Gene IRAK4 (Mouse)

IRAK4

Species: Mouse
Alias: Irak4, IRAK4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
IRAK4.AA Protein Sugen 459 None Fasta, JSON
IRAK4.NA RNA Sugen 1529 None Fasta, JSON
IRAK4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 269 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of IRAK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death IRAK4.AA Death 20-104 20 8.4e-07 25.1 Pfam 1-87 (87) Show / Hide 
Range on Protein: 20-104
Range on HMM: 1-87/87
Sequence Identity: 20% (19 aa)

RKLSDFI----DPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGK---SPTCELLFDWGTT---NCTVGDLVDLLVQIELFAPATLLLPDA
.||....    .| . |..||  .        . . .|...|   | ..   |.|...| .|      | ||..|...| ....   | ..  ..
QKLCRLLDPDHHPGKDWRRLARKL-------GMSDNEIDQIEHD-QNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL
Kinase IRAK4.AA IRAK 186-454 45 1.1e-164 553.37 In-house 1-317 (317) Show / Hide 
Range on Protein: 186-454
Range on HMM: 1-317/317
Sequence Identity: 45% (144 aa)

SAGGNRMGEGGFGVVYKG-CVNNT-IVAVKKLGAMVEISTEELKQQFDQ---EIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDG-
....||.||||||.||.| ..|.| |.||||| .|...|..|..|.|.|   |.||...|.|.|.|.|.|........|||| ||||||| |||.|.|| 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-TP-PLSWHTRCKVAQGTANGIRFLHENH----HIHRDIKSANILLDKDFTAKISDFGLAR----ASARLAQTV---MTSRIVGTTAYMAPEALR---GE
 .| |||||.||....|||.||.|||.||    .||.||||||||||..||.||.||||.|    ||....||.   |||...|||.||.||..|   |.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

ITPKSDIYSFGVVLLELITGL-AAVDENREPQLLLDIKEEIEDEEK-------------------------TIEDYTDEKMSDADPASVEAMYSAASQCL
.|.|.|.||||.||||..||. |..|...|...|.|..|||..|..                         ..|...|..|....|.....|...|..|.
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG

HEKKNRRPDIAKVQQLL
|...|||.|.|.|.|.|
HHRANRRCDMAWVMQQL
Kinase IRAK4.AA TKL 192-454 23 2.4e-79 269.92 In-house 1-364 (364) Show / Hide 
Range on Protein: 192-454
Range on HMM: 1-364/364
Sequence Identity: 23% (87 aa)

MGEGGFGVVYKGCVNN----------TIVAVKKLGAMVEISTEE-----------------------LKQQFDQEIKVMATCQHENLVELLGFSSDSDN-
 |.||||.||||  ..          . |||||.  . . ....                       ..... .||..|  ..|.|.| ..|.. .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCLVYAYMPNGSLLDRLSCLDGTPPLSWHTRCKVAQGTANGIRFLHENH--------HIHRDIKSANILLDKDFT-------------
            ||.|. |.|.||||..|          || ||. |...| |. .|| ..         ||||.||.|||.|...|             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-AKISDFGLAR-ASARLAQTVM----------------TSRIVGTTAYMAPEALR-----------------GEITPKSDIYSFGVVLLELITGLAAVDE
 .||.||||.|  | .  .. .                |....||...||||.||                 .| ..|.|.||||.|| |..|.    ..
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

NREPQLLLD-------IKEEIEDEEKTIE-----DYTDEKMSDADPASVEAMYSAASQCLHEKKNRRPDIAKVQQLL
. ... ..        ..   . .  .|       .  . |    |   . | . . .| ... . ||   .. . |
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK4.AA S_TKc 186-458 23 3.8e-50 173.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 186-458
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

SAGGNRMGEGGFGVVYKGCVNN--TIVAVKKLGAMVEISTEELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPN--GSLLDRLSCLDGTP
   ..  |.|.||.|||.  ..   |||.|..            ... .||...   .|.|.| |...  | |.|..|  |...  |.|.|..    . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

P---LSWHTRCKVAQGTANGIRFLHENHHIHRDIKSANILLDKDFTAKISDFGLARASARLAQTVMTSRIVGTTAYMAPEALRGEITP-KSDIYSFGVVL
.   ..  . ..... ..... ..|... ||||.| .|||||.  . ||.||||||           . ..||  ||||| |    .. |.|..|.|..|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCIL

LELITGLAAVDENREPQLLLDIKEEIEDEEKTIEDYTDEKMSDADPASVEAMYSAASQCLHEKKNRRPDIAKVQQ-----LLQEMS
 |...|    .   ..|.....                         | ||     ..||.   ..|| . .. |      . .  
YEMLCGYPPFP---QMQMMFKKIG-----------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK4.AA Pkinase 191-383 30 1.9e-48 172.05 Pfam 6-208 (293) Show / Hide 
Range on Protein: 191-383
Range on HMM: 6-208/293
Sequence Identity: 30% (63 aa)

RMGEGGFGVVYKGCVNNT--IVAVKKLGAMVEISTEELKQQFD-QEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNG----SLLDRLSCLDGTPPL
. |.|.||.|||..  .|  |||||..    ... ..... .  .||..|. ..|.| |.|...  |.|....|  |...|    .| |..|  .   ..
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCF

--SWHTRCKVAQGTANGIRFLHENHHIHRDIKSANILLDKDFTA----KISDFGLARASARLAQTVMTSRIVGTTAYMAPEALR--GEITPKSDIYSFGV
  |... ....  .. |. ..|..  ||||.|..|||.|.. .     ||.|||||.    .   . .. ..||  ||||| .|   ...||.|..|.|.
YFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGC

VLLELITG
.| |...|
ILYEMLCG
Kinase IRAK4.AA Pkinase_Tyr 193-382 33 6.8e-45 152.66 Pfam 8-209 (270) Show / Hide 
Range on Protein: 193-382
Range on HMM: 8-209/270
Sequence Identity: 33% (70 aa)

GEGGFGVVYKGCVN------NTIVAVKKL--GAMVE-ISTEELKQQFDQEIKVMATC-QHENLVELLGFSS-DSDN--LCLVYAYMPNGSLLDRLSCL-D
||| ||.||||  .      .. ||||.|  ||| |      ... | .|.|.| .  .|.|.| |.|  . ...   ...|  |||.|.||| |    .
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN----CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRE

GTPPLSWHTRCKVAQGTANGIRFLHENHHIHRDIKSANILLDKDFTAKISDFGLARASARLAQT-VMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVV
. .||. .. .. ..  |.|  .|.... ||||.   |.|.......||.||||||.     .  ....        ||||... |. | |||..||||.
DKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVL

LLELIT
. |..|
MWEIFT
Kinase IRAK4.AA TKL-Unique 189-383 33 9.9e-45 154.93 In-house 2-224 (290) Show / Hide 
Range on Protein: 189-383
Range on HMM: 2-224/290
Sequence Identity: 33% (75 aa)

GNRMGEGGFGVVYKGCVNNTIVAVKKLGAMVEISTEELKQQFDQEIKVMATCQ-HENLVELLGFSS----DSDNLCLVYAYMPNGSLLDRLS---CLD--
.|  ||||.|.||||  . ..||.|..    | |  |..| |  |...| . . |.|.| . |..     .  |.|.|  |.| ||| | |.    .   
WNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--GTPPLSWHTRCKVAQGTANGIRFLHENH--HIHRDIKSANILLDKD-----FTAKISDFGLARASARLAQTVMT-------SRIVGTTAYMAPEALRG
     .|..  | | |.  | |  .|| .    ||||.|| |.|.| .     . .||.||||.. ...  ..  .       .  .|.. .|||| ||.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

---EITPKSDIYSFGVVLLELITG
    .. |||.||||.|| |..|.
NFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK4.AA STE 186-383 25 1.3e-44 154.55 In-house 1-264 (359) Show / Hide 
Range on Protein: 186-383
Range on HMM: 1-264/359
Sequence Identity: 25% (69 aa)

SAGGNRMGEGGFGVVYKGCVN-----------------NTIVAVK--KLGAM-----------VEISTEELKQQFDQEIKVMATCQ--HENLVELLGFSS
  |  . |.|.||.|||.. .                 ..|.|.|  .|              .|.. .| .||. .|||.|  |.  |.| |. .|   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DS-------DNLCLVYAYMPNGSLLDRLS--CLDGTP---------PLSWHTRCKVAQGTANG-IRFLHENHHIHRDIKSANILLDKDFTAKISDFGLAR
.        |.|...  ||..||| | .   .  | |         ... .  ..... .  |   .||..| ||||||.|||||     .|..|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

ASAR--------------LAQTVMTSRIVGTTAYMAPEALRGE-------ITPKSDIYSFGVVLLELITG
  .               . .  ..  .|||  .|||| ....        . |.||.|.| ...|..||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG
Kinase IRAK4.AA TyrKc 189-454 27 8.3e-43 149.45 SMART 4-280 (280) Show / Hide 
Range on Protein: 189-454
Range on HMM: 4-280/280
Sequence Identity: 27% (80 aa)

GNRMGEGGFGVVYKGCVNNTIVAVKKLGAMVEISTEELKQQFDQEIKVMATC--QHENLVELLGFSSDS-------DNLCLVYAYMPNGSLLDRLSCLDG
|   ||| ||.||||  . . ||||.| .         .. | .|...|     .|.|.| |.|  ...       . |..|  |||.|.|.|.|    .
GKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

TPPLSWHTRCKVAQGTANGIRFLHENHHIHRDIKSANILLDKDFTAKISDFGLARASARL------AQTVMT-----SRIVGTTAYMAPEAL-RGEITPK
.  |.. . .. .   |.| ..||... ||||.   |.|.....|.|||||||.|.           .. ..     .. .     ||||..  |. |.|
K--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDIYSFGVVLLELITGLAAVDEN-----REPQLLLDIKEEIEDEEKTIEDYTDEKMSDADPASVEAMYSAASQCLHEKKNRRPDIAKVQQLL
||..||||.. |. |  .   ..      ..| ..   .. .  ..  .||  . ||   .   ..||.  .|| ||. . ||  . . ...
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK4.AA MLK 193-383 29 1.2e-42 145.79 In-house 8-232 (291) Show / Hide 
Range on Protein: 193-383
Range on HMM: 8-232/291
Sequence Identity: 29% (67 aa)

GEGGFGVVYKGCVNNTI-----VAVKKLGAMV--EISTEELKQQFDQEIKVMATCQHEN----LVELLGFSSDSDN-LCLVYAYMPNGSLLDRLSCLDGT
|.|.||.|.||   |..     ||||.  |.     .|.. ...|..|..  .  .|.|     ....| .... . .|.|  |...||| . |   .. 
GSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSK

PP-----------LSWHTRCKVAQGTANGIRFLHENHH---IHRDIKSANILLD------KDFTAKISDFGLARASARLAQTVMTSRIVGTTAYMAPEAL
.             . .   . |   |.|. .||..     ||||.|| |||.|      .. |.||.|||..|   .   | |.|.. || |.||||..
WMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYAWMAPEVI

----RGEITPKSDIYSFGVVLLELITG
     .  . |.|..|.|||| |..|.
QQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAK4.AA TK 193-382 18 2.7e-42 139.09 In-house 8-389 (486) Show / Hide 
Range on Protein: 193-382
Range on HMM: 8-389/486
Sequence Identity: 18% (72 aa)

GEGGFG---VVYKGCVNN---------------------------TIVAVKKLGAMVEISTEELKQ-------------QFDQEIKVMAT--CQHENLVE
||| ||   .|||| ...                           | |||| | .  . | || ..             .. .|.|.|    ..|.|.| 
GEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVR

LLGFSSDSDN------------LCLVYAYMPNGS----LLDRLS-CLDGTPP------------------------------------------------
|.| ......            ...|  |||.|.    |.| |  | ... .                                                
LYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKD

------------------------LSWHTRCKVAQGTANGIRFLHEN------HHIHRDIKSANILLDKDFT-----------AKISDFGLARA----SA
                        |. |...  ..  |.| ..||..      . .|||.   |.|.... .           .||.||||.|.     |
HPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLA

RLAQT--VMTSRIVGTTAY--------------------------MAPEALR----------GEITPKSDIYSFGVVLLELIT
|  .     ...  ..|.                           ||||.|.          |  |.|||..||||.. |. |
RDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK4.AA Dicty4 187-383 33 1.9e-40 132.75 In-house 2-213 (277) Show / Hide 
Range on Protein: 187-383
Range on HMM: 2-213/277
Sequence Identity: 33% (72 aa)

AGGNRMGEGGFGVVYKGCVNNTIVAVKKLGAMVEISTEELKQQFDQEIKVMATCQHENLVELLGFSS----DSDNLCLVYAYMPNGSLLDRLSCLD----
. ..| |.|.|| |||| .  ..|||||| .  . . |.. . | .|.. |.  .| |.. ..| .      .  .| |  ||| |.|.  |  .|    
NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLL--HDKPSE

--GTPPLSWHTRCK---VAQGTANGIRFLHE-N-HHIHRDIKSANILLDKDFTAKISDFGLAR---ASARLAQTVMTSRIVGTTAYMAPEALRGEI-TPK
     .|.| .. .    |  .| |.  ||. |   ||||.||.|.| ||....|..||||..       . .  ||   .||...|||| ....  . |
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT--ACGTPCWMAPEVMMHQPYNEK

SDIYSFGVVLLELITG
.| |||| || |. |.
ADVYSFGIVLWEILTR
Kinase IRAK4.AA LRRK 180-389 25 1.5e-39 137.57 In-house 1-285 (351) Show / Hide 
Range on Protein: 180-389
Range on HMM: 1-285/351
Sequence Identity: 25% (74 aa)

FDEQPASAGGNRMGEGGFG-VVYKGCVNN----------------------------TIVAVKKLGA------------------------------MVE
. ...        |.|||| .||.. ...                            . ||.||.                                 ..
LKIEEQ------IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNH

ISTEELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSCLDGTP------PLSWHTRCKVAQGTANGIRFLHENH--HIHRDI
... .  . | .|. .| . .| |.| |.||.   . ||.|  |.|.|.| ..|.    ..       .||... |.|   | |...|| ..   |||| 
EDCCRAFREFRHEVWIMSHLNHPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDL

KSANILL---D---------KDFTAKISDFGLARASARLAQTVMTSRIVGTTAYMAPEALRG----EITPKSDIYSFGVVLLELITGL-AAVDE
|| ||||   .          . .|||.|||. |      ..  ... ||.  .|||| .|.    | | |.|.||||..| ||.|..  . ||
KSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE
Kinase IRAK4.AA Ciliate-E2 193-383 20 8.5e-39 130.79 In-house 8-292 (365) Show / Hide 
Range on Protein: 193-383
Range on HMM: 8-292/365
Sequence Identity: 20% (60 aa)

GEGGFGVVYKGCVNNTIV-------------------AVKKLGAMVEISTEELKQQF--DQEIK-------------VMATCQHENLVELLGFSS--DSD
|.|.||.|||..| ..                     . .|. ||  ..  ...|..  .....             .. . .| |....  .    | .
GQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDN

NLCLVYAYMPNGSLLD--------RLSCLD-GTPPLSWHTRCKVAQGTAN---------------GIRFLHENH-HIHRDIKSANILLDKDFTAKISDFG
|. ||  |   |.|.|        |..... .  ....  .... .  ..               ....||...  ||||||  |||.      ||.|||
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFG

LARASA---------RLAQTVMTSR---------------------IVGTTAYMAPEALRGE----------ITPKSDIYSFGVVLLELITG
|..            ....  |  .                     |.||  ||||| |.|.           . |.||.|.||.| |...|
LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG
Kinase IRAK4.AA ULK 296-383 31 2.3e-25 85.54 In-house 140-252 (329) Show / Hide 
Range on Protein: 296-383
Range on HMM: 140-252/329
Sequence Identity: 31% (36 aa)

ANGIRFLHENHHIHRDIKSANILLDKDF------------TAKISDFGLARA------SARLAQTVM--TSRIVGTTAYMAPEALRGE-----IT-PKSD
.|| ..||..  |||||| .|||.....            ..||.|||.|.       ......|    . |. ||  ||||. | |.      .  |.|
LNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEK-RLCGTPLYMAPQILQGQGEQKPYYDYKCD

IYSFGVVLLELITG
|.|.|... |...|
IWSLGCIFYEMLYG
Kinase IRAK4.AA ULK 193-270 28 6.7e-13 41.46 In-house 8-107 (329) Show / Hide 
Range on Protein: 193-270
Range on HMM: 8-107/329
Sequence Identity: 28% (28 aa)

GEGGFGVVYKGCVNNT------IVAVKKLG--AMVEISTEE----LKQQFDQEIKVMATC--------QHENLVELLGFSSDS--DNLCLVYAYMPNGSL
|.| ||.||||  ..|      .||.|..    | ... |     ..|....|||.| .         .|.| |.|. .. .|  .|. ... | . | |
GKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDL
Kinase IRAK4.AA TK 423-454 25 0.026402 2.67 In-house 455-486 (486) Show / Hide 
Range on Protein: 423-454
Range on HMM: 455-486/486
Sequence Identity: 25% (8 aa)

PASVEAMYSAASQCLHEKKNRRPDIAKVQQLL
..  |..|    || |.. ..||. . ... |
HCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK4.AA Pkinase_Tyr 427-454 25 1.86119 2.17 Pfam 243-270 (270) Show / Hide 
Range on Protein: 427-454
Range on HMM: 243-270/270
Sequence Identity: 25% (7 aa)

EAMYSAASQCLHEKKNRRPDIAKVQQLL
. .|.   || |.. ..||  . ... |
DEIYDLMKQCWHYDPEDRPTFSEIHEQL