Gene FLT4 (Mouse)

FLT4

Species: Mouse
Alias: FLT4, Flt4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: VEGFR

Sequence

Name Sequence Type Origin Length Description Download
FLT4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 325 Kinase domain by global Sugen HMM Fasta, JSON
FLT4.AA Protein Sugen 1363 None Fasta, JSON
FLT4.NA RNA Sugen 5853 None Fasta, JSON

Protein domain

Protein domains of FLT4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG FLT4.AA IG 36-133 9 0.009703 14.73 SMART 1-58 (58) Show / Hide 
Range on Protein: 36-133
Range on HMM: 1-58/58
Sequence Identity: 9% (10 aa)

EDSYVIDTGDSLSISCRGQHPLEWTWPGAQEVLTTGGKDSEDTRVVHDCEGTEARPYCKVLLLAQTHANNT---GSYHCYYKYIKARIEGTTAA--STYV
   ..   |......|  .  . |.                                   | . .  ....   | | |  .       |.. .  .|..
PP-VTVKEGETVTLTC-VS-QIWWY-----------------------------------LTI-NVQPEDSQQHGTYYCQAT------HGQYWSIQGTTL

FVR
 |.
TVQ
IG FLT4.AA IG 237-328 19 8.4e-13 49.77 SMART 1-58 (58) Show / Hide 
Range on Protein: 237-328
Range on HMM: 1-58/58
Sequence Identity: 19% (19 aa)

KKSMELLVGEKLVLNCTVWAEFDSGVTFDWDYPGKQAERAKWVPERRSQQTHTELSSILTIHNVSQNDL---GPYVCEANNGIQRFR-ESTEVIVH
 . ..  .|| ..|.| |.       .. |                            ||| ||. .|    | |.|.|. . | .  ..|...|.
PP-VTVKEGETVTLTC-VS-------QIWWY---------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
V-set FLT4.AA V-set 231-327 14 2e-06 23.91 Pfam 1-128 (128) Show / Hide 
Range on Protein: 231-327
Range on HMM: 1-128/128
Sequence Identity: 14% (18 aa)

DIQLYP--KK----SMELLVGEKLVLNCTVW--AEFDSGV-TFDWDY-PGK---------------QAERAKWVPERRSQQTHTELSSI-----LTIHNV
..|...   .    . .  .|... |.|...   . .... .. | .                   . .. .....| .  ..   .       |||.|.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

SQNDLGPYVCEANNG-IQRFRESTEVIV
. .| | | | . |. .. | ..|...|
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
IGc2 FLT4.AA IGc2 243-317 22 0.000238 16.59 SMART 1-56 (56) Show / Hide 
Range on Protein: 243-317
Range on HMM: 1-56/56
Sequence Identity: 22% (17 aa)

LVGEKLVLNCTVWAEFDSGVTFDWDYPGKQAERAKWVPERRSQQTHTELSSILTIHNVSQNDLGPYVCEANNGIQ
. |. ..|.|   |. . . .. | . |.. .                 .. ||| ||. .| | |.|.| | . 
HEGQSVTLTCP--ATGNPDPNIHWYK-GQPLP----------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FLT4.AA I-set 295-327 39 0.005157 12.74 Pfam 60-92 (92) Show / Hide 
Range on Protein: 295-327
Range on HMM: 60-92/92
Sequence Identity: 39% (13 aa)

LTIHNVSQNDLGPYVCEANNGIQRFRESTEVIV
||| || . | | | | | |       . |..|
LTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 FLT4.AA IGc2 347-406 25 0.007816 2.07 SMART 1-56 (56) Show / Hide 
Range on Protein: 347-406
Range on HMM: 1-56/56
Sequence Identity: 25% (15 aa)

AGDELVKLPVKLAAYPPPEFQWYKDRKAVTGRHNPHALVLKEVTEASAGVYTLALWNSAA
  .. | |. . ...| |...|||  . .    .   | .|.||.. .|.||    |.. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP---WNWTLTIKNVTPEDSGYYTCYARNPWG
IG FLT4.AA IG 341-419 15 0.011716 14.02 SMART 1-58 (58) Show / Hide 
Range on Protein: 341-419
Range on HMM: 1-58/58
Sequence Identity: 15% (13 aa)

