Gene HCK (Mouse)

HCK

Species: Mouse
Alias: HCK, Hck
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Src
Subfamily: SrcB

Sequence

Name Sequence Type Origin Length Description Download
HCK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 251 Kinase domain by global Sugen HMM Fasta, JSON
HCK.AA Protein Sugen 524 None Fasta, JSON
HCK.NA RNA Sugen 2068 None Fasta, JSON

Protein domain

Protein domains of HCK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3_1 HCK.AA SH3_1 82-128 48 1.3e-22 79.13 Pfam 1-49 (49) Show / Hide 
Range on Protein: 82-128
Range on HMM: 1-49/49
Sequence Identity: 48% (24 aa)

VALYDYEAIHREDLSFQKGDQMVVLE-EAG-EWWKARSLATKKEGYIPS
||||||.| . ..|||.|||.. |.| . . .|||.|.. |..||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3 HCK.AA SH3 79-135 48 2.3e-22 81.52 SMART 1-58 (58) Show / Hide 
Range on Protein: 79-135
Range on HMM: 1-58/58
Sequence Identity: 48% (28 aa)

TIVVALYDYEAIHREDLSFQKGDQMVVLEE-AGEWWKARSLATKKEGYIPSNYVARVN
  |.|||||.| . ..|||.||| . |||.  ..|||.|   | .||..|||||....
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_2 HCK.AA SH3_2 80-134 20 2.8e-10 38.86 Pfam 1-68 (68) Show / Hide 
Range on Protein: 80-134
Range on HMM: 1-68/68
Sequence Identity: 20% (14 aa)

IVVALYDYEA-IHRED-----LSFQKGDQMVVL----EEAGEWWKA-RSLATKKE--GYIPSNYVARV
 .... ||..    ..     |.|.|||. .|.    .....||.. ........  |..||..|. .
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 HCK.AA SH2 142-224 56 1.5e-50 150.23 Pfam 1-81 (81) Show / Hide 
Range on Protein: 142-224
Range on HMM: 1-81/81
Sequence Identity: 56% (47 aa)

WFFKGISRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSLQELVLHY
|... |||..|||.|..|||. |.|..|.||.|.|.|.|||||..|  || ||||.|...| ||.||. | .|.|||||| ||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 HCK.AA SH2 140-230 44 1e-35 125.9 SMART 1-87 (87) Show / Hide 
Range on Protein: 140-230
Range on HMM: 1-87/87
Sequence Identity: 44% (41 aa)

EEWFFKGISRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISP--RSTFSSLQELVLHYKKGKDG
..|..  |||..||. |..||.  |.|..||||...|.|.||||.      . ||||.||..|.|..||    | .|.|| ||| ||.. ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase HCK.AA SrcB 260-510 83 2.8e-204 684.93 In-house 1-251 (251) Show / Hide 
Range on Protein: 260-510
Range on HMM: 1-251/251
Sequence Identity: 83% (209 aa)

LQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVSQEPIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDF
|...|||||||||||||..||.|.||||||||.|.||.||||||||.||.||||.||.|.|||..|||.|.||.||||.||||||..||||..||||||.
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

SAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGM
||||.||||.||..|||||||||||||||..|.||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

SNPEVIRALEHGYRMPRPDNCPEELYNIMIRCWKNRPEERPTFEYIQSVLD
.||||||.||.||||||||||||||||||..|||.||||||||.|.|||||
TNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase HCK.AA Src 260-509 66 6.30000000001e-194 650.54 In-house 1-255 (255) Show / Hide 
Range on Protein: 260-509
Range on HMM: 1-255/255
Sequence Identity: 66% (170 aa)

LQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVSQE-PIFIVTEFMAKGSLLDFLK-SEEGSKQPLPKLI
.....|||.||||||||...|..|||||||.|||.||.||||.||..||.|.|.|||.|.||.||| ||.||||.|..|||||.|| ..||.. .||.||
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIE--DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP
|..||..||||..|..|||||||.|.|.||. ..|||.|||||||.|.  |.||.||.|||||||||||||||.|.||||||||||||||.|||||||.|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMSNPEVIRALEHGYRMPRPDNCPEELYN-IMIRCWKNRPEERPTFEYIQSVL
||||.|.||....|.|||||.|.|||.|||. || .||...||.||||||.|..|
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase HCK.AA SFK-Src 260-513 56 4.6e-173 517.77 In-house 1-259 (259) Show / Hide 
Range on Protein: 260-513
Range on HMM: 1-259/259
Sequence Identity: 56% (147 aa)

LQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAV-VSQEPIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLID
 ..|||||.||||.||  . |. | |||||.|||.|| | ||.|| .|| |.|..|..|.||    |||.|.|| |. |||||.|.. .|    .|.|.|
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

FSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIE-DNE-YTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPY
  ||.  |||. |  |..|||| | |.||  . |||..|||..|... |.| |||.|||||||||||||| |   | |||||||||||.|||||||||||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMSNPEVIRALEH--GYRMPRPDNCPEELYNIMIRCWKNRPEERPTFEYIQSVLDDFY
|||.| ||.. ..   ||||| | |||.|.|.||. ||. .|..|||||  .  ..||.
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase HCK.AA SrcA 260-509 69 1.1e-171 547.16 In-house 1-250 (250) Show / Hide 
Range on Protein: 260-509
Range on HMM: 1-250/250
Sequence Identity: 69% (173 aa)

LQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVSQEPIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDF
...|..|| |.|||||| |.|  ||||.||.||| || |||| || .|| |.|||||.| |||| |||.||||.|.||||||||| ||| .  ||.|.| 
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

SAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGM
.||. ||||..|  ||||||||||||||   |.||||||||||.||||||||| |||||||||||||  .| |||||||||||||| |.|| ||.|||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

SNPEVIRALEHGYRMPRPDNCPEELYNIMIRCWKNRPEERPTFEYIQSVL
 | ||.   |.||.|| |..||| |...|..||.  |||||||||.|| |
NNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase HCK.AA Pkinase_Tyr 260-509 47 6.5e-150 508.34 Pfam 1-270 (270) Show / Hide 
Range on Protein: 260-509
Range on HMM: 1-270/270
Sequence Identity: 47% (129 aa)

LQMEKKLGAGQFGEVWMATYN-----KHTKVAVKTMKPGSMSV----EAFLAEANLMKSL-QHDKLVKLHAVVS--QEP--IFIVTEFMAKGSLLDFLKS
... ||||.|.||||...|..     ....||||..|.|.|.     |.|..||..||.| .|...|.|..|..  .||  |.||.|.|..|.|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E--EGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARII-EDNEY-TAREGAKFPIKWTAPEAINFGSFTIKSDVWSF
   .. . ... |.....||..||.. |..|.|||||.| |.||. ..|.||.|||||| | .| .| ..|.|.|.||||.|||.||.| ||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLMEIVTYGRIP-YPGMSNPEVIRAL-EHGYRMPRPDNCPEELYNIMIRCWKNRPEERPTFEYIQSVL
|.|. ||.|||..| |||||| ||.... |.|||||.|.|||.|.|..| .||.  ||.||||..|.. |
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase HCK.AA Frk 260-513 56 4.3e-133 448.46 In-house 1-260 (260) Show / Hide 
Range on Protein: 260-513
Range on HMM: 1-260/260
Sequence Identity: 56% (146 aa)

LQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVS-QEPIFIVTEFMAKGSLLDFLK--SEEGSKQPLPKL
.|. ..||.|||||||   .|  | |||||.|||.|  . ||.|| .||.|.| ||..|.||   .|||.|.|| | .|||...|.  ...|..  ...|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

IDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR-IIEDNE--YTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGR
.| .||.  |||..|..||||||| | |.||  ...|||||||||| .. |||  | .| ||.||||||||||.|  .||||||||||||||.||.||||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

IPYPGMSNPEVIRALEHGYRMPRPDNCPEELYNIMIRCWKNRPEERPTFEYIQSVLDDFY
.||||| | ||.  ..||||||.| |||..||.||. ||.  |..||||| .|  |.|..
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase HCK.AA Src-Unclassified 260-509 44 4.8e-133 448.31 In-house 1-284 (284) Show / Hide 
Range on Protein: 260-509
Range on HMM: 1-284/284
Sequence Identity: 44% (125 aa)

LQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPG---SMSVEAFL--------AEANLMKSLQHDKLVKLHAVVSQE-PIFIVTEFMAKGSLLDFLKSEE
..  .||| ||||||| . .     ||||||.||    || ||||        .||..|| ..| .||.| || ||| |..|.||.| .||||..|.   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GSKQPLPKL------------IDFSAQISEGMAFIEQRNYIHRDLRAANILVSASL-----VCKIADFGLA--RIIEDNEYTAREGAKFPIKWTAPEAIN
|.  ... .            .| .||.  ||   | . |.|||| | |.|.         | |..|||||  ....| .| .| ||.||.||.|||.. 
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRP--DNCPEELYN-IMIRCWKNRPEERPTFEYIQSVL
 | |.|||||||.||||.|| |.|..||||| | ||.  .| |||||.|    ||. .|  || .||  .|. ||||.     .
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase HCK.AA TyrKc 260-509 42 2.4e-132 446.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 260-509
Range on HMM: 1-280/280
Sequence Identity: 42% (121 aa)

LQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSL--QHDKLVKLHAVVSQ--------EPIFIVTEFMAKGSLLDFLKSEEGS
....|||| |.||||. .|..  ..||||..|...  .|.|. ||..|..|  .|. .|.|..|..|        ||..||.|.|..|.|.|.|.. .. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDN--------EYTARE--GAK--FPIKWTAPEAINFGSFTIKSD
  ....|..|. ||..||......|.||||| | |.||.. ...||.||||.| |.|          |...|  |.|  .||.|.|||.||.| ||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLMEIVTYGRIPYPG-----MSNPEVIRALEHGYRMPRPDN--------CPEELYNIMIRCWKNRPEERPTFEYIQSVL
|||||... || |||  ||||     ||| |||. ...|||||.|.|        ||.|.|.|| .||.  ||.||||. | . .
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase HCK.AA Src-Echino1 260-509 51 2e-124 419.67 In-house 1-252 (252) Show / Hide 
Range on Protein: 260-509
Range on HMM: 1-252/252
Sequence Identity: 51% (130 aa)

LQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVSQE-PIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLID
|.|.||.| |..||||   .|  |.|||||.|...||  .||||||.|| ..|. .|...|| | . ||.|||| | .|.|.|.||.... .  ...|||
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

FSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPG
  |.|  || .....|..|||| | |.||    |||||||||||......| ...|||.|||||||||. .|.|||||||||||||. |.||.||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MSNPEVIRALEHGYRMPRPDNCPEELYNI-MIRCWKNRPEERPTFEYIQSVL
| | ||.  ...|||||....||. ||.. |..||   |  |||||.. . .
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase HCK.AA TK 260-509 25 1.5e-118 399.28 In-house 1-486 (486) Show / Hide 
Range on Protein: 260-509
Range on HMM: 1-486/486
Sequence Identity: 25% (122 aa)

LQMEKKLGAGQFG---EVWMATYNKH--------------------------TKVAVKTMKPG-SMSVEAFLA--------------EANLMKSLQ----
....||||.||||   ||...... .                          |.||||..|.| .|| |.|..              ||. || ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDKLVKLHAVVSQE-------------PIFIVTEFMAKGS----LLDFLK--SEEGSK-----------------------------------------
 |. .|.|..|..|.             |. ||.|.|..|.    |.|.|.  ......                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------QPLPKLIDFSAQISEGMAFIEQR------NYIHRDLRAANILVSASLV-----------CKIADFG---
                                ... |. ...||..||......      |..|||| | |.||. ..|           |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARII-EDNEYTARE------------------------GAKFPIKWTAPEAIN---------FGSFTIKSDVWSFGILLMEIVTYGRIPYPG-M
     ||| | .| .|....                        |.|.||.|.|||..|         .| ||.||||||||.|. ||.|||. ||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------PEVIRALEHG--------------YRMPRPDNCP--------------EELYNIMIRCWKNRPEERPTFEYIQSVL
||          ||.. |. |              .|||.|..||              ||.| .| .||.  ||.||||. ... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase HCK.AA SRM 260-510 45 4.8e-113 379.52 In-house 1-253 (253) Show / Hide 
Range on Protein: 260-510
Range on HMM: 1-253/253
Sequence Identity: 45% (114 aa)

LQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGS-MSVEAFLAEANLMKSLQHDKLVKLHAVVSQ-EPIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLI
  . .|||.| ||||| .      .||.|  |    |  . . .|   ||.| | ....||||.|  .|..|.|| |.||.|. .|.. ..   |.|.|.
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYP
||  |. |||.. | .||||||| | |.||   ..||..|||||| | |  |    . . |.|||||||.| . . .||||||||||| |. ||| .|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMSNPEVIRALEHGYRMPRPDNCPEELYNIMIRCWKNRPEERPTFEYIQSVLD
||.| | .   . |||||.|  || | .  |. ||.  ||.||.|      | 
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase HCK.AA Tec 260-511 42 1.3e-108 367.11 In-house 1-254 (254) Show / Hide 
Range on Protein: 260-511
Range on HMM: 1-254/254
Sequence Identity: 42% (109 aa)

LQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVS-QEPIFIVTEFMAKGSLLDFLKSEEGSKQPLP-KLI
| . | || |||| | .. .  . .||.|..| |||| | |. ||  |. |.| |||.|  | | | ||.||||.|..|.||..|.....  |     |.
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

DFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYP
.   ...||||. |. ..||||| | | ||.   | |..|||..| . | .||   |.|||.|| .||  ..  .  |||||.||.|  |. . |..||.
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

GMSNPEVIRALEHGYRMPRPDNCPEELYNIMIRCWKNRPEERPTFEYIQSVLDD
 ||| ||. .   |.|. ||. |....| || .||. .|||||||.   . . .
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase HCK.AA S_TKc 260-514 23 3e-53 184.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 260-514
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

LQMEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVSQEPIFIVTEFMAK--GSLLDFLKSEEG----SKQP
 .. .|.| | ||.|. .. .| . .||.| .|      | .. | ...|. .|. .|||. |   . ...|.|..    |.|.|..|.  .    .. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTI-KSDVWSFGILLMEIVTY
      . .|| ...... ... |||||  .|||..   . ||.||||||..                . ||| .   ...  |.|.||.|..| | .. 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-

GRIPYPGMSNPEVIRALEHGYRMPRPDNCPEELYNIMIRCWKNRPEERPTFEYIQS----VLDDFYT
|. |.|     .. . ...          ..|. ... .|..  ||.|||   .      .  . . 
GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HCK.AA Pkinase 260-512 24 3.7e-39 139.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 260-512
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

LQMEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSVEAF-----LAEANLMKSLQHDKLVKLHAVV-SQEPIFIVTEFMAKG----SLLDFLKSEEG
.. ..|.|.| ||.|. ..  .  | ||||..|  . . .       |.|. .||.|.|.  |.|. .. .   | .|.|.. .|    .| |... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SKQ--PLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVC----KIADFGLAR---IIEDNEYTAREGAKFPIKWTAPEAIN-FGSFTIKSDV
 .   .   ....  || .|.... ... |||||  .|||..   ..    ||.|||||.   .  .  .| . |  .   . ||| |.     . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDM

WSFGILLMEIVTYGRIPYPGM----SNPEVIRALEHGYRMPRPDNCP-----------------------EELYNIMIRCWKNRPEERPTFEYIQSVLDD
||.|..| | .. || |.||     .  . .  ..   . | . ..|                       ||.  .. .|..  |..|||   .. .| .
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQH

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PWF