Gene HSER (Mouse)

HSER

Species: Mouse
Alias: HSER, Gucy2c
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
HSER.AA Protein Sugen 1072 None Fasta, JSON
HSER.NA RNA Sugen 3951 None Fasta, JSON
HSER.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 272 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of HSER.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor HSER.AA ANF_receptor 53-387 16 9.1e-26 91.94 Pfam 1-364 (364) Show / Hide 
Range on Protein: 53-387
Range on HMM: 1-364/364
Sequence Identity: 16% (65 aa)

NLREAVEEGLDIVRKRLREADLNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDHKMGCALMGPSCTY-STFQMYLDTELNYPMISAGSYGLSC
.. .|..  .. . ..    . ..|... . ....         .|.| .   .       |. .|. ||||.| ..    . ...| ||||.|.   ..
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCY---------CSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCL

DY--KE---TLTRILPPARKL-MYFLVDFWKVNNASFKPFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYF--SE-----VLNFKDVLRR-------S--
..  |.   ...|..|..... ....||. .                        .. |   |. .  ...  ..     .  |.|.||.       .  
TDKAKNRYPYFFRTVPSDTYQYGWAMVDIIQH-----------------------HFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREHGGNCVYYAY

--------EQFQEILTGHN----RKSNVIVMCGTPESF----YDVKGDLQVA-------EDTVVILVDLFSNHYF--------EENTTAPEYMDNVLVLT
        . |...|.  .     |. |||||. |. .      .   .| |       .. | |..|.....|.        ..|... |.|..||..|
VSMVIPWDDDFMDYLKKIKDIIKMKARVIVMCCYPDDMGLLQRQI---MQQAHELGMMSGGYVWIYTDWWMHSYDMQWWYDDDMDNDKFREAMKGVLGFT

LPSEQSTSNTSVAERF---SSGRSDFSLAYLEGTLLFGHMLQTFLENGENVTGPK----------FARAFRN-LTFQGFAGPVTLDDSGDIDNIMSLLYV
.. . |...    .|.   ... . ...    ...|..|.|. .| ...|.. ..          ......|  .|.|..|.|..||.|.     .. ..
MH-P-SPEFQEFMQRWKKTDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIM

SLD
  |
NWD
Kinase HSER.AA RGC 509-746 34 4.7e-103 348.66 In-house 1-300 (300) Show / Hide 
Range on Protein: 509-746
Range on HMM: 1-300/300
Sequence Identity: 34% (106 aa)

DKKKVILKDLKHS----DGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDT------RIFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIA
.. .|..|.....    . .|.....  |... | .. ||.||.| .  ..      ... | |||.|||| ..| .     |   ||| || | ..||.
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILEN-----DDIKMDWMFKYSFIRDIV

KGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCN----------------------SILPP------KKDLWTAPEHLR----QATIS--------
||| |||.| | .||.|||.|||||||.||||||||.|                      .. ..      || |||||||||    .....        
KGMQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRG

-QKGDVYSFAIIAQEIILRKE-----TFYTL------SCRDHNEKIFRVENSYG-KPFRPDLFLETA---DEKELEVYLLVKSCWEEDPEKRPD-FKKIE
 ||||||||.||..|||.||.     .|. .      |... .|.. ......| |||||..  ...   .|   ... |.. ||.||||.||| |..| 
TQKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIR

STLAK
..|..
KQLKT
Kinase HSER.AA RGC 509-746 34 4.7e-103 348.66 In-house 1-300 (300) Show / Hide 
Range on Protein: 509-746
Range on HMM: 1-300/300
Sequence Identity: 34% (106 aa)

DKKKVILKDLKHS----DGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDT------RIFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIA
.. .|..|.....    . .|.....  |... | .. ||.||.| .  ..      ... | |||.|||| ..| .     |   ||| || | ..||.
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILEN-----DDIKMDWMFKYSFIRDIV

KGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCN----------------------SILPP------KKDLWTAPEHLR----QATIS--------
||| |||.| | .||.|||.|||||||.||||||||.|                      .. ..      || |||||||||    .....        
KGMQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRG

-QKGDVYSFAIIAQEIILRKE-----TFYTL------SCRDHNEKIFRVENSYG-KPFRPDLFLETA---DEKELEVYLLVKSCWEEDPEKRPD-FKKIE
 ||||||||.||..|||.||.     .|. .      |... .|.. ......| |||||..  ...   .|   ... |.. ||.||||.||| |..| 
TQKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIR

STLAK
..|..
KQLKT
Kinase HSER.AA TKL 525-744 22 4e-40 139.62 In-house 68-364 (364) Show / Hide 
Range on Protein: 525-744
Range on HMM: 68-364/364
Sequence Identity: 22% (68 aa)

FSEKQKIDLNKLLQSDYYNLTKFYGTVKLDTR-------------IFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKI--
| .. .  .. ... .  |. .|.| ..  .              .. | |||..|||...|.            |. ...   |||.||.||||..   
FRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKW

-----EVHGRLKSTNCVVDSRMV--------------VKITDFGCNSILPPKKD----------------------------LWTAPEHLRQA-------
      .|  ||| |. ||. .               .||.|||    . ....                             | ||| ||..       
CTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKV

---------TISQKGDVYSFAIIAQEIILRKETFYTLSCRDHN------EKIFRVENSYGKPFRPDLFLE-----TADEKELEVYLLVKSCWEEDPEKRP
         . |.| |||||.|.  ||. |.. .| . ....       | .  | .   .| .|.  ..       .    ..  | . ||..||||||
GIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP

DFKKIESTL
 |..| ..|
SFQEILKRL
Kinase HSER.AA TKL-Unique 543-669 27 7.6e-24 81.08 In-house 57-217 (290) Show / Hide 
Range on Protein: 543-669
Range on HMM: 57-217/290
Sequence Identity: 27% (45 aa)

NLTKFYGTVK----LDTRIFGVVEYCERGSLREVLND----TISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKI-EVHGRLKSTNCVVDSR-----MVV
|.....|. .       . . |.|||..|||..||..        .. . .... ...  .|||.|| |||...    |. |||.|  ||..     . .
NIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNI

KITDFGCNSILP-----PKKDL-------------WTAPEHLRQ--ATISQKGDVYSFAII
|| |||   ..      ... .             | ||| ||.  ...|.| |||||.|.
KICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIV
Kinase HSER.AA Dicty5 536-678 32 1.6e-20 67.31 In-house 52-201 (260) Show / Hide 
Range on Protein: 536-678
Range on HMM: 52-201/260
Sequence Identity: 32% (50 aa)

LLQSDYYNLTKFYGTVKLDTRI-FGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFG
. |||  |....||  . ...  | | ||| .|||.. ||| .    |  . .  ...   |||..| .|||  | .|  ||| |  .  .  .|| |||
IFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLND-QRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNI-IHRDLKSMNFLITENWKIKIIDFG

CNSILPPKKDLWT--------APEHLRQATISQKGDVYSFAIIAQEIILRKE
       ..   .        |.|     .  || |||||.|.  |.. |||
TSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKE
Kinase HSER.AA TK 543-668 15 6.9e-17 52.43 In-house 104-382 (486) Show / Hide 
Range on Protein: 543-668
Range on HMM: 104-382/486
Sequence Identity: 15% (43 aa)

NLTKFYG-TVKLDTR-----------IFGVVEYCERGS----LREVLNDTI------------------------------------SYPDGTF------
|. ..||  .. ...           .  |.||.. |.    ||. | .                                      ..|. ..      
NIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQDYDD

-----------------------------MDWEFKISVLNDIAKGMSYLHSSKIE-----VHGRLKSTNCVVDSRMV-----------VKITDFG-----
                             .. . ..    .||.||.|||| ..|     ||. |   || |....|           .||.|||     
DLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQG

---CNSILPPKKDL-----------------------------------WTAPEHLRQAT---------ISQKGDVYSFAI
       .....|                                    |.||| |.  .          . | ||.|| .
SGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV
Kinase HSER.AA Dicty4 560-669 31 1.5e-16 51.92 In-house 80-206 (277) Show / Hide 
Range on Protein: 560-669
Range on HMM: 80-206/277
Sequence Identity: 31% (40 aa)

VVEYCERGSLREVLND-TISYPDGTFMDWEFKIS---VLNDIAKGMSYLHSSK-IEVHGRLKSTNCVVDSRMVVKITDFGCNS-ILPPK--KD-------
| ||. .|.| ..|.|      . . .||.  ..      |.|.|| .||..  . .|  ||| |  ||  ..||..|||    . . .  ||       
VTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACG

--LWTAPEHLRQATISQKGDVYSFAII
  .|.||| ..     .| |||||.|.
TPCWMAPEVMMHQPYNEKADVYSFGIV
TyrKc HSER.AA TyrKc 494-744 20 1.6e-13 -3.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 494-744
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

DRRRDTIQR-----VRQCKYDKKKVILKDLKHSDGNFSEKQKIDLNKLLQSDYYNLTKF----------YGTVKLD-------TRIFGVVEYCERGSLRE
 .  ... .     |......  .|  | ||..             . . .    ..|.          || .  .         .. |.||.. |.|..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFG-------C-------NSILP----PKKDL----WTAP
 | ..          .. ..|   .||.||.|||| .. .|  |   || |... .|||.|||                 . .     .|..    |.||
YLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNC-IHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EHLRQATISQKGDVYSFAIIAQEIILRKETFYTLSCR--DHNEKIFRVENSYGKPFRPDLFLETADE-----KELEVYLLVKSCWEEDPEKRPDFKKIES
| ..  . . | ||.|| .   ||  . .. |         |. ...   . . . .|.  .    .        |.| . |.||.||||.|| |. | .
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY----PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

TL
 .
CF
Kinase HSER.AA MLK 560-634 32 2.6e-13 42.64 In-house 88-178 (291) Show / Hide 
Range on Protein: 560-634
Range on HMM: 88-178/291
Sequence Identity: 32% (30 aa)

VVEYCERGSLREVLNDTISYPDGTF--------MDWEFKISVLNDIAKGMSYLHSSKIE--VHGRLKSTNCVVDS------RMVVKITDFG
| |||| ||| .||..  | ...          .| .....   ..|.||.|||| .    .|  ||| | ..|        ...||.|||
VMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFG
Kinase HSER.AA DRK 560-634 41 2.4e-12 38.14 In-house 75-145 (258) Show / Hide 
Range on Protein: 560-634
Range on HMM: 75-145/258
Sequence Identity: 41% (32 aa)

VVEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSK-IEVHGRLKSTNCVVDSRMVVKITDFG
. ||  ||||  .| .. |.      |||   ..   |.|||| |||..  | .|  ||| |  ||    ||. |||
CMEYMPRGSLYNILHDESIE------MDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFG
S_TKc HSER.AA S_TKc 502-751 20 3.6e-12 1.61 SMART 14-231 (231) Show / Hide 
Range on Protein: 502-751
Range on HMM: 14-231/231
Sequence Identity: 20% (54 aa)

RVRQCKYDK--KKVILKDLKHSDGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCER--GSLREVLNDTISYPDGTFMDWEFKISVLNDI
.|..|.  |  ..| .| .|       |. .  .. | . .  |. |.|..    .... | |||.   |.|.... .  . . .  ..     ...  |
KVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQI

AKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDL-----WTAPEHLRQATISQ-KGDVYSFAIIAQEIILRKETFYTLSCRDHNEK
.... |.|| .| .|  ||  |  .|.  ..||.|||   .|   . .     . ||| |     .  | |..|. .|  | . ..  |.      . ..
CCALEYCHSHGI-IHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQM

IFRVENSYGKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIES--TLAKIFGLF
.|..                      |.  ... |.. ||||||   ..     ..|.   |
MFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HSER.AA UTK 542-634 32 6.2e-12 37.12 In-house 70-170 (296) Show / Hide 
Range on Protein: 542-634
Range on HMM: 70-170/296
Sequence Identity: 32% (33 aa)

YNLTKFYGTVKLDTRIFGVVEYCERGSLREVLNDTISYPD--GTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSR-------MVVKITD
.|. ...|..  .  .  |.||.|.|.|| .| .    |.  ... . . ...  .||| ||.|||| .. ||. |   || |..        ||.|| |
PNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF-VHRDLAARNCLVHMHRMMWHCMMVCKIAD

FG
||
FG
Kinase HSER.AA Pkinase 543-744 19 1.5e-11 41.93 Pfam 61-293 (293) Show / Hide 
Range on Protein: 543-744
Range on HMM: 61-293/293
Sequence Identity: 19% (48 aa)

NLTKFYGTVKLDTRIFGVVEYCERG----SLREVLNDTISYPDGTFM--DWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVV----KITD
|  ..|...  ...|  | |||| |    .| ...       ... .  ...  ....  |..|. |.|| .| .|  ||. |. .|.....    ||.|
NIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGI-IHRDLKPENILIDNNGHIDACVKICD

FGC-----NSILPPKKDL-----WTAPEHLR-QATISQKGDVYSFAIIAQEIILRKETFYTL----SCRDHNEKIFRVENSYGKPFRPDLFLETADEKE-
||.     .   .  ...     . ||| .| .  ...| |..|. .|  | ....  |.      . .|....|.|.     .. ...   .. ...  
FGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRI-----MGPPLHFDWPWWCSISY

----------------LEVYLLVKSCWEEDPEKRPDFKKIEST--L
                 |   ..|.|.. ||.||| .. |     .
FFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase HSER.AA TK 714-744 38 1.9e-09 27.05 In-house 456-486 (486) Show / Hide 
Range on Protein: 714-744
Range on HMM: 456-486/486
Sequence Identity: 38% (12 aa)

EKELEVYLLVKSCWEEDPEKRPDFKKIESTL
... |.|.| ..||..|||.||.|. . . |
CPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase HSER.AA UTK 717-744 39 4.5e-09 27.2 In-house 269-296 (296) Show / Hide 
Range on Protein: 717-744
Range on HMM: 269-296/296
Sequence Identity: 39% (11 aa)

LEVYLLVKSCWEEDPEKRPDFKKIESTL
..|| |...||. ||..||||. .....
HPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase HSER.AA MLK 722-744 52 1.1e-08 26.44 In-house 269-291 (291) Show / Hide 
Range on Protein: 722-744
Range on HMM: 269-291/291
Sequence Identity: 52% (12 aa)

LVKSCWEEDPEKRPDFKKIESTL
| | ||..||.|||.|. | . |
LMKQCWNQDPHKRPSFRQIVQHL
Kinase HSER.AA Dicty5 722-748 40 2.4e-08 24.8 In-house 234-260 (260) Show / Hide 
Range on Protein: 722-748
Range on HMM: 234-260/260
Sequence Identity: 40% (11 aa)

LVKSCWEEDPEKRPDFKKIESTLAKIF
|.|.|| . | .|| ||.|  .. .| 
LIKKCWQQKPHNRPSFKEICKYFESII
Kinase HSER.AA Pkinase_Tyr 718-744 51 3.4e-08 28.36 Pfam 244-270 (270) Show / Hide 
Range on Protein: 718-744
Range on HMM: 244-270/270
Sequence Identity: 51% (14 aa)

EVYLLVKSCWEEDPEKRPDFKKIESTL
|.| | |.||..|||.|| |. | . |
EIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase HSER.AA Pkinase_Tyr 560-634 36 4.3e-08 28.02 Pfam 85-156 (270) Show / Hide 
Range on Protein: 560-634
Range on HMM: 85-156/270
Sequence Identity: 36% (27 aa)

VVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFG
|.||.. |.|.. | .    .|.   . . ...   .|||||.||.| .. .|  |   || |.. .||||.|||
VMEYMPHGDLLDYLRKHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNC-IHRDLAARNCLVTENNVVKICDFG
Kinase HSER.AA DRK 646-677 53 3e-06 17.05 In-house 168-199 (258) Show / Hide 
Range on Protein: 646-677
Range on HMM: 168-199/258
Sequence Identity: 53% (17 aa)

WTAPEHLRQATISQKGDVYSFAIIAQEIILRK
||||| ||      | |||||||.  |.. |.
WTAPEVLRNQRYTEKADVYSFAIVLWECVTRQ
Kinase HSER.AA Dicty4 722-746 37 7e-06 15.76 In-house 251-277 (277) Show / Hide 
Range on Protein: 722-746
Range on HMM: 251-277/277
Sequence Identity: 37% (10 aa)

LVKSCWEEDPEKRPDFKKIEST--LAK
|.. ||..||..|| |. | .   |  
LIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase HSER.AA DRK 722-746 36 5.9e-05 12.77 In-house 234-258 (258) Show / Hide 
Range on Protein: 722-746
Range on HMM: 234-258/258
Sequence Identity: 36% (9 aa)

LVKSCWEEDPEKRPDFKKIESTLAK
| . ||.|||  || .  .   |  
LMNDCWNEDPQHRPSMQECLERLEA
Kinase HSER.AA TKL-Unique 722-744 43 0.000136 12.32 In-house 268-290 (290) Show / Hide 
Range on Protein: 722-744
Range on HMM: 268-290/290
Sequence Identity: 43% (10 aa)

LVKSCWEEDPEKRPDFKKIESTL
| . ||  ||..|| |  | . |
LIQQCWHHDPSQRPSFDEIIHRL
Kinase HSER.AA UTK 646-668 41 0.001528 7.99 In-house 205-228 (296) Show / Hide 
Range on Protein: 646-668
Range on HMM: 205-228/296
Sequence Identity: 41% (10 aa)

WTAPEHLRQA-TISQKGDVYSFAI
|.||| | .. . ..| ||.|| .
WMAPEALTHHTRFTTKSDVWSFGV
Kinase HSER.AA MLK 646-669 37 0.010611 5.35 In-house 199-225 (291) Show / Hide 
Range on Protein: 646-669
Range on HMM: 199-225/291
Sequence Identity: 37% (10 aa)

WTAPEHL---RQATISQKGDVYSFAII
| ||| .   |  . | | ||.|....
WMAPEVIQQFRCEKYSEKCDVWSWGVV
Kinase HSER.AA Pkinase_Tyr 646-668 39 2.361158 1.82 Pfam 180-202 (270) Show / Hide 
Range on Protein: 646-668
Range on HMM: 180-202/270
Sequence Identity: 39% (9 aa)

WTAPEHLRQATISQKGDVYSFAI
|.||| ..    . | ||.|| .
WMAPECINYGKFTTKSDVWSFGV
CYCc HSER.AA CYCc 787-982 45 1.5e-109 371.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 787-982
Range on HMM: 1-231/231
Sequence Identity: 45% (105 aa)

AERDRADHLNFMLLPRLVVKSLKEKG-IVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHD-----VYKVETIGDAYVVASGL
.|....|.|  ..||| | ..||...  |.|..|..|||.|.||||||..|. .|||.||.||||.|. ||.|.|.|.     .||||||||||.|.||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PMRNG-------------------NRHAVDISKMALDILSFIGTFELEHL----PGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGL
| ||.                    .||..|. .|||......||...|     |. |...|||.|.||...|||||.|||||.||||||.||||||||.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PLRIHMSSSTITIL------KRTDCQFLYEV
| .||.|..|. .|      .| ..||  |.
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc HSER.AA Guanylate_cyc 814-1001 42 1e-98 339.08 Pfam 1-214 (214) Show / Hide 
Range on Protein: 814-1001
Range on HMM: 1-214/214
Sequence Identity: 42% (92 aa)

VEPELYEEVTIYFSDIVGFTTICKYST----PMEVVDMLNDIYKSFDQIVDHH--DVYKVETIGDAYVVASGLPMR-----NGNRHAVDISKMALDILSF
|... |..|||.|.|||||| .| ...    ||..|.||||.|..|| ..|.|  ..|||.||||.| ..|||| .     ..  ||...  ||||.. .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

IGTFELEHLPGLP-----VWIRIGVHSGPCAAGVVG--IKMPRYCLFGDTVNTASRMESTGLPL--RIHMSSSTITILKRTDC-QFLY--EVRGETYLKG
....  .|... |     ...|||.|.||. |||.|  ..|||||..|||||.||||||||.|.  .||.| .| ..||. .. || .  . ||| ..||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

RGTE---TTYWLTG
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KGKMGEMETYFLHG