Gene IRAK2 (Mouse)
IRAK2
Sequence
Protein domains of IRAK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Death | IRAK2.AA | Death | 14-94 | 25 | 1.1e-17 | 61.65 | Pfam | 1-87 (87) | Show / Hide |
Range on Protein: 14-94 Range on HMM: 1-87/87 Sequence Identity: 25% (22 aa) DDLCRNI--DTLSEWDWMQFASYVITDLTQLRKIKS-MERVQGVSITRELLWWWSMR---QATVQQLVDLLCHLELYRAAQIVLSWK . ||| . | . .||...|.. . .... |.. .. | |...|| |..| .|||..|...|........|... || QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHDQNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL |
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| Kinase | IRAK2.AA | IRAK | 208-477 | 35 | 2.1e-156 | 525.92 | In-house | 1-317 (317) | Show / Hide |
Range on Protein: 208-477 Range on HMM: 1-317/317 Sequence Identity: 35% (111 aa) FDQSHRISEGTFADIYQGQRNGVA--FAFKKLREVAGSSPGSMDRFLQA---EMQLCLRCCHANVLPLLGFCTGRQFHSLIYPYMANGSLHDRLWAQGNS |....||.||.|...|.||..... .|.|||.|.| .|........|. |...|.||.|.|..||.|.||.||.|.|.||||.||||.||||.|... FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ DM---LPWPQRASICSGLLLAVEHLHSLD----IIHSNVKSANVLLDQHLNPKLAHPVAHPHP----DNKKTKYTVMRTHLFQASAAYLPEHFIR--VGQ .. |.|.||.|||.|.......||... |||...||||.|||||..||......|... ...|..||.|.|........|.|..||| .|| CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ LTKQVDIFSCGIVLAEVLTGIPAMDKDRSPVYLKDLLLSEIPNSTSS-----------------------------VCSRKTSMGKAVVKEICQRHVEKR |||..|..|.||||.|||||..|...||...|....|..||...... ...|.........||.||...... LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG AGLLPEACEEAWATAVS .. ....|..||... HHRANRRCDMAWVMQQL |
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| Kinase | IRAK2.AA | TKL | 214-409 | 17 | 6.2e-42 | 145.63 | In-house | 1-285 (364) | Show / Hide |
Range on Protein: 214-409
Range on HMM: 1-285/364
Sequence Identity: 17% (50 aa)
ISEGTFADIYQGQRNG----------VAFAFKKLREVAGSSPGSMD-----------------------RFLQAEMQLCLRCCHANVLPLLGFCTGRQF-
| .|.|. .|.|. .| | ||... .. ... |. |. ...|..| |.....|.|. ..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------HSLIYPYMANGSLHDRLWAQGNSDMLPWPQRASICSGLLLAVEHLHSLD--------IIHSNVKSANVLLDQHLN-------------
. ... |. .|||...| |.|| ... . .....||| . ||| . ||.|.|.|....
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW
-PKLAHP----VAHPHPDNKKTKYTVM----------RTHLFQASAAYLPEHFIR----------------VGQLTKQVDIFSCGIVLAEVLTG
.|... . ... ....|..|.| .|. . .... .| .. ....|..| |||| |.||.
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR
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| Kinase | IRAK2.AA | TK | 208-350 | 12 | 1.3e-18 | 58.36 | In-house | 1-293 (486) | Show / Hide |
Range on Protein: 208-350
Range on HMM: 1-293/486
Sequence Identity: 12% (36 aa)
FDQSHRISEGTFA---DIYQGQRNG---------------------------VAFAFKKLREVAGSSPGSMDR--------------FLQAEMQLCL-RC
. . || | ..|.|. .| . | | |.| ...|. . ........|. .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
CHANVLPLLGFCTGR------------QFHSLIYPYMANGS----LHDRLWAQGNSDM------------------------------------------
| |.. |.| || . .. ||..|. |.| |.. . .
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LPWPQRASICSGLLLAVEHLHSLDI------IHSNVKSANVLLDQHLN-----------PKLA
|. .|. .| . . |.|||. . .| .. |.|...... |.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA
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| Kinase | IRAK2.AA | Pkinase | 208-350 | 20 | 2.1e-16 | 59.11 | Pfam | 1-154 (293) | Show / Hide |
Range on Protein: 208-350 Range on HMM: 1-154/293 Sequence Identity: 20% (31 aa) FDQSHRISEGTFADIYQGQRNGVA--FAFKKLREVAGSSPGSMDRFLQAEMQLCLRCCHANVLPLLGFCTGRQFHSLIYPYMANG----SLHDRLW--AQ . .| .|.|. |.... | .| |... . .| . ... .| |. .|..| |.. |..... .. .. .|. .| .|.|.. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GNSDMLPWPQRASICSGLLLAVEHLHSLDIIHSNVKSANVLLDQHLNP----KLA |. ... . ... .| ..|..|| ||| .|..|.|.|.. .. |.. GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC |
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| Kinase | IRAK2.AA | S_TKc | 208-473 | 18 | 6.8e-16 | 56.2 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 208-473
Range on HMM: 1-231/231
Sequence Identity: 18% (53 aa)
FDQSHRISEGTFADIYQGQRNG--VAFAFKKLREVAGSSPGSMDRFLQAEMQLCLRCCHANVLPLLGFCTGRQFHSLIYPYMAN--GSLHDRLWAQGNSD
.. | .|.|. |... .. .| |... . .. |.|.. . | |. |.... .. .. |. . |.|.|.. .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG
M---LPWPQRASICSGLLLAVEHLHSLDIIHSNVKSANVLLDQHLNPKL-----AHPVAHPHPDNKKTKYTVMRTHLFQASAAYL-PEHFIRVGQLTK-Q
.| . .... ...|.|..||. ||| .| .|.|||. . |. | . . | . |. || . . .|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------TTFCGTPWYMAPEVL----GYGKCK
VDIFSCGIVLAEVLTGIPAMDKDRSPVYLKDLLLSEIPNSTSSVCSRKTSMGKAVVKEICQRHVEKRAGLLPEACE-------EAWA
.|. |||..|.| |.| | . . . .... .. .| .. ..|. ||| . || . |
CDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA--EALQDEWDIKCHPWF
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| Kinase | IRAK2.AA | RIPK | 264-350 | 27 | 3.6e-12 | 37.76 | In-house | 55-151 (290) | Show / Hide |
Range on Protein: 264-350 Range on HMM: 55-151/290 Sequence Identity: 27% (27 aa) HANVLPLLGFCTGRQF------HSLIYPYMANGSLHDRLWAQG--NSDMLPWPQRASICSGLLLAVEHLHSLD--IIHSNVKSANVLLDQHLNPKLA . ...|..||| .. .. ||.|||| . | .. .||| | . ... ||| . ||| | .|.|.| ... |.| CEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIA |
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| Kinase | IRAK2.AA | STE | 208-350 | 19 | 9.3e-12 | 37.91 | In-house | 1-189 (359) | Show / Hide |
Range on Protein: 208-350
Range on HMM: 1-189/359
Sequence Identity: 19% (37 aa)
FDQSHRISEGTFADIYQGQRN-----------------GVAFAFKKLREVAGSSP-------------GSMDRFLQAEMQLCLRCC--HANVLPLLGFCT
.. .| .|.| |.. .. |. .| |... .. . .. |.... .| | |. .| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
-------GRQFHSLIYPYMANGSLH---DRLWAQGNS--------DMLPWPQRASICSGLLLA-VEHLHSLDIIHSNVKSANVLLDQHLNPKLA
.. .. ||..||| .. . |.. . .| .| | || .| . ..|||. ||| .|.||.|| ||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLC
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| Kinase | IRAK2.AA | CAMK | 213-350 | 10 | 3.9e-10 | 28.13 | In-house | 1-238 (425) | Show / Hide |
Range on Protein: 213-350 Range on HMM: 1-238/425 Sequence Identity: 10% (26 aa) RISEGTFADIYQGQR--NG------------VAFAFKK-------------------LREVAGSS-----PGSMDRFLQAEMQLCLRCC-------HANV . .|.|. . ... .. . .| | .. ... ... .... |.... .. | |. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI LPLLG---------------FCTG-----RQFHSLIY---PYMANG----SLHDRLWAQGN------------SDMLPWPQRASICSGLLLAVEHLHSLD . |. . . ... .. |. .| | |.. ..|. . .. . . . .. ||...||.. IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IIHSNVKSANVLLDQH-----------------LNPKLA |.| | |.|||.. | |.. IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII |
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| Kinase | IRAK2.AA | KHS | 208-350 | 27 | 9.5e-10 | 28.83 | In-house | 1-138 (258) | Show / Hide |
Range on Protein: 208-350 Range on HMM: 1-138/258 Sequence Identity: 27% (39 aa) FDQSHRISEGTFADIYQGQRNGVAFAFKKLREVAGSSPGSMDRFLQAEMQLCLRCCHANVLPLLGFCTGRQFHSLIYPYMANGSLHDRLWAQGNSDMLPW .. |. ||. |.|. |. .. .. | || .| |. . | |.|.. | |. .. | ||| | . |. | YELLQRVGSGTYGDVYKA-RDIQSDELAAVK-VIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSEL-- PQRASICSGLLLAVEHLHSLDIIHSNVKSANVLLDQHLNPKLA | | .| | ....||| .| .| ||.|| .. . ||| -QIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLA |
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| Kinase | IRAK2.AA | AGC | 312-350 | 42 | 3.9e-09 | 18.22 | In-house | 157-197 (395) | Show / Hide |
Range on Protein: 312-350 Range on HMM: 157-197/395 Sequence Identity: 42% (18 aa) SICSG-LLLAVEHLHS-LDIIHSN-VKSANVLLDQHLNPKLA .| .| ..||.|.||| ..||| .| |.|||.. . ||. KI-CGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLT |
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| Kinase | IRAK2.AA | TyrKc | 208-472 | 18 | 6.6e-09 | -78.63 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 208-472
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)
FDQSHRISEGTFADIYQGQRNGVAFAFKKLREVAGSSPGSMDRFLQAEMQLCLRC--CHANVLPLLGFCTGR-------QFHSLIYPYMANGSLHDRLWA
. . || | .|.|. . . | |.|.| | . |.. |... . | |.. |.| || . . .. ||..|.|.|.| .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMR-EARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK
QGNSDMLPWPQRASICSGLLLAVEHLHSLDIIHSNVKSANVLLDQHLNPKLAHP-VAHPHPDN----KKTKYTVMRT--HLFQ-ASAAYL-PEHFIRVGQ
.. |.... |.| |.||| .|| |.|.. . | . . . | ..| .... . . || . . |
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGK
LTKQVDIFSCGIVLAEVLTGIPAMDKD-----RSPVYLKDLLLSEIPNSTSSV--------CSRKTSMGKAVVKEICQRHVEKRAGLLPEACEEAW
| . |..| |... |..| . |. . .. . |. . | . . |. ... |.| ... | .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP--DEMYQ-IMKQCWHEDPEDRPTF--SEIHECF
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| Kinase | IRAK2.AA | Dicty5 | 286-349 | 30 | 6.9e-09 | 26.71 | In-house | 80-145 (260) | Show / Hide |
Range on Protein: 286-349 Range on HMM: 80-145/260 Sequence Identity: 30% (20 aa) YMANGSLHDRLWAQGN--SDMLPWPQRASICSGLLLAVEHLHSLDIIHSNVKSANVLLDQHLNPKL | |||| . | | . . ..|. .. .. . .|||| ||| .|| |.|. . |. YCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKI |
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| Kinase | IRAK2.AA | MLK | 208-350 | 18 | 1.2e-07 | 22.68 | In-house | 1-175 (291) | Show / Hide |
Range on Protein: 208-350 Range on HMM: 1-175/291 Sequence Identity: 18% (32 aa) FDQSHRISEGTFADIYQGQRNGVA-----FAFKKLR---EVAGSSPGSMDRFLQAEMQLCLRCCHAN----VLPLLGFCTGRQFH-SLIYPYMANGSLHD .. .. | .|.| . . |. . |.|. | . . |. .. .. .. | . . .| | . ...| |. . | .. |...|||.. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN RLWA-QGNSD----------MLPWPQRASICSGLLLAVEHLHSLD---IIHSNVKSANVLLDQ------HLNPKLA | . ..... . . .... ... |||.. ||| || |.|.|. |.. | . VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKIC |
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| Kinase | IRAK2.AA | Pkinase_Tyr | 208-331 | 22 | 1e-06 | 23.17 | Pfam | 1-134 (270) | Show / Hide |
Range on Protein: 208-331
Range on HMM: 1-134/270
Sequence Identity: 22% (31 aa)
FDQSHRISEGTFADIYQGQRN------GVAFAFKKLREVAGSSPGS--MDRFLQAEMQLCLRC-CHANVLPLLGFCT-GRQF--HSLIYPYMANGSLHDR
. . || | ..|.| . .. | |.|.| |... .. |.. |... | |.. |.| || .. . .. .||..|.|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY
LWAQ-GNSDMLPWPQRASICSGLLLAVEHLHSLDIIH
| .. . . |. .. ..| . |.|.| .||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH
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| Kinase | IRAK2.AA | Pkinase | 391-473 | 16 | 0.000843 | 14.52 | Pfam | 190-293 (293) | Show / Hide |
Range on Protein: 391-473 Range on HMM: 190-293/293 Sequence Identity: 16% (18 aa) TKQVDIFSCGIVLAEVLTG-IPAMDK------DRSPVYLKDLL---LSEIPNSTS-------------SVCSRKTSMGKAVVKEICQRHVEKRAGLLPEA .. ||..|||..|.|.|.| | .. | .. ... ...|.. | . . .. .| ..| .... .|| . ... GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPT-AEQI CEEAWA .. | LQHPWF |
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| Kinase | IRAK2.AA | MLK | 381-409 | 35 | 0.008548 | 5.68 | In-house | 202-232 (291) | Show / Hide |
Range on Protein: 381-409 Range on HMM: 202-232/291 Sequence Identity: 35% (11 aa) PEHF--IRVGQLTKQVDIFSCGIVLAEVLTG || . .| .. .. .|..| |.|| |.||. PEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR |
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