PVLEATAGDELVKLPVKLAAYPPPEFQWYKDRKAVTGRHNPHALVLKEVTEASA---GVYTLALWNSAAGLRQN-ISLELVVN
|        | |.|.   .     ...||              |.. .|... .   |.|. . .   .|  .   . .| | 
PP-VTVKEGETVTLTC-VS-----QIWWY--------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ
I-set FLT4.AA I-set 352-380 25 0.945325 5.06 Pfam 18-49 (92) Show / Hide 
Range on Protein: 352-380
Range on HMM: 18-49/92
Sequence Identity: 25% (8 aa)

VKLPVKLAAYPPPEFQWYKDRKAVTG---RHN
... ..   .|||. .|.|| . ..    ||.
ARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQ
IG FLT4.AA IG 430-552 9 0.000223 21.79 SMART 1-58 (58) Show / Hide 
Range on Protein: 430-552
Range on HMM: 1-58/58
Sequence Identity: 9% (12 aa)

SSPSIYSRHSRQTLTCTAYGVPQPLSVQWHWRPWTPCKTFAQRSLRRRQQRDGMPQCRDWKEVTTQDAVNPIESLDSWTEFVEGKNKTVSKLVIQDANVS
..    .. .. |||| .       ...|.                                                             |.| .. ..
PP-VTVKEGETVTLTC-VS------QIWWY-------------------------------------------------------------LTI-NVQPE

-----AMYKCVVVNKVGQDER--LIYFYVT
     . | |..    ||..    .. .|.
DSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set FLT4.AA I-set 532-544 46 0.901475 5.13 Pfam 73-85 (92) Show / Hide 
Range on Protein: 532-544
Range on HMM: 73-85/92
Sequence Identity: 46% (6 aa)

YKCVVVNKVGQDE
|.||..|..|..|
YTCVATNSFGEAE
IG FLT4.AA IG 563-673 17 7.8e-11 43.24 SMART 1-58 (58) Show / Hide 
Range on Protein: 563-673
Range on HMM: 1-58/58
Sequence Identity: 17% (20 aa)

EPSEDPLEGQSVRLSCRADNYTYEHLRWYRLNLSTLHDAQGNPLLLDCKNVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDE---GDYVCEVQDRR
 |     ||..|.|.| .      ...||                                              |.| .| |||.   |.|.|...   
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------------------------------LTI-NVQPEDSQQHGTYYCQAT---

SQDKHC-HKKYLSVQ
. .... .  .|.||
HGQYWSIQGTTLTVQ
IGc2 FLT4.AA IGc2 569-660 21 6.7e-09 36.81 SMART 1-56 (56) Show / Hide 
Range on Protein: 569-660
Range on HMM: 1-56/56
Sequence Identity: 21% (20 aa)

LEGQSVRLSCRADNYTYEHLRWYRLNLSTLHDAQGNPLLLDCKNVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGDYVCEVQDRRS
.|||||.| |.|...     .||.   . |                                      .|.| .|.|||.| |.|... . .
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP----------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IGv FLT4.AA IGv 573-655 20 0.000158 16.31 SMART 1-76 (76) Show / Hide 
Range on Protein: 573-655
Range on HMM: 1-76/76
Sequence Identity: 20% (17 aa)

SVRLSCRADNYTYEHLRWYRLNLSTLHDAQGNPLLLDCKNVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGDYVCEV
||.|||.. ..|. .. |||   .  ....|  ...       .   ..      .  .   . .| . .. |||.| | |..
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY-----SYKGRFTWSKDNITR-WSKNQFYLTMSNLRPEDTGTYYCAR
V-set FLT4.AA V-set 559-657 19 0.001553 14.02 Pfam 1-114 (128) Show / Hide 
Range on Protein: 559-657
Range on HMM: 1-114/128
Sequence Identity: 19% (23 aa)

SIESEP-SED----P---LEGQSVRLSCRAD-NY----TYEHLRWYR-LNLSTLHDAQGNPLLLDCKNVHLFATPLEANLEEAEPGARH-----A--TLS
... .. ..     .    |||||.|.|    .|    .  .. |||  ..     .|.. ..  . . |...     . ..  .| ..        ..|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPP-----GQKPQWIISY-YTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFS

LNIPRVAPEDEGDYVCEVQD
|.|  . |.|.| | | | .
LTISNLQPSDSGTYYCAVWN
I-set FLT4.AA I-set 637-656 45 0.402056 6.32 Pfam 59-78 (92) Show / Hide 
Range on Protein: 637-656
Range on HMM: 59-78/92
Sequence Identity: 45% (9 aa)

SLNIPRVAPEDEGDYVCEVQ
.| | .| |.||| | | ..
TLTISNVQPDDEGKYTCVAT
I-set FLT4.AA I-set 570-581 33 24.19662 0.28 Pfam 14-25 (92) Show / Hide 
Range on Protein: 570-581
Range on HMM: 14-25/92
Sequence Identity: 33% (4 aa)

EGQSVRLSCRAD
||...|..|...
EGETARFECQVT
IGc2 FLT4.AA IGc2 690-755 31 1.3e-19 72.38 SMART 1-56 (56) Show / Hide 
Range on Protein: 690-755
Range on HMM: 1-56/56
Sequence Identity: 31% (21 aa)

NVSDSLEMRCPVAGAHVPSIVWYKDERLLEKESGIDLADSNQRLSIQRVREEDAGRYLCSVCNAKG
.  .|....||..|...|.| ||| .  |.         .|..|.|..|..||.|.| |...|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set FLT4.AA I-set 678-765 26 1.3e-14 52.09 Pfam 1-92 (92) Show / Hide 
Range on Protein: 678-765
Range on HMM: 1-92/92
Sequence Identity: 26% (24 aa)

PRLTQNLTDLLVNVSDSLEMRCPVAGAHVPSIVWYKDERLLEK-ESGIDLADSN---QRLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAV
|. || ..|. |.. ....  | | |   |...|.||.. |   .. .    ..   ..| |..|  .|.| | | . |  | . ..|.. |
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG FLT4.AA IG 684-766 19 7.5e-13 49.94 SMART 1-58 (58) Show / Hide 
Range on Protein: 684-766
Range on HMM: 1-58/58
Sequence Identity: 19% (17 aa)

LTDLLVNVSDSLEMRCPVAGAHVPSIVWYKDERLLEKESGIDLADSNQRLSIQRVREEDA---GRYLCSVCNAKGCVNS--SASVAVE
   ..|.. ......| |.     .| ||                    | | .|..||.   | | | .   .|.. |  .. . |.
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set FLT4.AA V-set 677-750 14 0.001112 14.52 Pfam 1-112 (128) Show / Hide 
Range on Protein: 677-750
Range on HMM: 1-112/128
Sequence Identity: 14% (16 aa)

APRLTQ-NLT----DLLVNVSDSLEMRCPVA-GA----HVPSIVWYKDERLL-------------------------EKESGIDLADSNQ----RLSIQR
.  .|| . .     . |.. .|....| .  .     |. .| ||.. . .                         ..   . .. ...     |.|. 
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

VREEDAGRYLCSV
....| | | | |
LQPSDSGTYYCAV
Kinase FLT4.AA VEGFR 845-1169 68 6.4e-263 879.73 In-house 1-332 (332) Show / Hide 
Range on Protein: 845-1169
Range on HMM: 1-332/332
Sequence Identity: 68% (228 aa)

LHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTK--PNGPLMVIVEFCKYGNLSNFLRVK
|.||..||.||||.|.|||||||.|...|.||||||||||||||||||||||||.|||||.||||||.||.|||  ..||||||||.|..|||||.|| |
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RDTFNPYAEKSPEQRRRFRAMVEGAKADRRR---PGSSDRALFTRFLMGKGSARRAPLVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLA
|..|.||..|||..|.|...|......|..|   .|.|....|..|.. |.|..... ....||.|..|||||||.||||||||||||||||||||||||
RMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLA

ARNILLSESDIVKICDFGLARD-IYKDPDYVRKGS-ARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAP
||||||.|...||||||||||. |||||||||||. .|||.|||||||||||||||.|||||.||.||||||||.||||||||.||||.|||||.|||||
ARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAP

ELATPAIRHIMQSCWSGDPKARPAFSDLVEIL
...||.|.|||..||...|..||.||.|||.|
DYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase FLT4.AA Pkinase_Tyr 845-1169 38 1.1e-151 514.34 Pfam 1-270 (270) Show / Hide 
Range on Protein: 845-1169
Range on HMM: 1-270/270
Sequence Identity: 38% (129 aa)

LHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASE--HRALMSELKILIHIGNHLNVVNLLGACTKPNGP--LMVIVEFCKYGNLSNFLR
...|..||.||||.|... ..|  ... . .||||||||||. ..  ....|.|.||. ..|.| |.|.|.|.||.  .|  .....|....|.| ..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VKRDTFNPYAEKSPEQRRRFRAMVEGAKADRRRPGSSDRALFTRFLMGKGSARRAPLVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAA
 .|                                                             .  ||||.||.....|.|.|||.|.|..||||||||
KHR------------------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAA

RNILLSESDIVKICDFGLARDIYKDPDY-VRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASP-YPGVQINEEFCQRL-KDGTRMRAP
||.|..|. .|||||||||||||.|  | . .|...|| ||||||.|.....||.|||||||||.||||..|..| |||.  |||..... .|| || .|
RNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCP

ELATPAIRHIMQSCWSGDPKARPAFSDLVEIL
|.... | ..|..||  ||. || ||...|.|
ENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase FLT4.AA TyrKc 845-1169 34 6.8e-137 462.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 845-1169
Range on HMM: 1-280/280
Sequence Identity: 34% (122 aa)

LHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIG-NHLNVVNLLGACTKPN------GPLMVIVEFCKYGNLSN
..||..||.||||.|... .          .||||||||.|    ....|.|..|. ..| .| |.|.|.|.||..       .|||...|....|.| .
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRVKRDTFNPYAEKSPEQRRRFRAMVEGAKADRRRPGSSDRALFTRFLMGKGSARRAPLVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRD
.|| .|..                                                               |.|.||. ...|.|.|||.|.|..|||||
YLRKHRPK---------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRD

LAARNILLSESDIVKICDFGLARDIYKD------PDYVRKG---SAR--LPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGV----QINE
|||||.|..|  .|||.||||.|||| |       || ||    ...  ||..|||||.|.....||.||||||||..||||..|..||||.      |.
LAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ

EFCQRLKDGTRMRAPEL--------ATPAIRHIMQSCWSGDPKARPAFSDLVEIL
|  ...|.| ||. |.         .....  ||..||  ||. || ||...|..
EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase FLT4.AA TK 845-1169 26 9.5e-129 434.02 In-house 1-486 (486) Show / Hide 
Range on Protein: 845-1169
Range on HMM: 1-486/486
Sequence Identity: 26% (134 aa)

LHLGRVLGHGAFG---KVVEASAFGIN--------------------KGSSCDTVAVKMLKEGATASEHRALM----------------SELKILIH-IG
..||..||.|.||   .| .. ..|.|                    |.  . .|||||||||...|. . ..                .|.|.. | .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHLNVVNLLGACTKP-----------NGPLMVIVEFCKYGN----LSNFLRVKRDTFNPYAEKSPEQRRRFRAMVEGAKADRRRPGSSDRALFTRFLMGK
.| |.|.|.|.||..           ..|.|...|....|.    | ..|| .|..|.........|..  . .. .  .                 | |
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LH-HC----------------M-K

G----SARRAPLVQEAEDLWLS--------PLTMEDLVC-------------------YSFQVARGMEFLASRKC------IHRDLAARNILLSESDI--
|    |....    . |. ...        |||. ||..                   ...|.|.|||.|.|..|      .||||||||.|..|...  
GDITYSHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCK

---------VKICDFG--------LARDIYKDPDYVRKG------------------------SARLPLKWMAPESIFDKV---------YTTQSDVWSF
         .||.|||        ||||||.| ||.||.                        ...||..|||||...|.|         .||.||||||
WHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSF

GVLLWEIFSLGASPYPGVQIN---------EEFCQRLKDG--------------TRMRAPELAT--------------PAIRHIMQSCWSGDPKARPAFS
|||.||||..|. ||.|   |         .|....|..|               || .|....              ...  .||.||. ||. || ||
GVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFS

DLVEIL
.|.| |
QLHEQL
Kinase FLT4.AA PDGFR 1008-1169 62 1.1e-109 353.41 In-house 197-358 (358) Show / Hide 
Range on Protein: 1008-1169
Range on HMM: 197-358/358
Sequence Identity: 62% (102 aa)

PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEI
.|| .||.|.|.|||.|||||||  |.||||||||.|| .  .|||||||||||| .|  || ||.||||.|||||||||| ||||||||||.|.|||||
VLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEI

FSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEIL
|||| .||||. ....|    |.| ||  |. |.  |  |||.||  ||. || |. |...|
FSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase FLT4.AA FGFR 996-1169 56 1.5e-87 297.15 In-house 118-293 (293) Show / Hide 
Range on Protein: 996-1169
Range on HMM: 118-293/293
Sequence Identity: 56% (100 aa)

PLVQEAE-DLWLSP-LTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSA-RLPLKWMAPESIFDKVYT
|.  | . |. | | ||  |||   .|||||||.|||||||||||||||.| .. .. ||||||||||| .. || || .  ||| ||||||. ||.|||
PRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDI-HCIDYYRKTTNGRLPIKWMAPEALFDRVYT

TQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEIL
.||||||.|||||||. .| .|||..   ||  . || | ||  |.. .  | |.| .||   |..|| |  ||| |
HQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase FLT4.AA UTK 845-1169 28 4.5e-83 282.31 In-house 1-296 (296) Show / Hide 
Range on Protein: 845-1169
Range on HMM: 1-296/296
Sequence Identity: 28% (102 aa)

LHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLK-EGATASEHR---ALMSELK---ILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSN
..||| ||.|||| | .|..  ..  .  . |||| .. ....  |..    .| | .   .. .   | ||..|.| ||.  .|.|...|... |.|..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQE-EPWMIVTEYMENGDLRS

FLRVKRDTFNPYAEKSPEQRRRFRAMVEGAKADRRRPGSSDRALFTRFLMGKGSARRAPLVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRD
.||  |.|..                                                     |...|   ||.....|.. ..||||..|.|....|||
YLRRHRPTPP-----------------------------------------------------ACPHW---LTLHQRLCMAWDIARGMQYLHSCGFVHRD

LAARNILLSES-------DIVKICDFG---LARDIY---------KDPDYVRKGSARLPLKWMAPESIFDK-VYTTQSDVWSFGVLLWEIFSLGASPYPG
|||||.|. ..        ..||.|||   ..|...          .. | . .  |.|..|||||.. .   .||.||||||||..|||.. |. ||||
LAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPG

VQINEEFCQRLKDG--TRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEIL
   |.. .... .|   ||..|.    ..  .|..||  ||  || | |||. .
MS-NMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase FLT4.AA TK-Unique 1006-1169 46 2.2e-77 263.42 In-house 125-294 (294) Show / Hide 
Range on Protein: 1006-1169
Range on HMM: 125-294/294
Sequence Identity: 46% (80 aa)

LSPLTMEDLVCYSFQVARGMEFLAS--RKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGS-ARLPLKWMAPESIF--DKVY-TTQSDVWS
..|....||. . .|.|.|||.|||  .|..||||.|||.||.|  ..||||||.|||.|.. .|....|  |.|..||||||.   ...| ||.|||||
TEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWS

FGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELA-TPAIRHIMQSCWSGDPKARPAFSDLVEIL
||||.||||.||| ||||.   . . ....|| ||  ||   ..... .|.|||. .|. || |.... .|
FGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase FLT4.AA Ret 1008-1171 45 1.6e-69 236.62 In-house 126-293 (293) Show / Hide 
Range on Protein: 1008-1171
Range on HMM: 126-293/293
Sequence Identity: 45% (77 aa)

PLT-----MEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGV
...     | ... .  |. .|| .|.. | .||||||||.|. |  | || |||| ||.| |  ||..   |.| ||||.|| .| ||||.||||||||
VINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGV

LLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEILGD
|.|||  .||.||||.   |  .| ||.| ||  ||    ..  ||  ||   |  || | ..   .  
LCWEIVTMGANPYPGI-PPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase FLT4.AA RTKB 1008-1169 46 3.9e-66 221.96 In-house 105-264 (264) Show / Hide 
Range on Protein: 1008-1169
Range on HMM: 105-264/264
Sequence Identity: 46% (75 aa)

PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQS-DVWSFGVLLWE
.|  . || .. |.|.|| || ... |||||.|||.|.. .   ||||||.|| |  | . .... .||| |||||||. .. |||.| |||||||  ||
SLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREI--DHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWE

IFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEIL
|||||. ||.  . | .  . | .| |.  |... .|..|||| ||. .. .||.|. ||. .
IFSLGGTPYQ-QYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase FLT4.AA PDGFR 845-956 54 2.2e-59 189.14 In-house 1-111 (358) Show / Hide 
Range on Protein: 845-956
Range on HMM: 1-111/358
Sequence Identity: 54% (62 aa)

LHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVKRD
| .|..|| ||||||||| |.|. |     .|||||||. | .||  ||||||||. | |.|.|.||||||||.  ||  .| |.| || | |.|. ||.
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTH-GGPIYIITEYCCYGDLLNYLHRKRH

TFN-PYAEKSPEQ
.|  . .|| |..
SFHQHHPEK-PKK
Kinase FLT4.AA InsR 1007-1171 43 4.5e-58 193.61 In-house 114-278 (278) Show / Hide 
Range on Protein: 1007-1171
Range on HMM: 114-278/278
Sequence Identity: 43% (73 aa)

SPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSAR-LPLKWMAPESIFDKVYTTQSDVWSFGVLLW
.. . ....    ... || .||..| .|||||.|| . ...  ||| |||..|||| . || |||  . ||  ||||||. | |.||.||||||||.||
HVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIY-EHDYYRKGGKGMLPVRWMAPESLKDGVFTTHSDVWSFGVVLW

EIFSLGASPYPGVQINEEFCQRL-KDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEILGD
|. .||. || |   ||.  .   .||  .| ||   ..   .|. ||   ||.|| | |....| |
EMVTLGEQPYQGLS-NEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase FLT4.AA Tie 1007-1169 46 2.4e-57 172.76 In-house 109-267 (267) Show / Hide 
Range on Protein: 1007-1169
Range on HMM: 109-267/267
Sequence Identity: 46% (76 aa)

SPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWE
| |. . .. .   |||||..|. ..||||||||||||  |  . || ||||.|    |  ||.|   ||| .||| ||.   ||||.|||||.||||||
STLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRG---DEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWE

IFSLGASPYPGVQINEEFCQRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEIL
| |||  || |.   | . ..|  | ||  |      . ..|. ||   |  ||.|. ..  |
IVSLGGTPYCGMTCAELY-EKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase FLT4.AA Pkinase 845-1169 19 3.6e-40 143.1 Pfam 1-293 (293) Show / Hide 
Range on Protein: 845-1169
Range on HMM: 1-293/293
Sequence Identity: 19% (72 aa)

LHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKML-KEGATASEHRALMS--ELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYG----NLSN
.|.||..| |.||.| ..   | .|     .|||| . |...  ......    |..|. .. || |.| |.....  .. . .. |.|  |     |. 
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFD

FLRVKRDTFNPYAEKSPEQRRRFRAMVEGAKADRRRPGSSDRALFTRFLMGKGSARRAPLVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRD
....                                                            .. ... ...... .|  |..||.|.. |...||||
YIST-----------------------------------------------------------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRD

LAARNILLSESDIV----KICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIF-DKVYTTQSDVWSFGVLLWEIFSLGASPYPGV------QINEEFCQ
|   |||... . .    ||||||||. ..    ..   .    . .|||| |  .. |.. .|.||.|..|.| .. |  |.||         .. .|.
LKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICR

RLKDGTRMRAPELAT-------------------PAIRHIMQSCWSGDPKARPAFSDLVEI--L
...  ..   |.. .                   .. .... .|.  ||| || . ....   .
IMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase FLT4.AA FGFR 845-943 49 1e-37 126.09 In-house 1-100 (293) Show / Hide 
Range on Protein: 845-943
Range on HMM: 1-100/293
Sequence Identity: 49% (50 aa)

LHLGRVLGHGAFGKVVEASAFGINKG--SSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVK
| || .|| |.||.|. | |.|| .       ||||||||...|  .   | ||. ..  || | |..||||.||  .||| ||||.|. |||  ||| .
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQ-EGPLYVIVEYCHHGNLRDFLRAR

R
|
R
Kinase FLT4.AA Ret 845-943 47 1.3e-35 119.03 In-house 1-100 (293) Show / Hide 
Range on Protein: 845-943
Range on HMM: 1-100/293
Sequence Identity: 47% (48 aa)

LHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEG-ATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNG--PLMVIVEFCKYGNLSNFLRV
| |. .|| | ||.|| | || |       ||||||||.. |. || ..| ||. .|  . || .|. |.|||. . .  |...|||.|||| |  ||| 
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACI-QDDPFPTCLIVEYCKYGCLREFLRL

KR
 |
SR
Kinase FLT4.AA TK-Unique 845-945 41 2e-30 102.18 In-house 1-102 (294) Show / Hide 
Range on Protein: 845-945
Range on HMM: 1-102/294
Sequence Identity: 41% (42 aa)

LHLGRVLGHGAFGKVVEASAFGINKGSSCD-TVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVKR
| .|.|.| |||| |  . ..||.|... .  |||||||..||  .......|.... ..| | |.|..||.|||. .| | | |.| .||| ..|| .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DT
..
PA
Kinase FLT4.AA S_TKc 845-1168 20 5.3e-30 106.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 845-1168
Range on HMM: 1-231/231
Sequence Identity: 20% (70 aa)

LHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKY--GNLSNFLRVK
 ...|..|.||||||  .   .     .   ||.|..|        . ...|..|| .  .| |.|.|....    . | .. |.|    |.|  ... .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

RDTFNPYAEKSPEQRRRFRAMVEGAKADRRRPGSSDRALFTRFLMGKGSARRAPLVQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARN
.   ..                                                          .|..  .  .|  |.....|.. |.. |||||   |
GRHGLR----------------------------------------------------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPEN

ILLSESDIVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTT-QSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMRAPELAT
|||.|   .||||||||| .          .    . .|||| .    |..  .|.||.|..|.| .. |  |.|  |... | . .            .
ILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG------------S

PAIRHIMQSCWSGDPKARPAFSDLVE----------I
|  ..... |.  ||. ||   .. .          .
PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase FLT4.AA Tie 853-943 42 2.6e-26 76.53 In-house 1-87 (267) Show / Hide 
Range on Protein: 853-943
Range on HMM: 1-87/267
Sequence Identity: 42% (39 aa)

HGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVKR
 | ||.|. |    | |      ||.||.||.|   .||  | || ..  .| | |..||.||| .  | | | .|. .|||| .|||  |
EGNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEH-RGYLYVAIEYAPYGNLLDFLRKSR
Kinase FLT4.AA RTKB 845-945 35 1.8e-18 58.91 In-house 1-99 (264) Show / Hide 
Range on Protein: 845-945
Range on HMM: 1-99/264
Sequence Identity: 35% (36 aa)

LHLGRVLGHGAFGKVVEASAFGINKGSS-CDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVKR
..||. ||.|||| |    |.  |...     .|.| || ||   |. .  ||. ..  .| | ||. ..| | .   |... ||.| .|||  .||  |
VWLGEKLGNGAFGEVFQ--AWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQ-DEPYILLVELCELGNLRDYLRMCR

DT
 .
AS
Kinase FLT4.AA InsR 845-943 32 8e-18 56.35 In-house 1-99 (278) Show / Hide 
Range on Protein: 845-943
Range on HMM: 1-99/278
Sequence Identity: 32% (33 aa)

LHLGRVLGHGAFGKVVEASAFGINKGSSCD--TVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRVK
. |.| .| |.||.| |  | || ..       .|.| ..|.|.. |     .|  .   . |. .||.||| |..   | .|. |. .||.| ..|| .
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEF-NCHHVVRLLGVCSRGQ-PMYVVMEMMTYGDLKSYLRSR

R
|
R