Gene CDKL3 (Mouse)

CDKL3

Species: Mouse
Alias: Cdkl3, CDKL3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
CDKL3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 283 Kinase domain by global Sugen HMM Fasta, JSON
CDKL3.NA RNA Sugen 2007 None Fasta, JSON
CDKL3.AA Protein Sugen 610 None Fasta, JSON

Protein domain

Protein domains of CDKL3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDKL3.AA CDKL 4-286 56 2.8e-201 674.95 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-286/286
Sequence Identity: 56% (163 aa)

YETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYE-KPEKSVNKIATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRL
||.||||||||||.||||..|.||.|||||.|.| .....|.||| ||||.|||..|||.||||||||.|.|.|||||..|||||.||..|..|......
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

RKYLFQILRAIEYLHNNNIIHRDIKPENILVS-QSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGHPFL
|||..|||.||...|..|.|||||||||||.. ..|..|||||||||.||.||..|||||||||||||||...||.|||||||||.||...||..|.|..
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQVQHPKTARKKYPKLN-GLLADIVHACLQIDPAERTSSTDLLRHDYF
|..||.|.|..|. ..|.|.|. ..||||.|.|.|...|...|.....|.||... ....|....||..||.||.....|..|.||
PGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase CDKL3.AA CMGC 4-286 21 5.9e-113 372.71 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-513/513
Sequence Identity: 21% (110 aa)

YETLGKVGEGSYGTVMKCKH--------------KDTGRIVAIKIFY-EKPEKSVNK----------IATREIKFLKQFR-----------------HEN
|| ..|.|||.||.| ||..              ..|..|||||..  .. ..   |          .| ||||.||...                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNLIEVFRQKK-----------------KIHLVFEFIDHTVLDELQH--------YCHGLESKR------------LRKYL------FQILRAIE--YL
.|.|...|. |.                 ...||||..||. .. ...        . ..|.                ....      .||||...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HNNN--IIHRDIKPENILVSQSGIT--------------------KLCDFGFARTLAAPGDV---------------------YTDYVATRWYRAPELVL
| ..  |||||.||||||... .                      |.||||.|| .  . |.                     ||.||.||||||||. |
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

KD---------TSYGKPVDIWALGCMIIEMATG--------HPFLP-----------SSSDLDLLHKIVLKVGNLT---------------PH-------
 .         . |..|.|.|..||.. || ||        .|. |            .|..| |.||.   |. |               .        
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------LHNIFSKSPIFAGVVLPQVQ--HPKTARKKYPK--------------------------------LNGLLADIVHACLQIDP
                   ...| . .|. .  .|...  . |   ...|.                                .. .. | .  .||.||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

AERTSSTDLLRHDYF
..| .  . |.|.||
DKRITAEQALQHPYF
Kinase CDKL3.AA S_TKc 4-286 31 1.4e-97 331.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-231/231
Sequence Identity: 31% (93 aa)

YETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDH---TVLDELQHYCHG----
|| | |.|.|..|.|.||.||.|||||||||          . . |||. ||. .|.|.|.|..||.  .....|.|..|.   ...| .... ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGK-PVDIWALGCMIIEM
 .   . |.|. ||..|.||.|...|||||.||||||...    |.||||.|| |       | .. |.||.|||..    .||| ..|.|..||...||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

ATGHPFLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQVQHPKTARKKYPKLNGLLADIVHACLQIDPAERTSSTDLLR-------HDYF
..| |  |   ..... |...                                           . |..  ||| ||..| .  ..|.       | .|
LCGYPPFP---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDKL3.AA CDK 4-286 32 1.7e-96 309.24 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-284/284
Sequence Identity: 32% (104 aa)

YETLGKVGEGSYGTVMKCKHKDTG-----RIVAIKIFY------EKPEKSVNKIATREIKFLKQFRHENLVNLIEVFRQK-----------KKIHLVFEF
|| | |.|||.||.| |...|.||     .|||.| .       |. .  ..  | |||. ||.  |.| |.|..|. .|           .|. .|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

IDHT---VLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGI-----TKLCDFGFARTLAA------PGDVYTDYVATRWYR
.||    ..|              . |..|.||...|.| |.|.|||.|| |||..  |.      |. |||.||          |  .||  | |.|||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

APELVLKDTSYG--KPVDIWALGCMIIEMAT---GHPFLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQVQHPKTARKKYPKLNGLLADI
|||| | .. |.   |.|.|..|| ..||.|   . |..| .|..| |.||    |  |.     ..| | .                          | 
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DL

VHACLQIDPAERTSSTDLLRHDYF
   .|. ||. | |... | |.||
LNKMLCYDPKKRISAEQALQHPYF
Kinase CDKL3.AA Pkinase 4-286 30 3.2e-93 320.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-293/293
Sequence Identity: 30% (93 aa)

YETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKS-VNKIATR--EIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHT----VLDELQH--YC
|....|.|.||.|.| ||.||.||.|||.||.  . ||| ......|  ||. .| ..|.| | |...|. |..|..|.|. ...     | .. .  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HGL--ESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGIT----KLCDFGFARTL-AAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWAL
 ..  . . ...|. ||||..||.|...|||||.||||||... | .    |.||||.|. .   ..  .|... |.||.|||...... ||..||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCMIIEMATGHPFLPSS----SDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQVQHPKTARKKYPKLNGLLADIVHACLQIDPAERTSSTDLLRH
||...||..|.|  |..    . .| ...|... |  ..      .  . |  .   .    . .... ....  . |..  ||. ||..| . ...| |
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

DYF
..|
PWF
Kinase CDKL3.AA RCK 4-214 35 3.1e-75 238.08 In-house 1-227 (298) Show / Hide 
Range on Protein: 4-214
Range on HMM: 1-227/298
Sequence Identity: 35% (81 aa)

YETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFR-HENLVNLIEVFRQKK--KIHLVFEFIDHTVLDELQH---YCHGL
| .. ..|.|.||.||| . |.|| |||||    | ..    .  ||||.|. .  |.|...|.||.|...    ..|||. |  .   ...     . |
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

ESKR--LRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQ---------SGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWA
 ..   ......||| .....|.... |||.|||||...          ... |..||| .|        ||||| ||||||||. |..| | .|.||||
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRS-KPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWA

LGCMIIEMATGHPFLPSSSDLDLLHKIV
.|| ..|  . .|  | || .| ..||.
VGCIMYELYMLRPLFPGSSEIDQIFKIC
Kinase CDKL3.AA CDC2 4-213 38 5.8e-75 229.69 In-house 1-221 (301) Show / Hide 
Range on Protein: 4-213
Range on HMM: 1-221/301
Sequence Identity: 38% (86 aa)

YETLGKVGEGSYGTVMKCKHKDTGRIVAIK-IFYEKPEKS--VNKIATREIKFLKQFR-HENLVNLIEVFRQKKKIHLVFEFIDH---TVLDELQHYCHG
|. . |.|||.|| | |||...|..|||.| |  |  .    |   | |||  ||  . |.|.| | .|. | .|. .|||..|.     .|...     
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYT--DYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEM
...  ...|..|||......| . |.|||.|| |||.. .|  |. ||| ||.   | ..||    | |.||||||. | .  |  |||.|..|| ..||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ATGHPFLPSSSDLDLLHKI
   .| .|. .  |  | | ||
FMDVTKKPLFHGDSEIDQLFKI
Kinase CDKL3.AA CDK5 4-286 32 5.8e-71 223.31 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 32% (94 aa)

YETLGKVGEGSYGTVMKCKHKDTGRIVAIK-IFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRL
|| . |.||| |||| | . |.|. |||.| .  .     |   | |||  ||  .|.| | |. |    ||. |||||.|      .     ... .  
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMA-TGHPFL
. ...| |. ... |.... ||| || | |... |. || ||| ||    |   |.  | | |||.|   .    |  ..|.|  || . ||| .| |  
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQVQHPKTA--RKKYPKLNGLLADIVHACLQIDPAERTSSTDLLRHDYF
| ... | | .|   .|  .       .| | .   . .   .| .    .  |||.. . |. .  ||..|..| |  . |.| ||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDKL3.AA STE 4-286 22 4.5e-63 215.87 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-359/359
Sequence Identity: 22% (85 aa)

YETLGKVGEGSYGTVMKCKHKD---------------TGRIVAIKIFYEKPEK----------------SVNKIATREIKFLKQFR--HENLVNLIEVFR
.| ..|.|.|..||| |.....               ||.|.|||.   ....                .  .   .|||..|...  |.| |. .  . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QK-------KKIHLVFEFIDH-TVLDELQHYCHGLES-------------KRLRKYLFQILRA-IEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFAR
..        ..... |..|  .. | ..|..  ...             . ......|||..  .|||...|||||||| |||.      ||||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

TLAA---------------PGD-VYTDYVATRWYRAPELVLK-----DTSYGKPVDIWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVGNLT------
 |.                 ..   .  | |  . ||| ...     |  |.  .||| |||.|||||||.| .   ...  .  |  . .         
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

------PHLHNIFS-----------KSPIFAGVVLPQVQHPKTARKKYPKLNGLLADIVHACLQIDPAERTSSTDLLR--HDYF
      | | . .|           . .                     |.   . | .  |||.|| .| ....||.  |  .
IVNGPPPPLPDHLSQNEMISYGGSGT-T------------------YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase CDKL3.AA MAK 4-214 30 2.1e-62 197.32 In-house 1-261 (352) Show / Hide 
Range on Protein: 4-214
Range on HMM: 1-261/352
Sequence Identity: 30% (81 aa)

YETLGKVGEGSYGTVMKCKH------------------------------KDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFR-HENLVNLIEVFR--
| .. ..| |.||.||. |                               .||| .||||    |       .  ||.|.||    | |.| | ||.|  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

QKKKIHLVFEFIDHTVLDELQHYCH-GLESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQS-----------------GITKLCDFGFARTLAA
   . ..|||..     . . .     .    .|  ..||| .. ..| ..  |||.|||||... .                  . |. ||| || .  
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

PGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGHPFLPSSSDLDLLHKIV
    ||||| ||||||||  |. |.|..|.|.||.||   |. |  |  | ||  | . ||.
K-PPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKIC
Kinase CDKL3.AA ERK7 4-286 35 1e-61 209.74 In-house 1-292 (292) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-292/292
Sequence Identity: 35% (104 aa)

YETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIAT-REIKFLKQFR-HENLVNLIEVFRQK--KKIHLVFEFIDHTVLDELQHYCHGLES
|| . ..| | || | |   | |. .||.|  .     ..    | ||| ||..|. |.|.. ||.|.| .  . | ||||| . | |       . |. 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFME-TDLHAVIRKGNILKD

KRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPG------DVYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIE
   .  ..|.|||| |.|  |.||||.|| |||.      |.|||| ||..|          . |.|||||||||||  |  . | | || | .|| . |
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

MATGHPFLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQV--QHPKTARKKYPKLNGLLADIVHACLQIDPAERTSSTDLLRHDYF
| .| |  | .| .. . ||.  ...  |   .| .  . .| ..| |.  |..||  . .|.      |.. . |.  | .| . .. |.| | 
MLRGKPMFPGTSTMNQIEKILETIPK--PTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase CDKL3.AA CDK7 105-213 45 1.2e-50 132.82 In-house 107-215 (288) Show / Hide 
Range on Protein: 105-213
Range on HMM: 107-215/288
Sequence Identity: 45% (50 aa)

YLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGHPFLPSS
|  ..|. .||.| | | |||.|| | |... |. |. ||| ||   .|  .||  | |||||||||     .||  ||.|. || . |     |.||  
YMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGD

SDLDLLHKI
||.| | .|
SDIDQLTRI
Kinase CDKL3.AA CDK7 4-83 40 3.7e-29 74.46 In-house 1-85 (288) Show / Hide 
Range on Protein: 4-83
Range on HMM: 1-85/288
Sequence Identity: 40% (34 aa)

YETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFY-----EKPEKSVNKIATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFID
||.. ..||| ..|| |   . ||.|||||        .  .  .|  | |||| |.  .|.| ..|| .| .|  | |||.|.|
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMD
Kinase CDKL3.AA Pkinase_Tyr 4-196 29 1.9e-22 76.66 Pfam 1-209 (270) Show / Hide 
Range on Protein: 4-196
Range on HMM: 1-209/270
Sequence Identity: 29% (64 aa)

YETLGKVGEGSYGTVMKCKHK----DTGRIVAIKIFYEKPEKS---VNKIATREIKFLKQF-RHENLVNLIEVFR-QKKK--IHLVFEFIDH-TVLDELQ
 . . | |||..|.|.|.. |    .|.  ||.|.  |.  ..     .    |.| .||. .|.|.|.|. |   |..   | .|.|.  |   || |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

HY---CHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVAT------RWYRAPELVLKDTSYGKPV
      . |  |.| .. .|| .. |||...|.||||.   |.||. ... | |||| ||..  . | |  ....      .|. |||       .    
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKS

DIWALGCMIIEMAT
|.|. |  . |. |
DVWSFGVLMWEIFT
Kinase CDKL3.AA TyrKc 4-286 23 1.2e-16 46.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

YETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQF--RHENLVNLIEVFRQK-------KKIHLVFEFIDHTVLDELQHYC
 . . | ||| .|.|.|.. |   . ||.|   |     .  .  ||.. ....  .|.|.|.|. | .|.       . . .|.|. .|  |..  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFM-REARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

HG-LESKRLRKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAP------GDVYT------DY--VATRWYRAPELVLKDTSYG
.. |  | | .. .|| .  |||| .|.||||.   |.||.  .. | .||| .| .         .|.|.          .  ||. ||| ....  . 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APE-CINYGKFT

KPVDIWALGCMIIEMAT-GHPFLPS-----SSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQVQHPKTARKKYPKLNGLLADIVHACLQIDPAE
   |.|. | .. |. | | .  |       |. .....  .| |.  |  .|.    |.                  ..     . .|   | . ||..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEY--VKQGYRMPQPPNDY---PMS-----------------FVCCPDEMYQIMKQCWHEDPED

RTSSTDLLRHDYF
| . ...  |..|
RPTFSEI--HECF
Kinase CDKL3.AA RCK 261-286 34 5.2e-07 17.98 In-house 273-298 (298) Show / Hide 
Range on Protein: 261-286
Range on HMM: 273-298/298
Sequence Identity: 34% (9 aa)

DIVHACLQIDPAERTSSTDLLRHDYF
.... .||.|| .| .   .|.| ||
ELMEKMLQWDPQKRITAQQALQHPYF
Kinase CDKL3.AA CDC2 267-286 50 1.7e-05 12.27 In-house 282-301 (301) Show / Hide 
Range on Protein: 267-286
Range on HMM: 282-301/301
Sequence Identity: 50% (10 aa)

LQIDPAERTSSTDLLRHDYF
||.||. | |. . |.| ||
LQYDPQKRISAKEALQHPYF
Kinase CDKL3.AA MAK 261-286 26 2.8e-05 12.28 In-house 327-352 (352) Show / Hide 
Range on Protein: 261-286
Range on HMM: 327-352/352
Sequence Identity: 26% (7 aa)

DIVHACLQIDPAERTSSTDLLRHDYF
...  .|| || .|    ..... ||
ELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase CDKL3.AA CDK7 267-286 30 3.7e-05 9.2 In-house 269-288 (288) Show / Hide 
Range on Protein: 267-286
Range on HMM: 269-288/288
Sequence Identity: 30% (6 aa)

LQIDPAERTSSTDLLRHDYF
.  .| .|.. |. | ..||
WTMNPCKRWTCTQCLKMPYF