Gene EphA2 (Mouse)

EphA2

Species: Mouse
Alias: EphA2, Epha2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
EphA2.NA RNA Sugen 3907 None Fasta, JSON
EphA2.AA Protein Sugen 977 None Fasta, JSON

Protein domain

Protein domains of EphA2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA2.AA Ephrin_lbd 27-200 54 4.2e-127 396.3 Pfam 1-190 (190) Show / Hide 
Range on Protein: 27-200
Range on HMM: 1-190/190
Sequence Identity: 54% (104 aa)

EVVLLDFAAMKGELGWLTHPYGKG---------WDLMQNI-MDDMPIYMYSVC-NVVSGDQDNWLRTNWVYREEAERIFIELKFTVRDCNSFPGGASSCK
||||.|. .  ..|||.|.||. |         |. .... . ..||..|.|| || ...|.|||||||..|..|.||..|||||.||||||||.|..||
EVVLMDTKTATSDLGWTTYPYN-GRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCK

ETFNLYYAESDV--DYG---TNFQKRQFTKIDTIAPDEI-TVSSDFEARNVKLNVEERMVGPLTRKGFYLAFQDIGACVALLSVRVYYKKC
|||||||.|||.  |.|   .|....|.|||||||.||. .. .||. | .|||.| |..|||...||||||||.|||.||.|||||||||
ETFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA2.AA EPH_lbd 27-200 55 5.5e-115 389.22 SMART 1-184 (184) Show / Hide 
Range on Protein: 27-200
Range on HMM: 1-184/184
Sequence Identity: 55% (102 aa)

EVVLLDFAAMKGELGWLTHPYGKG-WDLMQNIMDD-MPIYMYSVCNVVS---GDQDNWLRTNWVYREEAERIFIELKFTVRDCNSFPGGAS-SCKETFNL
||||.|. ...|||||.|.|...| |. ......  .||..|.|||| .   ..|.|||||.|.||..|.||..|||||.|||||.||.|. ||||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYAESDVDYG---TNFQ-KRQFTKIDTIAPDEITVSSDFEARNVKLNVEERMVGPLTRKGFYLAFQDIGACVALLSVRVYYKKC
|| ||| |..   |.|. .....||||||.||..  .||..|..|.|.| |..|||..|||||||||.|||.||.||||.||||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphA2.AA GCC2_GCC3 274-307 31 0.000118 18.1 Pfam 11-45 (49) Show / Hide 
Range on Protein: 274-307
Range on HMM: 11-45/49
Sequence Identity: 31% (11 aa)

CRACSPGFFKSEASESPCLECPEH-TLPSTEGATS
| .|  |....|..   |..|| . |  ...|.||
CEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGSTS
FN3 EphA2.AA FN3 330-420 15 6.1e-09 36.95 SMART 1-69 (69) Show / Hide 
Range on Protein: 330-420
Range on HMM: 1-69/69
Sequence Identity: 15% (17 aa)

PSAPNY---LTAIGMGA-------KVELRWTAPKDTGGRQDIVYSVTCEQCWPESGECGPCEASVRYSEPPHALTRTSVTVSDLEPH----MNYTFAVEA
|..|     |..   ..        |.|.|..|        . |.                                 .||..|.|.     .|.| | |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR---------------------------------YTVTGLKPGQYPWTEYEFRVRA

R----NGVS
.    .| .
VNGNDAGEG
FN3 EphA2.AA FN3 437-517 20 2e-12 48.49 SMART 1-69 (69) Show / Hide 
Range on Protein: 437-517
Range on HMM: 1-69/69
Sequence Identity: 20% (20 aa)

QTEPPK---VRLEDRSTT------SLSVTWSIPVSQQSRVWKYEVTYRKKGDANSYNVRRTEGFSVTLDDLAPD----TTYLVQVQALTQ--EGQG
   ||    .|..| ..|      |....|. |          .|.||                 .|...| |.    |.| ..|.| .    |.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------IVGYR-----------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA2.AA Eph 614-872 78 6.2e-214 717.01 In-house 1-264 (264) Show / Hide 
Range on Protein: 614-872
Range on HMM: 1-264/264
Sequence Identity: 78% (207 aa)

VARQKVIGAGEFGEVYKGTLKASSGKKEI---PVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMIITEYMENGALDKFLREKDG
.  .|||||||||||..|.||..|||.|.   ||||||||||||||||.||||||||||||.|.|||||||||.|..|.||.|||||||.||.|||..||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

EFSVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDP--EATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSYGIVM
.|.|.||||||||||||||||..||||||||||||||||||||||||||||||||||||  ||||||.||||||||||||||.|||||||||||||||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERSRRPKFADIVSIL
||||.|||||||..||..|.|||..|.|||.|||||.|..|||..|||..|..||.|..|||||
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphA2.AA Pkinase_Tyr 614-872 46 2.4e-152 516.61 Pfam 1-270 (270) Show / Hide 
Range on Protein: 614-872
Range on HMM: 1-270/270
Sequence Identity: 46% (127 aa)

VARQKVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQ--RVDFLSEASIMGQF-SHHNIIRLEGVVS-KYKP--MMIITEYMENGALDKFLRE
.   |..|.|.||||||||.| . ....||||.|.|| |....|  | ||..||.|| |. .|.||.|| ||.. . .|  ..|..|||..| |...||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K---DGEFSVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVL-EDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWS
.   .. ... .|..| . ||.|| ||...|..||||||||.||..|.|.|..||||.| . .||   .....|||.||.|.|||.|.|.|||..|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGIVMWEVMTYGERP-YWELSNHEVMKAI-NDGFRLPTPMDCPSAIYQLMMQCWQQERSRRPKFADIVSIL
.|..|||..|||| | |...||.||...|  || |.| |..||  ||.||.|||... ..|| |..|...|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphA2.AA TyrKc 614-872 41 6.9e-138 465.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 614-872
Range on HMM: 1-280/280
Sequence Identity: 41% (121 aa)

VARQKVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQF--SHHNIIRLEGVVSKY-------KPMMIITEYMENGALDKF
.   |..| |.||||||||.|       |.||.|.||..     | ||..||.|| ..  .| ||.|| ||...        .|.||..|||..|.|...
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LREKDGEFSVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD-----PEATYTTS---GGK--IPIRWTAPEAISYRK
||.. ..... .|. .   ||.|| ||. .|..||||||||.||..|...|.||||||| ..||      . .|...   |||  .||||.|||.| |.|
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FTSASDVWSYGIVMWEVMTYGERPYWE-----LSNHEVMKAINDGFRLPTPMD--------CPSAIYQLMMQCWQQERSRRPKFADIVSIL
||..|||||.|..|||..|||. ||..     .|| ||.. . .|.|.| | .        ||...||.| |||. . . || |..|....
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA2.AA TK 614-872 25 8.9e-125 420.5 In-house 1-486 (486) Show / Hide 
Range on Protein: 614-872
Range on HMM: 1-486/486
Sequence Identity: 25% (122 aa)

VARQKVIGAGEFG---EVYKGTLKASSGKKE---------------------IPVAIKTLKAGYTEKQRV-------------DFLSEASIMGQFS----
.   |..|.|.||   |||||...  .....                     .|||.|.||.| .. |.              |||.||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HHNIIRLEGVVSKY------------KPMMIITEYMENGA----LDKFLREKDGE--------------------------------------------
 | ||.|| ||...             .|.||..|||..|     |...||.....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FSVLQLVGMLRGIASGMKYLANM------NYVHRDLAARNILVNSNLV-----------CKVSDFG---
                               ... ||. | . ||.|| ||. .      |.|||||||||.||..|.|           ||..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRVLEDDPEATYTT-----------------------SGGKIPIRWTAPEAIS---------YRKFTSASDVWSYGIVMWEVMTYG-ERPYWEL
     |.| ...| . . ..                       ||||.||||.|||..          |.|||..|||||.|..|||..||| | .|...
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------HEVMKAINDG--------------FRLPTPMDCP--------------SAIYQLMMQCWQQERSRRPKFADIVSIL
||         .|||. . .|              .|.| |..||               ..|.||.|||. . ..|| |..... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphA2.AA Src 614-872 42 8.8e-113 380.98 In-house 1-255 (255) Show / Hide 
Range on Protein: 614-872
Range on HMM: 1-255/255
Sequence Identity: 42% (113 aa)

VARQKVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMIITEYMENGALDKFLR-EKDGE-
. . . .|.| ||||..|.      .....||.||||.|    .  .|| || || ...| ....|  |.|. .|  |.||||..| | ..|. ...|  
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

FSVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATY-TTSGGKIPIRWTAPEAISYRKFTSASDVWSYGIVMWE
 .. ||. |   .|.||.||  |||.||||||||.||. |.|||| |||| |....| .  |   .| |.||.|||||||.|..||  |||||.|| ..|
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

VMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQ-LMMQCWQQERSRRPKFADIVSIL
..|||  ||   .||||....  |.|.| |. ||  .|. .|.|||...  .|| |. . . |
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA2.AA UTK 614-872 36 1.2e-108 367.25 In-house 1-296 (296) Show / Hide 
Range on Protein: 614-872
Range on HMM: 1-296/296
Sequence Identity: 36% (109 aa)

VARQKVIGAGEFGEVYKGTL-KASSGKKEIPVAIKTLKAGYT-EKQRV---DFLSEAS---IMGQFS-HHNIIRLEGVVSKYKPMMIITEYMENGALDKF
|.. . .|.|.||||.|... ..|   .|  ||.|..... . ....    ||. ||    .|.||. | |..|| ||.....|.||.||||||| |...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------EKDGEFSVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSN-------LVCKVSDFG---LSRVLED--------DPEATYTTSGGK
||       . .  ..  |...| . ||.|| ||.....|||||||||.||...       .|||..|||   .|| . .        . .  . .. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAISYR-KFTSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDG--FRLPTPMDCPSAIYQLMMQCWQQERSRRPKFADIVSIL
.||||.||||. .. .||..|||||.|.|.||..|.| .|| ..||..| ... .|   |.| | ||| ..|.||..||... ..|| | |.|. .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphA2.AA SFK-Src 614-876 42 6e-105 312.01 In-house 1-259 (259) Show / Hide 
Range on Protein: 614-876
Range on HMM: 1-259/259
Sequence Identity: 42% (114 aa)

VARQKVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMIITEYMENGALDKFLREKDGE-F
.. .|  |.| ||.|.||.       .   ||.|||| | .  .   ||.|| .| .  | | |.|  |     |. |||| | .| |  .|.|  |.  
IRLEKKLGSGQFGDVWKGRW-----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSL

SVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSYGIVMWEVM
 . ||| |   .|.|| ||   |.|||||||||.||  | |||| |||.||||..| |      | | ||.|||||| .. .|   |||||.|| | |. 
RMPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIV

TYGERPYWELSNHEVMKAIND--GFRLPTPMDCPSAIYQLMMQCWQQERSRRPKFADIVSILDKLI
|||  ||  ..| ||.. ..   | |.| |  || . |..|..|||.| . || |      ..   
TYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphA2.AA Fer 614-873 34 3.2e-99 335.94 In-house 1-283 (283) Show / Hide 
Range on Protein: 614-873
Range on HMM: 1-283/283
Sequence Identity: 34% (99 aa)

VARQKVIGAGEFGEVYKG--TLKASSGKKEI----PVAIKTL-KAGYTEKQRVDFLSEASIMGQ-FSHHNIIRLEGVVSKYKPMMIITEYMENGALDKFL
|  .|..| | |||||||  |||   ||.      .|. |..  .. |..|. .|. || || . ..| |.... || .   | ||. |.. .|.||..|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

REKDGE-FSVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNS-NLVCK--VSDFGLSRVLEDDPEATYTT-SGGKIPIRWTAPEAISYRKFTSASD
......  |. ... |. ..|.||.||  .| .|||.||||.|.   ....|  .||||.|| ..|. .. .      |.||||.|||..... .....|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSYGIVMWEVMTYGERPYWE----LSNHEV----MKA-INDGFRLPTPMDCPSAIYQLMM-QCWQQERSRRPKFADIVSILD
|||.|...||..| |. || .    . . .|    .|. |..| ..| |  .|..|.|.|| ||||.. . ||....|. .| 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphA2.AA TK-Unique 614-872 34 1e-96 327.61 In-house 1-294 (294) Show / Hide 
Range on Protein: 614-872
Range on HMM: 1-294/294
Sequence Identity: 34% (103 aa)

VARQKVIGAGEFGEVYKGTLKASSGKKEIP--VAIKTLKAGYTEKQRVDFLSEASIMGQFS-HHNIIRLEGVVSKYK-PMMIITEYMENGALDKFLREKD
.  ..||| |.||.|..|...  ... . .  ||.|.||.. |. .. |||.|...| .   | ||....|.  |   |.||| ||...| |...||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GE-------------------------FSVLQLVGMLRGIASGMKYLAN--MNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSG--GKI
..                          |  .|.  . .||.||.|||   .. |||||.|||.|.....|||..|||..| ...  .  | ...  |.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRI

PIRWTAPEAIS--YRKF-TSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDC-PSAIYQLMMQCWQQERSRRPKFADIVSIL
|||| |||...  .. . |. |||||.|..|||..|.|..|| .... ..|..| ||.|.| |  | . ..|.|| .||| |.. || |..|...|
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphA2.AA Frk 614-876 41 9.5e-88 297.83 In-house 1-260 (260) Show / Hide 
Range on Protein: 614-876
Range on HMM: 1-260/260
Sequence Identity: 41% (112 aa)

VARQKVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMIITEYMENGALDKFLR---EKDG
.   . .|.| ||||. |         ..|||.||||.|  . .  ||| || || .  |  .|.|  |    .|..|||| |..|.| ..|.   .|  
IQLIRRLGSGQFGEVWEGLWNN-----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGR

EFSVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATY-TTSGGKIPIRWTAPEAISYRKFTSASDVWSYGIVMW
.  . ||| |   .|.|| || ..||.||||||||.||. ...||. |||| |||  | |  | .  | ..||.||||||. | |||  |||||.||.. 
QCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

EVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERSRRPKFADIVSILDKLI
|..|||  ||  . | ||.. .. |.|.| | .||  .|..|..||...  .|| |  .   |.. .
EIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA2.AA Tec 614-874 39 5.3e-87 295.35 In-house 1-254 (254) Show / Hide 
Range on Protein: 614-874
Range on HMM: 1-254/254
Sequence Identity: 39% (105 aa)

VARQKVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAG-YTEKQRVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMIITEYMENGALDKFLREKDGEF
 .  | .| | || |  | ....     . ||||..| |   |    ||. || .|   || . ..| || |. .|. |.|||||.| |  .|||. ..|
LTFMKELGSGQFGVVHLGKWRHQ-----YDVAIKMIKEGSMSEE---DFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHF

SVLQ--LVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSR-VLEDDPEATYTTSG-GKIPIRWTAPEAISYRKFTSASDVWSYGIVM
.  .  | .|   .  || ||   ...|||||||| ||... | ||||||..| || |.    || |.  | |..| .||  .| .. | ||||..|. |
QKNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQ----YTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLM

WEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERSRRPKFADIVSILDK
||| . |  || ..|| || ...  |.||  |  |.  ||| | .||. .   || |..  . . .
WEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase EphA2.AA Syk 614-866 40 2.4e-86 293.19 In-house 1-257 (257) Show / Hide 
Range on Protein: 614-866
Range on HMM: 1-257/257
Sequence Identity: 40% (104 aa)

VARQKVIGAGEFGEVYKGTLKASSG---KKEIPVAIKTLKAGYTEKQ-RVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMIITEYMENGALDKFLREKD
. . . || |.|| | ||.... ||   |. |.||||.|||  ...     |. ||..| |  |  |.|. | . .  .|| . |  | |.. |.| .. 
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIG-ICHAEMMMMVMEMAELGPMHKYLQQHR

GEFSVLQLVGMLR-GIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSYGIVM
 | ..   . ..   .|.||.||   . |||||||||.|       |.||||.|. |  | .    |..|| |..| ||| | |.|| ..|||||.|. |
HEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTM

WEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERSRRPKFA
||   || .|| | .. |||| |  | |.. |  ||  .|||| .||  .   || | 
WEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase EphA2.AA S_TKc 614-876 21 1.3e-47 165.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 614-876
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

VARQKVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIRLEGVVSKYKPMMIITEYMEN--GALDKFLREKDGE
    ..|| | ||.|||.. |         |||| .|         ....| .|. .  | ||..| .|    . . ...||...  | | ...... ..
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FSVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTS-ASDVWSYG
     |.  .   ... |.....|. ... .||||   |||...  . |..||||.|.|          .       . ||| .   ...  ..|.|| |
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

IVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERSRRPKFADIVS-----ILDKLI
....| .. |. |..    ....| |            ..   .....|.| . ..||   ..        ..  .
CILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphA2.AA Pkinase 614-872 22 1.2e-42 151.92 Pfam 1-293 (293) Show / Hide 
Range on Protein: 614-872
Range on HMM: 1-293/293
Sequence Identity: 22% (68 aa)

VARQKVIGAGEFGEVYKGTLKASSGKKEIPVAIKTLKAGYTEK--QRVDFL-SEASIMGQFSHHNIIRLEGVVSKYKPMMIITEYMENG----ALDKFLR
  . ..||.| ||.|||.. | ..      ||.|..|   ...  .. ... ||..||  ..| ||.|| ...   . . ...||.|.|     |  ...
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

-EKDGEF--SVLQLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVC----KVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAIS-YRKFTSA
 ...| |  |  ..  ... |..|..|. .|. .||||   |||...| ..    |..||||.....        ...    ... ||| |  ... ...
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVWSYGIVMWEVMTYGERPYWEL----SNHEVMKAINDGFRLPTPMDCP-----------------------SAIYQLMMQCWQQERSRRPKFADIVSI
.|.||.|....|... |. |...     . |. |. |.   . |.. |.|                       ..  ...  |...  ..|| ...|.  
VDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
SAM_1 EphA2.AA SAM_1 903-967 51 1.3e-29 107.78 Pfam 1-66 (66) Show / Hide 
Range on Protein: 903-967
Range on HMM: 1-66/66
Sequence Identity: 51% (34 aa)

EGVPFRTVSEWLESIKMQQYTEHFMVAGYTAIEKVVQMSNEDIKR-IGVRLPGHQKRIAYSLLGLK
.. .|..|.||||||.||||..||| |||. .... ||. ||... .||.||||.|.|.||. .||
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM EphA2.AA SAM 902-969 35 5.6e-24 86.91 SMART 1-67 (67) Show / Hide 
Range on Protein: 902-969
Range on HMM: 1-67/67
Sequence Identity: 35% (24 aa)

SEGVPFRTVSEWLESIKMQQYTEHFMVAGYTAIEKVVQMSNEDIKRIGVRLPGHQKRIAYSLLGLKDQ
 .  ....|..|||||.|.||...|. .|..  . . ..| ||.|..|. .|||.|.|.... ..|||
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
Sam7 EphA2.AA sam7 905-967 32 1.4e-21 74.57 In-house 1-70 (70) Show / Hide 
Range on Protein: 905-967
Range on HMM: 1-70/70
Sequence Identity: 32% (23 aa)

VPFRTVSEWLESIKM---QQYTEHFMVAGY----TAIEKVVQMSNEDIKRIGVRLPGHQKRIAYSLLGLK
 .|..|.||||.|.|   |||...|. .|.    | .. . .|. ||....|. .|||.|.| ...  ..
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR
SAM_2 EphA2.AA SAM_2 902-967 33 1.5e-15 56.23 Pfam 1-71 (71) Show / Hide 
Range on Protein: 902-967
Range on HMM: 1-71/71
Sequence Identity: 33% (24 aa)

SEGVPFRTVSEWLESIKM-QQYTEHFMVAGYTAIEKV-VQMSNEDI--K-RIGVRLPGHQKRIAYSLLGLK
 .   | .|.|||.||.| .||.. |. .|.| .| .  .|. .|   | |.|. ..||.|.|  ..  .|
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK