Gene DDR2 (Mouse)

DDR2

Species: Mouse
Alias: DDR2, Ddr2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: DDR

Sequence

Name Sequence Type Origin Length Description Download
DDR2.AA Protein Sugen 854 None Fasta, JSON
DDR2.NA RNA Sugen 3249 None Fasta, JSON
DDR2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 286 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of DDR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FA58C DDR2.AA FA58C 29-185 26 1.2e-45 158.87 SMART 1-199 (199) Show / Hide 
Range on Protein: 29-185
Range on HMM: 1-199/199
Sequence Identity: 26% (54 aa)

ICRYPLGMSGGHIPDEDITASSQWSE-------STAAKYGRLDSEEG-----DGAWCPEIPV------QPDDLKEFLQIDLRT-LHFITLV-GTQGR---
 |..|||| ||||||..|||||....        ......||. ...     |.||||. ..         .  .....||.. .|..|.| .|  |   
ECNEPLGMEGGHIPDWQITASSSHYWNRDMPWWYWWPHIARLNGNGSNHDYWDNAWCPWKNDYEDWIFD-YHCPHWWLVDLGRKTHRVTGVTITGRRRRG

--HAGGHGIEFAPM-YKINY------SRDGSRWISWRNRH------GKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHS------MNVCMRVELYG
  .........  | ||...        .| .|. .. .       .  | .|| .. ........||.|||..|..|.. ..      .|.|||.||||
HGWGHDDWWTYYWMMYKDDRRDNNERQ-NGHTWTTYKDFWIEHGTGNSMVFYGNWDNNHPWHNMFHPPMVARYIRIWPTWWNTNATGWHHNYCMRWELYG

C
|
C
F5_F8_type_C DDR2.AA F5_F8_type_C 45-182 29 1e-33 118.02 Pfam 1-140 (140) Show / Hide 
Range on Protein: 45-182
Range on HMM: 1-140/140
Sequence Identity: 29% (44 aa)

DITASSQWSESTAA---KYGRLDSE--EGDGAWCP-EIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDG--S-RWISWRNR
 ||||||||.....      ..|    .. ..|.. . .   .| ....|.||   . || | .|.| .||.  ...  ||| || ||  .  |.. .. 
QITASSQWSGYWGNGWPPDNAIDGNGYPN-TFWHSQKWS--NNDDPQWIQVDLGKPYKITGVVYQWRQDGGN--GWVKKYKIQYSNDGGDESNWTTYKDH

HGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPV-TDHSMNVCMRVEL
 | .| .|| .   .   ...|||.||.||..|. .. . . .||.|.
DG-KVFYGN-DND-PVKNMFFPPIKARYVRIHPTSWNNHNWWAMRWEF
Kinase DDR2.AA DDR 563-848 63 1.5e-221 742.34 In-house 1-306 (306) Show / Hide 
Range on Protein: 563-848
Range on HMM: 1-306/306
Sequence Identity: 63% (194 aa)

LAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLK-DPNIIRLLAVCITEDPLCMITEYMEN-G
|.|.||.||||||||||||||||......||..||....|.||||||||.||.|.|||||.||||.||..| .|||.||..||....|.|||.||||| |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLNQFLSRHEPLSSCSSDA----------TVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFG--MSRNLYSGDYYRIQG----
|||||...||. .|.....          |.||.......||||||||||.|.||||||||||||||||.|.|||.|||  |||||||.||||..|    
DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTGR

-RAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPALCPDSVY-KLMLSCWRRETKHRPSFQ
 |...|||||.|||||||||||.|||||||||.||.|.||.||||.||.|||||||..||||.||.|.|||.|..||...| .||..||||....||||.
QRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSFE

EIHLLL
|||..|
EIHKFL
Kinase DDR2.AA TyrKc 563-848 38 3.4e-136 459.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 563-848
Range on HMM: 1-280/280
Sequence Identity: 38% (122 aa)

LAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRL--KDPNIIRLLAVCITE-------DPLCMI
. ...|||||.||||....                     . ||||||..||    | ||..|..||..|  . |||.||..||...       .||...
ITLGKKLGEGAFGEVYKGTWK-------------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV

TEYMENGDLNQFLSRHEPLSSCSSDATVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG-------DYYRI----
.|||..|||...| .|.|         .. . |  ...|||.|| ||.| |..|||||.||||||.|.|.||.|||.||..|..       ||||     
MEYMPHGDLKDYLRKHRPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHK

QGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQ----LSDEQVIENTGEFFRDQGRQIYLPQPAL----CPDSVYKLMLSCWRRE
.|...||||||..|.|  |||||.||||.|||..|| ||..|. .. .    .|...|||.  . .|    . ..  | .    ||| .|..|..||...
GGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQIMKQCWHED

TKHRPSFQEIHLLL
 . ||.|.||| ..
PEDRPTFSEIHECF
Kinase DDR2.AA Pkinase_Tyr 563-848 42 2e-121 411.83 Pfam 1-270 (270) Show / Hide 
Range on Protein: 563-848
Range on HMM: 1-270/270
Sequence Identity: 42% (125 aa)

LAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNA--RNDFLKEIKIMSRL-KDPNIIRLLAVCI-TEDP--LCMITEY
. | .|||||.||||....  |               |. . ||||||. .| . .  | ||..|.|||. | . |||.||..||.  ..|  .....||
ITFGKKLGEGAFGEVYKGTWKG------------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEY

MENGDLNQFLSRHEPLSSCSSDATVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYY-RIQGRAVLPIRWMSW
|..|||  .| .|      ...  ..   |  |..|||.|| ||.| |..|||||.|||||..| ..||.|||..| .|. ||| | .| . |||.||. 
MPHGDLLDYLRKHR-----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAP

ESILLGKFTTASDVWAFGVTLWETFTFCQEQP-YSQLSDEQVIENT-GEFFRDQGRQIYLPQPALCPDSVYKLMLSCWRRETKHRPSFQEIHLLL
|.|  |||||.||||.|||..|| ||... || |  .|.|.|.|    .  |       .|.| .||| .|.||..||. . ..||.|.|||  |
ECINYGKFTTKSDVWSFGVLMWEIFTYGE-QPTYPGMSNEEVYEYIYEDGYR-------MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase DDR2.AA TK 563-848 26 4.1e-119 401.17 In-house 1-486 (486) Show / Hide 
Range on Protein: 563-848
Range on HMM: 1-486/486
Sequence Identity: 26% (128 aa)

LAFKEKLGEGQFG---EVHLCEVEGMEKFKDKDFALDV---------SANQPVLVAVKMLRADANKNARN-------------DFLKEIKIMSRLK----
. . .||||||||   ||...|..|. . . |.|...          . .... ||||||..... ...              |||.|  .|. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-DPNIIRLLAVCITE------------DPLCMITEYMENGD----LNQFLSRHEPLSSCSSDAT------------------------------------
  |||.||..||  .             |.....|||..||    | ..| .. |  ....|                                      
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VSYANLKFMATQIASGMKYLSSL------NFVHRDLATRNCLVGKNYT-----------IKIADFGMS-
                               .. . |  |. |||.|| ||.|.      ||||||||.||||||.|..           .||||||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RNLYS------------------------GDYYRIQGRAVLPIRWMSWESIL---------LGKFTTASDVWAFGVTLWETFTFCQEQPYSQL
       | .||                         |||| | .. ||||||..|...          |||||.||||.|||..|| ||..||..| ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SD---------EQVIENTGEFFR-------DQGRQIYLPQPALCP--------------DSVYKLMLSCWRRETKHRPSFQEIHLLL
|.         ..|.|.  .  |       ..|.   .|||..||              . .| ||..||... ..||.|...|  |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase DDR2.AA Trk 563-848 44 1.6e-102 346.86 In-house 1-275 (275) Show / Hide 
Range on Protein: 563-848
Range on HMM: 1-275/275
Sequence Identity: 44% (130 aa)

LAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMENGDL
. .|  |||| || | | | . .   .||           ..|||| |. || .||| || .| ...  |. ..|...  ||  .||| |. |||..|||
IVLKWELGEGAFGKVFLAECYNLCPEQDK-----------MMVAVKTLK-DASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDL

NQFLSRHEPLSSCSSDATV-------SYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYS-GDYYRIQGRAVLPIRWMS
|..|  | |  .|  .              ... | |||||| |. |. |||||.||||||||.|  .||.|||||| .||  ||||. ..  |||||| 
NKYLRQHGPDAMCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMP

WESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPALCPDSVYKLMLSCWRRETKHRPSFQEIHLLL
 |||.  |||. |||| |||..|| ||. . ||. |||   |||     .  |||.  | .|  ||  ||..|| ||.|| ..| .  .|| ..
PESIMYRKFTYESDVWSFGVVMWECFTYGK-QPWYQLSNHEVIE-----CIHQGRHR-LERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase DDR2.AA Ror 599-845 44 1.2e-96 327.33 In-house 26-272 (308) Show / Hide 
Range on Protein: 599-845
Range on HMM: 26-272/308
Sequence Identity: 44% (114 aa)

ANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMENGDLNQFLSRHEP-----LSSCSS-DATVSYANLKFM--A
. .. .||.| .. ||.   . || .||..|..|. |||. || ||  . |.||. ||| .|||  || .. |      ||    .   | ... |.  |
MYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHSDHGCSSDDDRMVKSSLDHPDFLHIA

TQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQ
.|||.|| ||||  |||||||.||||||   ..||.||| .|  ||.||||.|.....|||||| |.|. |||...||.| |||.||| . .   |||  
IQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSEDSDIWSFGVVLWEIWSYGM-QPYYG

LSDEQVIENTGEFFRDQGRQIYLPQPALCPDSVYKLMLSCWRRETKHRPSFQEIH
 |  .||    |  |   |.. || |  ||  .| ||  ||      || | .||
YSNQEVI----EMIRN--RHL-LPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIH
Kinase DDR2.AA UTK 563-848 35 4.9e-91 308.76 In-house 1-296 (296) Show / Hide 
Range on Protein: 563-848
Range on HMM: 1-296/296
Sequence Identity: 35% (111 aa)

LAFKEKLGEGQFGEVHLCEV-EGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNAR--NDFLKEIK---IMSRLK-DPNIIRLLAVCITEDPLCMITE
... ..||.|.|||||.... .  |  .. | |..|             .|||... .   ||..| .   .|....  ||..||..||  | |....||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ----------HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTE

YMENGDLNQFLSRHEPLSSCS-SDATVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN-------YTIKIADFG---MSRNLY---------
||||||| ..| || |  ..   .. ..   .  || .||.|| ||.| .||||||| |||||...       ...||||||   |||...         
YMENGDLRSYLRRHRP--TPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYW

SGDYYRIQGRAVLPIRWMSWESILLG-KFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPALCPDSVYKLMLSCWRRE
. .||. |..  .|||||. |..  . .|||.||||.|||..||..|.   .||  .|..||... ..  |       .|.|. ||..||.||..||. .
ESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW-GRLPYPGMSNMQVWHQVCNGGR-----YRMPCPWDCPHPVYRLMHRCWHYD

TKHRPSFQEIHLLL
   ||.|...   .
PQERPDFEDLVQQM
Kinase DDR2.AA Musk 563-848 39 1.4e-89 296.21 In-house 1-282 (282) Show / Hide 
Range on Protein: 563-848
Range on HMM: 1-282/282
Sequence Identity: 39% (119 aa)

LAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMENGDL
  .   .||| || |      |.           |   . ..||||||..|| |    ||  |  .| .   |||..|| ||    |.|.  |||  |||
IIYVRDIGEGAFGRVFQARAPGL-----------VPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDL

NQFL---SRHEPLSSCSSDAT------------VSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAV
| ||   | |   |  ..|               . . .  || ||| || |||   ||||||||||||.. .  .||||||.||. |. |||. ..   
NEFLHSCSPHRTCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDH

LPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPALCPDSVYKLMLSCWRRETKHRPSFQEIHLL
 |||||  |||.  .||..|||||.|| ||| | .  .|||  .. | ||  . . ..       |  |  || .||.||  || ..   ||.|..||  
IPIRWMPPESIWYNQFTYESDVWAYGVCLWEIFSYA-LQPYYGMTHEEVIYYIRQGNI-------LSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHC

L
.
I
Kinase DDR2.AA TK-Unique 563-848 35 2e-89 303.37 In-house 1-294 (294) Show / Hide 
Range on Protein: 563-848
Range on HMM: 1-294/294
Sequence Identity: 35% (110 aa)

LAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLK-DPNIIRLLAVCITED-PLCMITEYMENG
| .....|||.||.|. .||.|            .. .... ||||||...|..  . ||||||..|. |.  |||...| .|.. | | ..| ||...|
LEVGDVIGEGAFGQVWRGEVWGIW----------KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCG

DLNQFLSRHEPL-----------------SSCSSDATVSYANLKFMATQIASGMKYLSS--LNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY-SGDYY
.|  .| .  |                   .  .....|.  |   | |||.||.||.|   ..|||||..||.|.. ....||.||||.| .|  |.| 
NLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYS

RIQGRAVLPIRWMSWESIL--LGKF-TTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPALC-PDSVYKLMLSCWRRETK
.....  .|||||. ||..   | . || ||||.|||..|| ||. . .||.........|.  . .|       .|||. | .. .|.|| |||..| .
MMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGA-CPYPGMPWKDIMECIRDGYR-------MPQPEHCCSHEMYNLMKSCWQWEPE

HRPSFQEIHLLL
.|||| .|   |
ERPSFRQIKHRL
Kinase DDR2.AA InsR 563-850 35 9.6e-84 281.15 In-house 1-278 (278) Show / Hide 
Range on Protein: 563-850
Range on HMM: 1-278/278
Sequence Identity: 35% (106 aa)

LAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMENGDL
..   ..|.| || | .   .|...     |           .|.| . ..|    | .||.|  .| . .  ...||| || .  |   . | |. |||
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFG---------RCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDL

NQFLSRHEPLSS-CSSDAT-----VSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWE
  .|  . |.      . .      ..  .  || .|..|| || ...||||||| |||.| . .|.||.|||| | .|  ||||  |.  ||.|||. |
KSYLRSRRPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPE

SILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFF-RDQGRQIYLPQPALCPDSVYKLMLSCWRRETKHRPSFQEIHLLLLQ
|.  |.|||.|||| ||| |||  |.  ||||  || |||    ...  .| .   .| .|  ||. ...||  ||.   |.||.| .|  .| .
SLKDGVFTTHSDVWSFGVVLWEMVTLG-EQPYQGLSNEQV----LKYIGMDGN---VLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase DDR2.AA CTKA 563-848 37 2.6e-82 276.37 In-house 1-290 (290) Show / Hide 
Range on Protein: 563-848
Range on HMM: 1-290/290
Sequence Identity: 37% (113 aa)

LAFKEKLGEGQFGEVHLCEVEGMEK-FKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMS--RLKDPNIIRLLAVCITEDPLCMITEYMEN
.    |.|||..|.|      .    ||           .  .||||||...|.  .|  || |  . |   .  ||..||| ||  . |. ||.|.|  
HCIMFKIGEGHYGQVFRAWLMPDPDDFK-------AQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQY

GDLNQFLSRHEPLS--SCSSDA-----------TVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG-DYYRIQGR
|||  .| .  | .   |   |            |.     .|| ||| || ||... ||||||| ||||.|.  .||||||| .| | ..  || .. .
GDLHCYLRACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQ

AVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEF--FRDQGRQIYLPQPALCPDSVYKLMLSCWRRETKHRPSFQE
 |.|.|||. | .  |||..||||||||| ||| ...  | |.  .||  | .        |       || |  ||. .| .|  ||. | . ||.|  
RVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMG-EKPWRHMSDQEVCQAYTSHGMRR-------LPVPRNCPQVLYHCMQECWKFEPNQRPTFET

IHLLL
.   |
LQRML
Kinase DDR2.AA Src 600-848 36 3.1e-74 251.62 In-house 21-255 (255) Show / Hide 
Range on Protein: 600-848
Range on HMM: 21-255/255
Sequence Identity: 36% (91 aa)

NQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMENGDLNQFLSRHEPLSSCSSDATVSYANLKFMATQIASGMKY
|. . |||| |...    . ..||.|..||  |. .....|.||| .|.|   .||||..| | ..| .       .   ...  .|  ||.|.|.||.|
NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK------DGEGRHLHLPQLIDMAAQVAEGMAY

LSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG-DYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIE
|.| |..||||| || |||.|   |.||||  | .  . | |  .  | .||.|.  | |. |.||. |||| ||. |.| .|. .  ||   . ..|..
LESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGR-VPYPGMTNHEVLQ

NTGEFFRDQGRQIYLPQPALCPDSVYK-LMLSCWRRETKHRPSFQEIHLLL
.    .|       .|.|. |||..|. .|| ||... . || |  ..  |
QVERGYR-------MPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase DDR2.AA Pkinase 563-844 22 8.4e-40 141.82 Pfam 1-287 (293) Show / Hide 
Range on Protein: 563-844
Range on HMM: 1-287/293
Sequence Identity: 22% (73 aa)

LAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKN--ARNDFL-KEIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMEN
. ...|.|.| ||.| .|   | .|                .|||| .. . .|    .....  ||.|| ||. |||.||. .. ..| ..|..||.|.
YHIGRKIGSGSFGCVYKCHHKGTGK----------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEG

G----DLNQFLSRHEPLSSCSSDATV--SYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI----KIADFGMSRNLYSGDYYRIQGRAVLP
|    ||  ..|.       ... ..  |.  .||...||..|..|. | ...||||   |.|. .|..|    ||.||| .. ..    ..     .  
GLYVMDLFDYIST-------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGT

IRWMSWESIL-LGKFTTASDVWAFGVTLWETFTFCQEQPYSQL----SDEQVIENTGEFFRDQGRQIYLPQPALCP-------------------DSVYK
...|. | |.   . ....|.|..|..|.| ..   . |...     .    ..    ..|. |...  . | .|.                   ..  .
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC--GRPPFPGHCWHDN-HDQMQM---ICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD

LMLSCWRRETKHRPSFQEI
.. .|...  | ||....|
FIKWCLCKDPKKRPTAEQI
Kinase DDR2.AA S_TKc 563-848 19 1.8e-39 138.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 563-848
Range on HMM: 1-231/231
Sequence Identity: 19% (58 aa)

LAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRLLAVCITEDPLCMITEYMEN--G
  . .|.|.| ||.|..|   .                   .||.|...        .....||.|... . |||..|. |. . | |.|..||...  |
YEILRKIGKGAFGKVYKCRHKK----------------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLG

DLNQFLSRHEPLSSCSSDATVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILL
|| ... .. .   .      .    .|.. ||.....|. |....||||   | |. .  .|||.|||..| |            .    .|. | .  
DLFDYIKKRGRHGLR---FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL--

GKFTT-ASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLPQPALCPDSVYKLMLSCWRRETKHRPSFQEIHL---------LL
 .... ..|.|..|..|.| ..   . |..   ....... |                  ....  ..  |.... ..||.  |.            .
-GYGKCKCDWWSCGCILYEMLC--GYPPFP--QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDR2.AA Src 563-577 60 2.6e-05 13.97 In-house 1-15 (255) Show / Hide 
Range on Protein: 563-577
Range on HMM: 1-15/255
Sequence Identity: 60% (9 aa)

LAFKEKLGEGQFGEV
. ...|||.||||||
IKLCRKLGQGQFGEV
Kinase DDR2.AA Ror 563-578 56 9.5e-05 15.26 In-house 1-16 (308) Show / Hide 
Range on Protein: 563-578
Range on HMM: 1-16/308
Sequence Identity: 56% (9 aa)

LAFKEKLGEGQFGEVH
. | |.|||.||| |.
VRFMEELGECQFGKVY