Gene ITK (Mouse)

ITK

Species: Mouse
Alias: ITK, Itk
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Tec

Sequence

Name Sequence Type Origin Length Description Download
ITK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 250 Kinase domain by global Sugen HMM Fasta, JSON
ITK.AA Protein Sugen 625 None Fasta, JSON
ITK.NA RNA Sugen 4299 None Fasta, JSON

Protein domain

Protein domains of ITK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
BTK ITK.AA BTK 119-155 56 6.9e-24 86.59 SMART 1-37 (37) Show / Hide 
Range on Protein: 119-155
Range on HMM: 1-37/37
Sequence Identity: 56% (21 aa)

NNSLVSKYHPNFWMDGRWRCCSQLEKPAVGCAPYDPS
||....||||.|||||.|.||.| .|.|.||.|..|.
NNHRMQKYHPCFWMDGHWLCCQQTCKNAPGCCPCHPH
BTK ITK.AA BTK 124-155 53 8.8e-17 66.87 Pfam 1-32 (32) Show / Hide 
Range on Protein: 124-155
Range on HMM: 1-32/32
Sequence Identity: 53% (17 aa)

SKYHPNFWMDGRWRCCSQLEKPAVGCAPYDPS
.||||.|||.|.|.||.|..| |.||.|....
QKYHPCFWMNGHWSCCHQTDKNAPGCQPCHHW
PH ITK.AA PH 5-119 23 1.1e-14 56.01 SMART 1-82 (82) Show / Hide 
Range on Protein: 5-119
Range on HMM: 1-82/82
Sequence Identity: 23% (27 aa)

ILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQTLVYLQVVHDNYLLYVFAPDCES
...| .| |||         ..| |.|||.  .| |..|.     ..|||| || ....| .                  .....| .  .|..... |.
VIKEGWLYKKS-------K-RWKKRWFVLFNDCLYYYKDK-----KPKGSIPLSDCTVRE-P------------------CFEIHH-DRTYYFQCESEEE

RQRWVLTLKEETRNN
.|.|.  ... ..||
MQEWMQAIQKAIHNN
PH ITK.AA PH 5-117 21 1.4e-13 51.57 Pfam 1-92 (92) Show / Hide 
Range on Protein: 5-117
Range on HMM: 1-92/92
Sequence Identity: 21% (24 aa)

ILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQTLVYLQVVHDNY-LLYVFAPDCE
. .| .| ||.      . ...| |.|||.   | |..|..    ..|||| || .........                ..|... .   .|..|.. |
VIKEGWLHKKG------KRKSWKKRWFVLFNNCLYYYKDDK---YRPKGSIPLSDCQVTKVPDN------------KRPHCFQIRT-DRRTYYFQAESEE

SRQRWVLTLKEETR
....|.  ...  |
EMNDWMQAIQSACR
SH3 ITK.AA SH3 180-236 34 2.3e-16 61.63 SMART 1-58 (58) Show / Hide 
Range on Protein: 180-236
Range on HMM: 1-58/58
Sequence Identity: 34% (20 aa)

TLVIALYDYQTNDPQELALRCDEEYYLLDSSEIHWWRVQDK-NGHEGYAPSSYLVEKS
  |.||||||  .|.|| .. .. ...|. .. .||... . .| ||. ||.|. |. 
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 ITK.AA SH3_1 183-229 36 3.5e-16 57.53 Pfam 1-49 (49) Show / Hide 
Range on Protein: 183-229
Range on HMM: 1-49/49
Sequence Identity: 36% (18 aa)

IALYDYQTNDPQELALRCDEEYYLLDSSEI-HWWRVQDKN-GHEGYAPS
.|||||| ..|.|| ..  ....... |.  .||.....| |.||. ||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 ITK.AA SH3_2 181-235 17 2.7e-08 31.95 Pfam 1-68 (68) Show / Hide 
Range on Protein: 181-235
Range on HMM: 1-68/68
Sequence Identity: 17% (12 aa)

LVIALYDYQT-NDPQE-----LALRCDEEYYLL---DSSEIHWWRVQDK--NGHE--GYAPSSYLVEK
..... ||.  ....|     | .. ..  ...   | . ..||.....  .|..  |..||... | 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 ITK.AA SH2 245-328 36 1.1e-38 115.37 Pfam 1-81 (81) Show / Hide 
Range on Protein: 245-328
Range on HMM: 1-81/81
Sequence Identity: 36% (31 aa)

WYNKSISRDKAEKLLLD-TGKEGAFMVRDSR-TPGTYTVSVFTKAIISENPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYH
|| ..||| .||.||.  ....|.|.||.|. ||| ||.||...     .. .|||.|..|..    ||....  |.|.. |....
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP---GDRVKHYRIQRTDNG--GYYITGRHKFCSLQELVEHY
SH2 ITK.AA SH2 243-334 36 3.9e-31 110.68 SMART 1-87 (87) Show / Hide 
Range on Protein: 243-334
Range on HMM: 1-87/87
Sequence Identity: 36% (35 aa)

YEWYNKSISRDKAEKLLLDT-GKEGAFMVRDSRT-PGTYTVSVFTKAIISENPCIKHYHIKETNDSPKRYYVAE--KYVFDSIPLLIQYHQYNGGG
..||   |||..||.||.   ...|.|.||||.. || |..||..|       ..|||.|....|  ..||..|  .. |.|.  |....| | .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK------GKVKHYRIRRNDD--GKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase ITK.AA Tec 368-619 72 3.7e-210 704.47 In-house 1-254 (254) Show / Hide 
Range on Protein: 368-619
Range on HMM: 1-254/254
Sequence Identity: 72% (184 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAET--LL
|||..|.||||||.||||.| ....||||.|.||.||||||||||.|||||||||||||||||..|.||..|.|.||||||..|||.... |....  ||
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

GMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYE
.||.||||||||||..|.|||||||||||||...|.|||||||||.|||||||||.||||||||..||||..||||||||||.||||||||||.||.|||
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

NRSNSEVVEDISTGFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQLAE
|.|||||||..|.|.|||.|.|.|.|.||||.|||.||||.||.|.|||.|..|
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase ITK.AA Pkinase_Tyr 368-617 45 1.7e-142 483.19 Pfam 1-270 (270) Show / Hide 
Range on Protein: 368-617
Range on HMM: 1-270/270
Sequence Identity: 45% (123 aa)

LTFVQEIGSGQFGLVHLGYWL-----NKDKVAIKTIQEGAMSE----EDFIEEAEVMMKL-SHPKLVQLYGVCL-EQAP--ICLVFEFMEHGCLSDYLRS
.|| ...|.|.|| |..|.|      .| .||.|.. ||||.|    |||..||..|..| .||..|.|||||. .. |  |..|.|.|.||.| ||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

Q---RGLFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFV-LDDQY-TSSTGTKFPVKWASPEVFSFSRYSSKSDVWSF
.   .. .  ..||.||.....||.|||    ||||||||||||.|| |.|..|||..| .  ||.| ....|.|.|.|| .||.........|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLMWEVFSEGKIP-YENRSNSEVVEDI-STGFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQL
||||||.|. |..| |.. ||.||.| |   | |. .|....  .|..| .||...||||| ||....||
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ITK.AA TyrKc 368-617 41 1e-135 458.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 368-617
Range on HMM: 1-280/280
Sequence Identity: 41% (117 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKL--SHPKLVQLYGVCLEQ-------APICLVFEFMEHGCLSDYLRSQRGL
.|. ...|.|.|| |..| |    .||.|...|.|  .|||..||..|.||  .|| .|.|||||..|        |...|.|.|.||.| ||||. |. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDD--------QYTSST--GTK--FPVKWASPEVFSFSRYSSKSDV
.  ..|| .|.....||.||.. ..|||||||||||||||...|.||||..|.. ||         |....  |.|  .|..| .||.. ......||||
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSFGVLMWEVFSEGKIPYEN-----RSNSEVVEDISTGFRLYKPRL--------ASCHVYQIMNHCWKEKPEDRPPFSQLLSQL
|||||.|||.|. |. ||..      ||.||.|.. .|.|. .|          ..  .||||  ||.|.||||| ||.. ...
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ITK.AA Src 368-617 46 1.2e-116 393.78 In-house 1-255 (255) Show / Hide 
Range on Protein: 368-617
Range on HMM: 1-255/255
Sequence Identity: 46% (119 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLR-SQRGL-FAAETLL
.......|.|||| |  ||| .. |||.||. .| || |.| .||..| ||.|.|||||| || .  ||  | |.|.||.| |||. ...|     ..|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

GMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVL--DDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIP
 |   | |||||||.  .||||||||| ||||| | || |||  | .   || |....| |||.||  || ... |.. ||||||||.|..|... |..|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YENRSNSEVVEDISTGFRLYKPRLASCHVYQ-IMNHCWKEKPEDRPPFSQLLSQL
|.  .| ||.. .. |.|. .|.     .|. || .||...||.|| |  | . |
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ITK.AA SFK-Src 368-621 46 5.3e-115 342.37 In-house 1-259 (259) Show / Hide 
Range on Protein: 368-621
Range on HMM: 1-259/259
Sequence Identity: 46% (120 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRS--QRGLFAAETLL
    .  |||||| |  | | |.  ||.||   ||||.| | .|| || || ||.|.||| ||    ||  . | |  | | |||..   |.|    .| 
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSL-RMPQLV

GMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQ--YTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIP
 |  .|  ||||||    .|||||||| |||.| |.|| |||| | . .|.  ||  .| |||.||  ||  . .|.| ||||||||.|| |.   | ||
DMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIP

YENRSNSEVVEDIST--GFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQLAEIA
|.  .| ||.  .    | |. .|       |.||  ||...|.||| |  |. |. .  
YPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase ITK.AA TK 368-617 24 7.69999999999e-115 386.6 In-house 1-486 (486) Show / Hide 
Range on Protein: 368-617
Range on HMM: 1-486/486
Sequence Identity: 24% (120 aa)

LTFVQEIGSGQFG---LVHLGYWLNKD--------------------------KVAIKTIQEG-AMSEEDFIE--------------EAEVMMKLS----
.|.....|.||||    |..| | ...                          .||.|.. || |||.|.|..              |||.|....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPKLVQLYGVCLEQ------------APICLVFEFMEHGC----LSDYLRSQRGL--------------------------------------------
 || .|.|||||...             |...| |.|.||.    | ||||. |.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FAAETLLGMCLDVCEGMAYLEKA------CVIHRDLAARNCLVGENQV-----------IKVSDFGMT-
                               .  ..|| ||.....||.||..        ..|||||||||||||| |           .|..|||.. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RFV-LDDQYTSST------------------------GTKFPVKWASPEVFS---------FSRYSSKSDVWSFGVLMWEVFSEG-KIPYENR
       | .  || |....                        |.|.|..| .||..          . ....|||||||||||||.|. | . .|.. 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------SEVVEDIST------------GFRLYKPRLASCH---------------VYQI-MNHCWKEKPEDRPPFSQLLSQL
||          ||.| . .            | |. .|. . |.               .|.. |  ||...||||| ||||..||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ITK.AA UTK 368-617 33 2.3e-95 323.15 In-house 1-296 (296) Show / Hide 
Range on Protein: 368-617
Range on HMM: 1-296/296
Sequence Identity: 33% (98 aa)

LTFVQEIGSGQFGLVHLGYWLN------KDKVAIKTIQEGAM---SEE---DFIEEAE---VMMKLS-HPKLVQLYGVCLEQAPICLVFEFMEHGCLSDY
. . ...|.|.|| ||.. . .      ...||.|. |..|.   ..|   ||.|||    .|.... ||....|.|||. . |...| |.|| | |..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSQRG-------LFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGEN-------QVIKVSDFG---MTRFVL---------DDQYTSSTG-TK
||..|        ..  ...|.|..|. .||.||.   ..|||||||||||...       .|.|..|||   |.| |          ...|  ... ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPVKWASPEVFSFS-RYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTG--FRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQL
 |..| .||..    |...|||||||||..||... |. ||.. || .|.. .. |   |. .|.  .  ||..|. ||.  |..|| | .|..|.
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ITK.AA Csk 368-617 43 4.1e-92 312.31 In-house 1-251 (251) Show / Hide 
Range on Protein: 368-617
Range on HMM: 1-251/251
Sequence Identity: 43% (112 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEG-AMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQA-PICLVFEFMEHGCLSDYLRS-QRGLFAAETL
|.  ..|| | || | .| ..|. |||.| | .      . |. || || .|.|| |||| || |.|   . .| |.|  | | |||||  | ..  . |
LHLGECIGHGEFGDVMQGEYQNR-KVAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQL

LGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSS--TGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKI
|   .||||||.|||.  ..|||||||| || |  | |||||| ..   ......   |. |||.|| .|| .  ...|.||||||||.|.||..| | .
LKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAK---EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYSFGRV

PYENRSNSEVVEDISTGFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQL
||   . ..||. .  |.|   |     |||..|. ||   | .||.| |...||
PYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase ITK.AA SrcB 368-618 44 4.1e-92 311.92 In-house 1-251 (251) Show / Hide 
Range on Protein: 368-618
Range on HMM: 1-251/251
Sequence Identity: 44% (112 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGL-FAAETLLG
| .|. .|.|||| | .||. |. |||.||...|.|| | |..|| || .| | .||.|| |     || .. |.|..||| |.|... |   . . |. 
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

MCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYEN
|   . |||||.|.   ||||| | | || |  . |. |||. | . |. ||   | |||.||  ||   |  .  ||||||||.|. |.   |.|||  
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPG

RSNSEVVEDISTGFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQLA
..|.||.. .. |.|. .|      .|.|| .||||.||.|| |  | | | 
MTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase ITK.AA Abl 368-617 43 6.9e-92 306.83 In-house 1-252 (252) Show / Hide 
Range on Protein: 368-617
Range on HMM: 1-252/252
Sequence Identity: 43% (110 aa)

LTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRS-QRGLFAAETLL
..  . .| ||.| |  |.|   |. ||.||..| .|  ..|..|| .| .. || |||| |||   .|  .. ||| .| | ||||. .| .  | .||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

GMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYE
 |   .  || ||||   ||||||||||||||....|| |||..|.. || ||   | |||.||  ||   . ..||||||| ||||.||.   |  || 
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYP

NRSNSEVVEDISTGFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQL
    |.| . .  |.|. .|.    .||..| .||. .. ||| | ..  ..
GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase ITK.AA SrcA 368-617 44 7.1e-92 290.58 In-house 1-250 (250) Show / Hide 
Range on Protein: 368-617
Range on HMM: 1-250/250
Sequence Identity: 44% (111 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRG-LFAAETLLG
..  . .| |.|| | .| |  . ||||||.. | || | |.||| .| || | |||||| |  |  || .| |.| .| | |.|. . |       |  
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEE-PIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD

MCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYEN
|   | |||||.|.   ||||| | | ||||| . |. |||. | . |. ||.  |.|||.||  ||   . |.  ||||||||.|. |.   |..||  
MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPG

RSNSEVVEDISTGFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQL
  | ||.| .  |...  |.     ....|..||.  ||.|| |  | | |
MNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase ITK.AA Frk 368-621 41 2.6e-90 306.33 In-house 1-260 (260) Show / Hide 
Range on Protein: 368-621
Range on HMM: 1-260/260
Sequence Identity: 41% (109 aa)

LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLR--SQRGL-FAAETL
. .....|||||| |  | | |.  ||.||.. |.|  .||. || .| || ||||.||| ||  . || .. | |.|| | .||.  ...|     ..|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQ--YTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGK
. |   |  ||||||.   ||||||||| ||||....|. |||. | .. |..  | | .| .||.||  ||    .... ||||||||.|. |.   |.
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

IPYENRSNSEVVEDISTGFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQLAEIA
.||    | ||.. .. |.|. .|     ..|.|| .||...|. || |  |  .| .  
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase ITK.AA S_TKc 368-618 24 4.8e-54 186.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 368-618
Range on HMM: 1-231/231
Sequence Identity: 24% (66 aa)

LTFVQEIGSGQFGLVHLGYWLN-KDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEH--GCLSDYLRSQRGL-----F
 .....||.| || |..... . . .|||| |       |... | ....|  || .|.||.|. .   ...|.|....  | | ||......      |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

AAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSS-KSDVWSFGVLMWEVFS
   .   ..  .|....|. .  .|||||   | |. |  .||..|||. |..     |.  || .   . .|||.    |.  |.|.||.|....| ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPW---YMAPEVL---GYGKCKCDWWSCGCILYEMLC

EGKIPYENRSNSEVVEDISTGFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLS--------QLA
 |. |..     .. . |            |  . .....|..  ||.||   ..|         .  
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ITK.AA Pkinase 368-617 22 2.3e-42 150.88 Pfam 1-293 (293) Show / Hide 
Range on Protein: 368-617
Range on HMM: 1-293/293
Sequence Identity: 22% (68 aa)

LTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIQEGAMSEEDFIE-----EAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHG----CLSDYLR-SQR
..... |||| || | .... .  | ||.|.|     ...  ..     |...| .|.||  |.||... .   |..|.|..|.|     |.||.. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GLF--AAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVI----KVSDFGMTR---FVLDDQYTSSTGTKFPVKWASPEVFS-FSRYSSKSDV
| |    ...  ... ...|..|. .  .|||||   |.|. .| .|    |..|||  .      .  .|. .|| .   ...|||    . |..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDM

WSFGVLMWEVFSEGKIPYENR-------SNSEVVEDISTGFRLYKPRLAS-------------------CHVYQIMNHCWKEKPEDRPPFSQLLSQ--L
||.|....|... |. |. ..        .  .... .. ..   | . |                       .... |.. .|..|| . |.|    .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF