 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 223-312 Range on HMM: 1-58/58 Sequence Identity: 17% (16 aa) PQDVVVARNEEAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLRRAVVFANGSLLLTQVRPRNA---GVYRCIGQGQRGPPIV-LEATLHLA |. |.| . | . ..| .| ...| | . .|.| .. |.|.| . | ..||. PP-VTVKEGETVTLTC-VS-----QIWWY--------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | CCK4.AA | IGc2 | 229-300 | 18 | 3e-06 | 28.25 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 229-300 Range on HMM: 1-56/56 Sequence Identity: 18% (13 aa) ARNEEAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLRRAVVFANGSLLLTQVRPRNAGVYRCIGQGQRG . . . | .. | |. .|.. ..|. |..| .. |.| .|.|.|.... | HEGQSVTLTCPATGNPDPNIHWYK--GQPLP--------------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| V-set | CCK4.AA | V-set | 217-293 | 13 | 7.2e-05 | 18.63 | Pfam | 1-110 (128) | Show / Hide |
Range on Protein: 217-293 Range on HMM: 1-110/128 Sequence Identity: 13% (15 aa) ARVVLA--PQ----DVVVARNEEAMFHCQFS-----AQPPPSLQWVF-EDE--------------TPITNRSRPPHLR--RAVVFANGS-----LLLTQV . .| . | |.|.. . . ..|..| ... ...|.. . .. ........ | ...|.| | .... QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL RPRNAGVYRC .| |.| | QPSDSGTYYC |
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| I-set | CCK4.AA | I-set | 404-490 | 27 | 1.6e-16 | 58.59 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 404-490 Range on HMM: 1-92/92 Sequence Identity: 27% (25 aa) PTWLRKPQDSQLEEGKPGYLHCLTQATPKPTVIWYRNQMLISE-DSRFEVSKNG----TLRINSVEVYDGTLYRCVSSTPAGSIEAQARVQV |. ..||.| . ||. . | . .|.|.| |... ... ..|. .. .| ||.| |. | |.|| . ..|. |. |...| PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| I-set | CCK4.AA | I-set | 339-400 | 29 | 4.7e-10 | 36.62 | Pfam | 25-92 (92) | Show / Hide |
Range on Protein: 339-400 Range on HMM: 25-92/92 Sequence Identity: 29% (20 aa) QGLPTPSVWWEHAGVPLPA---HGRVHQKG---LELVFVTIAESDTGVYTCHASNLAGQRRQDVNITV .| |.|.| | . | ||. . .....| | . . .|.|.||| |.| .|. ... || TGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV |
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| IG | CCK4.AA | IG | 410-491 | 17 | 1.6e-09 | 38.86 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 410-491 Range on HMM: 1-58/58 Sequence Identity: 17% (15 aa) PQDSQLEEGKPGYLHCLTQATPKPTVIWYRNQMLISEDSRFEVSKNGTLRINSVEVYDG---TLYRCVSSTPAGSIEA--QARVQVL |. || . |.| . .. || |.| .|.. | |.|. . .|.... ....|. PP-VTVKEGETVTLTC-VS-----QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | CCK4.AA | IGc2 | 326-390 | 32 | 1e-08 | 36.23 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 326-390 Range on HMM: 1-56/56 Sequence Identity: 32% (21 aa) IAGDEERVTCPAPQGLPTPSVWWEHAGVPLPAHGRVHQKGLELVFVTIAESDTGVYTCHASNLAG . |. . ||| | |.|.. | . | ||| .. .| . ....| |.||| |.| .| HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | CCK4.AA | IG | 320-401 | 17 | 2e-06 | 28.47 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 320-401 Range on HMM: 1-58/58 Sequence Identity: 17% (15 aa) FEPRVFIAGDEERVTCPAPQGLPTPSVWWEHAGVPLPAHGRVHQKGLELVFVTIAESDT---GVYTCHASNLAGQRRQ--DVNITVA . . .|. . || .. ..|| |.. . ..|. |.|.| |. .|| . ...|| PP-VTVKEGETVTLTC-VS------QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ |
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| IGc2 | CCK4.AA | IGc2 | 416-480 | 27 | 1e-05 | 26.26 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 416-480 Range on HMM: 1-56/56 Sequence Identity: 27% (18 aa) EEGKPGYLHCLTQATPKPTVIWYRNQMLISEDSRFEVSKNGTLRINSVEVYDGTLYRCVSSTPAG .|| . | | . | |.. ||. .. .|.||.| .|.. | .|.|. . |.| HEGQSVTLTCPATGNPDPNIHWYK-GQPLP--------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IGv | CCK4.AA | IGv | 378-475 | 16 | 0.000781 | 9.35 | SMART | 1-76 (76) | Show / Hide |
Range on Protein: 378-475 Range on HMM: 1-76/76 Sequence Identity: 16% (18 aa) TGVYTCHASNLAGQRRQDVNITVATVPTWLRKPQ-----DSQLEEGKPGYLHCLTQATPKPTVIWYRNQMLISEDSRFEVSKNG---------TLRINSV . ..|..|. . .|.|.|. ...|| || | .||..||. .|..... SVTLSCKFSGFTF------------YMHWYRQPPDSTPKGKGLE--WMGY----------------------SYKGRFTWSKDNITRWSKNQFYLTMSNL EVYDGTLYRCVS .. | | | . RPEDTGTYYCAR |
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| V-set | CCK4.AA | V-set | 404-490 | 14 | 0.001279 | 14.31 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 404-490 Range on HMM: 1-128/128 Sequence Identity: 14% (19 aa) PTWLRK--PQ----DSQLEEGKPGYLHCLTQ-----ATPKPTVIWYR-NQM------LI-----------------SEDSRFEVSKNGT-----LRINSV . .. | .||. |.| . .. .. ||| . .| . |...| |.. |.|... QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL EVYDGTLYRCVSSTP-AGSIEAQARVQV .. | | |..... .. .. |..| QPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| V-set | CCK4.AA | V-set | 375-400 | 29 | 0.024632 | 9.88 | Pfam | 102-128 (128) | Show / Hide |
Range on Protein: 375-400 Range on HMM: 102-128/128 Sequence Identity: 29% (8 aa) ESDTGVYTCHASNL-AGQRRQDVNITV .||.|.|.| ..| .. . .. || PSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| I-set | CCK4.AA | I-set | 494-580 | 31 | 4.1e-17 | 60.58 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 494-580 Range on HMM: 1-92/92 Sequence Identity: 31% (30 aa) LKFTPPPQPQQCMEFDKEATVPCSATGREKPTVKWVRADGSSLPE----WVTDNAG----TLHFARVTRDDAGNYTCIASNEPQGQIRAHVQLTV ||| .|......| . |. | .|| .|.| | . |. |.. . .. | || . .|..||.| |||.|.|. |. ....||| PKFTQKPKDVEVQE-GETARFECQVTGDPPPQVSWFKD-GQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNS-FGEAECTAELTV |
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| I-set | CCK4.AA | I-set | 584-661 | 33 | 3e-15 | 54.24 | Pfam | 1-80 (92) | Show / Hide |
Range on Protein: 584-661 Range on HMM: 1-80/92 Sequence Identity: 33% (28 aa) ITFKVEPERTTVYQGHTALLRCEAQGDPKPLIQWKGKDRILDPTKLGP--RMHIFQNG----SLVIHDVAPEDSGSYTCIAGNS .| | . .| | || . |...|||.| ..|. ... | | . |... ..| .| | .| |.|.|.|||.| || PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP----DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNS |
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| IGc2 | CCK4.AA | IGc2 | 596-663 | 35 | 1.4e-13 | 52.39 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 596-663 Range on HMM: 1-56/56 Sequence Identity: 35% (24 aa) YQGHTALLRCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGSYTCIAGNSCN .| .. |.|.| |.| | |.|. . |. |..| | .|.||||| |||.| |. . HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | CCK4.AA | IG | 590-674 | 24 | 3.3e-13 | 51.14 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 590-674 Range on HMM: 1-58/58 Sequence Identity: 24% (22 aa) PERTTVYQGHTALLRCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDS---GSYTCIAGNSCNIRH-TEAPLLVV |. .|| | |. |.| .. |.|. |.| .| |||| | |.| | . .. .. | | PP-VTVKEGETVTLTC-VS-----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ |
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| IGc2 | CCK4.AA | IGc2 | 507-569 | 33 | 6.1e-13 | 50.24 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 507-569 Range on HMM: 1-56/56 Sequence Identity: 33% (21 aa) EFDKEATVPCSATGREKPTVKWVRADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNEPQ . . .| .| |||.. |...|.. |..|| . .||.. .||..|.|.|||.|.|. HEGQSVTLTCPATGNPDPNIHWYK--GQPLP-----WNWTLTIKNVTPEDSGYYTCYARNPWG |
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| IG | CCK4.AA | IG | 500-581 | 19 | 1.2e-11 | 45.98 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 500-581 Range on HMM: 1-58/58 Sequence Identity: 19% (17 aa) PQPQQCMEFDKEATVPCSATGREKPTVKWVRADGSSLPEWVTDNAGTLHFARVTRDDA---GNYTCIASNEPQGQIRA--HVQLTVA |. . .| .| .| .. ...| |.. .|...|. |.|.| |. ||. . ..||| PP-VTVKE-GETVTLTC-VS-----QIWWY-----------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ |
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| V-set | CCK4.AA | V-set | 583-674 | 17 | 0.000254 | 16.73 | Pfam | 1-128 (128) | Show / Hide |
Range on Protein: 583-674 Range on HMM: 1-128/128 Sequence Identity: 17% (23 aa) FITFKV-EPE----RTTVYQGHTALLRCEAQGDP--------------KPL--------IQWKGKDRILDPTKLGPRM----HIFQNGS-----LVIHDV .. .. |. || .| ...|.| . |. |. ... .... . .. .|| ....|.| | |... QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL APEDSGSYTCIAGNSCNIRHTEAPLLVV |.||| |.| . |. . . |.| QPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| IGv | CCK4.AA | IGv | 511-658 | 9 | 0.000275 | 13.89 | SMART | 1-76 (76) | Show / Hide |
Range on Protein: 511-658
Range on HMM: 1-76/76
Sequence Identity: 9% (15 aa)
EATVPCSATGREKPTVKWVRAD-----GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNEPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLRC
.|..|...| .. |.| . . .||.
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY---------------------------------------------------------------
EAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNG---------SLVIHDVAPEDSGSYTCIA
.. | . . .|..... |||.| |.|
----------------------SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
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| V-set | CCK4.AA | V-set | 546-580 | 25 | 0.002889 | 13.09 | Pfam | 94-128 (128) | Show / Hide |
Range on Protein: 546-580 Range on HMM: 94-128/128 Sequence Identity: 25% (9 aa) TLHFARVTRDDAGNYTCIASNEPQGQIRAHVQLTV .|. ....| | |.| ..|.. .. . ..||| SLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV |
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| Kinase | CCK4.AA | CCK4 | 788-1053 | 68 | 1.7e-227 | 762.06 | In-house | 1-273 (273) | Show / Hide |
Range on Protein: 788-1053 Range on HMM: 1-273/273 Sequence Identity: 68% (186 aa) LQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQ-SRDEQQQLDFRREVEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKNKD ||||...|..||||||||||||...|||||||.||.|| ..||||..|||||.||||||||.|||||||||||.|||||||||||.|||||||.....|. LQPIIQIGHGEFGEVFLAKAQGIKDGATETLVMVKALQKTKDEQQCQDFRREIEMFGKLNHKNVVRLLGLCREKEPHYMVLEYVDWGDLKQFLQATRGKN -EKLK----SQPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAVLEGDFSTKSDV .|.| ..||.|.||.|.|.|||||||||.||||.|.||||||||||.|.||||...||.|||||.||.|.||.|.|.|||.||...|...|||||| NTKNKGSSSPPPLTTSQKIAICYQVALGMEHLYNNRFIHRDLAARNCLISPQMQVKVCYMGLCKDVYNREYHHHRQKWIPIRWMPPECIFEDEYSTKSDV WAFGVLMWEVFTHG-EMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTL ||.||.|||||..| .|||..|..|.|..|.||||...||||.||.||||.|.||||.|||||.|||||...| WAYGVFMWEVFNQGTKMPHEQQDNDQVMQDMQAGKLMWPQPEDCPDKLYRMMHRCWADNPKDRHSFSEITHHL |
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| Kinase | CCK4.AA | TyrKc | 788-1053 | 36 | 1.4e-117 | 397.89 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 788-1053 Range on HMM: 1-280/280 Sequence Identity: 36% (109 aa) LQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQLDFRREVEMFGKL--NHANVVRLLGLCREA-------EPHYMVLEYVDLGDLKQF .. . .|| .||||..... . | ||.|.. . ||.|| .. || .| |.|||.| |.. ||...|.||...||||.. ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY LRISKNKDEKLKSQPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNS-------EYYHFR---QAW--VPLRWMS || ...| |..|... | |.| |||.|. ....| ||||||||......||.| |||.|.|. .||. . .. .|.|||. LRKHRPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA PEAVLEGDFSTKSDVWAFGVLMWEVFTHGEMPHGG-----QADDEVLADLQAGKARLPQPEG--------CPSKLYRLMQRCWAPNPKDRPSFSEIASTL ||. .| |.||||||.|||.|||.|| |..|. | ..||......|. |.|||. ||...|..|..||. .|.|||.|||| . . PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY-RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | CCK4.AA | Pkinase_Tyr | 788-1053 | 41 | 3.2e-117 | 397.63 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 788-1053 Range on HMM: 1-270/270 Sequence Identity: 41% (114 aa) LQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSL-QSRDEQQ--QLDFRREVEMFGKL-NHANVVRLLGLCR-EAEP--HYMVLEYVDLGDLKQFLR .. . .||. .||||..... | ... |.. | ||.| .. ...| . || ||... .| .| |.|||.| | . || .|.|.||. .|||. .|| ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR ISKNKDEKLKSQPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYHFRQAW---VPLRWMSPEAVLEGDFST . |||..|... | |.| |||.|......| ||||||||.. ...||.. ||..|.|| .|| .|.. .| .||.||. .| |.| KHR-----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTT KSDVWAFGVLMWEVFTHGEMP-HGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTL |||||.|||||||.|| ||.| | . ||.. . |.|.||.|| ..|.||..||...|.|||.|||| . | KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | CCK4.AA | TK | 788-1053 | 23 | 6.7e-110 | 369.74 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 788-1053
Range on HMM: 1-486/486
Sequence Identity: 23% (112 aa)
LQPITTLGKSEFG---EVFLAKAQGVE--------------------EGATETLVLVKSLQ---SRDEQQQLD--------------FRREVEMFG--KL
.. . .||. .|| ||......| .. ..| | || | . ......| . .| .|. ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
NHANVVRLLGLCREA------------EPHYMVLEYVDLGD----LKQFLRISKNKDEK-----------------------------------------
.| |.|||.| | . || ..|.||...|| |...|| ...| .
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
------LKSQPLSTKQKVA-------------------LCSQVALGMEHLSNN------RFVHKDLAARNCLISAQRQ-----------VKVSALG----
. ..||.||. . | |.| |||.|. . .||| ||||||||.. . . .|.. |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ
----LSKDVYN-SEYYHFR------------------------QAWVPLRWMSPEAVL---------EGDFSTKSDVWAFGVLMWEVFTHG-EMPHGGQA
|..|.|. ..|| . ....|.|||.||... .| |.||||||.|||||||.||.| |...||
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS
D---------DEVLADLQAG-------------KARLPQPEGCP--------------SKLYRLMQRCWAPNPKDRPSFSEIASTL
. .||. |..| . |.|||..|| .|.|||.||...|.|||.||.. . |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | CCK4.AA | UTK | 788-1053 | 34 | 4.3e-97 | 328.88 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 788-1053 Range on HMM: 1-296/296 Sequence Identity: 34% (104 aa) LQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQL-----DFRREVE---MFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQF .|. .||. .||||..|... . | ..| .| || .|... || ||..| | .... | ||.||.|.| || ..|.|| ||| .. VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY LRISKNKDEKL-KSQPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQR-------QVKVSALG---LSKDVY---------NSEYYHFR-Q || ..... |. |.. ....| ||..|.. .||| ||||||||. ..| ..|.. .| .|..|. .|.|| . | LR--RHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ AWVPLRWMSPEAVLEG-DFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGK-ARLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTL .|.|||.|||. .. .|.||||||.|||..||..|.| .| .| ....|.. . .| .|.|.|..|| .||||.|||...| .||.| .. ... DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | CCK4.AA | TK-Unique | 788-1053 | 32 | 1.1e-83 | 284.37 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 788-1053 Range on HMM: 1-294/294 Sequence Identity: 32% (97 aa) LQPITTLGKSEFGEVFLAKAQGVEEGATET-LVLVKSLQSRDEQQ-QLDFRREVEMFGKLN-HANVVRLLGLCREA-EPHYMVLEYVDLGDLKQFLRISK | ..|. .||.|. ... |. .. .. |.|| |. . .. . || .| .|. .| | |.|..|| | . ||.....||. |.| .|| .. LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR NK-----------------DEKLKSQPLSTKQKVALCSQVALGMEHLSN--NRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYHFRQ--AWVPL . .| |.| |. . . |.| |||.|. ..||.||.|||.|.. ..|.. .|...|||. . | . .|. PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI RWMSPEAVL--EGDF-STKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGC-PSKLYRLMQRCWAPNPKDRPSFSEIASTL |||.||. . .| . .||||||.|||||||.|| |..| .| ..... ....|. |.||||.| . .| ||..|| .|..||||..|.. | RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGY-RMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | CCK4.AA | ALK | 788-1055 | 37 | 5.2e-80 | 272.13 | In-house | 1-273 (273) | Show / Hide |
Range on Protein: 788-1055 Range on HMM: 1-273/273 Sequence Identity: 37% (102 aa) LQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQ-SRDEQQQLDFRREVEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKNKD .. . ||. ||||. .. .. . . . | .|.| . .|...|| | || || ||||..|.| .. | . |||| ||.|.||| . .. ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP EKLKSQPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLIS---AQRQVKVSALGLSKDV-YNSEYY-HFRQAWVPLRWMSPEAVLEGDFSTKSDV | |. .| | .| || | | |.|.| | |||||| . ..| .|. | ..|. | ..|| .| | || ||| ..| | .|.|| ESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKTDV WAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTLGD |.||||.||.| | || |. ||. . .| .|. | .|| ||.| || . | |||.| | . . WSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEG-GRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY |
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| Kinase | CCK4.AA | Musk | 791-1053 | 36 | 6.3e-76 | 250.35 | In-house | 4-282 (282) | Show / Hide |
Range on Protein: 791-1053 Range on HMM: 4-282/282 Sequence Identity: 36% (103 aa) ITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSR-DEQQQLDFRREVEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR-----ISKN . .| || || |.| | . ||.| || | ..| | || || | . | |.|.||| | | . .|| ||| ||. . VRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHRTCS KDEKLKS----------QPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAVLEG . . .. .|.. . . |.| || || .||| ||| ||||| . ||.. |||. .| .|| .| ||| ||... RTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYN DFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTL |.. |||||.||..||.| .. | | . ||. . | .| || || |.| || ||| || |||.| .| . QFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGN-ILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI |
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| Kinase | CCK4.AA | Trk | 788-1053 | 34 | 9.7e-75 | 252.79 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 788-1053 Range on HMM: 1-275/275 Sequence Identity: 34% (94 aa) LQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQLDFRREVEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR------- . . || || ||||. . ..| || | |. ||.|| |. .| | ..|.. |.|.. .| || || |||...|| IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDAM ISKNKDEKLKSQPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYN-SEYYHF-RQAWVPLRWMSPEAVLEGDFSTK . . ... || .| . .|.| || . ||| |.|.||||. .. ||.. |.| ||| ..|| . | ||| ||... |.. CYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTYE SDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTL |||| ||| |||.|| | | . || .|. || .|..|| .| .| || |. | . .| . SDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII |
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| Kinase | CCK4.AA | CTKA | 788-1053 | 32 | 9.9e-74 | 247.09 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 788-1053 Range on HMM: 1-290/290 Sequence Identity: 32% (94 aa) LQPITTLGKSEFGEVFLAKAQGVEE-----GATETLVLVKSLQSRDEQQQL-DFRREVEMFG--KLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFL .. .| .|.|| | . . ..| ||.| . | |. . .. | ||.||||.| .| .|. |. .|||. .| HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYL RISKNKD-------------EKLKSQPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSE---YYHFRQAWVPLR | . | ... .| |.| ||. |. ||| |||.||||. .|.. .|... .| || | | | RACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGR-TLRTESQYYYVSSQRVMPVR WMSPEAVLEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAG-KARLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTL ||.|||. .| ||. |||||||||.||... || | . | || .. ||| | ||. || .|| || . |. ||.| . | WMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML |
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| Kinase | CCK4.AA | DDR | 788-1053 | 33 | 2.4e-71 | 243.35 | In-house | 1-306 (306) | Show / Hide |
Range on Protein: 788-1053 Range on HMM: 1-306/306 Sequence Identity: 33% (104 aa) LQPITTLGKSEFGEVFLAKAQGVEE-----------GATETLVLVKSLQS-RDEQQQLDFRREVEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDL-G | .| .|||| | . | . ||| ||.| . ||..|. ... | |.|||.| | . || |..||. | LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG DLKQFLRISKNKDEKLKSQP----------LSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALG--LSKDVYNSEYYHFRQ---- ||.||. .. . |. . .|. . | | |.| || .|.. .||| |||.||||. .|. | .| | ..|| DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTGR --AWVPLRWMSPEAVLEGDFSTKSDVWAFGVLMWEVFTHG-EMPHGGQADDEV------LADLQAGKARLPQPEGCPSKLY-RLMQRCWAPNPKDRPSFS . |.|||..|..| | |.|||||||||| |||.|. | | . |. | . . | . ||.| ||...| || ||| .. ||||. QRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSFE EIASTL || | EIHKFL |
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| Kinase | CCK4.AA | Src | 788-1053 | 33 | 1.8e-70 | 238.64 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 788-1053 Range on HMM: 1-255/255 Sequence Identity: 33% (91 aa) LQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQLDFRREVEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKNKDE .. . ||. ||||. .. .| .| | ||.| . . .. .| .| . || | ..|.|. | . || | | || | | ..|. IKLCRKLGQGQFGEVWMGYWNG------NTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK------ KLKSQPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVY--NSEYYHFRQAWVPLRWMSPEAVLEGDFSTKSDVWAFG . . . |. .| . . ||| ||. |. ....| |||||| |.. . .|| || . . || | .| .|. |||...| |..||||| || DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFG VLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYR-LMQRCWAPNPKDRPSFSEIASTL .|..|..|.| .| | ||| ...| |.|.|..|| .|| .|..|| |..|| | . . | ILLTEIVTYGRVPYPGMTNHEVLQQVERG-YRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | CCK4.AA | Pkinase | 788-1053 | 20 | 4.2e-33 | 118.14 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 788-1053 Range on HMM: 1-293/293 Sequence Identity: 20% (62 aa) LQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQLD--FRR--EVEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLG----DLKQFL .. . ..|. ||.|.... .| .. .| || . |.| . | || |... .||| |.|||.. ... |||.||.. | ||. .. YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI RISKNKDEKLKSQPL--STKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQV----KVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAVL-E . .. .. | .. . |.. |.|.. .....| || |.||. . .. |.. ||.| ... . . . ...|.|| .. ST-------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG GDFSTKSDVWAFGVLMWEVFTHGEMPHGGQ------ADDEVLADLQAGKARLPQPEGCP-------------------SKLYRLMQRCWAPNPKDRPSFS . ..|.|.|..|....|... |. | |. ...... .. . . |. |. . . .. .|....||.||.. QYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE EIAST--L .| . QILQHPWF |
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| Kinase | CCK4.AA | S_TKc | 788-1051 | 19 | 1.2e-32 | 115.68 | SMART | 1-220 (231) | Show / Hide |
Range on Protein: 788-1051 Range on HMM: 1-220/231 Sequence Identity: 19% (52 aa) LQPITTLGKSEFGEVFLAKAQGVEEGATETLVLVKSLQSRDEQQQLDFRREVEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDL--GDLKQFLRISKNK . . ..|| ||.|.... . | .| .| . ..|||... | .| |.|.|.. ... . |||.||.| |||.... |.. YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI---KKR DEKLKSQPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAVLEGDFST-KSDVWAF . . .|.. . .. |.....|.. .....| || | |.. ..|.. ||.. . . . . .|.|| . ... |.|.|.. GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSC GVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIAS |....| .. |. | ..... .. .. . ....|. .|..||. |. GCILYEMLC-GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQ |
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