Gene EphB2 (Mouse)

EphB2

Species: Mouse
Alias: EphB2, Ephb2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphB2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
EphB2.NA RNA Sugen 3322 None Fasta, JSON
EphB2.AA Protein Sugen 987 None Fasta, JSON

Protein domain

Protein domains of EphB2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphB2.AA Ephrin_lbd 20-197 63 1.7e-144 450.44 Pfam 1-190 (190) Show / Hide 
Range on Protein: 20-197
Range on HMM: 1-190/190
Sequence Identity: 63% (120 aa)

EETLMDSTTATAELGWMVHPPSG---------WEEVSGYDENMNTIRTYQVC-NVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKE
|..|||..|||..|||. .|..|         ||||||.|||...||||||| ||.|..|||||||..|.||||.||.||.||..|||.|.| |.|.|||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNLYYYEADF-DLATKTFPNWMENPWVKVDTIAADES-FSQVDLGGRVMKINTEVRSFGPVSRNGFYLAFQDYGGCMSLIAVRVFYRKC
||||||||.|  | |.|..||||||...|.|||||||| |.|.|.|.|.||.||||||.||.|. ||||||||.|.||.|..|||.|.||
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphB2.AA EPH_lbd 20-197 67 3.1e-132 446.51 SMART 1-184 (184) Show / Hide 
Range on Protein: 20-197
Range on HMM: 1-184/184
Sequence Identity: 67% (125 aa)

EETLMDSTTATAELGWMVHPPSG--WEEVSGYDENMNTIRTYQVCNVFE---SSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPG-SCKETFNL
|..|||..|.|.||||. .||.|  ||||||.||..|.|||||||||.|   ..|||||||..|.||||.||.||.||..|||.|.| |.| ||||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYYEADFDLATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRNGFYLAFQDYGGCMSLIAVRVFYRKC
||||.| | ||...| |||||..|.|||||||||.|.|.|.||||.|||||||||.|..||||||||.| ||.|..|||||.||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphB2.AA GCC2_GCC3 259-302 28 2e-08 30.37 Pfam 1-45 (49) Show / Hide 
Range on Protein: 259-302
Range on HMM: 1-45/49
Sequence Identity: 28% (13 aa)

GFEAVENGTVCRGCPSGTFKANQGDEACTHCPIN-SRTTSEGATN
|     ..  |  || ||.. . |  .| .|| . . | ..|.|.
GTYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGSTS
FN3 EphB2.AA FN3 325-417 17 9.4e-09 36.33 SMART 1-69 (69) Show / Hide 
Range on Protein: 325-417
Range on HMM: 1-69/69
Sequence Identity: 17% (19 aa)

PSAPQA----VISSVNET------SLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAH----TQYTFEIQA
|..|.     ....|..|      |. |.|.||                               |.|             ...| ..    |.|.| ..|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------------------------------IVGYR----------YTVTGLKPGQYPWTEYEFRVRA

VNG--VTDQ
|||  .   
VNGNDAGEG
FN3 EphB2.AA FN3 436-517 24 7.4e-13 49.96 SMART 1-69 (69) Show / Hide 
Range on Protein: 436-517
Range on HMM: 1-69/69
Sequence Identity: 24% (24 aa)

PSAVSI---MHQVSRTVD------SITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAG----AIYVFQVRARTV--AGYG
|....     . .. | .      |.||||. |      |. |.                      .|| |||.|      |.|.|||..   ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphB2.AA Eph 622-881 86 8.60000000001e-226 756.4 In-house 1-264 (264) Show / Hide 
Range on Protein: 622-881
Range on HMM: 1-264/264
Sequence Identity: 86% (228 aa)

VKIEQVIGAGEFGEVCSGHLKLP-GKREI---FVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDG
.|||.|||||||||||.|.|||| ||||.   .|||||||.|||||||.||||||||||||||||.|.|||||||| ||||.||.||||||||||||.||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTS-DPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIV
|||||||||||||||.|||||.|||||||||||||||||||||||||||||||.||||.| ..|||.. ||||||||||||||.||||||||||||||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIV

MWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTL
|||||||||||||||.|||||.||||.||||||||||.||||||||||||||||||.| |||..|
MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphB2.AA Pkinase_Tyr 622-881 43 4.4e-150 508.91 Pfam 1-270 (270) Show / Hide 
Range on Protein: 622-881
Range on HMM: 1-270/270
Sequence Identity: 43% (119 aa)

VKIEQVIGAGEFGEVCSGHLK-LPGKREIFVAIKTLKSGYTEKQ--RRDFLSEASIMGQF-DHPNVIHLEGVVT-KSTP--VMIITEFMENGSLDSFLRQ
... ...|.|.||||. |..| .|.. .| ||.|.|| |....|  |.||..||.|| |. .|||.. | ||.| .. |  ..|..|.|..|.|...||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTY-TSALGGKIPIRWTAPEAIQYRKFTSASDV
.   ....|. .|..| . ||.|| ||...|..||||||||.||..|.|.|..||||.| .   ..| .| ... |||.||.|.|||.|.|.|||..|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSYGIVMWEVMSYGERP-YWDMTNQDVINAI-EQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTL
||.|..|||...||| | |..|.|..|...| |. ||.|.|..||  ...||..||..| ..|| | .|.. |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphB2.AA TyrKc 622-881 40 4.2e-141 475.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 622-881
Range on HMM: 1-280/280
Sequence Identity: 40% (117 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQF--DHPNVIHLEGVVTKS-------TPVMIITEFMENGSLDSFL
.. ....| |.||||. |..|      | ||.|.||..     |.||..||.|| ..  .|||.. | ||.|..        |.||..|.|..|.|...|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDD----TSDPTYTSAL--GGK--IPIRWTAPEAIQYRKF
| . ..... .|. .   ||.|| ||...|..||||||||.||..|...|.|||||||...||     |. .|...   |||  .||||.|||.|.|.||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSASDVWSYGIVMWEVMSYGERPYWD-----MTNQDVINAIEQDYRLPPPMD--------CPSALHQLMLDCWQKDRNHRPKFGQIVNTL
|..|||||.|..|||...||. ||..     |.||.||. ..| ||.|.| .        ||....|.|..||. | . || | .|.  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphB2.AA TK 622-881 24 1.5e-126 426.54 In-house 1-486 (486) Show / Hide 
Range on Protein: 622-881
Range on HMM: 1-486/486
Sequence Identity: 24% (119 aa)

VKIEQVIGAGEFG---EVCSGHLKLPG----------------------KREIFVAIKTLKSGYTEKQRR-------------DFLSEASIMGQFD----
.......|.|.||   ||. | .. ..                      . .. ||.|.||.| .. |..             |||.||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVIHLEGVVTKS------------TPVMIITEFMENGS----LDSFLRQNDG---------------------------------------------
 |||...| ||.|..             |.||..|.|..|.    |...||....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFTVIQLVGMLRGIAAGMKYLADM------NYVHRDLAARNILVNSNLV-----------CKVSDFGLSR
                              |.|. ||. | . ||.|| ||...      |.|||||||||.||..|.|           ||..||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----FLEDDTSDPTYTSAL------------------------GGKIPIRWTAPEAIQ---------YRKFTSASDVWSYGIVMWEVMSYG-ERPYWDM
        |. ||  |...                         |||.||||.|||...         |.|||..|||||.|..|||...|| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------QDVINAIEQD--------------YRLPPPMDCP--------------SALHQLMLDCWQKDRNHRPKFGQIVNTL
.|         |.|.. ...               .|.|.|..||               ....||..||..| ..|| | |... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphB2.AA UTK 622-881 36 8.60000000001e-110 371.05 In-house 1-296 (296) Show / Hide 
Range on Protein: 622-881
Range on HMM: 1-296/296
Sequence Identity: 36% (109 aa)

VKIEQVIGAGEFGEVCSGHLKLPG--KREIFVAIKTLK-SGYTEKQRR---DFLSEAS---IMGQFD-HPNVIHLEGVVTKSTPVMIITEFMENGSLDSF
|.. . .|.|.||||. .... .     |  ||.|... .. ......   ||. ||    .|.||. ||||. | ||.|.. | ||.||.||||.|.|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSN-------LVCKVSDFG---LSRFLED------DTSDPTYTSALGGK
||       ... ..|  |...| . ||.|| ||. ...|||||||||.||...       .|||..|||   .|| . .      . ... |...  ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIRWTAPEAIQYR-KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQD--YRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTL
.||||.||||. .. .||..|||||.|.|.||....| .|| .|.|..|. ...    ||.|.| ||| .. .||..||..|   || | ..| ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphB2.AA Src 622-881 44 7.2e-109 367.99 In-house 1-255 (255) Show / Hide 
Range on Protein: 622-881
Range on HMM: 1-255/255
Sequence Identity: 44% (116 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR-QNDGQ-F
.| .. .|.| ||||  |      . .. ||.||||.|    .  .|| || || ...|.....|  |...  |. |.||.|..|||  .|. . .|.  
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWE
 . ||. |   .|.||.||  |||.||||||||.||. |.|||| |||| | ...|  |  |..  | |.||.|||||||.|..||  |||||.|| ..|
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED--DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

VMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQ-LMLDCWQKDRNHRPKFGQIVNTL
...||  ||  |||..|. ..|. ||.| |. ||  |.. .|| ||.||   || |  . . |
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphB2.AA SFK-Src 622-885 42 1.8e-105 313.57 In-house 1-259 (259) Show / Hide 
Range on Protein: 622-885
Range on HMM: 1-259/259
Sequence Identity: 42% (114 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQ-NDGQFT
.. |.  |.| ||.|  |           ||.||||.| .  .   ||.|| .| .  ||| | |  | |   |. |||| | .|||  .|.. .    .
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEV
. ||| |   .|.|| || . |.|||||||||.||  | |||| |||.|| |..|  |  ||   | | ||.|||||| .. .|   |||||.|| | |.
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQD--DEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEI

MSYGERPYWDMTNQDVINAIEQ--DYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMI
  ||  ||  |||. |.  ...   ||.| |  || .....|.||||.    || |.     ..   
VTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphB2.AA Fer 622-882 35 1.5e-99 337.06 In-house 1-283 (283) Show / Hide 
Range on Protein: 622-882
Range on HMM: 1-283/283
Sequence Identity: 35% (102 aa)

VKIEQVIGAGEFGEVCSG--HLKLPGKREIFV---AIKTLKS---GYTEKQRRDFLSEASIMGQ-FDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL
|... ..| | ||||..|   ||.  .. ..|   |.|. |    . |..|...|. || || . .|||||. . || .   |.||. ||. .|||||.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RQNDGQ-FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNS-NLVCK--VSDFGLSRFLEDDTSDPTYTSA-LGGKIPIRWTAPEAIQYRKFTSA
. |...  .. ... |. ..|.||.||  .| .|||.||||.|.   ....|  .||||.|| ..|...|  |. .    |.||||.|||..|.. ....
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYD--YKMKEKACKVPIRWLAPETWQTGIYSPK

SDVWSYGIVMWEVMSYGERPYWD----MTNQDV----INAIEQ-DYRLPPPMDCPSALHQLML-DCWQKDRNHRPKFGQIVNTLD
.||||.|...||... |. || .    |..  |    . .|.. .|..|.|  .|... |.|. .||||| . ||.. .|...| 
TDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphB2.AA TK-Unique 622-881 34 9.7e-94 317.73 In-house 1-294 (294) Show / Hide 
Range on Protein: 622-881
Range on HMM: 1-294/294
Sequence Identity: 34% (102 aa)

VKIEQVIGAGEFGEVCSGHLKLPG---KREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFD-HPNVIHLEGVVTKST-PVMIITEFMENGSLDSFLRQND
.....||| |.||.|. | .. .     . . ||.|.|| . |. ...|||.|...| . . |||.....|. |||. |.||| |....|.|...||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-GQFTV---------------------IQ---LVGMLRGIAAGMKYLAD--MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALG-GK
 .....                     |.   |.  . .|| ||.|||   .. |||||.|||.|.....|||..|||..| ...   .  | .  . |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---NGVYSMMCSQGR

IPIRWTAPEAIQ--YRKF-TSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDC-PSALHQLMLDCWQKDRNHRPKFGQIVNTL
||||| |||...  .. . |. |||||.|..|||....|..|| .| . |....|.. ||.| |  | . ....||  |||... .|| | ||.. |
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphB2.AA Frk 622-885 43 2.6e-91 309.65 In-house 1-260 (260) Show / Hide 
Range on Protein: 622-885
Range on HMM: 1-260/260
Sequence Identity: 43% (117 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR---QNDGQ
... . .|.| ||||  |        .. ||.||||.|  . .  ||| || || .  || .|.|  | |   |..|||| |..|||  .|.   ..  |
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMW
  . ||| |   .|||| || ..||.||||||||.||. ...||. |||| | |  |  |  | |  | ..||.||||||..| |||  |||||.||.. 
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNED-IYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

EVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMI
|.. ||  ||  |||..|.. ....||.| | .||  | ..||.||..| ..|| |  .   |.. .
EIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphB2.AA Tec 622-883 37 2e-86 293.45 In-house 1-254 (254) Show / Hide 
Range on Protein: 622-883
Range on HMM: 1-254/254
Sequence Identity: 37% (100 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSG-YTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFT
 .. . .| | || |  | ..     ...||||..| |   |    ||. || .|    ||. . | || ..  |. |.||.||.|.| ..||.. ..| 
LTFMKELGSGQFGVVHLGKWRH----QYDVAIKMIKEGSMSEE---DFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQ

VIQ--LVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMW
  .  | .|   .  || ||   ...|||||||| ||... | ||||||..|.  ||     |||  | | |..| .||  .| .. | ||||..|. ||
KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDD----QYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMW

EVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDK
|| | |  ||  |.| .|. .. | .||  |  |.  . | | .||.     || | |   .. .
EVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase EphB2.AA SrcB 622-882 43 2.7e-85 288.51 In-house 1-251 (251) Show / Hide 
Range on Protein: 622-882
Range on HMM: 1-251/251
Sequence Identity: 43% (114 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDG-QFT
.|... .||| ||||  |      .... ||.||.| |    .   || || .| .  |  ...|  ||||  |. ||||.|..|.|  ||. ..| . .
LKLVKKLGAGQFGEVWMGYY----NNHMKVAVKTMKQGTMSPEA--FLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLS

VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEV
. .|. |   || || |.  |||.|||| | ||||   |.||. |||| | .||.     ||   | | ||.|||||||..  ||  |||||.||.. |.
LPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDN----EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEI

MSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLD
. ||  ||  ||| .||...|. ||.| |  ||  | ..|  ||..    || |  .   ||
VTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase EphB2.AA S_TKc 622-885 20 2.6e-51 177.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 622-885
Range on HMM: 1-231/231
Sequence Identity: 20% (58 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMEN--GSLDSFLRQNDGQ-
 .| ..|| | ||.|. .. |        |||| .|        .....| .|. . .|||...| .|    . . ...|....  |.| ...... .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTS-ASDVWSY
    |.  .   ... |. ...|. ... .||||   |||...  . |..||||.|.|                    . ||| .   ...  ..|.|| 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVN-----TLDKMI
|....| .. |. |..  . | ... |            .. . ...  |.||| ..||   .. .      ..  .
GCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphB2.AA Pkinase 622-881 22 1.5e-47 169.12 Pfam 1-293 (293) Show / Hide 
Range on Protein: 622-881
Range on HMM: 1-293/293
Sequence Identity: 22% (69 aa)

VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEK--QRRDFL-SEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENG----SLDSFLR-
 .|...||.| ||.|. .| |  ||    ||.|..|   ...  ...... ||..||  ..|||.. | .... .. . ...|..|.|    .| .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

QNDGQF--TVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVC----KVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQ-YRKFTS
...| |  .  ..  ... |. |..|. .|. .||||   |||...| ..    |..||||.....       .. . .    ... ||| |. ... ..
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

ASDVWSYGIVMWEVMSYGERPYWDM----TNQDVINAIEQDYRLPPPMDCP-----------------------SALHQLMLDCWQKDRNHRPKFGQIVN
..|.||.|....|... |. |...     .  | .  |... . |.. |.|                       ... ... .|..|| . || . ||..
KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

T--L
   .
HPWF
SAM_1 EphB2.AA SAM_1 912-976 48 7.8e-31 112.16 Pfam 1-66 (66) Show / Hide 
Range on Protein: 912-976
Range on HMM: 1-66/66
Sequence Identity: 48% (32 aa)

DYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILR-VGVTLAGHQKKILNSIQVMR
||..|..|.||||.|.|.||...|. ||....| ..|| .||... .||||.||.|||..||| ..
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM EphB2.AA SAM 911-978 38 4.5e-26 93.87 SMART 1-67 (67) Show / Hide 
Range on Protein: 911-978
Range on HMM: 1-67/67
Sequence Identity: 38% (26 aa)

PDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQ
.|  ....| .|||.|.|.|||. |. .|..... .... .||....|.|..||.||||..|| |..|
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
SAM_2 EphB2.AA SAM_2 911-976 40 6.8e-25 88.27 Pfam 1-71 (71) Show / Hide 
Range on Protein: 911-976
Range on HMM: 1-71/71
Sequence Identity: 40% (29 aa)

PDYTSFNTVDEWLEAIKM-GQYKESFANAGFTSFDVV-SQMMMEDI--L-RVGVTLAGHQKKILNSIQVMR
..|..|..| |||..|.| .|||..|  .|.|.|...  .| ..|     | |.|..||.|||.|.|| |.
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
Sam7 EphB2.AA sam7 914-976 41 4.2e-24 83.49 In-house 1-70 (70) Show / Hide 
Range on Protein: 914-976
Range on HMM: 1-70/70
Sequence Identity: 41% (29 aa)

TSFNTVDEWLEAIKM---GQYKESFANAGF----TSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMR
..|..| ||||.|.|   .||...| ..|.    |..|.. .| .||... |.|. ||.|||.|.|| ||
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR