Gene COT (Mouse)

COT

Species: Mouse
Alias: Map3k8, COT
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE-Unique

Sequence

Name Sequence Type Origin Length Description Download
COT.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON
COT.AA Protein Sugen 467 None Fasta, JSON
COT.NA RNA Sugen 2507 None Fasta, JSON

Protein domain

Protein domains of COT.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase COT.AA STE-Unique 201-388 34 1.3e-103 350.54 In-house 367-616 (616) Show / Hide 
Range on Protein: 201-388
Range on HMM: 367-616/616
Sequence Identity: 34% (86 aa)

DTVHLFMEAGEGGSVLEKLESCGP---------MREFEIIWVTKHILKGLDFLHSKK--VIHHDIKPSNIVFMS------TKAVLVDFGLSVKMTED---
..|..|||..|.|.. .....||.         ..|.|.||.|..||.||..|||..  .||.|.||.||..|.      .|....|||.......|   
NWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFE

-----------------------------------VYLPKDLRGTEIYMSPEVILCR-----GHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYL
                                   .| .|...||..||.||||.||     ...||.||.|||....||..|.|||..||...||....
KDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMC

YIIHKQAP--PLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLKHEAL
..||.|.|  |.|.|. .|.|.....||..|||||.|||.|..||.|..|
IHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase COT.AA STE 138-388 25 2.8e-80 273.03 In-house 1-359 (359) Show / Hide 
Range on Protein: 138-388
Range on HMM: 1-359/359
Sequence Identity: 25% (92 aa)

NIGSGFVPRGAFGKVYLAQDMK---------------TKKRMACKLIPIDQFKP----------------------SDVEIQACFR--HENIAELYGAVL
  | ... .||||.||.| ..|               |...|| | ..... ..                       ...|  ...  |.|| . ||. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

WG-------DTVHLFMEAGEGGSVLEKLE-SCGPMR-------------EFEIIWVTKHILKG-LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVK
 .       |.....||  .|||. . ..  .|. .             | .|..... |||| |..|||...|| ||||.|| .    . |.|||.. .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

MTEDVY----------------LPKDLRGTEIYMSPEVILC------RGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYL--YIIH--------
.|...                   . . ||  .|.||||..       |..||.||.||| |.|.| || ||| . .| .|.   .  |...        
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--KQAPPLEDIAG----------------DCSPGMRELIEAALERNPNHRPKAADLLK--HEAL
  .. |||.|                    .|| ... |.  |...||.||.| .|||  |. .
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
S_TKc COT.AA S_TKc 133-388 26 1.3e-57 198.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 133-388
Range on HMM: 1-231/231
Sequence Identity: 26% (71 aa)

KLTYRNIGSGFVPRGAFGKVYLAQDMKTKKRMACKLIPIDQFKPSDVEIQACFRHENIAELYGAVLWGDTVHLFMEAGEG--GSVLEKLESCGP------
    | ||     .|||||||.... ||....|.| |.  .   . ..|    .|.||  ||..    | ....||  .|  |.... ....|.      
YEILRKIG-----KGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MREFEIIWVTKHILKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVKMTEDVYLPKDLRGTEIYMSPEVILCRGHST-KADIYSLGATLIHMQTG
. | ..  ... |...|...||...|| |.||.|| . .    . ||||. ..       . . ||  ||.|||.   |... |.|..|.| .|. | .|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

TPPWVKRYPRSAYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLK-------HEAL
 ||.           .  ...|            || ....|.  |...|..|| | ..|.       |. .
YPPFP---------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase COT.AA Pkinase 146-388 25 4.1e-51 180.93 Pfam 9-293 (293) Show / Hide 
Range on Protein: 146-388
Range on HMM: 9-293/293
Sequence Identity: 25% (73 aa)

RGAFGKVYLAQDMKTKKRMACKLIPIDQFKP---------SDVEIQACFRHENIAELYGAVLWGDTVHLFMEAGEGG----SVLEKLE--SCGPM--REF
.|.||.||.... .| |. |.| |. .  |.         | ..| . ..|.|| .||...  .| ... ||  |||    .  . ..  . |..   | 
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEW

EIIWVTKHILKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-----LVDFGLSVKM-TEDVYLPKDLRGTEIYMSPEVIL-CRGHSTKADIYSLGATLIHMQ
|.. . . ||.||...||...|| |.||.|| . ..  .     . ||||. .. .     .... ||  ||.||||. ......|.|..|.| .|. | 
ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML

TGTPPWVKR--YPRSAYPSYLYIIHKQAPPLEDIAGDCS-------------------PGMRELIEAALERNPNHRPKAADLLKHEAL
.| ||.  .   .. . . ...   ...|. .|.  .||                   . ....|.  |...|. || |...|.|. .
CGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase COT.AA STE20 146-388 30 6.1e-45 155.63 In-house 9-288 (288) Show / Hide 
Range on Protein: 146-388
Range on HMM: 9-288/288
Sequence Identity: 30% (87 aa)

RGAFGKVYLAQDMKTKKR----MACKLIPIDQFK---PSDVEIQA-------CFRHENIAELYGAVLWG----DTVHLFMEAGEGGSVLEKLE---SCG-
.|..||||.| . .|..      | | ..... .   ..  .||        |  |.|| . ||. | .    |   . ||  .|||... ..   .|| 
QGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGK

-----PMREFEIIWVTKHILKGLDFLHSKKVIHHDIKPSNIVFMST-KAVLVDFGLSVKMTED---VYL-P-KDLRGTEIYMSPEVILC-----RGHSTK
     || | .|  ... .|.|||.|||...|| |||  ||   .  .. |.|||.. ..|.    .   . . . ||  .|.||||.|      |. .|
NHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYK

ADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYII--HKQAPPLEDI-AGDCSPGMRELIEAALERNPNHRPKAADLLKHEAL
.||.||| |.| | .| ||  .  | .|    ..|.   .. |.|.|.    .||  .....  |...|. || | .||||. .
CDIWSLGITAIEMAEGEPPYFDMHPMRAM---FMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase COT.AA STE11 146-388 30 6.2e-40 138.99 In-house 9-303 (303) Show / Hide 
Range on Protein: 146-388
Range on HMM: 9-303/303
Sequence Identity: 30% (91 aa)

RGAFGKVYLAQDMKTKKRMACKLIPI-DQFK----------P------SDVEIQA--CFRHENIAELYGAVL---WGDTVHLFMEAGEGGSVLEKLE-SC
.||||.||.. ...| ..|| | |.| .. .          .         ||.    ..|.||   ||. |     |.|  |||  .|||. . |.   
KGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSMLRHKW

GP--MREFEIIWVTKHILKGLDFLHSKKVIHHDIKPSNIVFMSTKAV---LVDFGLSVKMTEDVY--------------LPKDLR----GTEIYMSPEVI
||  . | .|   || ||.|| .|||...|| |||. || .. .. .   |.||| .... .. .              ... .     ||  .|.||||
GPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANI-LLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVI

LCRG---HSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPS------YLYIIH-KQAPP-LEDIAGDCS---PGMRELIEAALERNPNHRPKAADLLKH
   |   ...|||| |||.| | | || |||      . | .      . .. . |..||  |..    |   .  |. .   .|..|. || |..||.|
KQEGRDGYGRKADIWSLGCTVIEMATGKPPW------HNYDHNHMAAMFKIGMGHKPHPPIPEHMSP-ISWISEECRDFLRHCFEHDPKKRPTANQLLQH

EAL
  .
PFI
Kinase COT.AA ASK 144-388 31 3.2e-39 127.99 In-house 2-254 (254) Show / Hide 
Range on Protein: 144-388
Range on HMM: 2-254/254
Sequence Identity: 31% (82 aa)

VPRGAFGKVYLAQDMKTKKRMACKLIPIDQFKPS-----DVEIQACFRHENIAELYGAVLWGDTVHLFMEAGEGGSVLEKLESC-GPMR--EFEIIWVTK
. .|..| || . ||.|..|.| | ||  . . .     ....    ||.|| .  |..  .. ...|||   |||. . |.|  |||.  |  . . ||
LGKGTYGIVYAGRDMHTQVRIAIKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYTK

HILKGLDFLHSKKVIHHDIKPSNIVFMSTKAVL--VDFGLSVKMTEDVYLPKDLRGTEIYMSPEVIL--CRGHSTKADIYSLGATLIHMQTGTPPWVK-R
 ||.|| .|| ....| |||  |..      |.   ||| . ..     . .  .||  || ||||    ||.   |||.|.| |.. | || ||..   
QILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPPFHELG

YPRSAYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLKHEAL
 |. |   .   ..|. |.   |  . |   .. |  . | .|..|. |.|||. . |
EPQAAM--FKVGMYKKHPE---IPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase COT.AA CAMK 143-388 15 5.4e-39 122.8 In-house 1-425 (425) Show / Hide 
Range on Protein: 143-388
Range on HMM: 1-425/425
Sequence Identity: 15% (66 aa)

FVPRGAFGKVYLAQDMKTK------------KRMACKLIPID---------------------------------QFKPSDVEIQAC-------FRHENI
   ||.||||.|... .|.            .. |.| |. .                                 .. .. .||           .|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

AELYGAVL------------WGDT--------VHLFM---EAGEGG----SVLEKLESCGP---------------MREFEIIWVTKHILKGLDFLHSKK
  || .                ..        ....|   |  .||     ..... . |.               . | |   . . |. .....||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHHDIKPSNIVFMST------------------KAVLVDFGLSVKMTEDV-----------------------YLPKDLRGTEIYMS-PEVILC-----
..| |.|| || . .                   .  ..|||.. |....                         . |.  ||  ||. |||..      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------RGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYP----------------SYLYI-IHKQAPP-----LEDIAGDCSPG--------MR
         .... |.|. |.|  |  | .|.||.   .  . .                 .  |  .... .|      ... .| |           .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

ELIEAALERNPNHRPKAADLLKHEAL
 ||   |...|..|..... |.|. .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase COT.AA Ciliate-E2 146-388 19 6.8e-39 131.14 In-house 9-365 (365) Show / Hide 
Range on Protein: 146-388
Range on HMM: 9-365/365
Sequence Identity: 19% (74 aa)

RGAFGKVYLAQDMKTKKRM------------------ACKLIPIDQFKPSDVEIQA----CFR-------------------HENIAELYGAVL--WGDT
.|.||.||.... |..|.                   . |.. . ..|....|..      .|                   | || ..| .      ..
QGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNN

VHLFMEAGEGGSVLEKLESC-----------GPMREFEIIWVTKHILK---------------GLDFLHSKK-VIHHDIKPSNIVFMSTKAVLVDFGLSV
. | ||  .||. .. ....           ... |.||. ..|.||.               .| .||||. .|| ||||.||.|      ..||||| 
IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSK

KMTED----------VYLPKDL----------------------RGTEIYMSPEVILCRG---------HSTKADIYSLGATLIHMQTGTPPWVKRYPRS
| ..|            ..                          ||  ||.||..   .         ...|.||.||| .|  | .| ||.       
KYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------

AYPSYLYIIHKQAPPLED----------------IAGDCSPGMRELIEA----ALERNPNHRPK-AADLLKHEAL
      ....|| .   .                .  ..|. .  ||       |...|. |.  . ..|.|. .
------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase COT.AA SLK 142-388 32 6.3e-37 122.04 In-house 5-259 (259) Show / Hide 
Range on Protein: 142-388
Range on HMM: 5-259/259
Sequence Identity: 32% (85 aa)

GFVPRGAFGKVYLAQDMKTKKRMACKLIPIDQFKP-----SDVEIQACFRHENIAELYGAVLWGDTVHLFMEAGEGGSVLE-KLESCGPMREFEIIWVTK
| .  ||||||| ||.  .|.  | | | |..         ...| .   | || .||.|  . . . ...|  .|| | .  .|   |..|  |  | |
GELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCK

HILKGLDFLHSKKVIHHDIKPSNIVF-MSTKAVLVDFGLSVKMTEDVYLPKDLRGTEIYMSPEVILC-----RGHSTKADIYSLGATLIHMQTGTPPWVK
|.. .|..|||.|||| |.|  ||.. |  .  | ||| | | ....       ||  .| |||..|     .    ||||.||| ||| |  . ||   
HMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPPHHE

RYPRSAYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALERNPNHRPKAADLLKHEAL
  |       |  | |  ||        |   ..... .|...|. |. .|.|..|. .
MNPMRV----LLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase COT.AA TKL 144-386 17 2.5e-34 120.39 In-house 1-364 (364) Show / Hide 
Range on Protein: 144-386
Range on HMM: 1-364/364
Sequence Identity: 17% (66 aa)

VPRGAFGKVYLAQDMKTK--------KRMACKLIPIDQ-----------------------------FKPSDVEIQAC---FRHENIAELYGAVLWGDT-
. .|.||.|| .. . .         | .| | .....                             |.   .|   .   .||.||  ..|... ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------VHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHILKGLDFLHS--------KKVIHHDIKPSNIVFMS-TK--------------AV
             .. ||  .||| |. |          ..   . | .|...|||        ...|| |.|..||   .  .              . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

LVDFGLSVKMTEDVY-------------------LPKDLRGTEIYMSPEVIL----------------CRGHSTKADIYSLGATLIHMQTGTPPWVKRYP
. |||||  |...                          .||  .|.|||.                 ..  |.|.|.|| |  |  . |. .|. .  .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

RSAYPS-------YLYIIHKQAPPLE---------DIAGDCSPGMRELIEAALERNPNHRPKAADLLKHE
.. ...       .. . ... ||.              || |.|..|..   . .|. || . ..||. 
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase COT.AA MEKK15 178-388 31 3.5e-34 119.9 In-house 51-264 (264) Show / Hide 
Range on Protein: 178-388
Range on HMM: 51-264/264
Sequence Identity: 31% (69 aa)

DVEIQACFRHENIAELYGAVLWGDTVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHILKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVK
.|..    .| ||    |  |   .| .||.   |||.   .   ||. |      || ||.|  .||   |.| |||  |.. |.|  . |.|||   .
EVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKR

MTED------VYLPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIAGDCSPGMRELIEAALE
..          . | .|||  .| ||||   |.  |.||.|.| |   | |. |||    .  |    .. |  .  |. ..    |   |. ... | 
LCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVFEMATRKPPWADMDRMAA----MFYIGAHRDPMPQLPVKFSEDARMFVRMCLT

RNPNHRPKAADLLKHEAL
|  . || | .||||  .
RDQHERPTASQLLKHPFI
Kinase COT.AA STE-Unique 139-200 35 2.8e-25 86.34 In-house 1-73 (616) Show / Hide 
Range on Protein: 139-200
Range on HMM: 1-73/616
Sequence Identity: 35% (26 aa)

IGSGFVPRGAFGKVYLAQDMKTKKRMACKLIPIDQFK-----------PSDVEIQACFRHENIAELYGAVLWG
... ...||.||.|...|..|...|.|.|.|...|||           .|..||..|..|.||...||..|||
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWG
Kinase COT.AA TyrKc 146-388 21 4.8e-11 -44.05 SMART 9-280 (280) Show / Hide 
Range on Protein: 146-388
Range on HMM: 9-280/280
Sequence Identity: 21% (62 aa)

RGAFGKVYLAQDMKTKKRMACKLIPIDQFKPSDVEIQAC----F--RHENIAELYGAVLWG-------DTVHLFMEAGEGGSVLEKLESCGP-MREFEII
.||||.||... .|     | | .  |     |    |     .  .|.||  |||... .       . . . ||  ..|. .. | ...|     . .
EGAFGEVYKGT-WK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLL

WVTKHILKGLDFLHSKKVIHHDIKPSNIVFMSTK-AVLVDFGLSVKMTED--------VYLPK---DLR--GTEIYMSPEVILCRGHSTKADIYSLGATL
     | .| ..||||..|| |.   |.   . . .   ||||| . ..|        .| .|   . .       |.||.|  .  .|| |..| | ..
SFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCM

--IHMQTGTPPWV----KRYPRSAYPSYLYIIHKQAPPLEDIAGD-----CSPGMRELIEAALERNPNHRPKAADLLKHEAL
  |    ..|..     .  .. ..  |.   .   .| .|         |.. | ....   ...|. ||  ...  || .
WEIFTYGQQPYPGMIQQMMSNQEVI-EYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF