Gene GPRK4 (Mouse)

GPRK4

Species: Mouse
Alias: Gprk2l, GPRK4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: GRK
Subfamily: GRK

Sequence

Name Sequence Type Origin Length Description Download
GPRK4.AA Protein Sugen 574 None Fasta, JSON
GPRK4.NA RNA Sugen 2408 None Fasta, JSON
GPRK4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of GPRK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS GPRK4.AA RGS 51-170 26 1.1e-36 123.0 Pfam 1-124 (124) Show / Hide 
Range on Protein: 51-170
Range on HMM: 1-124/124
Sequence Identity: 26% (33 aa)

DFSSLCDKQPIGRLLFRQFCDT-KPDLKRCIEFLDAVAEYEVT---IEEEQREF-GLAIFSRFFKEKSEVPLPEIPPDIVKECKWNLKQNSPSQNVFEEC
.| .||..|||||.|||||... .... ..|||..|. .....    .|.  .  . .|. ......|  ... |. |....|. ||.|..|. ..|.|.
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFKKMFSDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQAQPTPDCFDEA

AGIVCKYLSETPFEEYQESTYFNRF
   ....... .. ....| |..||
QRHIYTLMEKDSYPRFLKSDYYQRF
RGS GPRK4.AA RGS 51-171 25 7.1e-34 119.78 SMART 1-121 (121) Show / Hide 
Range on Protein: 51-171
Range on HMM: 1-121/121
Sequence Identity: 25% (31 aa)

DFSSLCDKQPIGRLLFRQFCDTKPDL-KRCIEFLDAVAEYEVTIEEEQREFGLAIFSRFFKEKSEV-PLPEIPPDIVKECKWNLKQNSPSQNVFEECAGI
.| .|||..||||..||.|....... |...||..|. |.... .|| |... .|..... ....    ..|... ...|. .|..  |. ..|.|.   
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMEDEERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCN--PHPDCFDEAQRH

VCKYLSETPFEEYQESTYFNRFL
|...... .. .. .| |. |.|
VYQLMEKDSYPRFLRSDYYKRYL
Kinase GPRK4.AA GRK 186-448 72 4.6e-230 732.87 In-house 1-272 (272) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-272/272
Sequence Identity: 72% (198 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSR---FVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGD--
||||||||||||||||||||||||||||||.|.||||||||||.||||||.||||.|||   |.|..||.||||||||||.||||||||.|||||.|.  
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSRDCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGNNE

PGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGE-MVRGRVGTVGYMAPEIINHEK-YTFSPDWWGLGCLIYEM
|||.|.|..|||||.|||||...|.|||||||||||||||||||.||||||||.|.|||. |..|||||.||||||....|. |.||||||.|||.||||
PGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYEM

IAGHSPFRKYKEKVNREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRD--GVSAVKQHPIF
|.||||||..||||.|||..||||.....|...|||.||.||.||| |||..||||...  |...||.||.|
IEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQEVKEHPFF
Kinase GPRK4.AA GRK 186-448 80 4.8e-229 767.19 In-house 1-265 (265) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-265/265
Sequence Identity: 80% (212 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLG-DPGFE
|||||||||||||||||||||||||||||||||||||||||||.||||||.||||.||||||||||.||||||||||.|||||||||.||||.| .|||.
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVHSRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGENPGFD

EPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHSP
|.||.|||||.|||||.|.|.||||||.|||||||||||||||||||||.|.|||.|.|||||||||||||....|.||||||||||||||||||.|.||
EERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQMIRGRVGTVGYMAPEVVKNERYTFSPDWWGLGCLIYEMIEGRSP

FRKYKEKVNREELERRVKNETEEYS-ERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIF
||..||||.|||..||||...|.|| |.|||.||.||.||| |||..||||...|...|.|||.|
FRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREEGCDEVRQHPFF
Kinase GPRK4.AA AGC 186-448 28 2e-153 399.98 In-house 1-395 (395) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-395/395
Sequence Identity: 28% (112 aa)

FRQYRVLGKGGFGEVCACQVR------ATGKMYACKKLEKKR-IKKRK--GEAMALNE------------KRILEKLH----------SRFVVS-LAYTY
|. ..|.|||.||.|. .. .      .|||.||.|.|.||. |...|   ......|            ..||||..          . |.|. | |..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKDA--LCLVLTIMN---------GG-DLKYHIYNL-GDPGFEEPRAVFYAAE-------LCCGLEDLQR-KRIVYRD-LKPENILLDDHGHIRISDLG
..||   |..|.  |.         || .| .|...  .   |.|.|| |||||       ....|| | . . |..|| |||||||||..|||...| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAMEVP---------------------------------------------------EGEMVRGRVG--TVGYMAPEIINHEKYTFSPDWWG--LGCLIY
|. |..                                                   ....    .|  |  ||||||.    |... |||.  ||||.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMIAGHSPFRK------------YKEKVNREELERRVKNETEEYS----------ERFSEDAKSICSMLLIKDPSKRLGCQRD-----GVSAVKQHPIF
||..|..||.              .|. .. .  |...|. ...           . ||..||.....|| |||.|||||...     |.. .|.|| |
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase GPRK4.AA BARK 186-448 46 4.9e-88 298.79 In-house 1-264 (264) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-264/264
Sequence Identity: 46% (124 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSR----FVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDP
|   |..|.||||||  |    |||||| | |.||||| ..|| .||||. .|.         |.| ..| ..| | || .| .|||||| ||.   |  
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG--

GFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGEMVRGRVGTVGYMAPEIINH-EKYTFSPDWWGLGCLIYEMIA
 | |    |||||.  ||| . .. .||||||| |||||..||.|||||||| .  .       ||| ||||||...    |  | ||. |||..| .. 
VFSEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLLR

GHSPFRKYKEKVNREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIF
||||||. | |  ..|..|       |  . ||.. ...  .|| .| ||||||.  |   ||.|| |
GHSPFRQHKTK-DKHEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCMGRGAQEVKEHPFF
Kinase GPRK4.AA S_TKc 186-448 32 4.8e-87 296.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNG--GDLKYHIYNLGDPG-
..  |..|||.||.|. |. . ||. .|.|..            ....| .||.| |  ..| | ..... | |..|.  ..|  |||. .| . | .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEGEMVRGRVGTVGYMAPEIINHEKYTF-SPDWWGLGCLIYEM
   | | .| ||....||.|| . ...|..|||||||||||.  || |.| ||| ..      .  .||  |||||..   .|.. . ||| .||..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

IAGHSPFRKYKEKVNREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDGV--SAVKQHPIF
..|  ||.      . ... ....          |..||.. . .| |||.||...       ...|.|| |
LCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GPRK4.AA RSK 189-448 35 6.5e-81 275.12 In-house 1-278 (278) Show / Hide 
Range on Protein: 189-448
Range on HMM: 1-278/278
Sequence Identity: 35% (98 aa)

YRVLGKGGFGEVCACQVR---ATGKMYACKKLEKKRIKKR-KGEAMALNEKRILEKLH-SRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPG-
 .|||.||.|.|  |.     .||. || | |.|. |..| |  . .. | .|||    . |.|.| |...|.. | |..  ..||.| .|... .  | 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDD---HGHIRISDLGLAME-VPE-GEMVRGRVGTVGYMAPEIIN---HEK-YTFSPDWWGLGC
| | .| ||.||. . .| |  . |..|||||||||.||   .|||...| |.. . ... ...    ..|. |||||...   ... .. . ||| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIYEMIAGHSPFRKYKEKVNREELERRVKNET--EEYS--ERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIF
|.||| .|..||.   .. ||.|. .|... .   .    .  |..||.. ...| .||.||||| ..... .|||| |
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase GPRK4.AA Akt 186-448 38 1.8e-74 237.44 In-house 1-264 (264) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-264/264
Sequence Identity: 38% (104 aa)

FRQYRVLGKGGFGEVCACQVRATGKMY-ACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPGFE
|.  .||||| || |  ..  .|.|.| | | | |..| ...  . .. |..||..  . |.|.| |   |.| |..|.  .|||.| ||..   .. | 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQR--KRRFS

EPRAVFYAAELCCGLEDLQRKRIVYRD-LKPENILLDDHGHIRISDLGLAM-E-VPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWG-LGCLIYEMIA
|.|| ||.||. ...| |  | |.||| |||||||.| .|||.. | ||.  . . ....     ||  |.||||.|   .| . |||| |||..|||. 
EDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMC

GHSPFRKYKEKVNREELERRVKNETEEYS--ERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIF
|  ||  |..  .....    ||.  ..   ...| ..|.. | || |||.||||   ...  .|.|| |
GRPPF--YNQ--DHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase GPRK4.AA PKC 186-448 38 5.9e-74 239.06 In-house 1-262 (262) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-262/262
Sequence Identity: 38% (102 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSR-FVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPGFE
|.  .||||| || |     . | ..|| | | |  | .      ...|||.|.      | ..|  .  |.| |  |.   ||||| .|| . .   |.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQR--RFK

EPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLA-MEVPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHS
|..|.||||| .|.|  | .| |.||||| .|.|||  |||.| | |..  .. .|.. .   ||  |.||||.  ..|..| ||| .| | ||| ||.|
EEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQS

PFRKYKEKVNREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDG---VSAVKQHPIF
||       . .|| . . ...  |   .|..|.|||. .. |.|.|||||....     ....|| |
PFHGE----DEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase GPRK4.AA AktR 186-448 37 7.1e-74 251.74 In-house 1-268 (268) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-268/268
Sequence Identity: 37% (101 aa)

FRQYRVLGKGGFGEVCACQVR-ATGKMYACKKLEKKRIKKRKGEAMALNEKRILE-KLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPGF
|. |..||||.||.|  .| .  ..|.|| | . || |..|. .  ...|. |.| .    | | | |. .||. | ... .. ||.| .|. . .   |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK--F

EEPRAVFYAAELCCGLEDLQRK-RIVYRDLKPENILLDDHGHIRISDLGLAM-EVP--EGEMVRGRVGTVGYMAPEIINH-EKYTFSPDWWGLGCLIYEM
.| .| ||.|. . .|| |  .  |.|||||||||||| .||..|.| ||.  ..   . |. .  .||. |||||.|.  . ...| ||| .|..||||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

IAGHSPFRKYKEKVNREELERRVKN-ETEEYSERFSEDAKSICS-MLLIKDPSKRLGCQRDGVSAVKQHPIF
..|. ||  | .. |.. .  . |.    .|.. ||. .|...   || |.| |||| .. | . .| || |
VTGCPPF--YHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase GPRK4.AA Pkinase 186-448 28 5.5e-68 236.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-293/293
Sequence Identity: 28% (88 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMAL-NEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGG----DLKYHIY--NL
..  |..|.|.||.|. |. . |||..|.|...|...|. | .. .. .| .|. .|.. ..| | ...|.|| ...|.  ..||    ||. .|   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GDPGF--EEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHI----RISDLGLAME--VPEGEMVRGRVGTVGYMAPEIIN-HEKYTFSPDWW
|  .|  .|  . ||. ....||| . ...|..|||||||||.|..|||    .|.| |||       ..   ...|| .|||||.|. ...|. . |.|
G--CFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

GLGCLIYEMIAGHSPFRKYK----EKVNREELERRVKNETEEYSERFS---------------------EDAKSICSMLLIKDPSKRLGCQRDGVSAVKQ
..||..|||. |. ||.  .    . ..  .. .|..    ....  .                     |..|.... .| |||.||..        ..|
SCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQ

HPIF
|| |
HPWF
Kinase GPRK4.AA Delta 186-448 38 1.4e-66 227.55 In-house 1-259 (259) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-259/259
Sequence Identity: 38% (103 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILE-KLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPGFE
|   .||||| || |    .. . | || | | |  . .       . |.|.|    .. |.  |  |. ||. |  |.  .||||| ||| . .   |.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHR--FD

EPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLA-MEVPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGHS
| || |||.|. |||. | .| |.||||| .|.|||  |||.| | |..  ..   ..     ||  |.|||||  .||..| |||  | |.|||. | |
EKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQS

PFRKYKEKVNREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIF
||    |    .|| . . |..  |    ...||.. . |. .|| |||| |.     ..||..|
PFHGEDE----DELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase GPRK4.AA Alpha 186-448 41 3.4e-66 226.22 In-house 1-259 (259) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-259/259
Sequence Identity: 41% (111 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSR--FVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGDPGF
|    ||||| || |     . |  .|| | | |  |       . ..|||.|  | ..  | |..  .. | | |  |.   ||||| |||  .|   |
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLA-LPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGK--F

EEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAME-VPEGEMVRGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIAGH
 || |||||||   ||  |..| |.|||||  |..||  |||.| | |.  | . |..  |   ||  |.|||||  . |  | |||  | | |||.|| 
KEPHAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQ

SPFRKYKEKVNREELERRVKNETEEYSERFSEDAKSICSMLLIKDPSKRLGCQRDGVSAVKQHPIF
 ||    |    .|| . ... .  |   .|  |..||  .|.| |.||||| .||   ...|| |
PPFDGEDE----DELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase GPRK4.AA TyrKc 186-442 21 5.7e-14 3.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 186-442
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKL--HSRFVVSLAYTYETK-------DALCLVLTIMNGGDLKYHIY
 .  ..|| | ||||. .. .    . | |.| .        ... ..| ||. ||  |   .| |     ..       . |..|.  | .|||| .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NLGDPGFEEPRAVFYAAELCCGLEDLQRKRIVYRDLKPENILLDDHGHIRISDLGLAMEVPEG-------EMVR------GR-VGTVGYMAPEIINHEKY
. ..  .  .  . ..   .|| | | .|... |||   |.|... ....||| ||. .. ..       .. |      |. .  .  |||| ||. |.
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TFSPDWWGLGCLIYEMIAGHSPFRKYKE-----KVNREELERRVKNETEEYSER--------FSEDAKSICSMLLIKDPSKRLGCQRDGVSAV
|.  | |  | ...|.         | .     . |.| .|.  . .  .  .          ...  .| ..    ||..|   .   ..  
TTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase GPRK4.AA S_TK_X 449-528 17 1.2e-05 25.55 SMART 1-79 (79) Show / Hide 
Range on Protein: 449-528
Range on HMM: 1-79/79
Sequence Identity: 17% (15 aa)

KDINFSRLEA--NMLDPPFIPDPQAIYCRNILDIGQFS--VVKGVNLDTNDEIFYAEFATGSVTIPWQNEMIESG----CFKDLNENE
..|.. .|..   .. |||.|.....|  .  |...|     ...         .  . .... . |||| .| .    .| ... . 
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase GPRK4.AA Pkinase_Tyr 316-385 30 0.00078 13.61 Pfam 141-216 (270) Show / Hide 
Range on Protein: 316-385
Range on HMM: 141-216/270
Sequence Identity: 30% (23 aa)

NILLDDHGHIRISDLGLAMEV-PEGEM-V--RGRVGTVGYMAPEIINHEKYTFSPDWWGLGCLIYEMIA-GHSP-F
|.|... ....|.| |||  . ....  .   |    .  |||| ||. |.|   | |  | |..|..  | .| .
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY
Kinase GPRK4.AA Pkinase_Tyr 186-206 33 0.723419 3.56 Pfam 1-21 (270) Show / Hide 
Range on Protein: 186-206
Range on HMM: 1-21/270
Sequence Identity: 33% (7 aa)

FRQYRVLGKGGFGEVCACQVR
 .  ..||.| ||||. .  .
ITFGKKLGEGAFGEVYKGTWK