Gene CDKL1 (Mouse)

CDKL1

Species: Mouse
Alias: Cdkl1, CDKL1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
CDKL1.NA RNA Sugen 1689 None Fasta, JSON
CDKL1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 284 Kinase domain by global Sugen HMM Fasta, JSON
CDKL1.AA Protein Sugen 352 None Fasta, JSON

Protein domain

Protein domains of CDKL1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKL1.AA CDKL 4-287 71 5.2e-231 773.73 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-286/286
Sequence Identity: 71% (205 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEPLV
|||.||.||||||||.||||..||||||||.|.|.||||..||||.|||.|||||||.|.|||.|||||||.||||||||||||||||..|..||.| .|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

KNITWQTLQAVNFCHKHNCIHRDVKPENILIT-KQSAIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLW
....||.|.|.||||||||||||.|||||||| |.. .|||||||||.|..||..|||||||||||.|||||||||||.|||.||||||.||...| |||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGVKIPDPEDMETLELKFPNIS-YSALGFLKGCLHMDPAERLTCEQLLQHPYF
||.||.||||.|.|.||.||||||..||.|..|.|.|.|..|.||.||...||.| . || |.|.||||||.||.|||||..||||
PGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase CDKL1.AA CMGC 4-287 24 7.79999999999e-133 439.23 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-513/513
Sequence Identity: 24% (127 aa)

YEKIGKIGEGSYGVVFKCRN--------------RDTGQIVAIKRFLETEDDPVIKK----------IALREIRMLKQLK-----------------HPN
||.|.|||||.||||.|||.              ..|..|||||.. . . ..  .|          .|||||..||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNLLEVFRRKR-----------------RLHLVFEYCDHTVLHELDRYQ---------------------------RGVPEPLVKNITWQTLQAVN--F
.|.|...|..|                   |.|||||.||. .. ....|                           .  .  ... ...| |....  .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

CHKHN--CIHRDVKPENILITKQ--------------------SAIKLCDFGFARLLTGP---------------------GDYYTDYVATRWYRSPELL
||.|.   |||| |||||||...                      .|.||||.|| .  .                     .  ||.||.|||||.||.|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

VGD---------TQYGPPVDVWAIGCVFAELLSG--------VPLWPGKSD-----------VDQLYLIRKTLGDLI---------------PR------
.|.         ..|..|.|.|..||.|||.. |         ||.||.|.           .|||..| |.||                  ..      
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

-------------------HQQVFSMNQYFSGVKIPDPE--DMETLELKFPN--------------------------------ISYSALGFLKGCLHMD
                   |.  |  |. .|. . | .   . . |. ..||                                ..  |. .||..|..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PAERLTCEQLLQHPYF
|..|.|.|| ||||||
PDKRITAEQALQHPYF
Kinase CDKL1.AA Pkinase 4-287 33 8.99999999999e-123 418.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-293/293
Sequence Identity: 33% (101 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALR--EIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHT----VLHELDR--YQ
|....|||.||.|.|.||....||.|||.|..   ....  .....|  ||...| |.||| | |...|..|.....|.|||...     |... .  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RGV--PEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQSAI----KLCDFGFARLL-TGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAI
...  .|  .|.. .|.|.....||....||||.||||||| ..  |    |.||||.|... . ..  .|... |.||..||.. |.. |||.||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVFAELLSGVPLWPGK----SDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGVKIPDPEDMETLELKFPNISYSALGFLKGCLHMDPAERLTCEQLLQH
||...|.|.| |..||.    . .||...|....|  .... .  . . ||. ... . .  . .... .|.| ... |.|.||..||..|.|.||.|||
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PYF
|.|
PWF
Kinase CDKL1.AA S_TKc 4-287 32 3.2e-107 363.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-231/231
Sequence Identity: 32% (98 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDH---TVLHELDRYQRG---
||.. |||.|..|.|.|||...||.|||||.           . ..|||..||. .|||.|.|..||.   .|..|.||||.   .... .....|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQSAIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGP-PVDVWAIGCVFAE
   ||  .. ...|...|...||.|. ||||.||||||...   ||.||||.||.|       | .. |.||..||.|    .||. ..|.|..||...|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGVKIPDPEDMETLELKFPNISYSALGFLKGCLHMDPAERLTCEQLLQ-------HPYF
.|.| |..|      |.... | .|                                     | .|. |...||..||..|.|. ..||       ||.|
MLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDKL1.AA CDK 4-219 38 1.3e-103 332.34 In-house 1-242 (284) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-242/284
Sequence Identity: 38% (98 aa)

YEKIGKIGEGSYGVVFKCRNRDTG-----QIVAIKRF-LETE----DDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRK-----------RRLHLVFEY
|||. |||||.||||.|.|...||     ||||.|.. .|.|    ..  .   |.||| .||.| ||| |.|..|.  |           ..| .||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CDHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQSA-----IKLCDFGFARLLTG------PGDYYTDYVATRWYRSPE
.||   . .|          .|...|| |.....||... .||| || ||||...       .|. |||.||.         |   ||  | |.|||.||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLVGDTQYG--PPVDVWAIGCVFAELLS---GVPLWPGKSDVDQLYLIRKTLG
|| |...|.  .|.|.|..||.|||..    . || ||.|. ||| .| ...|
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICG
Kinase CDKL1.AA CDC2 4-219 46 4.5e-94 289.51 In-house 1-226 (301) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-226/301
Sequence Identity: 46% (106 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRF-LETEDDP-VIKKIALREIRMLKQLK-HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQR---G
|.|| |||||.||||.||....|.||||.|.. ||.||.   .   |.|||  || || |||.| | .|.   ..| .||||.|.     .|...     
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

VPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQSAIKLCDFGFARLLTGPGDYYT--DYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAEL
.|. |||....| ||.|.||| .  .||| || |||| |. .||. ||| ||  . | . ||    | |.|||.||.| |. .|  |||.|.|||.|||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---LSGVPLWPGKSDVDQLYLIRKTLG
    .  || .|.|  |||. | ..||
FMDVTKKPLFHGDSEIDQLFKIFRILG
Kinase CDKL1.AA CDK5 4-287 37 6e-91 287.58 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-287/287
Sequence Identity: 37% (107 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEPLV
|||. ||||| ||.|.| ||..|. |||.||    ..|  .   |.||| .|| |||.| | |  |    ..| ||||.||      .|  . ..  ...
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KNITWQTLQAVNFCHKHNCIHRDVKPENILITKQSAIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELL-SGVPLW
| . .| |. . |||.|.  ||| || | || |.   || ||| ||    |   |.  | | ||| |  | |  .|  ..|.| .||.|||.  .| || 
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGKSDVDQLYLIRKTLGDLIPRHQQ---VFSMNQY-FSGVKIPDPEDMETLELKFPNISYSALGFLKGCLHMDPAERLTCEQLLQHPYF
|| .. ||| .| | .|   |   .   .  . .|    .. |  .  ....   |. .   . .|.. | ..|..|.. .. |.||||
PGNDVEDQLKRIFKIMG--TPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDKL1.AA RCK 4-219 41 1.8e-85 271.15 In-house 1-231 (298) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-231/298
Sequence Identity: 41% (96 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLK-HPNLVNLLEVFRRKR--RLHLVFEYCDHTVLHELDRY----QR
|  | ..|.|.||.|.| .| .||.|||||.   ..       . ||||. |. |. |||...|.||.| .   .|..||||.| . | .. .     ..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMD-MNLYQMMKDFKERRK

GVPEPL--VKNITWQTLQAVNFCHKHNCIHRDVKPENILITK---------QSAIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDV
 .||.   .|||  |.||. ...|||.  |||.|||||..|.         |  ||..||| .|        ||||| |||||.||.|  .|.|  |.|.
YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRS-KPPYTDYVSTRWYRAPECLLRCTYYNSPMDI

WAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG
||.||...|| .  ||.|| | .||.. | | .|
WAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMG
Kinase CDKL1.AA MAK 4-287 33 2.9e-76 242.17 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-352/352
Sequence Identity: 33% (121 aa)

YEKIGKIGEGSYGVVFKCRN------------------------------RDTGQIVAIKR----FLETEDDPVIKKIALREIRMLKQLK-HPNLVNLLE
|  | ..| |.|| | . .                                ||| .|||||    |   |.      . |||.  || |. |||.| |.|
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEE-----CMNLREVKSLKKLNAHPNIVKLKE

VFR--RKRRLHLVFEYCDHTVLHEL--DRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQ-----------------SAIKLCDFGF
|.|      |..||||     | ..  ||  |  ||| ..|| .| ||.  | |||.  ||| |||||...                     ||. ||| 
VIRDSENDHLYFVFEYMKEN-LYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGL

ARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRH---------------------Q
|| .      ||||| |||||.|| |   |.|. |.|.||.||. ||| .  || || | .||.. | . ||  . .                      |
AREIRSK-PPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQ

QVFSMNQYFSGVKIPDPEDMETLELKFPNISY-SALGFLKGCLHMDPAERLTCEQLLQHPYF
 . .||  |  .  |    ...|    ||.|   |.  .| .|  || .| | .|....|||
LAHMMNFRFPQCVPPSIMPLKHL---IPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase CDKL1.AA CDK7 103-287 40 2.3e-70 186.44 In-house 104-288 (288) Show / Hide 
Range on Protein: 103-287
Range on HMM: 104-288/288
Sequence Identity: 40% (76 aa)

VKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQSAIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLW
.|... .||| . .||..   ||| || | |. .   .|. ||| ||    |   ||  | |||||.|||| |  .||. ||.|..||.||||.  ||  
IKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYL

PGKSDVDQLYLIRKTLGDLIPRHQQ---VFSMNQYFSGVKIPDPEDMETLELKFPNISYSALGFLKGCLHMDPAERLTCEQLLQHPYF
|| ||.|||  | .|||   |  ..   . .|. |    . | .  .. |.  |   |  .| ...| . |.| .|.|| | |..|||
PGDSDIDQLTRIFQTLG--TPTEEEWPNMCCMMDYIKFKDFPGYSRTP-LRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDKL1.AA CDK-Unclassified 4-220 28 1.2e-65 214.84 In-house 1-257 (324) Show / Hide 
Range on Protein: 4-220
Range on HMM: 1-257/324
Sequence Identity: 28% (73 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKR-FLETEDD---------PVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLH-------------LVF
|. . |.||| .| |.| .  .| ..||||. ..  . .          ..| ...|||  |....| |.  .....    |.              .| 
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

EYCDHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQS-----AIKLCDFGFARLLT------------GPGDYYTDYVA
|| . |    |.          ..|   | |   .. |    .|||.||.||.|| .       .|. ||| |..              .|.. |.  |.
EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVS

TRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGD
|||||.|||| |. .|.. ||.|..||..||.. |.|. .|.....|.  | |.||.
TRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGT
Kinase CDKL1.AA MAPK 4-219 32 4.7e-61 209.14 In-house 1-252 (328) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-252/328
Sequence Identity: 32% (81 aa)

YEKIGKIGEGSYGVVFKCRNRD------TGQIVAIKRFLETEDDPVIKKIALREIRMLKQL-KHPNLVNLLEVFRRK-----------RRLHLVFEYCDH
|. . .||.|.||||.... .       .|..||||..    ..|.  | ..|||..|. . .|.| ..||..|. .           . . .|.|....
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

TVLHELDRYQRGVPEPLVKNITWQTLQA--VNFCHKHNCIHRDVKPENILITKQSAIKLCDFGFAR----LLTGPGD----------YYTDYVATRWYRS
  || . . |.   .  .. ...| | .  . . |  | |||| ||.|||...    |.|||| ||      . ...          . |.||||||||.
D-LHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLVGD--TQYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLG
||.. .   . |   ||.|..|| |||.|. . || |||. .||. || ..||
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLG
Kinase CDKL1.AA CDK7 4-84 40 6.9e-31 79.14 In-house 1-85 (288) Show / Hide 
Range on Protein: 4-84
Range on HMM: 1-85/288
Sequence Identity: 40% (34 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFL----ETEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCD
|||| .|||| ...|.| .   ||||||||.        | .  |   |.||| .|. ..|.| ..|. .|  |  . |||.. |
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMD
Kinase CDKL1.AA TyrKc 4-287 22 4.9e-17 52.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-287
Range on HMM: 1-280/280
Sequence Identity: 22% (72 aa)

YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQL--KHPNLVNLLEVFRRK-------RRLHLVFEYCDHTVLHELDRY
 ... |.||| .|.|.|.. .   . ||.|   |      .. . .||.|....|  .|||.|.|. | . .         | .|.||..|  |..  |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QRG-VPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPENILITKQSAIKLCDFGFARLLTGP------GDYYT------DY--VATRWYRSPELLVGDTQY
 |. .. .   .. ||  .  .. |..||||||    |.|....  .| .||| .| ..        .|||.          .  ||. .|| .  .  .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

GPPVDVWAIGCVFAELLS-GVPLWPG-----KSDVDQLYLIRKTLGDLIPRH----QQVFSMNQYFSGVKIPDPEDMETLELKFPNISYSALGFLKGCLH
 .  |||. | .  |... | . .||     .|. . . ....     .| .                               |.  .       | | |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------FVCCPDEMYQIMKQCWH

MDPAERLTCEQLLQHPYF
 ||..| | ...  | .|
EDPEDRPTFSEI--HECF
Kinase CDKL1.AA Pkinase_Tyr 4-85 29 6.6e-15 51.12 Pfam 1-91 (270) Show / Hide 
Range on Protein: 4-85
Range on HMM: 1-91/270
Sequence Identity: 29% (27 aa)

YEKIGKIGEGSYGVVFKCRNR----DTGQIVAIKRFLETEDDPV--IKKIALREIRMLKQL-KHPNLVNLLEVFR-RKRR--LHLVFEYCDH
 ... |.|||..|.|.|.. .    .|.. ||.|   |. ...   ...  .||....||| .|||.|.|. |   ...   . .|.||. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF-MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH
Kinase CDKL1.AA CDK 263-287 52 6.1e-11 31.08 In-house 260-284 (284) Show / Hide 
Range on Protein: 263-287
Range on HMM: 260-284/284
Sequence Identity: 52% (13 aa)

FLKGCLHMDPAERLTCEQLLQHPYF
.| ..| .||. |...|| ||||||
LLNKMLCYDPKKRISAEQALQHPYF
Kinase CDKL1.AA RCK 253-287 42 1.2e-10 29.68 In-house 264-298 (298) Show / Hide 
Range on Protein: 253-287
Range on HMM: 264-298/298
Sequence Identity: 42% (15 aa)

FPNISYSALGFLKGCLHMDPAERLTCEQLLQHPYF
.||.|. ..  .. .|  || .| | .|.||||||
IPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase CDKL1.AA MAPK 253-287 43 3e-09 27.91 In-house 290-328 (328) Show / Hide 
Range on Protein: 253-287
Range on HMM: 290-328/328
Sequence Identity: 43% (17 aa)

FPN----ISYSALGFLKGCLHMDPAERLTCEQLLQHPYF
|||     .  |. .|.  |..|| .|.| |. ||||||
FPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDKL1.AA CDK-Unclassified 263-287 32 1.8e-07 20.46 In-house 300-324 (324) Show / Hide 
Range on Protein: 263-287
Range on HMM: 300-324/324
Sequence Identity: 32% (8 aa)

FLKGCLHMDPAERLTCEQLLQHPYF
.. . .. .| .|..|...||||.|
CEFQMVMYQPYNRWKCMEILQHPWF
Kinase CDKL1.AA CDC2 268-287 50 6.4e-07 16.74 In-house 282-301 (301) Show / Hide 
Range on Protein: 268-287
Range on HMM: 282-301/301
Sequence Identity: 50% (10 aa)

LHMDPAERLTCEQLLQHPYF
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LQYDPQKRISAKEALQHPYF
Kinase CDKL1.AA Pkinase_Tyr 118-159 44 3.6e-05 18.12 Pfam 128-169 (270) Show / Hide 
Range on Protein: 118-159
Range on HMM: 128-169/270
Sequence Identity: 44% (19 aa)

HKHNCIHRDVKPENILITKQSAIKLCDFGFARLLTGPGDYY-T
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ESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYR