Gene IRAK1 (Mouse)

IRAK1

Species: Mouse
Alias: IRAK1, Irak1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
IRAK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 310 Kinase domain by global Sugen HMM Fasta, JSON
IRAK1.AA Protein Sugen 710 None Fasta, JSON
IRAK1.NA RNA Sugen 3831 None Fasta, JSON

Protein domain

Protein domains of IRAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death IRAK1.AA Death 28-103 20 5.5e-15 52.55 Pfam 1-87 (87) Show / Hide 
Range on Protein: 28-103
Range on HMM: 1-87/87
Sequence Identity: 20% (18 aa)

CRFYKVM--DALEPADWCQFAALIVRDQTELRLCER-SE-----QRTASVLWPWINR---NARVADLVHILTHLQLLRARDIITAWH
.......  |.. ..||...| ..  ...|.. .|.  .      .| . || |..|   || |..|. .|..... .....|..| 
QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHDQNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL
Kinase IRAK1.AA IRAK 212-518 52 1.9e-202 678.83 In-house 1-317 (317) Show / Hide 
Range on Protein: 212-518
Range on HMM: 1-317/317
Sequence Identity: 52% (167 aa)

FSEELRIGEGGFGCVYRAVMRNTT--YAVKRLKEEADLEWTMVKQSFLT---EVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQA
|....||||||||||||....|||  ||||.|||.||..|....|.|..   |.....|.||||||...|||.|.. .||||...|||||||.|. |...
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

CSP--LSWPQRLDILLGTARAIQFLHQDSP--SLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYLPEEYIK--TGR
|.|  |||.||..|..|||..||||||..|  ..|||||||.|.|||....||..||||.||...|..| .|..|...||.||||..|.|.|.|.  .|.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LAVDTDTFSFGVVILETLAGQRAVRTQGAKTKYLKDLIEDEAEEAGVTLKSTQPTLWVGVATDAWAAPIAAQIYKKHLDSRPGPCPPQLGLALAQLACCC
|...||..|||.|.||.|.|.|||........|||||.|...||.|. |.|.|.||||||||||||||...|||.|..|.|..||||.......|.||||
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGH-LDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCC

MHRRAKKRPPMTQVYKRL
.|.||..|..|..|...|
GHHRANRRCDMAWVMQQL
Kinase IRAK1.AA TKL 218-518 23 4.7e-75 255.67 In-house 1-364 (364) Show / Hide 
Range on Protein: 218-518
Range on HMM: 1-364/364
Sequence Identity: 23% (92 aa)

IGEGGFGCVYRAVMRN----------TTYAVKRLKEEADLEWTM-----------------------VKQSFLTEVEQLSRFRHPNIVDFAGYCAESGL-
||.||||.||... |.          .. |||..|.. | |.|.                        .. .  |. ..||.|||||| | ||| ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDS------PSLIHGDIKSSNVLLDERLM------------
            .|.|. . |.|||...||          |.||... |..||....||..       | .|| |.||.|.|.|| .             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKLGDFGLARFSRFAGAKASQSSTVA----------RTSTVRGTLAYLPEEYIK----------------TGRLAVDTDTFSFGVVILETLAGQRAVR
  .|..||||.||    | .  ...|.           .|.|..||..... | ..                 .     .| .|||.|. | |...|  .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

TQGAKTKYLKDLIEDEAEEAGVTLKSTQPTLWVGVATDAWAAPIAAQIYKKHLDSRPGPCPPQLGLALAQLACCCMHRRAKKRPPMTQVYKRL
 ..  . .. |    |.. ..| .|. .|..     .              |.   . ...|.    ...|. .|..  ..||| .... |||
DYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQN--------------HH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK1.AA MLK 212-364 26 2.8e-34 116.34 In-house 1-182 (291) Show / Hide 
Range on Protein: 212-364
Range on HMM: 1-182/291
Sequence Identity: 26% (49 aa)

FSEELRIGEGGFGCVYRAVMRNTT-----YAVKRLKEEADLEWTMV---KQSFLTEVEQLSRFRHPN----IVDFAGYCAESGL-YCLVYGFLPNGSLED
. ..  ||.|.|| |.....||..      |||| . ... .       .. | .|...|....|||    |. | | |....  .|.|  ....||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

QLHLQTQACS----------PLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDE------RLMPKLGDFGLARF
 || ..   .            .  . ... |  ||....||.. |  .|| |.||.|.|.||       .  |  |||..|.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRD
Kinase IRAK1.AA Pkinase 212-421 23 7.7e-33 117.2 Pfam 1-209 (293) Show / Hide 
Range on Protein: 212-421
Range on HMM: 1-209/293
Sequence Identity: 23% (52 aa)

FSEELRIGEGGFGCVYRAVMRNTT--YAVKRLKEEADLEWTMVKQSFL-TEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNG----SLEDQLHLQT
.  . .||.|.|||||... ..|   .|||..| . . .. . .. .. .|.. . |..||||| . ... ... ...|  ....|    .|    ...|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF--DYIST

QACSPL--SWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMP----KLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYLPEEYIK-
..  ..  |. .  .... ..|.....|.   . || |.|..|.|.|..  .    |..|||||.. .              ..|. ||. |.. | |. 
WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEVIRG

TGRLAVDTDTFSFGVVILETLAGQ
        | .|.|... | | |.
GQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK1.AA TKL-Unique 217-365 33 1.2e-32 112.55 In-house 4-167 (290) Show / Hide 
Range on Protein: 217-365
Range on HMM: 4-167/290
Sequence Identity: 33% (56 aa)

RIGEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFR-HPNIVDFAGYCA----ESGLYCLVYGFLPNGSLEDQLH------LQTQ
 |||||.| ||... | . .|.|......|.. .|. | |  ||  ..... ||||| . |||.      . .|.|  ..| ||| | ||          
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMM-QEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

ACSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDER-----LMPKLGDFGLARFS
  ..|.. ||... .  |..  .||  .|  ||.|.||||.|.|..     .  |. ||||..|.
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFN
Kinase IRAK1.AA RIPK 218-420 26 3.9e-30 99.87 In-house 1-224 (290) Show / Hide 
Range on Protein: 218-420
Range on HMM: 1-224/290
Sequence Identity: 26% (61 aa)

IGEGGFGCVYRAV--MRNTTYAVKRLK-EEADLE-WTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAES------GLYCLVYGFLPNGSLEDQLHLQTQ-A
.| |||| |..|.    .. .|.|  .  . . .    ...  . |.. . . |. .||   | | .       .|| .|  . .||||.. || ...  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

CSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAKASQSST--------VARTSTVR-GTLAYLPEEYIK
  |. || |  ..  .... ..||   | .|| | | .|.|.|  .  |. ||||| . .      |.| .           .|  | |||.|.| | . 
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMW-----SHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFR

TGRLAV------DTDTFSFGVVILETLAG
|.  .         |  ||..|. | |..
TDNKKPIKVVTPKYDVYSFAIVMWEVLTQ
Kinase IRAK1.AA TK 212-366 15 1.3e-27 88.97 In-house 1-307 (486) Show / Hide 
Range on Protein: 212-366
Range on HMM: 1-307/486
Sequence Identity: 15% (49 aa)

FSEELRIGEGGFG---CVYRAVMRN---------------------------TTYAVKRLKEEADLEWTMVKQ-------------SFLTEVEQLS--RF
   .  .||| ||    ||.. .|.                           |. ||| |||... . .. ..             ... | ....   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNIVDFAGYCAES------------GLYCLVYGFLPNGS----LE-----------------------------------------------------
.||||| . |.| ..            . ...|  . |.|.    |                                                      
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------DQLHLQTQACSP-----LSWPQRLDILLGTARAIQFLHQDSP----SLIHGDIKSSNVLLDERLM-----------PKLGDFGLA
               |.|....|.| .     |. .|.| . .  |.. ..||.        ..|.|.   |.|..|..             |..||||.
DDDLIKDHPPPLTTKDLLQMAWQWC-LTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

R-----FSR
|      .|
RQGSGVLAR
Kinase IRAK1.AA TKL-ciliate2 212-363 32 1.6e-27 88.48 In-house 1-167 (273) Show / Hide 
Range on Protein: 212-363
Range on HMM: 1-167/273
Sequence Identity: 32% (56 aa)

FSEELRIGEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLS
   . .| |||.| .|.|  | .. |||. | . | . ...   |. | . .   |||||| | | | ..  .|..  .   |||     || |   .|.
LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIRD--FVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWS--LLQNQDV-RLT

WPQRLDILLGTARAIQFLHQDSPSLIHGDIK--------------------SSNVLLDERLMPKLGDFGLAR
|  |  | |  || . .||   | .|| |.|                    | |||.|. .  || |||  |
WEDRRRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTR
Kinase IRAK1.AA S_TKc 212-516 17 6.7e-26 93.29 SMART 1-220 (231) Show / Hide 
Range on Protein: 212-516
Range on HMM: 1-220/231
Sequence Identity: 17% (56 aa)

FSEELRIGEGGFGCVYRAVMRN--TTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPN--GSLEDQLHLQTQ--
.     ||.|.||.||... ..    .|.|..|           .... |.. |.. .||||| . ... . . ...|  ....  |.| | .. .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

ACSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYLPEEYIKTGRLAV-D
 ..|..  .   ..  ...|....|.     || |.| .|.||||    |..||||||.                 .|. ||. |.. | .         
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL---GYGKCK

TDTFSFGVVILETLAGQRAVRTQGAKTKYLKDLIEDEAEEAGVTLKSTQPTLWVGVATDAWAAPIAAQIYKKHLDSRPGPCPPQLGLALAQLACCCMHRR
 |  |.|... | |.|.   .      . . ..|                                                      . .. . |... 
CDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------------------------------------------------SPEAKDFIRKCLQKD

AKKRPPMTQVYK
 .|||   .. .
PEKRPTA-EALQ
Kinase IRAK1.AA Dicty4 212-363 34 1.4e-25 82.44 In-house 1-162 (277) Show / Hide 
Range on Protein: 212-363
Range on HMM: 1-162/277
Sequence Identity: 34% (56 aa)

FSEELRIGEGGFGCVYRAVMRNTTYAVKRL--KEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCA----ESGLYCLVYGFLPNGSLEDQLHL---
   | |||.|.|| ||..  | .  ||| |  . . . | ..  ..|. ||. ..  |||||. | |.|     ..|  | |  ..| |.|.  ||    
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENML--NEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

QTQACSPLSWPQRLD---ILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMPKLGDFGLAR
  |   .|.|| ..    . . .|| .. ||   |  || |.||.| | |. .  | .||||..
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQ
Kinase IRAK1.AA LISK 217-363 34 2.9e-25 78.87 In-house 1-153 (296) Show / Hide 
Range on Protein: 217-363
Range on HMM: 1-153/296
Sequence Identity: 34% (54 aa)

RIGEGGFGCVYRAVMR--NTTYAVKRLKE-EADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAE-SGLYCLVYGFLPNGSLEDQLHLQTQACSPLSW
 ||.|.||.||.   |  ..  |.| ...   |...      .| ||. . ..|||||| | | | . .| . .|  .   | |.. |.   .  .||.|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

PQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDER----LMPKLGDFGLAR
|||..| |. |..  .||  |   || | || |.|..|.       |..|||.||
PQRVKIALDIACGMSYLH--SMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFAR
Kinase IRAK1.AA TK-Unique 212-416 24 1.3e-23 78.33 In-house 1-231 (294) Show / Hide 
Range on Protein: 212-416
Range on HMM: 1-231/294
Sequence Identity: 24% (60 aa)

FSEELRIGEGGFGCVYRAVMRN--------TTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFR-HPNIVDFAGYCAESG-LYCLVYGFLPNGSLEDQLH
.  . .|||| ||.|.|. ...        .  ||| ||..|...    || || | ....    |||||.. |.| .|.   .... ..|.|.|..  .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDT---DKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQH--Y

LQTQAC------------------------SPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMPKLGDFGLAR-FSRFAGAKASQSS
|.| ..                        .|.|  . . .. . |.. ..|..     .|.|. ..|||| |... |..|||.||  .           
LRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--------NG

TVART-STVRGTLAYLPEEYIK--TGRL-AVDTDTFSFGVVILE
 .... |  |  ..... |..|  .|      .|  ||||.. |
VYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWE
Kinase IRAK1.AA Pkinase_Tyr 212-363 29 1.9e-21 73.25 Pfam 1-159 (270) Show / Hide 
Range on Protein: 212-363
Range on HMM: 1-159/270
Sequence Identity: 29% (48 aa)

FSEELRIGEGGFGCVYRAVMR------NTTYAVKRLKEEADLE-WTMVKQSFLTEVEQLSRF-RHPNIVDFAGYCA-ESGL--YCLVYGFLPNGSLEDQL
 .    .||| || ||.....      ... ||| ||| |. |     ...|. |.. .. . .||||| . | |  ...   ...|  . |.|.| | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HLQTQACSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMPKLGDFGLAR
. .     ||. .. |.. .  |.. ..|..    .|| |.   |.|..| .  | .||||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLAR
Kinase IRAK1.AA TyrKc 212-518 20 2.6e-17 57.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 212-518
Range on HMM: 1-280/280
Sequence Identity: 20% (68 aa)

FSEELRIGEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRF--RHPNIVDFAGYCAES-------GLYCLVYGFLPNGSLEDQLHL
 . .  .||| || ||..... .. ||| |||.|       .. |. | . ....  .||||| . |.| ..       . ...|  . |.|.| | |. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QTQACSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFA---GAKASQSSTVART-STVR--GTLAYLPEEYI
       |.... |.. .  |.  ..||.    .|| |.   |.|..|..  | .||||.|.       |  .|..  .... .  .    .  .. | |
HRPK---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMAPECI

KTGRLAVDTDTFSFGVVILE--TLAGQRAVR-----------TQGAKTKYLKDLIED----EAEEAGVTLKSTQPTLWVGVATDAWAAPIAAQIYKKHLD
..|.    .| .||||.. |  |. .|                .  |. |  .  ..                                           
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------------

SRPGPCPPQLGLALAQLACCCMHRRAKKRPPMTQVYKRL
.   .| |.   .. |.  .| |. ...|| ........
F---VCCPD---EMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK1.AA TK 484-518 20 0.000186 10.01 In-house 438-486 (486) Show / Hide 
Range on Protein: 484-518
Range on HMM: 438-486/486
Sequence Identity: 20% (10 aa)

PCPPQLG--------------LALAQLACCCMHRRAKKRPPMTQVYKRL
|.||.                 ....| ..| |. ...|| ..|....|
PQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK1.AA MLK 499-518 30 0.01068 5.34 In-house 272-291 (291) Show / Hide 
Range on Protein: 499-518
Range on HMM: 272-291/291
Sequence Identity: 30% (6 aa)

CCMHRRAKKRPPMTQVYKRL
.|..  ..||| . |. . |
QCWNQDPHKRPSFRQIVQHL
Kinase IRAK1.AA Pkinase_Tyr 493-518 23 0.045464 7.63 Pfam 245-270 (270) Show / Hide 
Range on Protein: 493-518
Range on HMM: 245-270/270
Sequence Identity: 23% (6 aa)

LAQLACCCMHRRAKKRPPMTQVYKRL
. .| . |.|  ...|| ..... .|
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase IRAK1.AA TK-Unique 499-518 30 0.206081 0.78 In-house 275-294 (294) Show / Hide 
Range on Protein: 499-518
Range on HMM: 275-294/294
Sequence Identity: 30% (6 aa)

CCMHRRAKKRPPMTQVYKRL
.| .. ...||  .|. .||
SCWQWEPEERPSFRQIKHRL
Kinase IRAK1.AA Dicty4 506-520 29 0.291843 0.16 In-house 261-277 (277) Show / Hide 
Range on Protein: 506-520
Range on HMM: 261-277/277
Sequence Identity: 29% (5 aa)

KKRPPMTQVYKR--LEG
..|| . .. .|  || 
QHRPSFEEIIQRRILEH
Kinase IRAK1.AA TKL-Unique 500-518 31 0.371631 0.05 In-house 272-290 (290) Show / Hide 
Range on Protein: 500-518
Range on HMM: 272-290/290
Sequence Identity: 31% (6 aa)

CMHRRAKKRPPMTQVYKRL
| |.   .||  .....||
CWHHDPSQRPSFDEIIHRL