Gene CHK1 (Mouse)

CHK1

Species: Mouse
Alias: CHK1, Chek1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CHK1

Sequence

Name Sequence Type Origin Length Description Download
CHK1.AA Protein Sugen 476 None Fasta, JSON
CHK1.NA RNA Sugen 3397 None Fasta, JSON
CHK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of CHK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CHK1.AA CHK1 9-265 53 1e-186 626.56 In-house 1-276 (276) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-276/276
Sequence Identity: 53% (148 aa)

WDLVQTLGEGAYGEVQLAVN-RITEEAVAVKIVDMKRAI--DCPEN-IKKEICINKMLS----HENVVKFYGHRREGHIQYLFLEYCSGGELFDRIEPDI
...||||||||.|.|.|..| | .|||||.|....|..   ....| |.||.||.||||    ||||....|.|......|||.||..||.|||.||||.
YEVVQTLGEGAFGQVKLCENQRNPEEAVAMKEIHIKGQHKMCFMDNDIRKEYCIQKMLSKIGKHENVIRMMGMRMDPEFYYLFMEYADGGDLFDKIEPDC

GMPEQDAQRFFHQLMAGVVYLHGIG-ITHRDIKPENLLLDERD------NLKISDFGLATVFR-HNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVW
|||...|.|.|.||..|..|.|..| .|||||||||||||..|      ||||.||||||..| |...||.|.|.|||.||.|||....|.....|||.|
GMPSDEAHRYFKQLISGLKYIHCCGGVTHRDIKPENLLLDKHDSNDMPDNLKIADFGLATWYRRHDGEERMLDKRCGTPPYMAPEVCTGKQYRGPPVDIW

SCGIVLTAMLAGELPWDQPS-DSCQEYSDWKEKK--TYLNPWKKIDSAPLALLHKILVETPSARITIPDIKKDRWY
|||.||.|||.||||||||| ..||||..|...|  ....||.|||.....||.|||.|.|..|.||..|.||.||
SCGVVLMAMLTGELPWDQPSHMDCQEYCWWMDNKHWMHWCPWSKIDCRAICLLRKILCENPNKRATIEQIEKDPWY
Kinase CHK1.AA CAMKL 9-265 36 9.20000000001e-129 413.11 In-house 1-297 (297) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-297/297
Sequence Identity: 36% (109 aa)

WDLVQTLGEGAYGEVQLAVN-RITEEAVAVKIVDMKRAIDCPENIKK--------------EICINKMLS---HENVVKFYGHRREGHI------QYLFL
.....|||.|..|.|.||.. |.|.| ||.||.| |.. . | . |.              ||.| |||.   |.|..|.| ..            ||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCSGGE--LFDRI--EPDIG--MPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERD--NLKISDFGLATVFR-H-NNRERLLNKMCGTLPYV
|||||||  |||.|  ... .  ||| .|.|.| |....| |.|  || ||||||||.||||..  |.||.|||... .| . ......|.  ||..|| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APELLKR--KEFHAEPVDVWSCGIVLTAMLAGELPWDQPSD-----SCQEYSDWKEKK-TYLNPWKKIDSAPLALLHKILVETPSARITIPDIKKDRWY
|||....  |.... .||.||||..| ||. |.||.|....     ... |  ||... .| ..|....     |..|.|.  |. |.|| .|....|.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCGYYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase CHK1.AA CAMK 14-265 22 8.4e-102 328.85 In-house 1-425 (425) Show / Hide 
Range on Protein: 14-265
Range on HMM: 1-425/425
Sequence Identity: 22% (97 aa)

TLGEGAYGEVQLAVNRITE------------EAVAVKIVDMKRAID---------------------------CPENIKKEICINKMLS-------HENV
|||.|..|.| |.... |             . ||.||.| |.. |                             .|...||.| |.|.       |.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFYGHRREGHI-------------------QYLFL---EYCSGGEL----FDRI--EPD-------------IGMPEQDAQRFFHQLMAGVVYLHGIGI
.|.| .   .|                     |...   ||||||||    ||.|   ..               ..|..|.|.|.|.  .| |.|  .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

THRDIKPENLLLDERD-----------------NLKISDFGLATVFRHNNRER---------------------LLNKMCGTLPYVA-PELLKR------
 |||.||||.|||...                 |.||.|||.|..|.... ..                     ... .|||..|.| ||.|..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------KEFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEY-----------------SDWKEKKTYLNP---------WKKIDSA--------PLA
       |. . ...|.||||..| .|| |..|.. ..|....                   ..     |. |         |..|              
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLHKILVETPSARITIPDIKKDRWY
|. |.|.  |. |.|| ..... |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CHK1.AA S_TKc 9-265 30 2.8e-87 297.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-231/231
Sequence Identity: 30% (82 aa)

WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAIDCPENIKKEICINKMLSHENVVKFYGHRREGHIQYLFLEYCSG--GELFDRIEPDIG-----
.......|.||.|.| ..... | . ||.||..        |.|..|| | |.  |.|.||.|.. .. .  |...|||.|  |.|||.|.   .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-MPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLTA
 .|| .|.....|.  .. |.|  || |||.||||.||||  ..||.|||||...         . .|||. |.|||.|    .  ...|.||||..|  
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVETPSARITIPDIKK-------DRWY
||.|. |..       ..    .|          ..  . .. |.|.  |. |.|. .. .       . | 
MLCGYPPFP-------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CHK1.AA Pkinase 9-265 26 4.6e-75 260.47 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-293/293
Sequence Identity: 26% (78 aa)

WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAID-CPENIKK--EICINKMLSHENVVKFYGHRREGHIQYLFLEYCSGG----ELFDRIE--PD
. .....|.|..|.| ..... |.. |||||.. ... . ....  .  ||.| |.|.|.|.|..|.  ...   |. .||| ||    .|||.|.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

IGM--PEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL----KISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWS
 ..  .|....... |.  |. |.|  || |||.||||.|.|.....    ||.||||| .|. . . . ..  |||..|.|||...  . .  .||.||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

CGIVLTAMLAGELPWDQP----SDSCQEYSDWKEKK--TYLNPWKKID-------------------SAPLALLHKILVETPSARITIPDIKKDRWY
||..|  || |..|...     .  .| .   . ..  .  . .....                   .. . .. ..|   |. |.|...|... | 
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CHK1.AA MARK 9-224 38 4.5e-70 228.29 In-house 1-219 (262) Show / Hide 
Range on Protein: 9-224
Range on HMM: 1-219/262
Sequence Identity: 38% (87 aa)

WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAID-CP-ENIKKEICINKMLSHENVVKFYGHRR---EGH-IQYLFLEYCSGGELFDRIEPD--I
  ...|.|.|.|..| ||... |.. ||.||.. ..  | .  .|.. || | |.|.|.|..|..       |.| | || .||.|||||.|.|.     
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQI-YLIMEYASGGELYDYIKAHPNG

GMPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERD--NLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVL
 ..| .| |.|.|.  .| |.| ..| ||||||||.|.||.   | ||.|||... .   . ...||  |||.|| |||....|.  . .||.||.|.||
RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICI---PPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVL

TAMLAGELPWDQPSDSCQEYSDWKEK
 .|. | .|.|   ...|.| . ..|
YFMVCGYFPFD---GDTQDYKELYKK
Kinase CHK1.AA AMPK 9-209 40 2.1e-65 193.15 In-house 1-201 (254) Show / Hide 
Range on Protein: 9-209
Range on HMM: 1-201/254
Sequence Identity: 40% (82 aa)

WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAID--CPENIKKEICINKMLSHENVVKFYGHR-REGHIQYLFLEYCSGGELFDRIEPDIGMPEQ
  . .|.|||..| | ...  .| |.||.|| . .. .|    | |..|| | |.. | .... |          ....|| ||||||| |     ..|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

DAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAGE
.|.||| |  .|| |.| ..| ||| ||||||||.  |.|| ||||  .   .    .|   ||   | |||.   |      ||.||||..| ||| | 
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDG---EFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGY

LPWD
|| |
LPFD
Kinase CHK1.AA Ciliate-E2 9-265 23 5.1e-56 190.78 In-house 1-365 (365) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

WDLVQTLGEGAYGEVQLAVNRITEE------------------AVAVKIVDMKRAI-DCPENIKKEICINK----------------MLSHENVVKFYGH
 .... .|.|..| | .. .. . .                   |..||. ||. . .  |.||.|| |..                 |.| |..|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

RR---EGHIQYLFLEYCSGGELFDRIE--PDIG---------MPEQDAQRFFHQLMA---------------GVVYLHGIG-ITHRDIKPENLLLDERDN
     . .| || .|||.||.|||.|.  .            . |. ..... |.                 .. |||  . | ||||||||.|.     
FQEKDDNNI-YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LKISDFGLAT------------------VFRHNNRERLLNKM------------CGTLPYVAPELLKRKEF--------HAEPVDVWSCGIVLTAMLAGE
.||.||||..                   | .|...|   .|            |||..|.||| |..|.         . . .|.||.|..|  || |.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

LPWDQPSDSCQEYSDWKEKKTYLN----------------PWKKIDSAPLALLHK----ILVETPSARIT-IPDIKKDRWY
.|.         .   |..|  ..                 |||..     |. |    .|.  |. ||| . .|..  | 
PPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CHK1.AA GIN4 49-265 39 7e-56 176.78 In-house 78-293 (293) Show / Hide 
Range on Protein: 49-265
Range on HMM: 78-293/293
Sequence Identity: 39% (86 aa)

PENIKKEICINKMLSHENVVKFYGHRREGHIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDN-LKIS
| .| .|| | |..|| ||.. |    .    || |||  .||||. .     .||..| ..|.|.. || | | ..| |||.||||||||.. | .|| 
PYGIEREIVIMKLISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIA

DFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWK-KIDSAPLALLHKIL
|||.| .  .|.   ||.  ||   | |||.     .|  . ||||||..| |.| | ||.|.     ..      |  |  |   .| .    |. |||
DFGMAALETDNK---LLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKIL

VETPSARITIPDIKKDRWY
|  |  ||.. || |    
VVDPEKRIKTRDILKHPLI
Kinase CHK1.AA QIK 9-213 38 4.5e-54 185.96 In-house 1-223 (272) Show / Hide 
Range on Protein: 9-213
Range on HMM: 1-223/272
Sequence Identity: 38% (88 aa)

WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAIDCPENIKK---EICINKMLSHENVVKFYGHRREGHIQYLFLEYCSGGELFDRIEP-------
 |. .|.| | .. | || .||| . ||.||.| | ..|  ||..|   |. | |||.| ...| |   .     |.  ||||.||.|| .         
YDIERTIGKGNFAVVKLARHRITKTKVAIKIID-KSQLDE-ENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVK

-----DIG--------MPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFH
     |||        |.|..|.| | |....| |.|  .| |||.| ||.|||.  | || |||.   |     . ||.  ||. || |||... ||. 
MVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQ---GQLLMTWCGSPPYAAPEMFEGKEYD

AEPVDVWSCGIVLTAMLAGELPWDQPSD
   ||.|| |.|| .. .| || | ...
GPKVDIWSMGVVLYVLVCGALPFDGKTL
Kinase CHK1.AA MELK 9-265 31 2e-52 177.34 In-house 1-254 (254) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-254/254
Sequence Identity: 31% (81 aa)

WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAIDCPENIKKEICINKMLSHENVVKFYGHRREGHIQYLFLEYCSGGELFDRIEPDIGMPEQDAQ
... ...| | .. |.||.  .|.. ||.||.| ..  .    .| |.   | |.|... ..|      .  .. .|||.|||.|| |     . |....
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETR

RFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAGELPW
 || |... . |.|  |  |||.||||||.||  .||. ||||    . .  .  |.  || . | ||||.. |..  .  |||| ||.| ... | ||.
HFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPF

DQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVETPSARITIPDIKKDRWY
|   |  .       .  |  | | .      ||...|   |  || . .. .  | 
DD--DNMMIMYKKIMSGCYEEP-KWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase CHK1.AA ULK 9-265 24 2.3e-50 173.65 In-house 1-329 (329) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-329/329
Sequence Identity: 24% (80 aa)

WDLVQTLGEGAYGEVQLAVNRITE----EAVAVKIVDMKRAIDCPEN---------IKKEICINKMLS--------HENVVKFYGHRREGHI--QYLFLE
. | . ||.|..| |  . | .|.    |.||.|..| .  .  . .         .|.|| | |.|         |.|.||.|   .. .    |...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCSGGELFDRIEPDIGMPEQD----------AQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDN------------LKISDFGLATVFRHN-NRER
|| || |.. |. . ..||.           |. ||.|...|  .||  .| ||||||.| |... .             |||.|||.| ..  . . ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LLNKMC------GTLPYVAPELLK----RKEFH-AEPVDVWSCGIVLTAMLAGELP---WDQPSDS---CQEYSDWKEKKT----YLNPW-------KKI
..  .       ||  | ||..|.    .|... .. .|.|| |...  || |. |   |   ..    .|.  ... .        ..        ..|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYK-CDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

DSAPLALLHKILVETPSARITIPDIKKDRWY
 .    |. . |.  .. ||..... .  | 
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase CHK1.AA TyrKc 9-264 23 1e-15 31.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-264
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAIDCPENIKKEICINKML--SHENVVKFYGHRREG-------HIQYLFLEYCSGGELFDRIEPD
  | ..|||||.||| ... .   . |||| .         | . .|. | ..|  .|.|.|..||  ...       .  .. .||...| | |..   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

IG-MPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRHN----NRERLLNKM---CGT--LPY--VAPELLKRKEFHAE
 .  . .|   | .|  .|  |||  .. |||.   | |..|.   |||||||.    .      ..    |.   .|   ||.   ||| .. ..|  .
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

PVDVWSCGIVLT--AMLAGELPWD---QPSDSCQEYSDWKEKKTYLNPWKK--------IDSAPLALLHKILVETPSARITIPDIKKDRW
  |||| |...     . .. ...   |   | ||   . ..  .. . .           ..   .  .   | |. | |  .| ....
-SDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase CHK1.AA Pkinase_Tyr 9-152 30 3.4e-12 41.91 Pfam 1-158 (270) Show / Hide 
Range on Protein: 9-152
Range on HMM: 1-158/270
Sequence Identity: 30% (49 aa)

WDLVQTLGEGAYGEVQLAVNR----ITEEAVAVKIVDMKRAIDCP----ENIKKEICINKML-SHENVVKFYGHRR-EGHI--QYLFLEYCSGGELFDRI
  . ..|||||.||| ... .     |.  ||||..  |   . .    |   .|. | | | .|.|.|..||    .|     |. .||. .| | |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

EP----DIGMPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLA
      .   . .|   . .|  .|  ||. ... |||.   | |..|    ||.|||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase CHK1.AA GIN4 9-45 45 4.1e-09 24.8 In-house 1-37 (293) Show / Hide 
Range on Protein: 9-45
Range on HMM: 1-37/293
Sequence Identity: 45% (17 aa)

WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRA
| | .||| |. | |||| |  | .  |||..  |..
WKLGETLGFGSTGKVQLAKNMETGQRAAVKVISKKKI
Kinase CHK1.AA AMPK 241-265 40 3.4e-07 17.47 In-house 230-254 (254) Show / Hide 
Range on Protein: 241-265
Range on HMM: 230-254/254
Sequence Identity: 40% (10 aa)

LLHKILVETPSARITIPDIKKDRWY
|....|   |  |||| ||... |.
LIKHMLQVDPMKRITIHDIRNHPWF
Kinase CHK1.AA MARK 241-265 36 4e-06 16.06 In-house 238-262 (262) Show / Hide 
Range on Protein: 241-265
Range on HMM: 238-262/262
Sequence Identity: 36% (9 aa)

LLHKILVETPSARITIPDIKKDRWY
|....|.  |. |.|| .| |..| 
LIQRLLTVNPEERPTIEEIMKHPWM
Kinase CHK1.AA QIK 241-265 40 0.017157 5.98 In-house 248-272 (272) Show / Hide 
Range on Protein: 241-265
Range on HMM: 248-272/272
Sequence Identity: 40% (10 aa)

LLHKILVETPSARITIPDIKKDRWY
|  . ||  |. |.||  |.. || 
LIRHMLVVDPEHRYTIMQICQHRWM