IRAK2

Species: Mouse
Alias: IRAK2, Irak2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
IRAK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
IRAK2.AA Protein Sugen 622 None Fasta, JSON
IRAK2.NA RNA Sugen 3209 None Fasta, JSON

Protein domain

Protein domains of IRAK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death IRAK2.AA Death 14-94 25 1.1e-17 61.65 Pfam 1-87 (87) Show / Hide
Range on Protein: 14-94
Range on HMM: 1-87/87
Sequence Identity: 25% (22 aa)

DDLCRNI--DTLSEWDWMQFASYVITDLTQLRKIKS-MERVQGVSITRELLWWWSMR---QATVQQLVDLLCHLELYRAAQIVLSWK
. ||| .  | .  .||...|..   . .... |..  ..    | |...|| |..|   .|||..|...|........|... || 
QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHDQNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL

Kinase IRAK2.AA IRAK 208-477 35 2.1e-156 525.92 In-house 1-317 (317) Show / Hide
Range on Protein: 208-477
Range on HMM: 1-317/317
Sequence Identity: 35% (111 aa)

FDQSHRISEGTFADIYQGQRNGVA--FAFKKLREVAGSSPGSMDRFLQA---EMQLCLRCCHANVLPLLGFCTGRQFHSLIYPYMANGSLHDRLWAQGNS
|....||.||.|...|.||.....  .|.|||.|.| .|........|.   |...|.||.|.|..||.|.||.||.|.|.||||.||||.||||.|...
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

DM---LPWPQRASICSGLLLAVEHLHSLD----IIHSNVKSANVLLDQHLNPKLAHPVAHPHP----DNKKTKYTVMRTHLFQASAAYLPEHFIR--VGQ
..   |.|.||.|||.|.......||...    |||...||||.|||||..||......|...    ...|..||.|.|........|.|..|||  .||
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTKQVDIFSCGIVLAEVLTGIPAMDKDRSPVYLKDLLLSEIPNSTSS-----------------------------VCSRKTSMGKAVVKEICQRHVEKR
|||..|..|.||||.|||||..|...||...|....|..||......                             ...|.........||.||......
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG

AGLLPEACEEAWATAVS
.. ....|..||...  
HHRANRRCDMAWVMQQL

Kinase IRAK2.AA TKL 214-409 17 6.2e-42 145.63 In-house 1-285 (364) Show / Hide
Range on Protein: 214-409
Range on HMM: 1-285/364
Sequence Identity: 17% (50 aa)

ISEGTFADIYQGQRNG----------VAFAFKKLREVAGSSPGSMD-----------------------RFLQAEMQLCLRCCHANVLPLLGFCTGRQF-
| .|.|. .|.|. .|             | ||...   ..  ...                        |.  |. ...|..| |.....|.|.  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------HSLIYPYMANGSLHDRLWAQGNSDMLPWPQRASICSGLLLAVEHLHSLD--------IIHSNVKSANVLLDQHLN-------------
            . ... |. .|||...|          |.|| ... .  .....||| .        ||| . ||.|.|.|....             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKLAHP----VAHPHPDNKKTKYTVM----------RTHLFQASAAYLPEHFIR----------------VGQLTKQVDIFSCGIVLAEVLTG
 .|...     . ... ....|..|.|          .|.    . ....   .|                 .. ....|..| |||| |.||.
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR

Kinase IRAK2.AA TK 208-350 12 1.3e-18 58.36 In-house 1-293 (486) Show / Hide
Range on Protein: 208-350
Range on HMM: 1-293/486
Sequence Identity: 12% (36 aa)

FDQSHRISEGTFA---DIYQGQRNG---------------------------VAFAFKKLREVAGSSPGSMDR--------------FLQAEMQLCL-RC
    . . || |    ..|.|. .|                           .  | | |.| ...|.  .                ........|.  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

CHANVLPLLGFCTGR------------QFHSLIYPYMANGS----LHDRLWAQGNSDM------------------------------------------
 | |.. |.| ||              .   ..  ||..|.    |.| |..  .  .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LPWPQRASICSGLLLAVEHLHSLDI------IHSNVKSANVLLDQHLN-----------PKLA
                               |. .|.  .|  .  . |.|||. .      .| ..   |.|......            |.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA

Kinase IRAK2.AA Pkinase 208-350 20 2.1e-16 59.11 Pfam 1-154 (293) Show / Hide
Range on Protein: 208-350
Range on HMM: 1-154/293
Sequence Identity: 20% (31 aa)

FDQSHRISEGTFADIYQGQRNGVA--FAFKKLREVAGSSPGSMDRFLQAEMQLCLRCCHANVLPLLGFCTGRQFHSLIYPYMANG----SLHDRLW--AQ
.    .| .|.|.  |.... |    .| |... .  .|   . ... .| |. .|..| |.. |..... ..   .. .|. .|    .|.|..   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GNSDMLPWPQRASICSGLLLAVEHLHSLDIIHSNVKSANVLLDQHLNP----KLA
|.   ... .  ...  .| ..|..||  |||  .|..|.|.|.. ..    |..
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC

Kinase IRAK2.AA S_TKc 208-473 18 6.8e-16 56.2 SMART 1-231 (231) Show / Hide
Range on Protein: 208-473
Range on HMM: 1-231/231
Sequence Identity: 18% (53 aa)

FDQSHRISEGTFADIYQGQRNG--VAFAFKKLREVAGSSPGSMDRFLQAEMQLCLRCCHANVLPLLGFCTGRQFHSLIYPYMAN--GSLHDRLWAQGNSD
..    | .|.|.  |... ..    .| |...           . .. |.|.. .  | |.  |....   ..  ..  |. .  |.|.|..  .|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

M---LPWPQRASICSGLLLAVEHLHSLDIIHSNVKSANVLLDQHLNPKL-----AHPVAHPHPDNKKTKYTVMRTHLFQASAAYL-PEHFIRVGQLTK-Q
    .|  . ....  ...|.|..||. |||  .| .|.|||.  . |.     |  .                 . |  .  |. || .    . .|  
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------TTFCGTPWYMAPEVL----GYGKCK

VDIFSCGIVLAEVLTGIPAMDKDRSPVYLKDLLLSEIPNSTSSVCSRKTSMGKAVVKEICQRHVEKRAGLLPEACE-------EAWA
.|. |||..|.| |.| |  .    .  . ....              .. .|  .. ..|.  ||| .   || .         | 
CDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA--EALQDEWDIKCHPWF

Kinase IRAK2.AA RIPK 264-350 27 3.6e-12 37.76 In-house 55-151 (290) Show / Hide
Range on Protein: 264-350
Range on HMM: 55-151/290
Sequence Identity: 27% (27 aa)

HANVLPLLGFCTGRQF------HSLIYPYMANGSLHDRLWAQG--NSDMLPWPQRASICSGLLLAVEHLHSLD--IIHSNVKSANVLLDQHLNPKLA
. ...|..|||   ..       ..   ||.|||| . | ..       .||| |  .     ...  ||| .  |||   | .|.|.| ... |.|
CEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIA

Kinase IRAK2.AA STE 208-350 19 9.3e-12 37.91 In-house 1-189 (359) Show / Hide
Range on Protein: 208-350
Range on HMM: 1-189/359
Sequence Identity: 19% (37 aa)

FDQSHRISEGTFADIYQGQRN-----------------GVAFAFKKLREVAGSSP-------------GSMDRFLQAEMQLCLRCC--HANVLPLLGFCT
..   .| .|.|   |.. ..                 |. .| |...    ..               .    .. |.... .|   | |.   .| . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-------GRQFHSLIYPYMANGSLH---DRLWAQGNS--------DMLPWPQRASICSGLLLA-VEHLHSLDIIHSNVKSANVLLDQHLNPKLA
        ..   ..  ||..|||    .. .  |..        . .| .| | ||  .| .  ..|||. |||  .|.||.||      ||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLC

Kinase IRAK2.AA CAMK 213-350 10 3.9e-10 28.13 In-house 1-238 (425) Show / Hide
Range on Protein: 213-350
Range on HMM: 1-238/425
Sequence Identity: 10% (26 aa)

RISEGTFADIYQGQR--NG------------VAFAFKK-------------------LREVAGSS-----PGSMDRFLQAEMQLCLRCC-------HANV
 . .|.|.  . ...  ..            . .| |                    ..   ...      ... .... |.... ..        | |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LPLLG---------------FCTG-----RQFHSLIY---PYMANG----SLHDRLWAQGN------------SDMLPWPQRASICSGLLLAVEHLHSLD
. |.                . .      ...  ..     |. .|     | |.. ..|.            .  ..  . . .   .. ||...||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHSNVKSANVLLDQH-----------------LNPKLA
|.|   |  |.|||..                  | |..
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII

Kinase IRAK2.AA KHS 208-350 27 9.5e-10 28.83 In-house 1-138 (258) Show / Hide
Range on Protein: 208-350
Range on HMM: 1-138/258
Sequence Identity: 27% (39 aa)

FDQSHRISEGTFADIYQGQRNGVAFAFKKLREVAGSSPGSMDRFLQAEMQLCLRCCHANVLPLLGFCTGRQFHSLIYPYMANGSLHDRLWAQGNSDMLPW
..   |.  ||. |.|.  |. ..     .. |    ||     .| |. .   | |.|..   |    |.   ..  |   ||| |   . |.   |  
YELLQRVGSGTYGDVYKA-RDIQSDELAAVK-VIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSEL--

PQRASICSGLLLAVEHLHSLDIIHSNVKSANVLLDQHLNPKLA
 | | .|   | ....|||   .|  .| ||.|| .. . |||
-QIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLA

Kinase IRAK2.AA AGC 312-350 42 3.9e-09 18.22 In-house 157-197 (395) Show / Hide
Range on Protein: 312-350
Range on HMM: 157-197/395
Sequence Identity: 42% (18 aa)

SICSG-LLLAVEHLHS-LDIIHSN-VKSANVLLDQHLNPKLA
.| .| ..||.|.||| ..|||   .|  |.|||.. . ||.
KI-CGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLT

Kinase IRAK2.AA TyrKc 208-472 18 6.6e-09 -78.63 SMART 1-280 (280) Show / Hide
Range on Protein: 208-472
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

FDQSHRISEGTFADIYQGQRNGVAFAFKKLREVAGSSPGSMDRFLQAEMQLCLRC--CHANVLPLLGFCTGR-------QFHSLIYPYMANGSLHDRLWA
    . . || |  .|.|. . .  | |.|.| |      .  |.. |...  .    | |.. |.| ||         . . ..  ||..|.|.|.| .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMR-EARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QGNSDMLPWPQRASICSGLLLAVEHLHSLDIIHSNVKSANVLLDQHLNPKLAHP-VAHPHPDN----KKTKYTVMRT--HLFQ-ASAAYL-PEHFIRVGQ
 ..   |....  |.|       |.|||  .||      |.|..  .  | .    .  . |       ..| ....  .         . || . . | 
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGK

LTKQVDIFSCGIVLAEVLTGIPAMDKD-----RSPVYLKDLLLSEIPNSTSSV--------CSRKTSMGKAVVKEICQRHVEKRAGLLPEACEEAW
 | . |..| |... |..|       .      |.  .  .. .                 |.  . | . . |. ...  |.|     ... | .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP--DEMYQ-IMKQCWHEDPEDRPTF--SEIHECF

Kinase IRAK2.AA Dicty5 286-349 30 6.9e-09 26.71 In-house 80-145 (260) Show / Hide
Range on Protein: 286-349
Range on HMM: 80-145/260
Sequence Identity: 30% (20 aa)

YMANGSLHDRLWAQGN--SDMLPWPQRASICSGLLLAVEHLHSLDIIHSNVKSANVLLDQHLNPKL
|  |||| . |  | .     . ..|. .. ..   . .||||  |||  .|| |.|.   .  |.
YCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKI

Kinase IRAK2.AA MLK 208-350 18 1.2e-07 22.68 In-house 1-175 (291) Show / Hide
Range on Protein: 208-350
Range on HMM: 1-175/291
Sequence Identity: 18% (32 aa)

FDQSHRISEGTFADIYQGQRNGVA-----FAFKKLR---EVAGSSPGSMDRFLQAEMQLCLRCCHAN----VLPLLGFCTGRQFH-SLIYPYMANGSLHD
.. .. | .|.| . . |.  .        |.|. |   . . |. .. .. .. |  .  . .| |    . ...| |.  . |  ..  |...|||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

RLWA-QGNSD----------MLPWPQRASICSGLLLAVEHLHSLD---IIHSNVKSANVLLDQ------HLNPKLA
 | . .....            .  . ....     ... |||..   |||   || |.|.|.      |.. | .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKIC

Kinase IRAK2.AA Pkinase_Tyr 208-331 22 1e-06 23.17 Pfam 1-134 (270) Show / Hide
Range on Protein: 208-331
Range on HMM: 1-134/270
Sequence Identity: 22% (31 aa)

FDQSHRISEGTFADIYQGQRN------GVAFAFKKLREVAGSSPGS--MDRFLQAEMQLCLRC-CHANVLPLLGFCT-GRQF--HSLIYPYMANGSLHDR
    . . || | ..|.|  .      ..  | |.|.|  |...    .. |.. |...      | |.. |.| ||  ..   . .. .||..|.|.| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LWAQ-GNSDMLPWPQRASICSGLLLAVEHLHSLDIIH
| ..  . . |. ..  ..|     . |.|.|  .||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH

Kinase IRAK2.AA Pkinase 391-473 16 0.000843 14.52 Pfam 190-293 (293) Show / Hide
Range on Protein: 391-473
Range on HMM: 190-293/293
Sequence Identity: 16% (18 aa)

TKQVDIFSCGIVLAEVLTG-IPAMDK------DRSPVYLKDLL---LSEIPNSTS-------------SVCSRKTSMGKAVVKEICQRHVEKRAGLLPEA
.. ||..|||..|.|.|.|  |  ..      |   .. ...     ...|.. |              .  . .. .| ..| ....  .|| .  ...
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPT-AEQI

CEEAWA
..  | 
LQHPWF

Kinase IRAK2.AA MLK 381-409 35 0.008548 5.68 In-house 202-232 (291) Show / Hide
Range on Protein: 381-409
Range on HMM: 202-232/291
Sequence Identity: 35% (11 aa)

PEHF--IRVGQLTKQVDIFSCGIVLAEVLTG
|| .  .| .. .. .|..| |.|| |.||.
PEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR