Gene CDKL2 (Mouse)

CDKL2

Species: Mouse
Alias: Cdkl2, CDKL2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
CDKL2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 286 Kinase domain by global Sugen HMM Fasta, JSON
CDKL2.AA Protein Sugen 568 None Fasta, JSON
CDKL2.NA RNA Sugen 4022 None Fasta, JSON

Protein domain

Protein domains of CDKL2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKL2.AA CDKL 4-289 65 1.4e-219 735.75 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-286/286
Sequence Identity: 65% (190 aa)

YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLKLFPNGLDYQVV
||.||.|||||||.|||||||..|.|||||||.||.||.|||||||||||.||||.|||.|||.||...|....||||..|||.|..|. .|||.|..||
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

QKYLFQIINGIGFCHSHNIIHRDIKPENILVS-QSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLF
.||..||...| |||.||.|||||||||||.. ..|.||||||||||.||.|||.|||||||||||||||||||..|||.||||||||...||..||||.
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PGESDIDQLHHIMTCLGNLIPRHQELFYKNPVFAGVRLPEVKDAEAEPLESRYPKLP-EAVISLAKKCLHIDPDKRPFCADLLRHDFF
||.||||||.||. |||.|||||||.|.|||.|.|...||..  . ||||.|||..  .......|||||.|||.|..|..|..|..|
PGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIE--HMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase CDKL2.AA CMGC 4-289 23 2.9e-126 417.25 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-513/513
Sequence Identity: 23% (121 aa)

YENLGLVGEGSYGMVMKCRN--------------KDSGRIVAIKKFLESDDDKMVKK----------IAMREIKLLKQLR-----------------HEN
||... .|||.||.| |||.              .....||||||. .   ..  .|          .| ||||.||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNLLEVCKKKK-----------------RWYLVFEFVDHTILDDLKLFPN--------GLDYQV------------VQKYL------FQIINGIG--FC
.|.|..... |.                   |||||..||. .. .|  ..        .|.  .            .....      .||..|.   .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSHN--IIHRDIKPENILVSQS--------------------GVVKLCDFGFARTLAAP---------------------GEVYTDYVATRWYRAPELLV
|||.  |||||.||||||...                     |..|.||||.|| .  .                     .. ||.||.||||||||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GD---------VKYGKAVDIWAIGCLVIEMLMG--------QPLFPGESD-----------IDQLHHIMTCLGNLI---------------PR-------
|.          .|....|.|..||   ||..|        .|||||.|.           ||||..|.  ||.                 ..       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------HQELFYKNPVFAGVRLPEVKDAEAEPLESRYPK--------------------------------LPEAVISLAKKCLHIDP
                  |.  |..|... . |.|...    ..|. ..|.                                ...  | | ||.|..||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DKRPFCADLLRHDFF
|||. ... |.|..|
DKRITAEQALQHPYF
Kinase CDKL2.AA CDK 4-214 37 8.9e-102 326.41 In-house 1-237 (284) Show / Hide 
Range on Protein: 4-214
Range on HMM: 1-237/284
Sequence Identity: 37% (95 aa)

YENLGLVGEGSYGMVMKCRNKDSG-----RIVAIKKF-LESD----DDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKK-----------KRWYLVFEF
|| |  .|||.|| | |.|.|..|     .|||.||. .|..    ..  .   | |||.|||.| |.| |.|..||  |           .. |.|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VDHT---ILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGV-----VKLCDFGFARTLAA------PGEVYTDYVATRWYR
.||    ..|             .. |..|...|. .|||..|.|||.|| |||..  |.     .|. |||.||          |  .||  | |.|||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

APELLVGDVKYG--KAVDIWAIGCLVIEMLM---GQPLFPGESDIDQLHHI
||||| |. .|.   ..|.|..||  .||..   ..|||||.|.||||..|
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKI
Kinase CDKL2.AA S_TKc 4-289 30 1.6e-97 331.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-231/231
Sequence Identity: 30% (93 aa)

YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDH---TILDDLKLFPNG---
|| | ..|.|..| |.|||.|..|||||||.           . ..|||..||. .|.|.|.|..|.   .. |.|.|..|.   . .| .|  . .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGK-AVDIWAIGCLVIE
  ..  ....|. ||.... .||||.|||||.||||||...  ..|.||||.|| |       | .. |.||.|||.|    .||| ..|.|..||...|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPVFAGVRLPEVKDAEAEPLESRYPKLPEAVISLAKKCLHIDPDKRPFCADLLR-------HD
|| |.|.||   ..... ...                                           .. .... .|||. ||.||| . ..|.       | 
MLCGYPPFP---QMQMMFKKIG------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

FF
.|
WF
Kinase CDKL2.AA Pkinase 4-289 31 1.7e-97 335.01 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMR--EIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLKLF-------
|. .. .|.||.| | ||..|..|.|||.|..  ..... ..... |  ||...| |.|.| | |....  |.. |.|.|.....    . ||       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

PNGL--DYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVV----KLCDFGFARTL-AAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWA
 ...  .......|. ||. |. .|||..|||||.||||||... |..    |.||||.|. .   ... .|... |.||.|||.. |. .||..||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGCLVIEMLMGQPLFPGE----SDIDQLHHIMTCLGNLIPRHQELFYKNPVFAGVRLPEVKDAEAEPLESRYPKLPEAVISLAKKCLHIDPDKRPFCADL
.||...||| |.|.|||.    . .||.. |   .|  .... .  . .. |  .|  . .    . .. . ....|. ... |.||. || ||| ....
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

LRHDFF
| |..|
LQHPWF
Kinase CDKL2.AA CDC2 4-214 41 3.3e-95 293.04 In-house 1-221 (301) Show / Hide 
Range on Protein: 4-214
Range on HMM: 1-221/301
Sequence Identity: 41% (93 aa)

YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKF-LESDDDK-MVKKIAMREIKLLKQLR-HENLVNLLEVCKKKKRWYLVFEFVDHTILDDLK-LFP--NG
|. .  .|||.|| | ||.......|||.||. ||..|.   |   |.||| .|| |. |.|.| | .| .. .. |.|||..|.     .. ..|    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYT--DYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEM
.. |.|..|..||..|. |||.. |.|||.|| |||.. .|..|. ||| ||.   |  .||    | |.||||||.| |. .|  .||.|.|||. .||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---LMGQPLFPGESDIDQLHHI
    .  |||.|.| ||||  |
FMDVTKKPLFHGDSEIDQLFKI
Kinase CDKL2.AA CDK7 4-219 38 2.9e-90 240.53 In-house 1-220 (288) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-220/288
Sequence Identity: 38% (86 aa)

YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFL----ESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVD---HTILDDLKLFPN
|| . ..||| .. | | . . .|.||||||       |. .  .   |.||||.|. ..|.| ..|. .  .|   .|||.| |     .  | ..   
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSII--

GLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEML
 |    .  |  ..  |. .|| . | |||.|| | |... |..|. ||| ||   .| ..||  | |||||||||| |   || .||.|..||   | .
-LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELM

MGQPLFPGESDIDQLHHIMTCLG
   | .||.||||||  |   ||
LRVPYLPGDSDIDQLTRIFQTLG
Kinase CDKL2.AA RCK 4-289 34 1.2e-83 265.19 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-298/298
Sequence Identity: 34% (106 aa)

YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR-HENLVNLLEVCKKKK--RWYLVFEFVDHTILDDLKLFPNGLDY
|  .  .|.|.|| ||| .||..| ||||||       .    .  |||| |. |  |.|...|.|| . ..  . |.|||..|  .   .| |    . 
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKE-RRK

----QV--VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQ---------SGVVKLCDFGFARTLAAPGEV-YTDYVATRWYRAPELLVGDVKYGKAVD
    ..  . ....||. |. ..|.|.. |||.|||||...          ....|..||| .|      .  ||||| ||||||||.|  . .| . .|
YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRS--KPPYTDYVSTRWYRAPECLLRCTYYNSPMD

IWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQEL--FYKNPVFAGVRLPEVKDAEAEPLESRYPKLPEAVISLAKKCLHIDPDKRPFCAD
|||.||  .|  | .||||| | |||.. | . .|  .| ....  .||     . ..| .|   . ||..  | ..   |.| .|.| .||.||.  . 
IWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMG--TPNKKDWPDGYKLASQMNFNFPQCK---GMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQ

LLRHDFF
.|.| .|
ALQHPYF
Kinase CDKL2.AA CDK5 4-219 40 6.9e-78 245.59 In-house 1-217 (287) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-217/287
Sequence Identity: 40% (88 aa)

YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLKLFPNGLDYQVV
|| .  .||| ||.| | |||... |||.|.    ..|  |   |.||| ||| |.|.| | |  |    |.  |||||.|  .   .  .  ..| ...
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

QKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEML-MGQPLF
. ...|   |..|||.|.. ||| || | |... |  || ||| ||    |   |.  | | |||.|  | |  .|   .|.| .||   ||   |.|||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGESDIDQLHHIMTCLG
|| .. |||  |   .|
PGNDVEDQLKRIFKIMG
Kinase CDKL2.AA ERK7 4-289 34 9.4e-71 241.16 In-house 1-292 (292) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-292/292
Sequence Identity: 34% (103 aa)

YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR-HENLVNLLEVCKKK--KRWYLVFEFVDHTILDDLKLFPNGLDY
|| .  .| | ||.| |   | .. .||.||      ..       ||| .|.... |.|.. |..| . .  .  |||||| . | |       | |  
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFME-TDLHAVIRKGNILKD

QVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGE------VYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIE
  .|  ..|... | . || |.||||.|| |||.    .||.|||| ||..|   |      . |.||||||||||| |.|  .| |.|| | ||| . |
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

MLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPVFAGVRLPEVKDAEAEPLESRYPKLPEAVISLAKKCLHIDPDKRPFCADLLRHDFF
|| |.|.||| | ..|.  |.. ...  | ....   .. .| . | ...  . ..|.  .|. ... |.| |. |   |.||    . |.| . 
MLRGKPMFPGTSTMNQIEKILETIPK--PTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase CDKL2.AA MAPK 4-220 35 2.2e-70 240.12 In-house 1-253 (328) Show / Hide 
Range on Protein: 4-220
Range on HMM: 1-253/328
Sequence Identity: 35% (90 aa)

YENLGLVGEGSYGMVMKCRNKD------SGRIVAIKKFLESDDDKMVKKIAMREIKLLKQL-RHENLVNLLEVCKKK-----------KRWYLVFEFVDH
|..|  .|.|.||.| ... |       .|..|||||.    ....  | . ||||||. . .||| ..||.. . .           .  |.|.|. ..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

TILDDLKLFPNGLDYQVVQKYLFQIING--IGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAA-PGEVY-------------TDYVATRWYRA
  |  .   .. |. . .|  ..||..|  . . || |.||||.||.|||| . . .|.|||| ||...    . .             |.|||||||||
D-LHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLVGD--VKYGKAVDIWAIGCLVIEMLM-GQPLFPGESDIDQLHHIMTCLGN
||.. .    .| ||||.|..||   |||  ..|||||.. |||. .||  ||.
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGT
Kinase CDKL2.AA CDK-Unclassified 4-220 29 1.9e-69 227.62 In-house 1-257 (324) Show / Hide 
Range on Protein: 4-220
Range on HMM: 1-257/324
Sequence Identity: 29% (76 aa)

YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDK----------MVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWY-------------LVF
|. .  .||| .|.| | .  .  ..|||||   .                | .. |||..|... |.|.  ....  .  |               .| 
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

EFVDHTILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSG-----VVKLCDFGFARTLA------------APGEVYTDYVA
| .. |    |.   . |  . ..... |.. || . |.  |.||||||.||...  .     ..|. ||| |.  .             |.  |.  |.
EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVS

TRWYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGN
|||||||||| |. .|. .||||..|| . |.. | |.|.| ..|.|.|||   ||.
TRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGT
Kinase CDKL2.AA Pkinase_Tyr 4-214 28 4.3e-23 78.83 Pfam 1-228 (270) Show / Hide 
Range on Protein: 4-214
Range on HMM: 1-228/270
Sequence Identity: 28% (66 aa)

YENLGLVGEGSYGMVMKCRNK----DSGRIVAIKKFLESDDDKM--VKKIAMREIKLLKQL-RHENLVNLLEVCK-KKKR--WYLVFEFVDH-TILDDLK
 . .   |||..|.|.|.. |    . .  ||.|.  |. ...    ..    |.|..||| .|.|.|.|. ||  ...   .|.|.|.. |   || |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

LF---PNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVAT------RWYRAPELLVGDVKYGKAV
     .. |. .   .. .|| .|  . .|.|.||||.   |.||. ..||| |||| ||..  . . |  ....      .|. ||| .   . .  . 
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKS

DIWAIGCLVIEMLM-GQPL-FPGESDIDQLHHI
|.|. | |  |..  |.   .|| |. . ...|
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase CDKL2.AA TyrKc 4-289 22 2.3e-19 71.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQL--RHENLVNLLEVCKKK-------KRWYLVFEFVDHTILDDLKLF
 . .   ||| .| |.|.. |   . ||.|.  |.      ..  |||......|  .|.|.|.|. || ..       .  ..|.|...|  |.|    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

PNG-LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAP------GEVYT------DY--VATRWYRAPELLVGDVKY
. . |  .   .. .|| .|  . ||.|.||||.   |.||.  ..|| .||| .| .         ...|.          .  ||. ||| .  . |.
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

GKAVDIWAIGCLVIEML-MGQPLFPG-----ESDIDQLHHIMTCLGNLIPRH----QELFYKNPVFAGVRLPEVKDAEAEPLESRYPKLPEAVISLAKKC
  . |.|. | .  |..  ||.  ||      |... ......     .| .                               .  .  |... .. |.|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------F--VCCPDEMYQIMKQC

LHIDPDKRPFCADLLRHDFF
 | ||..||  ...  |..|
WHEDPEDRPTFSEI--HECF
Kinase CDKL2.AA CDK 257-289 39 1.6e-07 19.93 In-house 254-284 (284) Show / Hide 
Range on Protein: 257-289
Range on HMM: 254-284/284
Sequence Identity: 39% (13 aa)

KLPEAVISLAKKCLHIDPDKRPFCADLLRHDFF
|||.    |  |.|  ||.||  . . | |..|
KLPDY--DLLNKMLCYDPKKRISAEQALQHPYF
Kinase CDKL2.AA MAPK 250-289 34 0.000245 10.65 In-house 285-328 (328) Show / Hide 
Range on Protein: 250-289
Range on HMM: 285-328/328
Sequence Identity: 34% (15 aa)

PLESRYPK----LPEAVISLAKKCLHIDPDKRPFCADLLRHDFF
|.|. .|.         | | .| |..|||||   .. |.| .|
PWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDKL2.AA CDK7 259-289 22 0.000467 6.22 In-house 258-288 (288) Show / Hide 
Range on Protein: 259-289
Range on HMM: 258-288/288
Sequence Identity: 22% (7 aa)

PEAVISLAKKCLHIDPDKRPFCADLLRHDFF
..  . | .. .  .| ||  |.. | ...|
SDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDKL2.AA CDK5 247-289 29 0.002999 5.58 In-house 244-287 (287) Show / Hide 
Range on Protein: 247-289
Range on HMM: 244-287/287
Sequence Identity: 29% (13 aa)

EAEP-LESRYPKLPEAVISLAKKCLHIDPDKRPFCADLLRHDFF
.|.. ...  ||| |    | .| | ..|..|   .. |.| .|
PAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDKL2.AA CDC2 247-289 25 0.006758 4.15 In-house 250-301 (301) Show / Hide 
Range on Protein: 247-289
Range on HMM: 250-301/301
Sequence Identity: 25% (13 aa)

EAEPLESRYPK---------LPEAVISLAKKCLHIDPDKRPFCADLLRHDFF
..  |..  |.         |..  |.| .. |..|| || .  . |.| .|
KPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase CDKL2.AA CDK-Unclassified 270-289 30 0.033156 2.9 In-house 305-324 (324) Show / Hide 
Range on Protein: 270-289
Range on HMM: 305-324/324
Sequence Identity: 30% (6 aa)

LHIDPDKRPFCADLLRHDFF
.. .|..|. |  .| |  |
VMYQPYNRWKCMEILQHPWF