Gene ErbB3 (Mouse)

ErbB3

Species: Mouse
Alias: ErbB3, Erbb3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: EGFR

Sequence

Name Sequence Type Origin Length Description Download
ErbB3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
ErbB3.AA Protein Sugen 1339 None Fasta, JSON
ErbB3.NA RNA Sugen 5978 None Fasta, JSON

Protein domain

Protein domains of ErbB3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain ErbB3.AA Recep_L_domain 55-167 36 3.1e-45 153.82 Pfam 1-121 (121) Show / Hide 
Range on Protein: 55-167
Range on HMM: 1-121/121
Sequence Identity: 36% (45 aa)

KCEVVMGNLEIVLTGHN----ADLSFLQWIREVTGYVLVAMN--EFSVLPLPNLRVVRGTQVYDG-KFAIFVMLNYNTNSSHALRQLRFTQLTEILL--G
.|.|..||||| .....     ||||.. |||.|||.|....  ...  ..||||..||.|.... ..|.... |.|      |..| .  |..|.   |
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNM----GLQELWMWNLKNITRKNG

GVYIEKND--KLCHMDT-IDWRDIV
||||..|   |||...| |.|..|.
GVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like ErbB3.AA Furin-like 180-332 45 4.8e-85 279.47 Pfam 1-182 (182) Show / Hide 
Range on Protein: 180-332
Range on HMM: 1-182/182
Sequence Identity: 45% (82 aa)

GGNCP--------PCHEVC--------KGRCWGPGPEDCQILTKTICAPQCNG-RCFGPNPNQCCHDECAGGCSGPQ-DTDCFACRHFNDSGACVPRCPA
...||        |||..|          |||||.|..||.|||..|..||.. ||.|| |..|||..|.|||.||  ||||.|||||...|.||..|| 
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

PLVYNKLTFQLEPNPHIKYQY-GGVCV--ASCP-------HNFVV-DQTFCVRACPADKMEVDKNGLKMCEPCRGLCPKACE
...||. |||.||||. .||. |  ||  ..||       .|..| ... |.| || ...|...|. .|||||.|.||| |.
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKLSHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU ErbB3.AA FU 223-265 37 3.2e-12 47.86 SMART 1-48 (48) Show / Hide 
Range on Protein: 223-265
Range on HMM: 1-48/48
Sequence Identity: 37% (18 aa)

PNQC--CHDECAGGCSGPQDTDCFACRHFNDS---GACVPRCPAPLVY
 ..|  ||.|||.||.|| ...| .|.|...    |.||. ||.   .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
FU ErbB3.AA FU 180-220 35 0.023619 10.38 SMART 1-48 (48) Show / Hide 
Range on Protein: 180-220
Range on HMM: 1-48/48
Sequence Identity: 35% (17 aa)

GGNCPPCHEVCKGRCWGPGPEDCQ------ILTK-TICAPQCNGRCFG
.| |.|||. |.. ||||||..|.       | .  .| .||.   ..
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain ErbB3.AA Recep_L_domain 353-474 34 4e-45 153.44 Pfam 1-121 (121) Show / Hide 
Range on Protein: 353-474
Range on HMM: 1-121/121
Sequence Identity: 34% (45 aa)

NCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNR-GFSLLIMKNLN--VTSLGFRSLKEI
|||.| ||| ..... ...        ..|.|..|...|||||||.|. . . . |.|.|.||..| ||.|...  ..| |..| |   ..|....||.|
NCTVIYGNLEITWRDEHNE--------LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNI

SA--GRVYISANQ--QLCYHHS-LNWTRLL
.   |.|||. |   .|||.|. ..|  ..
TRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
FU ErbB3.AA FU 490-541 40 3.2e-09 37.88 SMART 1-48 (48) Show / Hide 
Range on Protein: 490-541
Range on HMM: 1-48/48
Sequence Identity: 40% (22 aa)

LGECVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRE---GVCVTHCNVLQGEPR
 |.|    | |.| |.. |||||||.||.||...      |.||. |.  .|. .
DGVC----KPCHPECAT-GCWGPGPDQCTSCPHGYYLHHNGTCVSQCP--PGYYP
Furin-like ErbB3.AA Furin-like 507-533 42 1e-06 22.48 Pfam 71-98 (182) Show / Hide 
Range on Protein: 507-533
Range on HMM: 71-98/182
Sequence Identity: 42% (12 aa)

GGCWGPG-PGQCLSCRNYSREGVCVTHC
||| ||. .  |..||... .|.||..|
GGCTGPNNDTDCVACRHFYHNGTCVDQC
FU ErbB3.AA FU 546-595 35 5.4e-08 33.8 SMART 1-48 (48) Show / Hide 
Range on Protein: 546-595
Range on HMM: 1-48/48
Sequence Identity: 35% (19 aa)

EAHCFSCHPECQPMEGTSTCNGSGSDACARCAHFRDGPH---CVNSCPHGILG
. .|  |||||       .|.|.| |.|  |.|.....|   || .|| |  .
DGVCKPCHPECAT-----GCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
FU ErbB3.AA FU 607-643 25 0.037226 8.01 SMART 1-48 (48) Show / Hide 
Range on Protein: 607-643
Range on HMM: 1-48/48
Sequence Identity: 25% (12 aa)

QNECRPCHENCTQGCKGPELQDCLG--QAEVL------MS---KPHLV
...|.|||..|  || ||   .|.      .|      .|     .  
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Kinase ErbB3.AA EGFR 707-964 66 1.2e-187 628.36 In-house 1-258 (258) Show / Hide 
Range on Protein: 707-964
Range on HMM: 1-258/258
Sequence Identity: 66% (171 aa)

LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRETLGP
|.|.||||||.||||.|||||||||..||||.|||.....|........|......|.||.|.|||||.|..|..||||||.|.|.|||.||||....|.
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS

QLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFG
|.||||.|||||||.|||||.||||||| |||..|||..|...|||.|.||..|.|.. ....|.||||||||.||...|||||||||||||.|||||||
QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFG

AEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFT
..||.|....||||||||||||.||.||||||||||||||||||..|||||||..|| 
QKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase ErbB3.AA Pkinase_Tyr 707-963 37 9.5e-114 385.87 Pfam 1-270 (270) Show / Hide 
Range on Protein: 707-963
Range on HMM: 1-270/270
Sequence Identity: 37% (101 aa)

LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQS--FQAVTDHMLAVGSL-DHAHIVRLLGLCP--GSS--LQLVTQYLPLGSLLDHVRQ
....|.||.| ||.|.||.| ..... |||| .|.. ...  .    ..    .    .| .| .||||.| |   | .  . .|. | |.|.|||. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---RETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQ-LLHSEAKTPIKWMALESIHFGKYTHQSDVWSY
|   .. | .. ||.. .|||||| |||.. ..||||| ||...... .| ..||| | .. .||     ....| ||||||.|.|..||.|..|||||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVTVWELMTFGAEP-YAGLRLAEIPDLL-EKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEF
||. ||..|.|..| |.|.  .|. ... |.|.|...|. |. ..|..| .||. | . ||||.|. ...
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ErbB3.AA TyrKc 707-963 33 2.3e-93 317.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 707-963
Range on HMM: 1-280/280
Sequence Identity: 33% (97 aa)

LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSL--DHAHIVRLLGLCPG--------SSLQLVTQYLPLGSLLDH
....|.||.| ||.|.||.|.       |.| .|.. . .     ..  . .    .|  .| .||||.| |            | .|. | |.|.|.|.
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

VRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDD-----KQLLHS----EAK--TPIKWMALESIHFGK
 | ||..| .. ||.. .|||.|| ||...  .||||| ||...... .| ..||| .  .  ||     |.  ..     .|   ||.|||.|.| .||
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTHQSDVWSYGVTVWELMTFGAEPYAG-----LRLAEIPDLLEKGERLAQPQI--------CTIDVYMVMVKCWMIDENIRPTFKELANEF
.|..|||||.||. ||..|.|..|| |     .  .|.  ....|.|. ||.         |. ..|..| .||. | . ||||.|.  .|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ErbB3.AA TK 707-963 20 1.5e-92 310.51 In-house 1-486 (486) Show / Hide 
Range on Protein: 707-963
Range on HMM: 1-486/486
Sequence Identity: 20% (99 aa)

LRKLKVLGSGVFG---TVHKGIWIPE---------------------GESIKIPVCIKVIEDKSGRQSFQAVT----------------DHMLAVGS--L
.. .|.||.| ||   .|.||.|...                     .|  |.|| .|.. .... .. .                     |    .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHAHIVRLLGLCPGSS-------------LQLVTQYLPLGS----LLDHVRQHRET--------------------------------------------
.| .||||.| |  .              . .|. | |.|.    |.|. |..|..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LGPQLLLNWGVQIAKGMYYLEEH------SMVHRDLALRNVMLKSPSQ-----------VQVADFG---
                               | .. || . .|||.|| ||...       .|||||| ||... .  .           . .||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----VADLLPPDDKQLLHS------------------------EAKTPIKWMALESIH---------FGKYTHQSDVWSYGVTVWELMTFGAEPYAGLR
      |  ...||    .|                         .| ||.||| |..          .||.|..|||||.||..||..|.|.|||.|  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

L----------AEIPDLLEKG--------------ERLAQPQICT--------------IDVYMVMVKCWMIDENIRPTFKELANEF
           .|. ..|..|               |..||. |.               ..| .| .||  | . ||||..| ...
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ErbB3.AA Ack 707-963 33 8.2e-69 231.24 In-house 1-266 (266) Show / Hide 
Range on Protein: 707-963
Range on HMM: 1-266/266
Sequence Identity: 33% (90 aa)

LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDK---SG--RQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSL-QLVTQYLPLGSLLDHVRQH
.. .. ||.| || |..| |     .  |.| .|.  .    ..   ..|     .|.   ||||.|.||| |.  .. . ..||   |.|||||  |.|
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMH---SLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKH

RE--TLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSP-SQVQVADFGVADLLPPDDKQLLHSEAK---TPIKWMALESIHFGKYTHQSDVWS
     .   .|... .|||.|| |||   ..||||| ||. | |.   | ..|||    |.  .     .. .    |. |.| |.. ... .| ||||.
CRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWM

YGVTVWELMTFGAEPYAGLRLAEIPDLLE-KGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEF
.||| ||  ..| ||.||.. ..|  ... .|||| .|  |  |.| .|..||  .   |||| ..   .
FGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase ErbB3.AA TK-Unique 707-963 29 6.3e-68 231.99 In-house 1-294 (294) Show / Hide 
Range on Protein: 707-963
Range on HMM: 1-294/294
Sequence Identity: 29% (87 aa)

LRKLKVLGSGVFGTVHKGIWIP--EGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLD-HAHIVRLLGLCP-GS-SLQLVTQYLPLGSLLDHVRQHR
|. ..|.|.| ||.|..|   .  .... .. | .|  .|..  .. |. ..      .|. | .||..|| |   . . ...  |.| |.|... |. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

ET-------------------------LGPQLLLNWGVQIAKGMYYLEE--HSMVHRDLALRNVMLKSPSQVQVADFGVA-DLLPPDDKQLLHSEAKTPI
 .                         . |..|.....|||.|| ||..  .  |||||. |||.| .  .. ..||| | |.  . . .   |. ..||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWMALESIH--FGKY-THQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQIC-TIDVYMVMVKCWMIDENIRPTFKELANEF
.|||.||.    | | | .|||||.||. ||..|.|| || |.. ..| .....| |. ||. | . ..| .|  ||  ..  ||.| ......
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ErbB3.AA UTK 707-963 26 4.9e-67 228.37 In-house 1-296 (296) Show / Hide 
Range on Protein: 707-963
Range on HMM: 1-296/296
Sequence Identity: 26% (80 aa)

LRKLKVLGSGVFGTVHKGIW--IP--EGESIK-IPVCIKVIEDKSGRQSFQ---AVTDHML---AVGSLD-HAHIVRLLGLC-PGSSLQLVTQYLPLGSL
.. .. ||.| ||.|||. .  ..  ..|... ..||    ......|.      .  .       . .. | ...||.|.|  .. . .|| | . |.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDL

LDHVRQHRETLG-PQLLLN------WGVQIAKGMYYLEEHSMVHRDLALRNVMLKSP-------SQVQVADFG---VADLLP---------PDDKQLLHS
.. .| ||.|.. ....|.      . ..|| || ||...  |||||| ||. . .        ... .||||    . ...          ..    ..
RSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH

EAKTPIKWMALESIHFG-KYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKG--ERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEF
  . ||.||| |..  . ..|..|||||.||..||..|.|. ||.|.  ...   ...|   |...|. |  .||..|..||. |   ||.|..|  ..
QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ErbB3.AA Syk 707-957 35 5.8e-62 212.08 In-house 1-257 (257) Show / Hide 
Range on Protein: 707-957
Range on HMM: 1-257/257
Sequence Identity: 35% (92 aa)

LRKLKVLGSGVFGTVHKGIWIPE---GESIKIPVCIKVIEDKSGRQSFQAVTDHMLA----VGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQ
| . . .|.| ||.||||        ||   |.| ||.  .  .     | .. ...       ||| .|||..| | . .. .|    .||....   |
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQ---PADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQ

HRETLGP-QLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEA-KTPIKWMALESIHFGKYTHQSDVWSYGV
||.       |  |  |.| || ||||   |||||| ||| |    .  . |||    | .|..      . | |.|| | |.| ..|  |.|||||.||
HRHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGV

TVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFK
| ||    |. ||.. . .|. ...|.|.|. .|  |  ..| .| |||  .   |||| 
TMWEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase ErbB3.AA Src 707-963 35 3.5e-60 203.14 In-house 1-255 (255) Show / Hide 
Range on Protein: 707-963
Range on HMM: 1-255/255
Sequence Identity: 35% (92 aa)

LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGS-SLQLVTQYLPLGSLLDHVR--QHRET
.. .. ||.| || | .|.|       ...| .|..  |.|  | .|      .  .|.| ..|.|.  |        || |   |||||  .  .   .
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTL--KPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

LGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLP-PDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWEL
|  . |.  . |.|.|| |||.  ..||||| |||     . . ||||| | |.   ||    ...|| ||||.| | |..|..|  |||||.|.  .|.
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

MTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYM-VMVKCWMIDENIRPTFKELANEF
.|.|  || | . .|  . .|.| |. .|. |   .|. .| .||  |   ||||. | . .
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ErbB3.AA Abl 707-963 36 3.1e-58 192.65 In-house 1-252 (252) Show / Hide 
Range on Protein: 707-963
Range on HMM: 1-252/252
Sequence Identity: 36% (96 aa)

LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVI-EDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSS-LQLVTQYLPLGSLLDHVRQ-HRET
.   . || | .| | .|.|       .  | .| . ||    . | .    |  .    |  .|.||| |   .   ..| ... | |||..|.  ||.
IMMKHKLGGGQYGEVYEGVW----KRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEM---KHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREE

LGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELM
| .  ||    ||| || |||... .||||| || ..     |.|||||.| ..  ||    |  || |||| | ||. . |.  .|||| .|| .||. 
LPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMM-KDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIA

TFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEF
|.|  || |. | .. ..|||| |. .|. |  .|| .| .||  ..  ||.|||. ...
TYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase ErbB3.AA Frk 707-967 31 6.8e-53 181.57 In-house 1-260 (260) Show / Hide 
Range on Protein: 707-967
Range on HMM: 1-260/260
Sequence Identity: 31% (84 aa)

LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVR---QHRE
.. .. |||| || |  | |       ..|| .| .  |.|    .        . .| |. ...|  .|     . ..|  .  |||.....   .. .
IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTL--KPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGR

TLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDK--QLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVW
 .  | |..   |.| || |||..  .||||| |||..     ...||||.| .|  |..     . .|. |||| | | ..  |.| .|||||.|. . 
QCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

ELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMA
|..|.|  ||.|.  ||. . ...| |. ||  |   .| .| .||  | . ||||  |   .    
EIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase ErbB3.AA Src-Echino1 707-963 33 2.6e-52 179.78 In-house 1-252 (252) Show / Hide 
Range on Protein: 707-963
Range on HMM: 1-252/252
Sequence Identity: 33% (88 aa)

LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGS-SLQLVTQYLPLGSLLDHVRQHRET-L
||  | .|.| .| | ||.|         || .| .  |.   |  .       .  . |  ||..  .|  .  . .||. .  |.|.|.... .   .
LRMDKKIGKGHCGEVWKGVW-----NGNTPVAVKTLKEKT--MSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHV

GPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMT
    |.. | .|| || ||..  .|||||| |||..     ...|||| | ..  .|    .  || |||| | | . .|..| .|||||.|. . |..|
KMTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMM-QKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVT

FGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMV-MVKCWMIDENIRPTFKELANEF
||  || |..  |. | ...| |. ... |.  .||. |.|||  |   ||||. | . |
FGRYPYPGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase ErbB3.AA S_TKc 707-964 20 6e-33 116.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 707-964
Range on HMM: 1-231/231
Sequence Identity: 20% (55 aa)

LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQLVTQYLPL--GSLLDHVRQHRE--
 ..|...|.| ||.|.|....      .  | ||.|         . .   .    . .| .||.|.. .  ..| .|. |..   |.|.|. ....   
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

---TLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTH-QSDVWSYGVT
    . .     .  ||.... |. .|  .||||   |..| .  .. ..|||.| .|         .       .|| | .   .|..  .|.|| |..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

VWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELAN--------EFT
..|... |  |.      ..  ...|          . ..   . ||.  | . |||  |. .        .. 
LYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ErbB3.AA Pkinase 707-963 19 8.7e-27 95.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 707-963
Range on HMM: 1-293/293
Sequence Identity: 19% (59 aa)

LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTD----HMLAVGSLDHAHIVRLLGLC-PGSSLQLVTQYLPLG----SLLDHV
.......||| ||.| |.... .|.     |..|.|. . .. | . .|.          .|.| .||||.. .  .... .|. |.. |    .| |..
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

R-QHRETL--GPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQV----QVADFGVADLLPPDDKQLLHSEAKTPIK----WMALESIH-FGK
. . . ..   .. . ..  ||..|..|. ... .|||| . |.....  ..     ..|||.| ..      . ...  | .     .|| | |    .
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQY

YTHQSDVWSYGVTVWELMTFGAEPYAGL----RLAEIPDLLEKGER----LAQPQICT-------------------IDVYMVMVKCWMIDENIRPTFKE
|.. .|.||.|....|... |  |. |     . ..   ....  .       |. |.                    .   .. .|.  | . |||...
YGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LANE--F
. .   |
ILQHPWF