Gene EphA10 (Mouse)

EphA10

Species: Mouse
Alias: EphA10
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA10.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 256 Kinase domain by global Sugen HMM Fasta, JSON
EphA10.AA Protein Sugen 1008 None Fasta, JSON
EphA10.NA RNA Sugen 3078 None Fasta, JSON

Protein domain

Protein domains of EphA10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA10.AA Ephrin_lbd 35-211 62 8.60000000001e-132 410.89 Pfam 1-190 (190) Show / Hide 
Range on Protein: 35-211
Range on HMM: 1-190/190
Sequence Identity: 62% (119 aa)

EVILLDSKASQAELGWTALPSTG---------WEEISGVDEHDRPIRTYQVC-NVLEPNQDNWLQTGWISRGRGQRIFVELQFTLRDCSSIPGATGTCKE
||.|.|.|. ...||||. |. |         |||.||.||..||||||||| || ||||.|||.|.||.|.  |||.|||.||.|||.|.||. |||||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNAYYLETET--DLGRGRPRLGGNRPRKIDTIAADES-FTQGDLGERKMKLNTEVREIGPLSRQGFHLAFQDVGACVALVSVRVYYKQC
||| ||.|...  |.|. .|..  |. .|||||||||| |||.|.|.|.||||||||.|||||. ||.|||||.|||.|||||||||| |
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA10.AA EPH_lbd 35-211 62 1e-111 378.35 SMART 1-184 (184) Show / Hide 
Range on Protein: 35-211
Range on HMM: 1-184/184
Sequence Identity: 62% (115 aa)

EVILLDSKASQAELGWTALPSTG--WEEISGVDEHDRPIRTYQVCNVLE---PNQDNWLQTGWISRGRGQRIFVELQFTLRDCSSIPGATG-TCKETFNA
||.|.|.|. ..|||||. |. |  |||.||.|||..|||||||||| |   |||.|||.|.||.|.  |||.|||.||.|||.|.||. | .|||||| 
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYLETETDLG-RGRPRLGGNRPRKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSRQGFHLAFQDVGACVALVSVRVYYKQC
|| |...| .   .|    |. .||||||||||||| |.|.|.||.|||||..||||. || |||||.|||.|||||||.|| |
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
FN3 EphA10.AA FN3 338-435 18 3.7e-08 34.34 SMART 1-69 (69) Show / Hide 
Range on Protein: 338-435
Range on HMM: 1-69/69
Sequence Identity: 18% (21 aa)

PSAPRD---LQYSLSRSP-----LALRLRWLPPADSGGRSDVTYSLLCLRCGRDGPAGACQPCGPRVAFVPRQAGLRERAATLLHLRPG----ARYTVRV
|..|..   |. .   |        ..|.| ||        |.|.                                   .|. .|.||     .|..||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR-----------------------------------YTVTGLKPGQYPWTEYEFRV

AALNG-VSGPA
.| ||   |. 
RAVNGNDAGEG
FN3 EphA10.AA FN3 451-537 24 9e-10 39.71 SMART 1-69 (69) Show / Hide 
Range on Protein: 451-537
Range on HMM: 1-69/69
Sequence Identity: 24% (24 aa)

PGAPWEEDEIRRDRVEPQ------SVSLSWREPVPAGAPGTNSTEYEIRYYEKGQSEQTYSTVKTGAPAVTVTNLKPA----TRYVFQIRAAS---PGPL
||.|    ..|   | .       ||.||| .|             ...|                   .|||.|||     |.|.|..|| .    |. 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA10.AA Eph 644-900 58 4.7e-185 621.06 In-house 1-264 (264) Show / Hide 
Range on Protein: 644-900
Range on HMM: 1-264/264
Sequence Identity: 58% (156 aa)

VTLEKSLGAGRRFGDLCCGCLQLP-GRQEL---PVAVHTLRDGCSDSQRLSFLAEALTLGQFDHSHIVRLEGVVTRGNPLMIVTEYMNLGALDDFLRHHE
...||..|||. ||..|||.|.|| |..|.   |||..||..|....||. ||.|| ..|||||..|.|||||||...|.|||||||..|.||.|||.|.
IKIEKVIGAGE-FGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHD

GELVAAQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLVSSGLLCKIS--GFGRGPRDRA--EAVYTTMSGRSPALWAAPETLQFGHFSSASDVWSFGIV
|.....||.|.|.|.||.|||||.|.||||.||||..||.| |.||.|  |..|...|..  ||.|||..|..|..|.|||......|.|||||||.|||
GQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIV

MWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPSQLHRLMLECWQKDPSERPRFSQIHSIL
|||||..|||||||||.||||||.|.|.|||||..||..||.|||.|||||...||.|.||.|||
MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphA10.AA Pkinase_Tyr 644-900 40 2.5e-101 343.81 Pfam 1-270 (270) Show / Hide 
Range on Protein: 644-900
Range on HMM: 1-270/270
Sequence Identity: 40% (110 aa)

VTLEKSLGAGRRFGDLCCGCLQ-LPGRQELPVAVHTLRDGCSDSQ--RLSFLAEALTLGQF-DHSHIVRLEGVVT-RGNP--LMIVTEYMNLGALDDFLR
.|. | ||.|  ||. . | .  .|. ...|||| .|..|....|  | .|..|| .. |. .| .|||| ||.| .| |  ..||.||| .| |.|.||
ITFGKKLGEG-AFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

HH---EGELVAAQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLVSSGLLCKISGFGRGPRDR-AEAVY-TTMS-GRSPALWAAPETLQFGHFSSASDVW
 |   .. |   .| .     |..| ||......|| |||| .||.... .||. ||   ||   .  | .. . |. |  | ||| ...| |...||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL-ARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGIVMWEVMAFGERP-YWDMSGQDVIKAV-EDGFRLPPPRNCPSQLHRLMLECWQKDPSERPRFSQIHSIL
|||..|||.. .|| | |..|| ..|.... ||| |.|.|.|||  ...||..||..||..||.||.||..|
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphA10.AA TK 644-900 22 2.4e-98 330.3 In-house 1-486 (486) Show / Hide 
Range on Protein: 644-900
Range on HMM: 1-486/486
Sequence Identity: 22% (109 aa)

VTLEKSLGAGR--RFGDLCCGCLQLPGR----------------------QELPVAVHTLRDGCSDSQRLSFL-------------AEALTLGQFD----
.||.| ||.|    ||. . | .. ...                      .. |||| .|..|...||.  |.             .||. . ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HSHIVRLEGVVTRG------------NPLMIVTEYMNLGA----LDDFLRHHEGE--------------------------------------------
 | .|||| ||.|.|             |.|||.|||..|     |.|.|| . ..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LVAAQLMGLLPGLASAMKYLSEM------GYVHRGLAARRVLVSSGLL-----------CKISGFG---
                               |  .||.     .|..| ||...      ..||| |||| .||....            |||. ||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RGPRDRAEAVYTTMS-------------------------GRSPALWAAPETLQ---------FGHFSSASDVWSFGIVMWEVMAFG-ERPYWDM
     .  ..  .  |...|                         |. |  | |||.|.         .|.|...|||||||..|||.. .| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SG---------QDVIKAVEDG--------------FRLPPPRNCP--------------SQLHRLMLECWQKDPSERPRFSQIHSIL
|          |.|.. ...|              .|.|.| .||                ...||..||..||..||.|||.|. |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphA10.AA TyrKc 644-900 36 9.1e-89 302.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 644-900
Range on HMM: 1-280/280
Sequence Identity: 36% (106 aa)

