Gene CDK9 (Mouse)

CDK9

Species: Mouse
Alias: CDK9, Cdk9
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK9

Sequence

Name Sequence Type Origin Length Description Download
CDK9.AA Protein Sugen 372 None Fasta, JSON
CDK9.NA RNA Sugen 1604 None Fasta, JSON
CDK9.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 297 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of CDK9.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK9.AA CDK9 19-315 70 2.9e-260 870.89 In-house 1-340 (340) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-340/340
Sequence Identity: 70% (238 aa)

YEKLAKIGQGTFG-----------EVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKG--SIYLVFDF
|||||||||||||           |||||.|......||.|||||||||||||||||||||.||||||||||||||||||||..|||.|.  ..||||||
YEKLAKIGQGTFGQVLQGRKSRNSEVFKARHKKNKRMVAMKKVLMENEKEGFPITALREIKMLQLLKHENVVNLIEICRTKATAYNRYKDRATFYLVFDF

CEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR--YTNRVVTLWYRPPELLLGE
|||||||||||..|||.|..||..||.|.||||||||||||||||||||||||.||.|||||||||||||..||..|||  ||||||||||||||||||.
CEHDLAGLLSNMNVKFSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGLARAFSQPKNDAPNRPLYTNRVVTLWYRPPELLLGD

RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKL------ELVKGQKRKVKDRLKAYVR-------------
|.||||||.||||||||||||||||||||||||||.|||||||||||.||||....||..|.      ||.||||||||||.|.|..             
RNYGPPIDMWGAGCIMAEMWTRSPIMQGNTEQHQLQLISQLCGSITPDVWPNCENMELWNKMSSEPNSELPKGQKRKVKDRMKNYMKFDAPDSKTDPFGK

---------DPYALDLIDKLLVLDPAQRIDSDDALNHDFF
         |..|..||||||..||..|.|||.||.||.|
NVKQHDSATDQQACHLIDKLLNIDPKKRMDSDEALDHDWF
Kinase CDK9.AA CDK 19-315 42 8.8e-166 534.52 In-house 1-284 (284) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-284/284
Sequence Identity: 42% (138 aa)

YEKLAKIGQGTFGEVFKAKHRQTG-----QKVALKKVLMEN-----EKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKG----SIYLVFD
||||.|||.||.|.|.||...|||     | |||||. |||     |||||||||.|||..|. | |.|.|.|...| ||....|. |.    ..|.||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

FCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV-----LKLADFGLARAFSLAKN-SQP--NRYTNRVVTLWYRP
...|||.....          ||  |..||.||.|.|.|.|.|||.| .| ||...|.     ||.|||||||||.  .. | .  . ||..|||||||.
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRA

PELLLGERDYG--PPIDLWGAGCIMAEMWT---RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRKVKDRLKAYVRDPYALDL
||||||...|.  .|||.|..|||.|||.|   | |...|..|..|| .|...||. |...||.| |. ..                           ||
PELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DL

IDKLLVLDPAQRIDSDDALNHDFF
..|.|..||..|| ...||.|..|
LNKMLCYDPKKRISAEQALQHPYF
Kinase CDK9.AA CRK7 19-315 41 1.4e-136 460.09 In-house 1-343 (343) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-343/343
Sequence Identity: 41% (144 aa)

YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENE---KEGFPITALREIKILQLLKHENVVNLIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGL
||... || ||.| | |||  .||. |||||| |.||   |||||||| ||||||. |.|.|.||| ||   |  ||  .. |||.|.||.   |||.||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LSNV-LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDY------
| .  ...| ....|  |  || |. |.|....|||| | .|.|.   | .|.||||||| .   ....   |||||.|||||||||||||  |      
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYN--SEEKRRPYTNRVITLWYRPPELLLGEERYTEQHIL

--------------------------------GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRK
                                || || |. |||..|  |. || ||| |  || .|...||| .|..||.|.|  ... .   .  .|.
KELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRR

VKDRLK----AYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
.         .   .. .||| ||.|.|||  |.   ..|.||.|
LREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK9.AA CMGC 19-315 24 3.2e-130 430.47 In-house 1-513 (513) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-513/513
Sequence Identity: 24% (128 aa)

YEKLAKIGQGTFGEVFKAKH--------------RQTGQKVALKKVL---MEN------EKEGFPITALREIKILQLLK-----------------HENV
||.. |||.||.|.|.|...              ..|...||.||.    .|.      ||.||||.||||||||. |.                 |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNLIEICRTKASPYNRCK---------GSIYLVFDFCEHDLAGLLSNVL--------VKFTLSE------------IKRVM------QMLLNGLY--YIH
|.|..|...| |  |  .          ..||||....|||.... |          ....  .            ||  |      ...|.||   |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

RNK--ILHRDMKAANVLITRD--------------------GVLKLADFGLARAFSLA--KNSQPNR---------------YTNRVVTLWYRPPELLLG
...  |.|||.| .|.||. .                    |.||..||||||...    .. |...               ||..|||.|||.||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

E---------RDYGPPIDLWGAGCIMAEMWTR--------SPIMQGNTE-----------QHQLALISQLCGSIT---------------PEVWPNVDKY
          ..|..||| |..|||.|||.|.         |. .|..|           ..||..| ...|..|               .| |||. |.
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

ELFEK-------------------------LELVKGQKRKVKDRLKAYVR---------------------------------DPYALDLIDKLLVLDPA
  ..|                         . . . .... |.  . . .                                 || |.||..|.|..||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRIDSDDALNHDFF
.||  ..||.|..|
KRITAEQALQHPYF
Kinase CDK9.AA CDK7 19-315 40 6.30000000001e-113 302.14 In-house 1-288 (288) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-288/288
Sequence Identity: 40% (124 aa)

YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVL----MENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL
|||...|| |.|. |.||   ||||.|| ||.      .  | |   ||.||||||| ..|.||..|| |   |         .|.||||| . ||    
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKS--------NIQLVFDFMDWDLEVVI

SNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLWYRPPELLLGERDYGPPIDLW
    . .| ..||  | |.| ||.| ||| |||||.|  | |.  .|.||.|||||||..       ||| ||  ||| ||| |||| | | ||. .|.|
KDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFY-----GSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMW

GAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKG-QKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH
  |||.||   | |.. |  .  ||  | |  |  |.| |||. .   . |.    |  .   ...  |   |  .|||. ... ..| .|.   ..|..
SVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDD--LLDLMCGMWTMNPCKRWTCTQCLKM

DFF
..|
PYF
Kinase CDK9.AA CDC2 19-315 36 2.9e-110 340.17 In-house 1-301 (301) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-301/301
Sequence Identity: 36% (116 aa)

YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEG--FPITALREIKILQLLK-HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS
|.|. ||| ||.|.|.|.|..||.| |||||.  |.| ||  .| ||.||| .|. || |.|.| | ..             ..|.||.....||  .. 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---------NKLYMVFEYLDMDLKKYMD

NVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT--NRVVTLWYRPPELLLGERDYGPPI
. ..   ..... .|  |  .|.|. . |...|.||| |  | || ..|..|.|||||||||.  .    . ||    |||||||.||.|||...|  |.
MSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPI----RTYTTEHEVVTLWYRAPEILLGCKRYSTPV

DLWGAGCIMAEM---WTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYE-------LFEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
|.|  |||.|||    |. |. .|  |  ||  | .  |. . . ||.|...         ...  | |  ... |..      || ..||....|..||
DMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQ-SCLDPEGIDLLMQMLQYDP

AQRIDSDDALNHDFF
..|| ...||.| .|
QKRISAKEALQHPYF
Kinase CDK9.AA PITSLRE 19-315 39 6.1e-105 354.95 In-house 1-295 (295) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-295/295
Sequence Identity: 39% (120 aa)

YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLME--NEKEGFPITALREIK-ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS
...| .|. ||.|.|..|| ..|.  ||||.. ||   ||||||||.||||. ||  |.|.|.||. ||   .       . .||.|... ||||..|. 
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSN------MDKIYMVMEYVEHDLKSLME

NVL---VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDL
|      .|...|||  || ||.|  . | |.|.||| | .| |..  |.||..|||||| .  .       ||  ||||||| |||||| . | .|.|.
NMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSP----IKPYTPCVVTLWYRAPELLLGCKKYSTPVDM

WGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLE-LVKGQKRKVKDRLK--AYVRDPYALDLIDKLLVLDPAQRIDSDDA
|  |||.||. |  |..||. |  |.  | .. |  |   || . .  .. ... . .      . | .  ... |  ..||  ..| ..|..||  .||
WSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISD-TGFDLLNQMLTYNPKNRITASDA

LNHDFF
| |..|
LKHPWF
Kinase CDK9.AA CDK5 19-315 39 7.2e-97 306.63 In-house 1-287 (287) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-287/287
Sequence Identity: 39% (117 aa)

YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL
|||. ||| ||.| |.||. ..|.  ||||.| ...| || | ||.||| .|. |||.|.| |. .  .           . ||| ||  ||   . .. 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEK--------KLTLVFEFCDQDLKKYMDSCN

VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI
..  .  ||  |  || || . | ...||||.|  | || . | ||||||||||||    .     |.  |||||||||  |.| . |  .||.| .|||
GEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC----YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCI

MAEMW-TRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRKVKDRLKAYVR--DPYALDLIDKLLVLDPAQRIDSDDALNHDFF
.|||  .  |   || .. || .| .. |. . . || . |   . | . ..  .. ..  ..  |.  |   .||  |.|...|.|||. ..||.| .|
FAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDY-KPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK9.AA Pkinase 19-315 30 1.6e-94 325.13 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-293/293
Sequence Identity: 30% (95 aa)

YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALR--EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-----DLA
|... |||.|.||.|.|..|. ||..||.|..  ..||.....|..|  ||.|.. |.|.|.| |......        |..||.|...||.     ||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDLF

GLLS-NVLVKF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL----KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGER
 ..|     .|  .  |.|..|  .| ||.|.|...|.|||.| .|.|| ..|..    |..|||||. |.    ...  .| ...|.||..||...| .
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS--MTTFCGTPWYMAPEVIRGGQ

DYGPPIDLWGAGCIMAEMWTRSPIMQGN----TEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
.|||..| |..|||..|| .. |. .|     .   |...| .  | .... ||. .   .|. .   .        ... .  .. ..|.|...| .||
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCKDP

AQRIDSDDALNHDFF
..|.  ...|.|..|
KKRPTAEQILQHPWF
Kinase CDK9.AA S_TKc 19-315 26 5.4e-94 319.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-231/231
Sequence Identity: 26% (82 aa)

YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH---DLAGLLS
||.| |||.|.||.|.|..|. ||..||.|..          ....|||.||.  .|.|.|.|......         ...|.|...|..   ||  .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIK

NVLVK-----FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGP-P
.   .     |.  .....|. ....| |.|...|.||| | .|.|...  ..|..|||||| .           |  ..|.||..||.|     ||. .
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----GYGKCK

IDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA
.| |  |||..|| .. |  .      |.... ...|                                      .| |.|.|.|.|. ||..|.   .|
CDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EA

LN-------HDFF
|.       | .|
LQDEWDIKCHPWF
Kinase CDK9.AA CDK10 19-315 37 1.2e-84 287.48 In-house 1-285 (285) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-285/285
Sequence Identity: 37% (112 aa)

YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL
.||| ..| ||.| |..|.  ..   |||||| |. ||.| || .||||..|  ..|||.|.| |.   .         ||.|| ..|| ||| || |. 
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQH------LDSIFLVMQYCEQDLASLLDNMP

VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI
  || ...| .|  .| || |.|.| ..|||.| .|.|.| .| .|.|||||||....     .   | ..|||||| |||||| |.    ||.| .|||
QPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVP----VKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCI

MAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
..|.    |.| || | ||. .| .| |.   ..||   .  . ..  | |     .| . .   .    . |.. |.. .| .|  ....|.  .|
LGELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQS--GRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK9.AA MAPK 19-315 30 4.1e-76 259.19 In-house 1-328 (328) Show / Hide 
Range on Protein: 19-315
Range on HMM: 1-328/328
Sequence Identity: 30% (101 aa)

YEKLAKIGQGTFGEVFKAKHRQ------TGQKVALKKVLMENEKEGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCK---GS------IYLV
|. | .|||| .| |..|...       .|.|||.||.    ... .   ..||||.|. . .|||...|..| . ..      .   .|      ||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEM------QDDQNSLEEFNDIYIV

FDFCEHDLAGLLS-NVLVKFTLSEIKRVMQMLLNG--LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA---KNSQPNR-------YTNRV
....|.||  ..  .   . .   |.  |  .|.|  | |||   ..||| | .|.|.. .. ||..|||||| .      ...|...        |  |
MELMETDLHQIIKSQQ--PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYV

VTLWYRPPELLLG--ERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVW---P-NVDKYELFEKLE-LVKGQKRKVKDRLKA
.| ||| ||..|.   ..|   .| | .|||.||| | | |. .|.  ..|. || ...|. ..|..   . .   ..... |  | | .|.  .. .. 
ATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPN

YV--RDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
..   .| |.||..|.||.|| .||. ..||.| .|
ANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDK9.AA Pkinase_Tyr 19-173 30 1.1e-23 80.87 Pfam 1-160 (270) Show / Hide 
Range on Protein: 19-173
Range on HMM: 1-160/270
Sequence Identity: 30% (51 aa)

YEKLAKIGQGTFGEVFKAKHR----QTGQKVALKKV---LMENE--KEGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH
 ... |.|.| ||||.|.. .    .|...|| |..    |. .  .| |    .||.||.  | .|.|.|.|. .|  .  |      .||.|. ...|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPH

-DLAGLLSNV---LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARA
 ||   | .      ..|....    .   .|. | ..... |||  | |.|.|...| | .||||||.
GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase CDK9.AA TyrKc 19-240 18 3.7e-12 -26.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-240
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLL--KHENVVNLIEICRTKASPYNRCK---GSIYLVFDFCEH-DLAG
 ... |.| | ||||.|.. .   ..|| |..  .          .||..|.  |  .|.|.|.|. .|...           . ...|. ...| ||  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKD

LLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA---------KNS----QPN----------------
 | .   |.....    .    .|  |.|.... |||  | |.|...... | .||||.|.             . .    . .                
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

RYTNRV------VTLW------YRPPE---------------LLLGERDYGPPI--------DLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
..|         |..|        |..               .  |.|   ||                || . | . | .  . ..    .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF