Gene ERK4 (Mouse)

ERK4

Species: Mouse
Alias: ERK4, Mapk4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK3

Sequence

Name Sequence Type Origin Length Description Download
Erk4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 293 Kinase domain by global Sugen HMM Fasta, JSON
Erk4.AA Protein Sugen 583 None Fasta, JSON
Erk4.NA RNA Sugen 4660 None Fasta, JSON

Protein domain

Protein domains of Erk4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Erk4.AA ERK3 20-312 76 1.8e-262 854.14 In-house 1-300 (300) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-300/300
Sequence Identity: 76% (230 aa)

FIDFQPLGFGVNGLVLSATDSRACRKVAVKKIVLSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDLQ-----GELFKFSVAYIVQEYMETDLAC
|.|..|||.|.||||.||.||..|.|||.|||||.|..|.|||||||||||||||||||||||||.|||||.|     |.||......||||||||||||
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIVLTDKKSCKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDLAC

LLEQGTLTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA
..||..|.|.||.||||||||||||||||||||||||||||||.||||||||||||.|||||.||||||||||||||||||||||||.||||||||||||
VMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAIDMWA

AGCILAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEELLRVMP-SFVS-STWEVKRPLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM
||||||||||||||||||||||||.||||.||||.||||.|||.||| .... ..|....||..||......|.||||..|||.|||||||||.||||||
AGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQHPYM
Kinase Erk4.AA MAPK 20-312 39 1.4e-144 486.63 In-house 1-328 (328) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-328/328
Sequence Identity: 39% (131 aa)

FIDFQPLGFGVNGLVLSATDSR------ACRKVAVKKIV--LSDARSMKHALREIKIIRRL-DHDNIVKVYEVLGPKGSDLQGELFKFSVAYIVQEYMET
. . .|.|.|  |.| ||.| |       ..|||.|||.   ... ..|...||||. |.. .|.||.|..... |...| |..| .|   |||.|.|||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLACLLEQGT-LTEDHAKLFMYQLLRG--LKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKG-----------YLSEGLVTKWYRS
||  .....  |..|| . ||||.|||  |||||||||.||||||.|| . ..... ||.||||||..|..|.|..           ...|  .| |||.
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDL-KICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PRLLLSP--NNYTKAIDMWAAGCILAEMLT-GKMLFAGAHELEQMQLILDTIPVVREEDKEELL-RVMP-SFVSS----TWEVKRPLRKLLPD----VNS
| ..|..  ..||||.|||..|||.||||| .| || | . ..|..||.....   ||. . .    .. ....|    ..  |.|..|..|.    .|.
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

EAIDFLEKILTFNPMDRLTAEMGLQHPYM
.|||.||| |.|.|..|.|.|. |||||.
QAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Erk4.AA CMGC 20-312 24 1.1e-108 358.43 In-house 1-513 (513) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-513/513
Sequence Identity: 24% (126 aa)

FIDFQPLGFGVNGLVLSATDSRACRK--------------VAVKKIVLS-DARSMK----------HALREIKIIRRL-----------------DHDNI
.   ...| |  | | ...| |  .|              ||.||| .  . . .|           ||||||| ..|                 .| ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKVYEVLGPKGSDLQGELFK------FSVAYIVQEYMETDLACLLEQGT----------LTEDH------------AKLFM------YQLLRGLK--YIH
|| |... .|.|| ... .|      |   |.| |||..||. ....            |.| |             | ||      ||.|||||  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SAN--VLHRDLKPANIFISTEDLV-------------------LKIGDFGLARIVDQHYSHKGY------------------LSEGLVTKWYRSPRLLLS
|..  ..||||||.|| |. .  .                   |||.||||||....| .|...                  ...  || |||.| .||.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

P---------NNYTKAIDMWAAGCILAEMLTG--------KMLFA-----------GAHELEQMQLILDTIPVVR---------------EEDKEELLR-
          ..||..||||..|||.|||.||        | ||            |.....|...| ...                   ||.  . .  
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

-----------------VMPSF--------VSSTWEVKRPLRKLLPD-----------------------------------VNSEAIDFLEKILTFNPM
                  ...|         .  |  ..|...| |.                                    ...|||.|.|.|...| 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

DRLTAEMGLQHPYM
.|.|||  ||||| 
KRITAEQALQHPYF
Kinase Erk4.AA Pkinase 20-312 30 4.5e-98 336.92 Pfam 1-293 (293) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-293/293
Sequence Identity: 30% (97 aa)

FIDFQPLGFGVNGLVLSATDSRACRKVAVKKIVLSDARSMKH--ALR--EIKIIRRLDHDNIVKVYEVLGPKGSDLQGELFKFSVAYIVQEYMET-----
.   ...| |  | |  ...   ...||||.| .....| |.  ..|  ||.| .||.|.|||. |..               .  |.|.||.|      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----------KDHIYMVMEYCEGGLYVM

DLACLLE---QGTL--TEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVL----KIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLL
||. ...   .|..  .|...| .|||.||||.|.|| ...||||||.||.|. .. ..    ||.|||||. .|  | ... ..   .| ||..| ...
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR

SPNNYTKAIDMWAAGCILAEMLTGKMLFAGA----HELEQMQLILDTIPVVREEDKEELLRVMPSFVSSTWEVKRPLRKLLPDVNSEAIDFLEKILTFNP
. . |....|||..||||.|||.|. .| |.    . ..|||.|  . .   ..| ... .....|  .. . .. .... . ...|..||....|...|
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDP

MDRLTAEMGLQHPYM
 .|.|||  ||||..
KKRPTAEQILQHPWF
Kinase Erk4.AA ERK1 20-312 42 6.9e-87 294.97 In-house 1-289 (289) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-289/289
Sequence Identity: 42% (126 aa)

FIDFQPLGFGVNGLVLSATDSRACRKVAVKKIVLSDARSM-KHALREIKIIRRLDHDNIVKVYEVLGPKGSDLQGELFKFSVAYIVQEYMETDLACLLEQ
... | .| |  |.| || | .  ..||.|||   .     .  ||||||. |  |.||... ...          . ..   ||||. |||||  ||  
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDII------RADTIEQMRDVYIVQCLMETDLYKLLKT

GTLTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCI
  |  ||   |.||.|||||||||||||||||||.|. . |    ||| ||||||| | .  | |.| |   |.||| | ..|    |||.||.|. |||
QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCI

LAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEELL--RVMPSFVSSTWEVKRPLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM
|||||  . .| | | |.|. .||  .    ..| . ..  .      |     | |...| |.  | |.|.|.|.|||||  |.| |  | |||.
LAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase Erk4.AA S_TKc 20-312 27 2.3e-81 277.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-231/231
Sequence Identity: 27% (86 aa)

FIDFQPLGFGVNGLVLSATDSRACRKVAVKKIVLSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDLQGELFKFSVAYIVQEYMET---DLACLL
.   ...| |  | |  ... .  |.||.|.|        .|..|||.| .. .|.|||| |.|               .  |.| ||...   ||  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD------------DHLYMVMEYCDGDLGDLFDYI

EQGT-------LTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTK-
..         ..| ||. .|||....|.|.|| ...||||||.||....   ..||.||||||..          .   .| ||..| .|     |.| 
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKC

AIDMWAAGCILAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEELLRVMPSFVSSTWEVKRPLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQ
..|.|. ||||.|||.|. .|   .. . ...|.                                        .||.||..|.|...| .|.||   ||
KCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

-------HPYM
       ||..
DEWDIKCHPWF
Kinase Erk4.AA ERK 20-245 40 4.1e-78 265.81 In-house 1-233 (307) Show / Hide 
Range on Protein: 20-245
Range on HMM: 1-233/307
Sequence Identity: 40% (97 aa)

FIDFQPLGFGVNGLVLSATDSR-----ACRKVAVKKI--VLSDARSMKHALREIKIIRRLD-HDNIVKVYEVLGPKGSDLQGELFKFSVAYIVQEYMETD
. . ...|.|  |.| ||.|          |||.|||  . .... .| .|||||. | .. |.||.. . .. |. ..   ..      |.|.|.||||
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDI------YCVEELMETD

LACLLEQG-TLTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSH-----KGYLSEGLVTKWYRSPRLLLSPNN
|.       .|..|| . ||||.|.||||||||||.|||||| || . ... .||| ||||||..| .|.      .....|  .| |||.| ..|| ..
LHQIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILV-NSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQK

YTKAIDMWAAGCILAEMLTGKMLFAGAHELEQMQLILDTI
||||.|.|..|||.|||| .| || |.  ..|...|...|
YTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQII
Kinase Erk4.AA ERK7 20-312 38 1.4e-77 264.01 In-house 1-292 (292) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-292/292
Sequence Identity: 38% (117 aa)

FIDFQPLGFGVNGLVLSATDSRACRKVAVKKI--VLSDARSMKHALREIKIIRRLD-HDNIVKVYEVLGPKGSDLQGELFKFSVAYIVQEYMETDLACLL
.   . || |  |.|  |.| |.   ||.|||     ..       ||| ... .. |.||.....|.  .  |.          |.| |.|||||    
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRAD-NDRD--------IYLVFEFMETDLHAVI

EQGTLTED-HAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHY---SHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDM
 .| . .| | .  |||||| .||.||.||.||||||.|| . .| .| |. |||||| . |      ... | |   | |||.|  ||.  .|||..||
RKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMV-KVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDM

WAAGCILAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEELLRVMPSFV--SSTWEVKRPLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHP
|  ||||.|||.|| .|.|   ..|. .||.||| . .|| | .   . . .  .   . ...| ...|.   .||| | ..| |||  |||||  ||||
WSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHP

YM
| 
YV
Kinase Erk4.AA CDK 20-245 35 4.7e-68 216.77 In-house 1-241 (284) Show / Hide 
Range on Protein: 20-245
Range on HMM: 1-241/284
Sequence Identity: 35% (91 aa)

FIDFQPLGFGVNGLVLSATDSRAC-----RKVAVKKIVLSD-----A--RSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDLQGELFKF-SVAYIVQE
.   . .| |  | |  | | .       . || ||| .       .       |.|||.. . | |.||||...|   | .| ..  .|. .  |.| |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

YMETDLACLLEQGTLTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDL----VLKIGDFGLARIV---------DQHYSHKGYLSEGLVTKW
||..||. ...         | .|.|||||| |.|| ...||||||.|| |.        .|||.||||||.           . |.|.       || |
YMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHE------VVTLW

YRSPRLLLSPNNYT--KAIDMWAAGCILAEMLT---GKMLFAGAHELEQMQLILDTI
||.| |||   .|.   .||||..|||.|||.|   .| || |  |..|. .| ...
YRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRIC
Kinase Erk4.AA ERK5 20-312 33 1.3e-67 230.92 In-house 1-295 (295) Show / Hide 
Range on Protein: 20-312
Range on HMM: 1-295/295
Sequence Identity: 33% (103 aa)

FIDFQPLGFGVNGLVLSATDSRACRKVAVKKI--VLSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDLQGELFKFSVAYIVQEYMETDLACLLE
.     .| |  | | ||   .  ..||.|||          |  .||.||.|   ||||. . ..| ||       .  .   |.| . || ||  .. 
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVP-----YSEMKDVYVVFDLMESDLHQIIH

QGT-LTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQ--HYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA
    .| .| . |.||.||||||.|||.|.||||||.|. .  |   |||||||.|| .       |. .. |   |.||| | |..| ..||.|||.|.
SNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLV-NENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWS

AGCILAEMLTGKMLFAGAHELEQMQLILDTI-----PVVREEDKEELLRVMPS-FVSSTWEVKRPLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQ
 |||. ||.. . .| |   ..|.|||.. .      ...    . .   . . |   .    ... |. |     |.| | ..| | | .|.|.   ||
VGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQ---PKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQ

HPYM
||..
HPFL
Kinase Erk4.AA p38 20-242 37 4.6e-64 217.78 In-house 1-217 (289) Show / Hide 
Range on Protein: 20-242
Range on HMM: 1-217/289
Sequence Identity: 37% (86 aa)

FIDFQPLGFGVNGLVLSATDSRACRK---VAVKKIV--LSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDLQGELFKFSVAYIVQEYMETDLAC
. . ||.| |  | | .| |.|   |   ||.||.     ..   | . ||..  . ..|.|...  .|  |       ..  |.  |.| . |..||  
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTP----PAHSMNDFQDVYMVTHFMGADLNN

LLEQGTLTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA
.. . .|..|| ..  ||.||||||||||.. |||||| || . .||  |.| ||||||  |.     ||     .|.|||.|  .|.   ||...|.| 
IMKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAV-NEDCELRILDFGLARHCDDEMT--GY----VATRWYRAPEIMLNWMHYTQTVDIWS

AGCILAEMLTGKMLFAGAHELEQMQLIL
 |||.||..||. || |   ..|.| |.
VGCIMAELITGRTLFPGDDHIDQLQRIM
Kinase Erk4.AA MAPK-Unclassified 24-173 37 1.8e-44 154.09 In-house 5-157 (575) Show / Hide 
Range on Protein: 24-173
Range on HMM: 5-157/575
Sequence Identity: 37% (60 aa)

QPLGFGVNGLVLSATDSRA-CRKVAVKKIV--LSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDLQG-ELFKFSVAYIVQEYMET---DLACLL
. .| |  | |  |.|..   ..|| ||.     .    | .|||| | | | | ||... ... .|  .|.. |   |   ||| .||.|   ||  ..
KNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNK--ELHNQE---FDDIYIVMDYMQTSLFDLHQII

EQGT--LTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLAR
 .    . . | . |.||.||||||.|||...||||||.|. | ..|. ..| |||..|
KSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLI-NQDCSVRICDFGMSR
Kinase Erk4.AA MAPK-Unclassified 180-243 25 3.2e-18 62.06 In-house 400-494 (575) Show / Hide 
Range on Protein: 180-243
Range on HMM: 400-494/575
Sequence Identity: 25% (24 aa)

SHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTG-----------KMLFAGAH--------------------ELEQMQLILD
.|......  || ||| | ..||  .|....|.|..|||.|||.             . || |                         | ..|.|
HHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFD
Kinase Erk4.AA ERK 271-312 43 1.6e-13 46.88 In-house 264-307 (307) Show / Hide 
Range on Protein: 271-312
Range on HMM: 264-307/307
Sequence Identity: 43% (19 aa)

KRPLRKLLPD--VNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM
..|. .. |.  .|..||| ||| |.|.| .|.|.|  |.||| 
PKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase Erk4.AA TyrKc 20-278 23 1.8e-11 -37.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-278
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FIDFQPLGFGVNGLVLSATDSRACRKVAVKKIVLSDARSMKHALREIKIIRRL--DHDNIVKVYEVLGPKGSDLQGELFKF---SVAYIVQEYMET-DLA
    . || |  | |  .| .   ..||||..  .    ..  .||..| ..|  .|.|||. | |   .|         |      .|| |||.  || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-------FMYIEPLMIVMEYMPHGDLK

CLLEQGT--LTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQH--------YSHKGY--LSEG-LVTKWYRSPRLL
  |      |. ..   |..|  .|  |.|| |. ||||   |. .. .  . ||.||||.| .. .        | .|     . . |  .|. .|  .
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI

LSPNNYTKAIDMWAAGCILAEMLT-GKMLFAG-AHELEQMQLILDTIPVVREEDKEELLRV--------MPSFV----SSTWEV---KRP----LRKLL
   . .| . | |. |  . |..| |..   | . .   |    . |  |.. .  .            .|. .    .. |.    .||    .....
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Erk4.AA CDK 278-312 45 2.2e-10 29.29 In-house 255-284 (284) Show / Hide 
Range on Protein: 278-312
Range on HMM: 255-284/284
Sequence Identity: 45% (16 aa)

LPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM
|||      |.|.| |...|  |..||  ||||| 
LPDY-----DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Erk4.AA p38 271-312 42 2.9e-10 30.97 In-house 248-289 (289) Show / Hide 
Range on Protein: 271-312
Range on HMM: 248-289/289
Sequence Identity: 42% (18 aa)

KRPLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM
.| ......  |  ||| |||.|   |  |.|||  .||||.
RRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase Erk4.AA MAPK-Unclassified 282-312 54 3.6e-09 28.78 In-house 545-575 (575) Show / Hide 
Range on Protein: 282-312
Range on HMM: 545-575/575
Sequence Identity: 54% (17 aa)

NSEAIDFLEKILTFNPMDRLTAEMGLQHPYM
| |.|||. | | |||  | ||.  |.|||.
NCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase Erk4.AA Pkinase_Tyr 117-183 34 2.1e-07 25.69 Pfam 104-172 (270) Show / Hide 
Range on Protein: 117-183
Range on HMM: 104-172/270
Sequence Identity: 34% (24 aa)

EQGTLTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIV--DQHY-SHKG
... ||  .   . .|  .|. | .| |  ||||   |. ..  ..| ||.|||||| .  |  |   .|
DKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDIYNDDYYYRKRG
Kinase Erk4.AA Pkinase_Tyr 39-81 31 0.028634 8.31 Pfam 24-70 (270) Show / Hide 
Range on Protein: 39-81
Range on HMM: 24-70/270
Sequence Identity: 31% (15 aa)

DSRACRKVAVKKIVLSDARSM---KHA-LREIKIIRRL-DHDNIVKVY
..  . .||||..   .| .    . . .||.|| . | .|.|||. |
PDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY