Gene GPRK6 (Mouse)

GPRK6

Species: Mouse
Alias: Gprk6, GPRK6
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: GRK
Subfamily: GRK

Sequence

Name Sequence Type Origin Length Description Download
GPRK6.NA RNA Sugen 3013 None Fasta, JSON
GPRK6.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
GPRK6.AA Protein Sugen 589 None Fasta, JSON

Protein domain

Protein domains of GPRK6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS GPRK6.AA RGS 52-171 26 8.4e-37 129.5 SMART 1-121 (121) Show / Hide 
Range on Protein: 52-171
Range on HMM: 1-121/121
Sequence Identity: 26% (32 aa)

DYHSLCERQPIGRLLFREFCATRPEL-TRCTAFLDGVSEYEVTPDEKRKACGRRLMQNFLSHTGPD-LIPEVPRQLVSNCAQRLEQGPCKDLFQELTRLT
..|.||...||||..||||. .....  ..  |.. . |.....||.|....|.... ..|  .|    ..........|.|.|.. |..|.|.|  | .
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMEDEERRQKAREIYDKYISPNAPCEHCVNIDHHTREQCQQCLCN-PHPDCFDEAQRHV

HEYLSTAPFADYLDSIYFNRFL
.....  .....| | |. |.|
YQLMEKDSYPRFLRSDYYKRYL
RGS GPRK6.AA RGS 52-170 26 2.8e-35 118.35 Pfam 1-124 (124) Show / Hide 
Range on Protein: 52-170
Range on HMM: 1-124/124
Sequence Identity: 26% (33 aa)

DYHSLCERQPIGRLLFREFCAT-RPELTRCTAFLDGVSEYEVT---PDEKRKAC-GRRLMQNFLSHTGPDLIPEVPRQLVSNCAQRLEQ-GPCKDLFQEL
..|.||. |||||.|||.|. .  .|. ..  |.. . .....   .|||.... .|. ......   |  .. ........|...|||  |..|.|.| 
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFKKMFSDSDEKMHQKDAREIYNKYIAPDSPCECHNIDHDTREHCQDNLEQAQPTPDCFDEA

TRLTHEYLSTAPFADYLDSIYFNRF
 | ......  ..  .|.| |..||
QRHIYTLMEKDSYPRFLKSDYYQRF
Kinase GPRK6.AA GRK 186-448 74 5.70000000001e-234 745.4 In-house 1-272 (272) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-272/272
Sequence Identity: 74% (203 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ--
||||||||||||||||||||||||||||||.|.||||||||||.||||||||||||.||   |.|..|||||||||||||.|.||||||..|||.||.  
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSRDCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGNNE

AGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ-TIKGRVGTVGYMAPEVVRNER-YTFSPDWWALGCLLYEM
.||.|.|..|||||||||||..||.|||||||||||||||||||.||||||||...|||| .|.|||||.|||||||..||| |.||||||.|||..|||
PGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYEM

IAGQSPFQQRKKKIKREEVERLVKEVAEEYTDRFSSQARSLCSQLLSKDPAERLGCRGG--GAREVKEHPLF
|.|.|||.|.|.|.|||||.|.|||....| |.|| .|...|..|| |||..|||||||  ||.||||||.|
IEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQEVKEHPFF
Kinase GPRK6.AA GRK 186-448 80 1.1e-229 769.28 In-house 1-265 (265) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-265/265
Sequence Identity: 80% (214 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG-QAGFP
|||||||||||||||||||||||||||||||||||||||||||.||||||||||||.||||||||||||||||||||.|.|||||||||||.|| ..||.
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVHSRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGENPGFD

EARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVRNERYTFSPDWWALGCLLYEMIAGQSP
|.||.|||||||||||.||||||||||.||||||||||||||||||||||..||||.|.||||||||||||||.|||||||||||.||||.||||.|.||
EERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQMIRGRVGTVGYMAPEVVKNERYTFSPDWWGLGCLIYEMIEGRSP

FQQRKKKIKREEVERLVKEVAEEYT-DRFSSQARSLCSQLLSKDPAERLGCRGGGAREVKEHPLF
|.|||.|.|||||.| |||  |.|. ..||..|...|..||.|||..|||||..|..||..||.|
FRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREEGCDEVRQHPFF
Kinase GPRK6.AA AGC 186-448 28 2e-157 410.55 In-house 1-395 (395) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-395/395
Sequence Identity: 28% (113 aa)

FRQYRVLGKGGFGEVCACQVR------ATGKMYACKKLEKKR-IKKRK--GEAMALNE------------KQILEKVN----------SRFVVS-LAYAY
|. ..|.|||.||.|. .. .      .|||.||.|.|.||. |...|   ......|            ..||||.|          . |.|. | |..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKDA--LCLVLTLMN--------GGDLKFHIYHMG--QAG-FPEARAVFYAAE-------ICCGLEDLHR-ERIVYRD-LKPENILLDDHGHIRISDLG
..||   |..|. .|.        ||.. .... .|  . | |.| || |||||       |...|| ||.   |..|| |||||||||..|||...| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAVHVP---------------------------------------------------EGQTIKGRVG--TVGYMAPEVVRNERYTFSPDWWA--LGCLLY
|.  ..                                                   .... .  .|  |  |||||..    |... |||.  ||||.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMIAGQSPFQQ------------RKKKIKREEVERLVKEVAEEYT----------DRFSSQARSLCSQLLSKDPAERLGCRGG-----GAREVKEHPLF
||..|..||.             .... .. .  |....  ...           . ||..|..|...|| |||..||||.|.     || |.|.|| |
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase GPRK6.AA BARK 186-448 50 4.7e-98 332.06 In-house 1-264 (264) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-264/264
Sequence Identity: 50% (137 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR----FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA
|   |..|.||||||  |    |||||| | |.||||| ..|| .||||. .|. |       |.| ..||..| | || .| |||||||    ||. | 
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLH---YHLSQH

G-FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVRN-ERYTFSPDWWALGCLLYEMI
| | |.   ||||||  ||| .|.  .||||||| |||||..||.||||||||    . .     ||| |||||||.     |  | ||..|||.|| ..
GVFSEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLL

AGQSPFQQRKKKIKREEVERLVKEVAEEYTDRFSSQARSLCSQLLSKDPAERLGCRGGGAREVKEHPLF
 | ||| | | | | .|..|.   .. |  | || . |.|   || .| ..||||.|.||.|||||| |
RGHSPFRQHKTKDK-HEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCMGRGAQEVKEHPFF
Kinase GPRK6.AA S_TKc 186-448 34 5.1e-92 312.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNG--GDLKFHIYHMGQAG-
..  |..|||.||.|. |. . ||. .|.|..            ....| |||.| .  ..| | ..... | |..|. ...|  |||. .| ..|  | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVRNERYTF-SPDWWALGCLLYEM
   ||| .| ||...|||.|| .|. .|..|||||||||||.  || |.| ||| ..      .  .||  ||||||.    |.. . |||..||.||||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

IAGQSPFQQRKKKIKREEVERLVKEVAEEYTDRFSSQARSLCSQLLSKDPAERLGCRGGGA--REVKEHPLF
..|. ||.         ..... | .        |..|... ...| |||..|...    .  ...| || |
LCGYPPFP---------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GPRK6.AA RSK 189-448 36 1.4e-82 280.68 In-house 1-278 (278) Show / Hide 
Range on Protein: 189-448
Range on HMM: 1-278/278
Sequence Identity: 36% (101 aa)

YRVLGKGGFGEVCACQVR---ATGKMYACKKLEKKRIKKR-KGEAMALNEKQILEKVN-SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-
 .|||.||.|.|  |.     .||. || | |.|. |..| |  . .. | .||| .. . |.|.| ||..|.. | |.. ...||.|  |... .. | 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVH-VPE-GQTIKGRVGTVGYMAPEVVR---NER-YTFSPDWWALGC
| | .| ||.||| . .| ||   |..|||||||||.||   .|||...| |..   ... .|  .  ..|. |||||...    .. .. . ||| ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYEMIAGQSPFQQRKKKIKREEVERLVKEVA--EEYT--DRFSSQARSLCSQLLSKDPAERLGCRGGGAREVKEHPLF
|.||| .|..|||.   .  |.|. . ...     .    .  |  |..| ...| .||. ||||  ..| |.|.|| |
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase GPRK6.AA AktR 186-448 36 1.5e-80 273.87 In-house 1-268 (268) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-268/268
Sequence Identity: 36% (101 aa)

FRQYRVLGKGGFGEVCACQVR-ATGKMYACKKLEKKRIKKRKGEAMALNEKQILE-KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF
|. |..||||.||.|  .| .  ..|.|| | . || |..|. .  ...|..|.| ..|  | | | |. .||. | ...  . ||.| .|. . ..  |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK--F

PEARAVFYAAEICCGLEDLHRE-RIVYRDLKPENILLDDHGHIRISDLGLAV--HVP-EGQTIKGRVGTVGYMAPEVVRN-ERYTFSPDWWALGCLLYEM
 | .| ||.|.|. .|| || .  |.|||||||||||| .||..|.| ||.    .  . .. .  .||. |||||.... . ...| ||||.|...|||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

IAGQSPFQQ--RKKKIKREEVERLVKEVAEEYTDRFSSQARSLCS-QLLSKDPAERLGCRGGGAREVKEHPLF
..|. ||..  .. .....  ..  ...  .|.  ||||...|.  .|| |.| .|||    |. |.|.|| |
VTGCPPFYHKNQNQMFQKIKIKQ-QNKF--PYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase GPRK6.AA SGK 186-448 36 5.9e-80 246.5 In-house 1-283 (283) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-283/283
Sequence Identity: 36% (107 aa)

FRQYRVLGKGGFGEVCACQVRAT------------------GKMYACKKLEKKRIK-------KRKGEAMALNEK-QILEKVNSRFVVSLAYAYETKDAL
|.   |.|||.||.|   .  ..                  .|.|| | | |. |        |.| .   . |.  || .... | |.| ||  ||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV-HVPEGQTIKGRVGTVGYMAPEVVR
 .|.  .|||.. .|.   .   ||| || |||||| | || ||   |.||||||||||||. ||... | ||.   . . .| .   ||. |.|||| |
YFVMDYVNGGEMFYHLQREKH--FPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLR

NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVAEEYTDRFSSQARSLCSQLLSKDPAERLGCRGGGAREVKEHPLF
 . .  . ||| |||.||||. |  ||  | |..  .   .. ..        .|..|..|  .|| ||| .||| .  ...|.|.|| |
KQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYD--NIINQPL--QIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase GPRK6.AA Pkinase 186-448 29 3.5e-79 274.17 Pfam 1-293 (293) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMAL-NEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGG----DLKFHIYHMGQ
..  |..|.|.||.|. |. . |||..|.|...|...|. | .. .. .| ||. ..|. ..| | ...|.|| ...|. ...||    ||. .|  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

AGF--PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI----RISDLGLAVH--VPEGQTIKGRVGTVGYMAPEVVR-NERYTFSPDWWAL
 .|  .|  . ||. .|..||| .|...|..|||||||||.|..|||    .|.| ||| .     ..  ....|| .||||||.| .. |. . |.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCLLYEMIAGQSPFQQR----KKKIKREEVERLVK---EVAEEYTDRFS-----------------SQARSLCSQLLSKDPAERLGCRGGGAREVKEHPL
||.||||. |. ||...    .   ... ..|  .   .  ...... |                 . ...... .| |||..|..     |.....|| 
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase GPRK6.AA PKC 186-448 38 3.5e-74 239.82 In-house 1-262 (262) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-262/262
Sequence Identity: 38% (104 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK-VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFP
|.  .||||| || |     . | ..|| | | |  | .      ...|| .|.   .  | ..|     |.| |  |.   ||||| |||  ..   |.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRR--FK

EARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA-VHVPEGQTIKGRVGTVGYMAPEVVRNERYTFSPDWWALGCLLYEMIAGQS
|..|.||||||.|.|  ||.  |.||||| .|.|||  |||.| | |..  .. .|.| .   ||  |.|||... . |..| ||||.| |.||| ||||
EEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQS

PFQQRKKKIKREEVERLVKEVAEEYTDRFSSQARSLCSQLLSKDPAERLGC--RG-GGAREVKEHPLF
||         .|. . . .    |   .|  | |.|.... |.|..||||  .. .|.....|||.|
PFHGE----DEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase GPRK6.AA Ciliate-E2 186-448 22 1.1e-68 234.47 In-house 1-365 (365) Show / Hide 
Range on Protein: 186-448
Range on HMM: 1-365/365
Sequence Identity: 22% (86 aa)

FRQYRVLGKGGFGEVCACQVRATGKM-----------------------YACKKLEKKRIKKRKGEAMAL----------NEKQILEKVNSRFVVSLAYA
.   ...|.|.|| |. |.|. ..|.                       || | ..|. |.  | |   .          |||.|||..|. ... . ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--TKDALCLVLTLMNGGDLKFHIY----------------HMGQAGFPEARAV--------FYAAEICCGLEDLHRER-IVYRDLKPENILLDDHGHI
..  ... . ||. . .||||. .|.                 . ....  .  .        ||.|.|...|| || .  |..||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

RISDLGLAVHVPEG--------------------------------QTIKGRVGTVGYMAPEVVRNER---------YTFSPDWWALGCLLYEMIAGQSP
 |.|.||.  . .                                 ....  .|| ||||||.....          |... |.|.||..||||. |. |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQQRKKKIKREEVERLVKEVAEEYTD----------RFSSQARSLCSQ----LLSKDPAERLGCRGGGAREVKEHPLF
|    ..||  ...   .|  .. |.            | ..  |...    .| ||| .|..    |. ....|| |
F---QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase GPRK6.AA Akt 186-385 40 4.9e-67 213.31 In-house 1-203 (264) Show / Hide 
Range on Protein: 186-385
Range on HMM: 1-203/264
Sequence Identity: 40% (84 aa)

FRQYRVLGKGGFGEVCACQVRATGKMY-ACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFP
|.  .||||| || |  ..  .|.|.| | | | |..| ...  . .. |. ||...|. |.|.| |.  |.| |..|.  .|||.| .|... .   |.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKR--RFS

EARAVFYAAEICCGLEDLHRERIVYRD-LKPENILLDDHGHIRISDLGLAV-H-VPEGQTIKGRVGTVGYMAPEVVRNERYTFSPDWWA-LGCLLYEMIA
| || ||.||| ...| ||   |.||| |||||||.| .|||.. | ||.  . . .... |   ||  |.|||.  .  .| . |||. |||..|||. 
EDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMC

GQSPF
|. ||
GRPPF
Kinase GPRK6.AA TyrKc 186-423 19 1.1e-14 14.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 186-423
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV--NSRFVVSLAYAYETK-------DALCLVLTLMNGGDLKFHI-
 .  ..|| | ||||. .. .    . | |.| .        ... ..| .|. |.  .   .| |  .  ..       . |..|. .| .|||| .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

YHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG-------QTIK------GR-VGTVGYMAPEVVRNER
.| ..  .. .  . ..  |.|| | ||. ... |||   |.|... ....||| ||.  . ..       ....      |. .  .  ||||. .  .
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTFSPDWWALGCLLYEMIA-GQSPFQQ-------------------RKKKIKR----------EEVERLVKEV-AEEYTDRFSSQARSLCSQL
.|.  | |. | ...|.   ||.|                      | .. .           .|. .. |.  .|.  || . ..  .....
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE--IHECF
Kinase GPRK6.AA Akt 410-448 46 1.1e-14 43.26 In-house 226-264 (264) Show / Hide 
Range on Protein: 410-448
Range on HMM: 226-264/264
Sequence Identity: 46% (18 aa)

DRFSSQARSLCSQLLSKDPAERLGCRGGGAREVKEHPLF
|..| ....| |.||.||| .|||   ..|.|.|.|| |
DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase GPRK6.AA S_TK_X 449-528 20 1.6e-10 42.22 SMART 1-79 (79) Show / Hide 
Range on Protein: 449-528
Range on HMM: 1-79/79
Sequence Identity: 20% (18 aa)

KKLNFKRLGA--GMLEPPFKPDPQAIYCKDVLDIEQFS--TVKGVDLEPTDQDFYQKFATGSVSIPWQNEMVETE----CFQELNVFG
.......| .  ...||||||.....|  .  |...|     ....        .. . ...... |||| .|||    .| ... . 
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase GPRK6.AA Pkinase_Tyr 186-333 22 0.000709 13.75 Pfam 1-158 (270) Show / Hide 
Range on Protein: 186-333
Range on HMM: 1-158/270
Sequence Identity: 22% (36 aa)

FRQYRVLGKGGFGEVCACQVR----ATGKMYACKKLEKKRIKKRK--GEAMALNEKQILEKV-NSRFVVSLAYAYE-TKDA--LCLVLTLMNGGDLKFHI
 .  ..||.| ||||. .  .     |.   | |.| |    ..    |..   | .|. .  .   .|.|  .    ..   ...|. .| .|||. . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

YHM--GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA
     ..  ..  . . ....|..|.| |.. ... |||   |.|... ....|.| |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase GPRK6.AA Pkinase_Tyr 352-386 32 0.007762 10.23 Pfam 181-217 (270) Show / Hide 
Range on Protein: 352-386
Range on HMM: 181-217/270
Sequence Identity: 32% (12 aa)

MAPEVVRNERYTFSPDWWALGCLLYEMIA-GQSP-FQ
||||. .. ..|   | |. | |..|..  |..| ..
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYP