Gene IRE2 (Mouse)

IRE2

Species: Mouse
Alias: IRE2, Ern2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: Other
Family: IRE

Sequence

Name Sequence Type Origin Length Description Download
IRE2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
IRE2.NA RNA Sugen 2973 None Fasta, JSON
IRE2.AA Protein Sugen 911 None Fasta, JSON

Protein domain

Protein domains of IRE2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PQQ IRE2.AA PQQ 33-64 39 6.6e-08 33.51 SMART 1-33 (33) Show / Hide 
Range on Protein: 33-64
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

SVRPES-LLFVSTLDGSLHALNKQTGDLKWTVK
.|. .  ...|.| ||.|.||.. ||...||.|
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE2.AA PQQ 38-75 31 9e-06 22.51 Pfam 1-37 (37) Show / Hide 
Range on Protein: 38-75
Range on HMM: 1-37/37
Sequence Identity: 31% (12 aa)

SLLFVSTLDGSLHALNKQTGDLKWTVKDDPIIQGPMYV
  ..| | || . ||.  ||..||..| .| ... . .
GDVYVHTWDGYIYALDADTGKVKWKFKTGPPDWW-PMT
PQQ IRE2.AA PQQ 115-147 24 0.000581 20.41 SMART 1-33 (33) Show / Hide 
Range on Protein: 115-147
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

PCRSSDGVFYTGRKQDAWFVVDPESGETQMTLT
|....||. |.|.... .. .|...|.   | .
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE2.AA PQQ 148-180 12 0.05139 12.25 SMART 1-33 (33) Show / Hide 
Range on Protein: 148-180
Range on HMM: 1-33/33
Sequence Identity: 12% (4 aa)

TEGLSTPQLFIGRTQYTVSMHDLRTPALRWNTT
.  ..   ...|...... . | .|  ..|. .
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE2.AA PQQ 192-223 24 0.007442 16.73 SMART 1-33 (33) Show / Hide 
Range on Protein: 192-223
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

SPGKYM-SHLTSCGMGLLLTVDPGSGIVLWTQD
.. ...  . .... | | ..|. .| ||||..
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
Kinase IRE2.AA IRE 511-768 46 2.9e-166 558.66 In-house 1-292 (292) Show / Hide 
Range on Protein: 511-768
Range on HMM: 1-292/292
Sequence Identity: 46% (135 aa)

KDVLGRGAGGTFVFRGQFEGRA-VAVKRLLRECFGLVRREVQLLQ--ESDRHPNVLRYFCTEHGPQFHYIALELCQASLQEYVES---------------
...||||..||.||.|...||. ||||....|.. ...||.|.|.  |||.||||.||.|.|...||.|.||||||.|||.|||.               
NNILGRGCNGTLVFKGIWNGRIPVAVKQMQKEFNPFISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNN

--PDLD----RWG--LEPTTVLQQMMSGLAHLHSLHIVHRDLKPANILMAG--PDSQG-QGRVVISDFGLCKKLPVGRCSFSL--HSGIPGTEGWMAPEL
  ....    .|.  ........|.|.||.||||..|||||||| |||.    |...| ..|..||||||||.|..||.||.   .||..||.||..||.
NNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNRFMISDFGLCKMLVEGRYSFTRNIRSGPTGTWGWHPPEM

LQ-LPPDSPTSAVDIFSAGCVFYYVLSGGSHPFG-ESLYRQANILSGDPCLAQLQEETHDK-VVALDLVRAMLSLLPQDRPSAGWVLAHPLF
|| ......|..|||||.|||||||...|.|||| ..|.||||||.|...|.||....|.. |.| ||...|..  ||.||.....|.||.|
LQEFCQKRKTKSVDIFSMGCVFYYVMTNGQHPFGNDKLHRQANILKGKYNLDQLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKECLNHPFF
S_TKc IRE2.AA S_TKc 508-768 25 4.8e-54 186.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 508-768
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

FNPKDVLGRGAGGTFVFRGQFEG--RAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQFHYIALELCQA---SLQEYVESPDLDRWG--L
.   ...|.|| |. |....  .  | ||.|..       .|||.|.|..  .|||. ... . .  .. |. .|.|     .| .| ..    ...  .
YEILRKIGKGAFGK-VYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

EPTTV---LQQMMSGLAHLHSLHIVHRDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQLPPDSPTS-AVDIFSA
 . ..   ..|. ..|...||..|.||||||.|||.         .. |.||||...|          . . ||  .||||.|     . .  ..|. | 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL----------TTFCGTPWYMAPEVL-----GYGKCKCDWWSC

GCVFYYVLSGGSHPFGESLYRQANILSGDPCLAQLQEETHDKVVALDLVRAMLSLLPQDRPSAGWVLA-------HPLF
||..|  |. |  ||   ...  ...                  |.|..| .|   |..||.|  .|.       || |
GCILYEMLC-GYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase IRE2.AA Pkinase 508-768 24 3e-39 139.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 508-768
Range on HMM: 1-293/293
Sequence Identity: 24% (75 aa)

FNPKDVLGRGAGGTFVFRGQFEGRA--VAVKRLLRECFGL-----VRR--EVQLLQESDRHPNVLRYFCTEHGPQFHYIALELCQA-----SLQEYVE--
.  . ..|.|. |. |....  |    ||||.. ..          ||  |.|....  .|||..|.... . ..  |. .|.|.      .| .|..  
YHIGRKIGSGSFGC-VYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

-SPDL--DRWGLEPTTVLQQMMSGLAHLHSLHIVHRDLKPANILMA---GPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQ-LPP
 .  .  . | .    .. |. .||...||  |.||||||.|||.     .|.    .| |.||||.|..     . |  ... || ..||||...  ..
RHGCFYFSEWECK--FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQY

DSPTSAVDIFSAGCVFYYVLSGGSHPFGES--------LYRQANILSGDPCLAQLQEETHDK----------------VVALDLVRAMLSLLPQDRPSAG
..|  .||..|.||..|..|. |  || ..        ... ..|.....     .. .                     ..|... .| . |..||.| 
YGP--KVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

WVLAHPLF
 .| || |
QILQHPWF
Kinase IRE2.AA Ciliate-E2 553-768 21 4.6e-33 110.82 In-house 85-365 (365) Show / Hide 
Range on Protein: 553-768
Range on HMM: 85-365/365
Sequence Identity: 21% (63 aa)

LQESDRHPNVLRYF--CTEHGPQFHYIALELCQA-SLQEYVE--------------SPDLDRWGLEPTTVLQ-----------QMMSGLAHLHSLH-IVH
..|.. |||.....    |   .  |. .|.||  .|..| .              ....   .   . .||           .....| .||| . |.|
ILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH

RDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRC----------------------------SFSLHSGIPGTEGWMAPELLQLPPDS-------PT
||.|| |||.          . |.||||.||.   ..                            .. ..  | || | |||| |.  ...        .
RDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD

SAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDPCLAQLQEETHDKVVAL---------------DLVRA----MLSLLPQDRPS-AGWVLAHPLF
 ..||.|.|...|. |.|  .||      | .|. ..  . . . . . .                   || .     ||   |. |.. .  .| || |
YKCDIWSLGVILYEMLFG-KPPF------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase IRE2.AA CAMK 513-706 18 5.2e-31 96.59 In-house 1-330 (425) Show / Hide 
Range on Protein: 513-706
Range on HMM: 1-330/425
Sequence Identity: 18% (61 aa)

VLGRGAGGTFVFRGQFE-G-------------RAVAVKRLLRE-------------------------------CFGLVRREVQLLQESD------RHPN
.||||. |. |....                 . ||.| . ..                                   ||||.....         .|||
TLGRGSFGK-VKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VLRYFC---------------TEHG-----PQFHYIAL---ELCQA-----SLQEYVE-SPD----------LDRWG-L---EPTTVLQQMMSGLAHLHS
... .                |        ... |. .   |.|.       | .|.   ..          . ..| .   |  .. .|. |.....||
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHS

LHIVHRDLKPANILMAGPDSQGQ------------GRVVISDFGLCKKLPVGRCSF--------------------SLHSGIPGTEGWMA-PELLQ----
..|||||||| |||.   ..  .            . . |.|||. .|.. |  .|                     . .   || . || ||.|.    
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

----------LPPDSPTSAVDIFSAGCVFYYVLSG
           |...|  ..|. |.|.. |  |.|
CNMQNATDEEKPYYGP--KCDMWSCGVILYIMLCG
Kinase IRE2.AA Ciliate-E2a 605-706 30 1.9e-28 80.84 In-house 106-212 (275) Show / Hide 
Range on Protein: 605-706
Range on HMM: 106-212/275
Sequence Identity: 30% (35 aa)

VLQQMMS-GLAHLHSLHIVHRDLKPANILMA--GPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIP-------GTEGWMAPELLQLPPD--SP--TSA
..||. . ||...|...|.|||||| |||.    ..|. .  ..|.|||| .. .           ..       || | .|||.| .. .  ..  .  
IMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD---------EKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTK

VDIFSAGCVFYYVLSG
.|..|.|..||  |.|
CDMWSCGVIFYILLCG
Kinase IRE2.AA TKL 514-701 18 6.9e-28 97.5 In-house 1-280 (364) Show / Hide 
Range on Protein: 514-701
Range on HMM: 1-280/364
Sequence Identity: 18% (54 aa)

LGRGAGGTFVFRGQFEG----------RAVAVKRLLR---ECFGL-------------------------VRREVQLLQESD-RHPNVLRYFCTEHGPQF
.|.|. |  |..|.. |          . ||||.. .    .| .                          ..|..... |  ||||....      |..
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------HYIALELC-QASLQEYVESPDLDRWGLEPTTVLQ---QMMSGLAHLHSLH--------IVHRDLKPANILMAGPDS---------QG
             ..|  |.|   || .|.           .   ..   .. .|...||| .        |.|||||..|||               . 
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

QGRVVISDFGLCKKLPVGRCSFSL----------------HSGIPGTEGWMAPELLQLPPD--------------SPTSAVDIFSAGCVFY
.... |.||||.. .     .                   .. . || .|||||.|.  ..              . . ..|..| | |..
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW
Kinase IRE2.AA Ciliate-E2-Unclassified 551-768 21 6e-26 87.0 In-house 69-352 (352) Show / Hide 
Range on Protein: 551-768
Range on HMM: 69-352/352
Sequence Identity: 21% (63 aa)

QLLQE---SDRHPNVLRYFCTEHGPQFHYIALELCQA-SLQEYVES-PD------------LDRWGLEPTTVL--------QQMMSGLAHLHSLH-IVHR
...|.   .  ||.....| ..   |  || .|.|.  .|..| .. .             . |  ..   ..         |  .|| .||. . |.||
KIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHR

DLKPANILMAGPDSQGQ-GRVVISDFGLCKKLP------------VGRCSFSLHSGIPGTEGWM----APELLQL-PPDSPTS-AVDIFSAGCVFYYVLS
|.|| |||.   |..|. ... |.|||..||.              .. .. . . . || . |    |||.||   .| ... ..||.| |...|. | 
DIKPENILF---DNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF

GGSHPF-GESLYR----------------QANILSGDPCLAQLQEE----THDKVVALDLVR----AMLSLLPQDRPSAGWVLAHPLF
|  .|| ... .                 . ..    ..  . ...     |    | |...     ||   |  |...  .| ||.|
GY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase IRE2.AA STE 508-699 21 1.2e-25 87.63 In-house 1-257 (359) Show / Hide 
Range on Protein: 508-699
Range on HMM: 1-257/359
Sequence Identity: 21% (60 aa)

FNPKDVLGRGAGGTFVFR-----------GQF-----EGRAVAVKRL-LREC-------------------FGLVRREVQLLQESDR-HPNVLRYFCT--
.   ...|.||.|| .             |.       |. .|.|.. |..|                   .  . .|........  |||. .|...  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----EHGPQFHYIALELCQA-SLQEYVESPDLDRWGL-----------EPTT--VLQQMMSG-LAHLHSLHIVHRDLKPANILMAGPDSQGQGRVVISD
     ..  .  .|..|.. . || . ...      .|           |.    ...|   | |..|||.||.|||.||||||.          | ..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCD

FGLCKKL-------------PVGRCSFSLHSG-----IPGTEGWMAPELLQLPP---DSPTS-AVDIFSAGCV
||.|..|                 |.  . ..     . ||  ||||| .|      |.. .  .|| | ||.
FGVCGQLTDSMANIQSNNIID---CI--ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCT
Kinase IRE2.AA ULK 508-706 21 1.7e-24 82.44 In-house 1-252 (329) Show / Hide 
Range on Protein: 508-706
Range on HMM: 1-252/329
Sequence Identity: 21% (57 aa)

FNPKDVLGRGAGGTFVFRGQ---FE---GRAVAVKRLLRE--CFGL-----------VRREVQLLQESD-------RHPNVLRYFCTEHGPQF--HYIAL
.. ...|| |. |  |..|     .   . .||.| ....     .           ...|...... .       .|||. ...     ...  .|| .
YCLNHCLGKGSFG-KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

ELCQA-SLQEYVE----SPDLDRWGLEPT------------TVLQQMMSGLAHLHSLHIVHRDLKPANILMAGPD--------SQGQGRVVISDFGLCKK
|.|.   |..| .    .|       |.|             ...| ..|. .||.  |.|||.||.|||.  ..         . .|.. |.|||..|.
EYCNGGDLEQYIKKNKKLP-------EDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKH

LPVG---RCSFSLHSG---IPGTEGWMAPELLQLP--PDSPT-SAVDIFSAGCVFYYVLSG
.  .      .   ..   . ||   |||..||       .. . .||.| ||.||. | |
VDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG
Kinase IRE2.AA CMGC 508-655 15 1.4e-20 63.47 In-house 1-254 (513) Show / Hide 
Range on Protein: 508-655
Range on HMM: 1-254/513
Sequence Identity: 15% (39 aa)

FNPKDVLGRGAGGTFVFRGQF----------------EGRAVAVKRLLRECFGLVR---------------REVQLLQES----------------DRHP
.   ...|.|. |  |....                  .. ||.|.. ..                     ||...|..                 . |.
YEIIKKIGEGTYG-VVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

NVL--RYFCTEHGPQ---------------FHYIALELCQASLQEYVESPDL-DRW----GLEPTT---------------VL------QQMMSGLA--H
|..  ..... ....                 |.  |... .| .| ..    ..     .|..                  .      .|.  ||.  .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSLH--IVHRDLKPANILMAGPDSQ---------------GQGRVVISDFGLCKKL
.||    |.||||||.|||.                      .||. | ||||....
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWY
Kinase IRE2.AA RSK 605-708 31 7.7e-20 69.46 In-house 109-210 (278) Show / Hide 
Range on Protein: 605-708
Range on HMM: 109-210/278
Sequence Identity: 31% (34 aa)

VLQQMMSGLAHLHSLHIVHRDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCS--FSLHSGIPGTEGWMAPELLQ--LPPDS-PTSAVDIFSAGCV
.. .  . . |||...|.|||||| ||| .  .  ..|.....|||.||..   ||.  . ...   .|   ||||.|     ...  . |.|..| |..
YMAEIVLAVEHLHQQGIIHRDLKPENILYDDES--NEGHIKLTDFGFCKQF---RCDHNQWTMT-FCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLGVL

FYYVLSGGS
 |  |.| .
MYEMLTGCP
Kinase IRE2.AA TyrKc 508-768 21 1.6e-11 -36.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 508-768
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

FNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQES-DRHPNVLRYF--CTEHGP-----QFHYIALELCQA-SLQEYVESPDLDRW
   ...||.|| |. |..|.   . |||| |  ..    .|| ... .   .|||..| .  ||..|      . ..| .|..   .|..|  ..  .  
ITLGKKLGEGAFGE-VYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

GLEPTTVLQQMM----SGLAHLHSLHIVHRDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVG--------RCSFSLHSGIP--GTEGWMAPELLQLPP
   ..  | ...    .| ..||| ...||||   |.| . .      .| ||||||....  .          . . |.|        ||||| .    
--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----

DSP--TSAVDIFSAGCVFYYVLSGGSHPFGE------SLYRQANILSGDPCLAQLQE-------ETHDKVVALDLVRAMLSLLPQDRPSAGWVLAHPLF
.    |.. |..| | . . ... |  |  .      | ..  . .     . | ..       . .|..    . .      | |||.   .  | .|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ--IMKQCWHEDPEDRPTFSEI--HECF
Kinase IRE2.AA CMGC 741-768 42 7e-06 14.32 In-house 486-513 (513) Show / Hide 
Range on Protein: 741-768
Range on HMM: 486-513/513
Sequence Identity: 42% (12 aa)

ALDLVRAMLSLLPQDRPSAGWVLAHPLF
|.||.  || . |..|..|   |.|| |
AIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase IRE2.AA Pkinase_Tyr 611-655 33 4.4e-05 17.85 Pfam 122-161 (270) Show / Hide 
Range on Protein: 611-655
Range on HMM: 122-161/270
Sequence Identity: 33% (15 aa)

SGLAHLHSLHIVHRDLKPANILMAGPDSQGQGRVVISDFGLCKKL
.|...|.| ...||||   |.| .      .. | |.||||.. .
KGMEYLESKNCIHRDLAARNCLVTE-----NNVVKICDFGLARDI
Kinase IRE2.AA CAMK 741-768 35 0.001209 6.82 In-house 398-425 (425) Show / Hide 
Range on Protein: 741-768
Range on HMM: 398-425/425
Sequence Identity: 35% (10 aa)

ALDLVRAMLSLLPQDRPSAGWVLAHPLF
. ||.| ||   |..|...  .|.|| .
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase IRE2.AA RSK 743-768 35 0.002466 8.48 In-house 248-278 (278) Show / Hide 
Range on Protein: 743-768
Range on HMM: 248-278/278
Sequence Identity: 35% (11 aa)

DLVRAMLSLLPQDRPS-----AGWVLAHPLF
||.|.||   |..|..     |  ...|| |
DLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase IRE2.AA CMGC 676-707 25 0.029183 2.19 In-house 293-339 (513) Show / Hide 
Range on Protein: 676-707
Range on HMM: 293-339/513
Sequence Identity: 25% (12 aa)

APELLQLPP--------DSPTSAVDIFSAGCVFYYVLSG-------G
|||.|   .        .  |...|. |.||.|.  . |       |
APEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRG
Kinase IRE2.AA Ciliate-E2a 741-768 39 0.110165 0.76 In-house 248-275 (275) Show / Hide 
Range on Protein: 741-768
Range on HMM: 248-275/275
Sequence Identity: 39% (11 aa)

ALDLVRAMLSLLPQDRPSAGWVLAHPLF
. ||.. ||   |. |..|   | || |
CKDLMKKMLEKDPKKRITAQQALNHPWF
Ribonuc_2-5A IRE2.AA Ribonuc_2-5A 773-899 48 8.8e-75 259.55 Pfam 1-137 (137) Show / Hide 
Range on Protein: 773-899
Range on HMM: 1-137/137
Sequence Identity: 48% (67 aa)

KELQFFQDVSDWLEKEPDQ--GPLVSALEAGSYKVVR-EDWHKHISAPLQADLKRF-RS---YKGTSVRDLLRAMRNKKHHYREL-PAEVRQTLGQLPAG
|.|.|..||||..|.|...   |...|||..|..||. .||||.| .....|.... |.   |.|.||||||||||||||||.|. |.|....||.|| |
KRLRFLCDVSDRFEIEDRDPPSPILQALERTSRCVVGFGDWHKKIDKAFMDDMGKYYRKRKNYYGDSVRDLLRAMRNKKHHYHEMKPEEMKEILGDLPDG

FIQYFTQRFPRLLLHTHRAMR--TCASESLFLPYYPP
|.|||| |||.||.|....|.   |. |..| .||.|
FLQYFTERFPHLLMHCYHVMQECHCEHEEHFHKYYKP
PUG IRE2.AA PUG 831-888 40 5.8e-24 86.84 SMART 1-66 (66) Show / Hide 
Range on Protein: 831-888
Range on HMM: 1-66/66
Sequence Identity: 40% (27 aa)

TSVRDLLRAMRNKKHHYREL--------PAEVRQTLGQLPAGFIQYFTQRFPRLLLHTHRAMRTCA
.|||||||.|||..||.||.        ........||.|.|| .|||..||.|..|.. ..  | 
ESVRDLLRYMRNIYHHPREEKFRKIRMENKAFKEKMGQVPGGFECYFTCGFPDLMIHAWEHYFFCK