VTLEKSLGAGRRFGDLCCGCLQLPGRQELPVAVHTLRDGCSDSQRLSFLAEALTLGQF--DHSHIVRLEGVVTRG-------NPLMIVTEYMNLGALDDF
.||.| || |  ||  . | .       ..||| .|....    |  |. ||  . ..  .| .|||| ||.| .        |||||.||| .|.|.|.
ITLGKKLGEG-AFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LRHHEGELVAAQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLVSSGLLCKISGFG--RGPRDR----AEAVYTTM----SGR--SPALWAAPETLQFGH
|| |...|  ..|       |. | ||......|| |||| .||.... .||| ||  |   |     ..  | ..    .|.   |  | |||....| 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FSSASDVWSFGIVMWEVMAFGERPYWD-----MSGQDVIKAVEDGFRLPPPRN--------CPSQLHRLMLECWQKDPSERPRFSQIHSIL
|...|||||||..|||.. .|. ||..     || |.||. |..|.|.|.| |        ||. ....|..||. ||..||.||.||...
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA10.AA Src 644-900 38 2.6e-76 258.79 In-house 1-255 (255) Show / Hide 
Range on Protein: 644-900
Range on HMM: 1-255/255
Sequence Identity: 38% (101 aa)

VTLEKSLGAGRRFGDLCCGCLQLPGRQELPVAVHTLRDGCSDSQRLSFLAEALTLGQFDHSHIVRLEGVVTRGNPLMIVTEYMNLGALDDFLR-HHEGE-
..|.. ||.|  ||.   |      ... .||| ||. |    .   ||.|| .. ...| ..|.|  |.... |  ||||||. | | |.|.   ||  
IKLCRKLGQG-QFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

LVAAQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLVSSGLLCKISGFGRGPRDRA--EAVYTTMSG-RSPALWAAPETLQFGHFSSASDVWSFGIVMWE
|   ||  .    |. |.||..| |.|| |||| |||. ...||.  ||   |     . .|.  .| . |  | ||| ...|.|.  |||||||| ..|
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLA-RLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

VMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPSQLHR-LMLECWQKDPSERPRFSQIHSIL
.. .|  ||  |. ..|...|| |.|.| |.||| .|.  .||.||.||| .|| |  ... |
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA10.AA UTK 644-900 33 4.1e-75 255.84 In-house 1-296 (296) Show / Hide 
Range on Protein: 644-900
Range on HMM: 1-296/296
Sequence Identity: 33% (100 aa)

VTLEKSLGAGRRFGDLCCGCLQLPG--RQELPVAVHTLRDGCSDSQRLS----FLAEAL---TLGQFD-HSHIVRLEGVVTRGNPLMIVTEYMNLGALDD
| | . ||.| .||. . . .. .   ..|. |||.... . .. |       |. ||     ..||. | ...|| ||.|.. |.|||||||  | |..
VQLGRQLGQG-AFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

FLR--HH----EGELVA-AQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLVSSG-------LLCKISGFGRGP--RDRA---------EAVYTTMSGRS
.||  ..    .....   |...     |..| ||...|.||| |||| .|| .        ..|||..||||   |. .         |. | ..... 
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

P--ALWAAPETLQFG-HFSSASDVWSFGIVMWEVMAFGERPYWDMSGQDVIKAVEDG--FRLPPPRNCPSQLHRLMLECWQKDPSERPRFSQIHSIL
.    | ||| |  . .|...|||||||.|.||....| .|| .|| ..|...|..|   |.|.|. || .. |||..||..||.|||.| .. . .
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphA10.AA TK-Unique 644-900 31 4.8e-73 248.99 In-house 1-294 (294) Show / Hide 
Range on Protein: 644-900
Range on HMM: 1-294/294
Sequence Identity: 31% (93 aa)

VTLEKSLGAGRRFGDLCCGCLQLPG---RQELPVAVHTLRDGCSDSQRLSFLAEALTLGQFD-HSHIVRLEGVVTRG-NPLMIVTEYMNLGALDDFLRHH
.......| | .||  . | .  .     .   ||| .|.|. .| ..  || |.  . . . | .||...|. |.  .| ||. ||.  | |...||  
LEVGDVIGEG-AFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

EGE-------------------------LVAAQLMGLLPGLASAMKYLSE--MGYVHRGLAARRVLVSSGLLCKISGFGRGPRDRAEAVYTTM-S-GRSP
 ..                         .   .|   . ..|..|.||..  .. ||| |.|| ||..... |||..||. .. ... || .| | || |
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

ALWAAPETLQ--FGHF-SSASDVWSFGIVMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNC-PSQLHRLMLECWQKDPSERPRFSQIHSIL
  | ||| |.   |.. .. |||||||..|||.. .|..|| .|.  |......||.|.| | .| . ... || .|||..|.||| |.|| ..|
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphA10.AA SrcB 644-901 40 2.1e-66 223.63 In-house 1-251 (251) Show / Hide 
Range on Protein: 644-901
Range on HMM: 1-251/251
Sequence Identity: 40% (105 aa)

VTLEKSLGAGRRFGDLCCGCLQLPGRQELPVAVHTLRDGCSDSQRLSFLAEALTLGQFDHSHIVRLEGVVTRGNPLMIVTEYMNLGALDDFLRHHEG-EL
. |.| ||||  ||.   |  .    ..  ||| |...|    .   |||||  . .  | ..|||  |||.  |. |.||||. |.| |||.  ||  |
LKLVKKLGAG-QFGEVWMGYYN----NHMKVAVKTMKQGTMSPE--AFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKL

VAAQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLVSSGLLCKISGFGRGPRDRAEAVYTTMSG-RSPALWAAPETLQFGHFSSASDVWSFGIVMWEVMA
   .|. .   .|  | |. .| |.|| | |  .|||  |.|||  ||   |   .  ||   | . |  | ||| ..|| |   ||||||||.. |.. 
SLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLA-RIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVT

FGERPYWDMSGQDVIKAVEDGFRLPPPRNCPSQLHRLMLECWQKDPSERPRFSQIHSILS
.|  ||  |.  .||...| |.|.| | |||  | ..| .||.. | ||| |  ..|.| 
YGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase EphA10.AA FAK 644-905 34 2.6e-66 221.13 In-house 1-285 (285) Show / Hide 
Range on Protein: 644-905
Range on HMM: 1-285/285
Sequence Identity: 34% (99 aa)

VTLEKSLGAGRRFGDLCCGCLQLPGR------------------------QELPVAVHTLRDGCSDSQRLSFLAEALTLGQFDHSHIVRLEGVVTRGNPL
.|| . .| |  |||   |   ..                          . . ||. | .  |.|...  |..||... |||| |||.| |...  .| 
ITLNRCIGEG-QFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEE-MPI

MIVTEYMNLGALDDFLRHHEGELVAAQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLVSSGLLCKISGFGRGPRDRAEAVYTTM-SGRSPALWAAPETL
 |. | . .| |  .|. .  .|  | |.     |. || ||    .|||  ||| |||||    |   ||       .  |     |. |  | .||  
WIIMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMHDHSYYKASPKGKLPIKWMSPESI

QFGHFSSASDVWSFGIVMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPSQLHRLMLECWQKDPSERPRFSQIHSILSKMGQ
 |  | .||||| ||. |||.. .| .|.  .  .|||  .| | ||| | |||  |  ||  ||  |||.|||| ..   |... |
NFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase EphA10.AA Abl 644-900 35 1.8e-63 210.41 In-house 1-252 (252) Show / Hide 
Range on Protein: 644-900
Range on HMM: 1-252/252
Sequence Identity: 35% (93 aa)

VTLEKSLGAGRRFGDLCCGCLQLPGRQELPVAVHTLRDGCSDSQRLS-FLAEALTLGQFDHSHIVRLEGVVTRGNPLMIVTEYMNLGALDDFLRHHEGEL
..... || |  .|.   |  .   | .. ||| ||..   |. ..  ||.||  . .  |  .|.| || ||  |  |.||.|  | | |.||. . |.
IMMKHKLGGG-QYGEVYEGVWK---RHDCTVAVKTLKE---DTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREE

VAA-QLMGLLPGLASAMKYLSEMGYVHRGLAARRVLVSSGLLCKISGFGRGPRDRAEAVYTTMSG-RSPALWAAPETLQFGHFSSASDVWSFGIVMWEVM
. |  |. .   .||.|.|| .  ..|| ||||  ||.   . |.  ||   |   . .||   | . |  | ||| | . .||| |||| ||...||. 
LPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLA-RMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIA

AFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPSQLHRLMLECWQKDPSERPRFSQIHSIL
 .|  ||  .  ..| . .|.|.|.  |. || .  .||..||| ....||.| .||  .
TYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase EphA10.AA Frk 644-904 36 4.7e-62 212.46 In-house 1-260 (260) Show / Hide 
Range on Protein: 644-904
Range on HMM: 1-260/260
Sequence Identity: 36% (97 aa)

VTLEKSLGAGRRFGDLCCGCLQLPGRQELPVAVHTLRDGCSDSQRLSFLAEALTLGQFDHSHIVRLEGVVTRGNPLMIVTEYMNLGALDDFLR---HHEG
. | . ||.| .||..  |       .. |||| ||. |  | .   ||.||  . .  |. ...|  | |. .|..|.|| |  |.| ..|.   ..  
IQLIRRLGSG-QFGEVWEGLWN----NTTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGR

ELVAAQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLVSSGLLCKISGFGRGP--RDRAEAVYTTMSG-RSPALWAAPETLQFGHFSSASDVWSFGIVMW
..   ||. .   .|. | || .. |.|| |||| |||  .. |||  ||         | .| .  | | |  | |||  .  .|.  ||||||||.. 
QCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

EVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPSQLHRLMLECWQKDPSERPRFSQIHSILSKMG
|.. .|  ||  | ...|.. |. |.|.| | ||| ||  .|||||..|| .|| |  ..  | .  
EIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA10.AA CTKA 758-900 46 7.1e-57 189.59 In-house 144-290 (290) Show / Hide 
Range on Protein: 758-900
Range on HMM: 144-290/290
Sequence Identity: 46% (68 aa)

MKYLSEMGYVHRGLAARRVLVSSGLLCKISGFGRGPRDRAEAVYTTMSGRS--PALWAAPETLQFGHFSSASDVWSFGIVMWEVMAFGERPYWDMSGQDV
| ||.||| ||| ||.| .|. ..   ||. || |   | |. | ..| ..  |  | |||.|.|| ||.|||||.||...||.| .|| |.  || | |
MNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEV

IKAVEDG--FRLPPPRNCPSQLHRLMLECWQKDPSERPRFSQIHSIL
 .|.  .   |||.|||||. |  .| |||.  | .|| | ..   |
CQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase EphA10.AA S_TKc 644-899 18 8.5e-15 40.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 644-899
Range on HMM: 1-231/231
Sequence Identity: 18% (51 aa)

VTLEKSLGAGRRFGDLCCGCLQLPGRQELPVAVHTLRDGCSDSQRLSFLAEALTLGQFDHSHIVRLEGVVTRGNPLMIVTEYMNL--GALDDFLRHHEGE
 .. . .| |  ||  ...           ||.  ..         ... |   | . .| .||.| .|    . | .|.||..   | | |..... ..
YEILRKIGKG-AFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LVAAQLMGLLPGLASAMKYLSEMGYVHRGLAARRVLVSSGLLCKISGFGRGPRDRAEAVYTTMSGRSPALWAAPETLQFGHFSS-ASDVWSFGIV
     .   .   ..  ...|..|. ..| .|| |    .|...    ||. ||   .         ..      . ||| |   ...  ..|.||.|..
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

MWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPSQLHRLMLECWQKDPSERPRFSQIHS----------I
..| .. |. |..    | ..| .            ....  ..  |.||||..||   ..            .
LYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphA10.AA CTKA 674-729 37 4e-14 43.71 In-house 37-94 (290) Show / Hide 
Range on Protein: 674-729
Range on HMM: 37-94/290
Sequence Identity: 37% (22 aa)

VAVHTLRDGCSDSQRLSFLAEALTLG--QFDHSHIVRLEGVVTRGNPLMIVTEYMNLG
|||  |.|   . .|  ||.|| .|   .|.|  ..|| ||.|.  |.  ..|.| .|
VAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYG
Kinase EphA10.AA Pkinase 812-891 17 7.1e-11 39.54 Pfam 177-282 (293) Show / Hide 
Range on Protein: 812-891
Range on HMM: 177-282/293
Sequence Identity: 17% (19 aa)

WAAPETLQ-FGHFSSASDVWSFGIVMWEVMAFGERPYWDM----SGQDVIKAVEDGFRLPPPRNCP-----------------------SQLHRLMLECW
..||| ..   . ....|.||.|....|..  |. |...     .  | .. ..   . |.....|                       . .  ..  |.
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

QKDPSERP
.|||..||
CKDPKKRP
Kinase EphA10.AA Pkinase 693-769 21 0.001262 13.9 Pfam 49-132 (293) Show / Hide 
Range on Protein: 693-769
Range on HMM: 49-132/293
Sequence Identity: 21% (18 aa)

AEALTLGQFDHSHIVRLEGVVTRGNPLMIVTEYMNLG----ALDDFLR-HHEGEL--VAAQLMGLLPGLASAMKYLSEMGYVHR
.|.  .  ..| .|||| ....... . .|.||.. |     | |... . .| .     ..   .  ......|. .|| .||
SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR
SAM_2 EphA10.AA SAM_2 930-995 30 8.1e-20 70.86 Pfam 1-71 (71) Show / Hide 
Range on Protein: 930-995
Range on HMM: 1-71/71
Sequence Identity: 30% (22 aa)

STFPSFGSVGAWLEALDL-CRYKDNFSAAGYGSLEAV-AEMTAQDL--G-SLGISSAEHREALLSGISALQ
  ...| .|..||..... |.|||||...|. ..|.. | ||..||     .||... ||  ....|  ..
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
Sam7 EphA10.AA sam7 933-995 27 3.3e-18 62.59 In-house 1-70 (70) Show / Hide 
Range on Protein: 933-995
Range on HMM: 1-70/70
Sequence Identity: 27% (19 aa)

PSFGSVGAWLEALDL---CRYKDNFSAAGY----GSLEAVAEMTAQDLGSLGISSAEHREALLSGISALQ
..| .|. |||....   ..|.|||...|.     .......|| .|| ..||..  ||  ... |  ..
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM EphA10.AA SAM 930-997 27 4.4e-18 67.33 SMART 1-67 (67) Show / Hide 
Range on Protein: 930-997
Range on HMM: 1-67/67
Sequence Identity: 27% (19 aa)

STFPSFGSVGAWLEALDLCRYKDNFSAAGYGSLEAVAEMTAQDLGSLGISSAEHREALLSGISALQTR
   ... .|..|||....|.|||||...|. . . ..... .|| ..||... ||  .|..|. ....
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
SAM_1 EphA10.AA SAM_1 931-995 30 1.8e-17 64.87 Pfam 1-66 (66) Show / Hide 
Range on Protein: 931-995
Range on HMM: 1-66/66
Sequence Identity: 30% (20 aa)

TFPSFGSVGAWLEALDLCRYKDNFSAAGYGSLEAVAEMTAQDLGS-LGISSAEHREALLSGISALQ
.  .| .|. |||.... .|.|.| .||| .......||..|| . .|. .. ||  ... |  | 
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK