Gene JAK1 (Mouse)
JAK1
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| JAK1.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 278 | Kinase domain by global Sugen HMM | Fasta, JSON |
| JAK1.NA | RNA | Sugen | 5299 | None | Fasta, JSON |
| JAK1.AA | Protein | Sugen | 1153 | None | Fasta, JSON |
| JAK1.kin_dom2 | Protein Kinase Domain | Sugen global kinase HMM prediction | 265 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of JAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| B41 | JAK1.AA | B41 | 32-286 | 20 | 9.8e-61 | 209.0 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 32-286
Range on HMM: 1-232/232
Sequence Identity: 20% (57 aa)
PEPGVEVTFYLLDREPLRLGSG-EYTAEELCIRAAQECSISPLCHNLFALYDEST---KLWYAPNRIITVDDKT-----SLRLHYRMRFYFTNWHGTNDN
... ... .|..|...| . .. ..|...|| ....|.|||..|..|.|. |.. . |. ... |. |. ...||.|..||...|||
SPKPRFCRVYFMDGTTLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPDWHG----
EQSVWRHSPKKQKNGYEKKRVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQ-------LPELPKDI
.. .. .|. ...|...| ..|... .| . .|.|||..|.|.. . . .. . . ...|..
---------------------FPNQLQEDPTRYNYFYLQCRHDILQGRHPCP----------HEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYK
SYKRYIPETLNKSIRQR-------NLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIF
||||..|. ...||.|. . .| || ...|.. .. .....|.|||........ ||.| |
SYKRFLPKQWIDSIKQSFMHYQMHHKEWRKRIMEWHKNH-----------CGMTPEEAKLKYLQICQRWPPMYGVEHF
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| Kinase | JAK1.AA | SH2 | 437-531 | 24 | 7.6e-16 | 59.88 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 437-531 Range on HMM: 1-87/87 Sequence Identity: 24% (24 aa) QNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEVLGGQKQFKNFQIEVQK-GRYSLHG-SMDHFPSLRDLMNHLKKQILR |. .||.| | | ..|...| ..| ...|.| . .. ..... | ...|...|. .. |.|.. . . |||| .| || .. |. QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES--NPGDYVLSVRWK-------GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| Kinase | JAK1.AA | Jak | 401-446 | 10 | 0.05712 | 3.0 | In-house | 97-146 (299) | Show / Hide |
Range on Protein: 401-446 Range on HMM: 97-146/299 Sequence Identity: 10% (5 aa) EALSFVS----LVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICT ....... . ... ..|.|...... ...... .... .||..|. PLDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCA |
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| Kinase | JAK1.AA | Jak | 582-846 | 37 | 2.1e-142 | 479.37 | In-house | 1-299 (299) | Show / Hide |
Range on Protein: 582-846 Range on HMM: 1-299/299 Sequence Identity: 37% (113 aa) IIQGEHLGRGTRTHIYSGTLLDYK---DEEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVC--VRDVENIMVEEFVEGGPLDL ... ||||.|.....|........ |.|....|.|..|..||..|.|...|..|....|.|.|.||||||...||| ... |..|| |... ||||. LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD FMH----RKSDALTT--PWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGID-SDIGPFIKLSDPGIPVSVLTRQEC--IERIPWIAPECVED-S ..| |... ... .||...|||......|||||...||.||..|.|..|||.. .. ||.||.||.... .. |... |||||.||||... . YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK KNLSVAADKWSFG-TTLWEIC----------------YNGEIPLKDKTLIEKERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDINK ..|..|.|||||| .|||||| ..|..|........|..|||...|...|. ..|...||..|..|||||||.||.|.||.|. FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ |
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| Kinase | JAK1.AA | Pkinase_Tyr | 582-844 | 28 | 4.3e-78 | 265.11 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 582-844 Range on HMM: 1-270/270 Sequence Identity: 28% (81 aa) IIQGEHLGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVL--DPSHRD-ISLAFFEAASMMRQV-SHKHIVYLYGVCV-RDVE--NIMVEEFVEGGPL |. |. ||.| ..| ||. . ...||.| |.| . .|.. .. .|.. |..|.| .|..|| |||||. .. ..| |....| | ITFGKKLGEGAFGEVYKGTWKG------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL DLFMHRK---SDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSV-------LTRQECIERIPWIAPECVE . . ... ..||.... . . | |....|||.| ..| ....| |... . ..| .| | . .|... |.| |||| LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECIN DSKNLSVAADKWSFGTTLWEICYNGEIP-LKDKTLIE-KERFYESRCRPVTPS--CKELADLMTRCMNYDPNQRPFFRAIMRDI ..| ... | |||| ..|||. ||.| .. . | .|..||...| | ..|. |||..|..|||..|| |..| ... YGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | JAK1.AA | TK | 582-844 | 15 | 1.1e-57 | 191.61 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 582-844
Range on HMM: 1-486/486
Sequence Identity: 15% (76 aa)
IIQGEHLGRGTRT---HIYSGTLL---DYKDEEGIA------------EEKKIKVILKVLDPSHRDISLAFFE--------------AASMMRQVS----
|. |. ||.| .| |.. ... ..... |..|..| |.| . . . . .||. |..| . .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
-HKHIVYLYGVCVRDVE------------NIMVEEFVEGGP----LDLFMHRKSDA--------------------------------------------
|..|| |||||..... ..|.|....| |. . .....
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LTTPWKFKVAKQLASALSYLEDK------DLVHGNVCTKNLLLAREGID----SDIGPFIKLSDPGIP-
||.... . |.|....||..| .||..... | |....... .. ||..|..| |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----VSVLTRQ--------------------------------ECIERIPWIAPECVEDSK--------NLSVAADKWSFGTTLWEICYNGEIPLKD--
. . . | | ||||..| . . . | |||| ..|||. .|. |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
-----------KTLIEKERF---------------YESRCRPVTPSC------------KELADLMTRCMNYDPNQRPFFRAIMRDI
. ..|. | .. . | |.. .|..|||..| .|||..|| |... . .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | JAK1.AA | TKL | 624-844 | 17 | 6.3e-24 | 83.05 | In-house | 62-364 (364) | Show / Hide |
Range on Protein: 624-844
Range on HMM: 62-364/364
Sequence Identity: 17% (53 aa)
DPSHRDISLAFFEAASMMRQVSHKHIVYLYG---------VCVR----DVENIMVEEFVEGGP-LDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKD-
|| . . . | . ||.. .| .|| ..| ||.. . . .| |...|| |... . ... |.. |....|| ..
DPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNP
-------LVHGNVCTKNLLLAREGI-------DSDIGPFIKLSDPGIPVSVL-----------------------TRQECIERIPWIAPECVEDSKNLSV
..| . .||.|. . . . . ..|..| |. .. |. .. . | |||. ... |..
KWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTE
AA---------------DKWSFGTTLWEICYNGEIPLKDKTL---------IEKERFYESRCRPVTP--------------SCKELADLMTRCMNYDPNQ
.. | .||| ||||. . ... .. . .. ..|| | .....||..|...||..
KVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEK
RPFFRAIMRDI
|| | |. .
RPSFQEILKRL
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| Kinase | JAK1.AA | Frk | 634-848 | 25 | 1.8e-18 | 60.35 | In-house | 41-260 (260) | Show / Hide |
Range on Protein: 634-848 Range on HMM: 41-260/260 Sequence Identity: 25% (57 aa) FFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMH---RKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDI | | .|... | .. || || .. ... | .. | | .. .| . . .| |.|. . |||.. .| . .|.|. . | FLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNI---- GPFIKLSDPGIPVSVLTRQE------CIERIP--WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCR-PVTPSC-KELA .|. | |. .. .| |.| | ||| .. .| .. .| |||| | || | .| | | . | | | | ..| ---CKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNK-FTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLY DLMTRCMNYDPNQRPFFRAIMRDINKLE ..| | . ||..|| | . ... EIMLECWHSDPMKRPTFETLQWKLEDYF |
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| Kinase | JAK1.AA | TK-Unique | 582-792 | 20 | 7.2e-17 | 54.8 | In-house | 1-239 (294) | Show / Hide |
Range on Protein: 582-792 Range on HMM: 1-239/294 Sequence Identity: 20% (51 aa) IIQGEHLGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLDPSHRDIS-LAFFEAASMMRQVS-HKHIVYLYGVCVRDV-ENIMVEEFVEGGPLDLFM . |. .|.| ... |.. . ..|...|..| | ...| . .|. ..||... |..|| ..|.|... .. |....| |. . LEVGDVIGEGAFGQVWRGEVWGIW----KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYL HRKSDA-------------------------LTTPWKFKVAKQLASALSYLED--KDLVHGNVCTKNLLLAREGID--SDIGPFIKLSDPGIPVSVL-TR ... .| .. . |.|.|....||. | ||...|..| ||.. .. .| | .... . ..| .. RTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQ QECIERIPWIAPECVE-DSKNL-SVAADKWSFGTTLWEICYNGEIP .. . | | ||| . .. . | |||| ..|||. .|. | GRIPIR--WMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACP |
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| Kinase | JAK1.AA | TyrKc | 582-844 | 22 | 2.1e-16 | 42.56 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 582-844 Range on HMM: 1-280/280 Sequence Identity: 22% (68 aa) IIQGEHLGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQV--SHKHIVYLYGVCVRD-------VENIMVEEFVEGG | |. ||.| .| ||. |.| |.| ... .| . |..|... .|..|| |||||. . .| |....| ITLGKKLGEGAFGEVYKGTWK-------------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG PLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTR-------QECI------ER--IP- |. . ... . |... . . . | |. .||..| ..| . | |..... .| || | . . .. .| DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI -WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP--------LKDKTLIEKERFYESRCRPVTP-------SCKELADLMTRCMNYDPNQRPFFRAI | |||| . . . . | |||| ..|||. .|. | .... .||. . . . .| . .|. ..|..| ..||..|| |..| RWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI MRDI ... HECF |
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| Kinase | JAK1.AA | S_TKc | 582-846 | 16 | 1.2e-14 | 37.95 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 582-846 Range on HMM: 1-231/231 Sequence Identity: 16% (47 aa) IIQGEHLGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEG--GPLDLFMH ....|.|. | .. . . .| .|... . ..... |..|| ||.|.. . || |...| | | ... YEILRKIGKGAFGKVYKCRHKK----------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIK RKSDA-----LTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWIAPECVEDSKNLSV-AA .. .. . ....|...|| |. .. .| . |.|| . ||..| |. . .. ..||| . . .. KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL---TTFCGTPWYMAPEVL----GYGKCKC DKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMR-------DINK | ||.| .|.| .. |. | . .. .. . .|. |.. .|...||..|| ... . DWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | JAK1.AA | UTK | 634-738 | 25 | 2.3e-11 | 35.12 | In-house | 53-168 (296) | Show / Hide |
Range on Protein: 634-738 Range on HMM: 53-168/296 Sequence Identity: 25% (29 aa) FFEAAS---MMRQVS-HKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSD-------ALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLA | | | || |.. | ... |.|||... ..| |. |.| |. .. | .. .|| . . | . |....||. . .||.... .| |.. FMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVH REGIDSDIGPFIKLSD . . . . ..|..| MHRMMWHCMMVCKIAD |
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| Kinase | JAK1.AA | Ack | 638-723 | 29 | 1.5e-10 | 31.83 | In-house | 53-140 (266) | Show / Hide |
Range on Protein: 638-723 Range on HMM: 53-140/266 Sequence Identity: 29% (27 aa) ASMMRQVSHKHIVYLYGVCVRDVEN-IMVEEFVEGGPLDLFMHRKSD----ALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAR .. | . | |.| |||| |.|. || |. ..| | .. ..| . | . |.|....||| | ..| . . |.||.. VAIMHSLDHPHLVRLYGV-VLDQPMLMMVTELAPCGSLLDCLRKHCRTAFFLIHTLCDF--CMQIAMGMRYLEMKRCIHRDLAARNILLFS |
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| Kinase | JAK1.AA | Syk | 582-711 | 28 | 1.7e-10 | 32.29 | In-house | 1-129 (257) | Show / Hide |
Range on Protein: 582-711 Range on HMM: 1-129/257 Sequence Identity: 28% (38 aa) IIQGEHLGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLDPSHRD--ISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIM-VEEFVEGGPLDLFM ..|.. .| | . .|. |. | |.. ||| .|.| | . | |. | | |..|| . |.| | | | | .|.||. .. LVQDNEIGCGNFGSVHKGW---YMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGIC--HAEMMMMVMEMAELGPMHKYL HRKSDALTTPWKFKVAK-QLASALSYLEDKDLVH . . |. .. | |. ||| | || QQHRHEITANNVLELWHTQVAMGMCYLEEKHFVH |
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| Kinase | JAK1.AA | EGFR | 611-721 | 26 | 2.4e-10 | 30.4 | In-house | 24-134 (258) | Show / Hide |
Range on Protein: 611-721 Range on HMM: 24-134/258 Sequence Identity: 26% (30 aa) AEEKKIKVILKVL-DPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDL .|. || | ||| . . . . .. . | .| | |.|.| | |||. . .| . | | ... |.. . | |. ..|||.. . GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKDNIGSQHLLNWCVQIAKGMQYLEEHRM VHGNVCTKNLLL || . . | |. VHRDLAARNVLV |
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| Kinase | JAK1.AA | Pkinase | 582-704 | 17 | 2.3e-08 | 30.63 | Pfam | 1-124 (293) | Show / Hide |
Range on Protein: 582-704 Range on HMM: 1-124/293 Sequence Identity: 17% (24 aa) IIQGEHLGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLDPSHRDISL---AFF--EAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGG---- . |. .|.|. | .. .. . .| .|... .|.. . .. |.. .|. ..|..|| ||... .. . || |..||| YHIGRKIGSGSFGCVYKCHHKGTGK----------IVAVKIIKKRHEKSWKDQTHRRLSEIQ-IMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVM PLDLFMH-RKSDAL--TTPWKFKVAKQLASALSYL | ... ... .. . ....|....| |. DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYC |
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| Kinase | JAK1.AA | Pkinase | 755-844 | 16 | 2.8e-08 | 30.37 | Pfam | 175-293 (293) | Show / Hide |
Range on Protein: 755-844 Range on HMM: 175-293/293 Sequence Identity: 16% (20 aa) IPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDK----TLIEKERFYESRCRPVTPSC------------------------KELADLMTRC ....||| . ... . ..| ||.| .|.| . |. | ... .. ....... ...|. .. .|. |....| PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC MNYDPNQRPFFRAIMRD--I ..||..|| .. |. . . LCKDPKKRPTAEQILQHPWF |
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| Kinase | JAK1.AA | Src | 633-711 | 28 | 6e-06 | 16.27 | In-house | 40-120 (255) | Show / Hide |
Range on Protein: 633-711 Range on HMM: 40-120/255 Sequence Identity: 28% (23 aa) AFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMH--RKSDALTTPWKFKVAKQLASALSYLEDKDLVH || . | | ...|...| || || .. | |. . | | . . .. .| | | | |. .||| . ..| AFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIH |
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| Kinase | JAK1.AA | UTK | 757-792 | 38 | 2e-05 | 14.56 | In-house | 205-240 (296) | Show / Hide |
Range on Protein: 757-792 Range on HMM: 205-240/296 Sequence Identity: 38% (14 aa) WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP | |||.. . . . | |||| ..|||. .| | WMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLP |
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| Kinase | JAK1.AA | Ack | 755-784 | 50 | 3.4e-05 | 13.48 | In-house | 175-203 (266) | Show / Hide |
Range on Protein: 755-784 Range on HMM: 175-203/266 Sequence Identity: 50% (15 aa) IPWIAPECVEDSKNLSVAADKWSFGTTLWE ..| |||| . | | | |.|| |||| FAWCAPECLR-HRQFSHASDVWMFGVTLWE |
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| Kinase | JAK1.AA | UTK | 818-844 | 37 | 8.2e-05 | 12.4 | In-house | 270-296 (296) | Show / Hide |
Range on Protein: 818-844 Range on HMM: 270-296/296 Sequence Identity: 37% (10 aa) ELADLMTRCMNYDPNQRPFFRAIMRDI .. .||.||..||| || |. . . PVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | JAK1.AA | EGFR | 755-845 | 27 | 0.00025 | 10.08 | In-house | 167-258 (258) | Show / Hide |
Range on Protein: 755-845 Range on HMM: 167-258/258 Sequence Identity: 27% (26 aa) IPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCR-PVTPSC-KELADLMTRCMNYDPNQRPFFRAIMRDIN | |.| ||.. . . | ||.| |.||. |. | . . | . | | | | | . .| .| |.. || |. .. . IKWMALECIHHRC-YTHQSDVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK |
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| Kinase | JAK1.AA | TK-Unique | 814-844 | 33 | 0.000743 | 9.32 | In-house | 262-294 (294) | Show / Hide |
Range on Protein: 814-844 Range on HMM: 262-294/294 Sequence Identity: 33% (11 aa) PSC--KELADLMTRCMNYDPNQRPFFRAIMRDI ..| .|. || .| ...| .|| ||.| . EHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | JAK1.AA | Syk | 757-784 | 53 | 0.001411 | 8.16 | In-house | 175-201 (257) | Show / Hide |
Range on Protein: 757-784 Range on HMM: 175-201/257 Sequence Identity: 53% (15 aa) WIAPECVEDSKNLSVAADKWSFGTTLWE | ||||. | | . | |||| |.|| WYAPECIYYYK-FSHKSDVWSFGVTMWE |
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| Kinase | JAK1.AA | Src | 757-792 | 38 | 0.007137 | 5.54 | In-house | 166-200 (255) | Show / Hide |
Range on Protein: 757-792 Range on HMM: 166-200/255 Sequence Identity: 38% (14 aa) WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP | |||.. . . .. .| |||| |.|| | .| WTAPEAI-NYGRFTIKSDVWSFGILLTEIVTYGRVP |
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| Kinase | JAK1.AA | Src | 821-844 | 33 | 0.021195 | 3.91 | In-house | 232-255 (255) | Show / Hide |
Range on Protein: 821-844 Range on HMM: 232-255/255 Sequence Identity: 33% (8 aa) DLMTRCMNYDPNQRPFFRAIMRDI ..|..| . || ||| | . QIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | JAK1.AA | Syk | 821-838 | 38 | 0.031908 | 3.43 | In-house | 240-257 (257) | Show / Hide |
Range on Protein: 821-838 Range on HMM: 240-257/257 Sequence Identity: 38% (7 aa) DLMTRCMNYDPNQRPFFR .|| .| |.. || | QLMNKCWIYKWCDRPTFV |
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| Kinase | JAK1.AA | Ack | 821-844 | 33 | 0.264727 | 0.16 | In-house | 243-266 (266) | Show / Hide |
Range on Protein: 821-844 Range on HMM: 243-266/266 Sequence Identity: 33% (8 aa) DLMTRCMNYDPNQRPFFRAIMRDI ..| .| .| || | || . QMMMQCWQHHPADRPTFSAIRDQL |
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| Kinase | JAK1.AA | Jak | 874-1150 | 41 | 1.9e-156 | 526.01 | In-house | 1-299 (299) | Show / Hide |
Range on Protein: 874-1150 Range on HMM: 1-299/299 Sequence Identity: 41% (123 aa) LKRIRDLGEGHFGKVELCRYDPEG------DNTGE--QVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKE ||....|||||||.|..||||... |...| ||.|| .. ... .|. |...||.|.....|..||||.|.|...........||....|.|.. LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD YLP----KNKNKINL--KQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQ---VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCK ||. ..|...|. ......|.|||.||.||....|.|.|..|||.||..|.. |||..|.|.... .|||||....|||....||||||| .|| YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK FYI--ASDVWSFG-VTLHELL-TYCDSDFSPMALFLKMIG-PTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFEA || |.|.|||| |||.|.. .|||.. ||.|.||.||| ....||...|..|....|.|||.|..|.||.|.||..||...|..|..|...|. ... FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ |
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| Kinase | JAK1.AA | Pkinase_Tyr | 874-1148 | 38 | 7.79999999999e-130 | 440.35 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 874-1148 Range on HMM: 1-270/270 Sequence Identity: 38% (108 aa) LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNH--IADLKKEIEILRNL-YHENIVKYKGICMEDGGN-GIKLIMEFLPSGSLKEYLPK .. .. ||||.||.| ........|||. .||||.||. . . ..|. .|..|...| .|.|||.. |.|...|. | ..||. | |.|..|| | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK N---KNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYY-TVKDDRDSPVFWYAPECLIQCKFYIASDVWS . |.....|. |....||.|||.|| |....||||||||.||.....|||.||||...| ....|| ..... . |..|.||||. .|| ..||||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS FGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTL-KEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGF |||.. |..||... | |. ..... . ..| |.|||.|||||.|.||..||...|..| ||. ..| . FGVLMWEIFTYGEQP-------------TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | JAK1.AA | TyrKc | 874-1148 | 37 | 2.8e-124 | 420.11 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 874-1148 Range on HMM: 1-280/280 Sequence Identity: 37% (111 aa) LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL--YHENIVKYKGICMEDGG-----NGIKLIMEFLPSGSLKEY .. .. ||||.||.| ..... .|||||.||... ..|. .|..|...| |.|||. |.|...|. . ..||. | |.||.| ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY LPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETD------KEYYTVKD--DRD--SPVFWYAPECLIQCK | |...|...|. |....||..||.|| |....||||||||.|| ..|.|||.||||...|. | |.||..| ... |. |.||||. .| LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK FYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPN--------CPDEVYQLMRKCWEFQPSNRTTFQNLIEGF | ..||||||||.. |..||... . |.. |. ..... .|.|.|.|.||| ||||.||.|..||...|..| ||....| | FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | JAK1.AA | TK | 874-1148 | 20 | 7.4e-96 | 321.84 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 874-1148
Range on HMM: 1-486/486
Sequence Identity: 20% (100 aa)
LKRIRDLGEGHFG---KVELCRYDPE---------------------GDNTGEQVAVKSLKPESGGNHIADLK----------------KEIEILRN--L
.. .. ||||.|| .| .... .. .... ..|||| ||.... . . . |...... .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
YHENIVKYKGICMEDGG----------NGIKLIMEFLPSGS----LKEYLPKNKNK--------------------------------------------
|.|||. |.|..... . ..||. | |. |..|| |...|
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------INLKQQLKYAIQICKGMDYLGSR------QYVHRDLAARNVLVESEHQ-----------VKIGDFG---
....|.| .. ||..|| || |. ..|||||||||.|| .... .||.|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----LTKAIETDKEYYTVKD-----------------------DRDSPVFWYAPECLI---------QCKFYIASDVWSFGVTLHELLTYCDSDFSP-M
|...|. |..||.... .. |. |.||||| || ..||||||||...|..||.. . . |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
AL-----FLKMIGPTHGQMTVTRLVNTLKEG--------------KRLPCPPNCP--------------DEVYQLMRKCWEFQPSNRTTFQNLIEGF
. ... ... |..| |.|.||.|| .|.|.||..||...|. | ||. | | .
SNQDVWKD---------G-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | JAK1.AA | Frk | 874-1152 | 36 | 1e-60 | 208.01 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 874-1152 Range on HMM: 1-260/260 Sequence Identity: 36% (103 aa) LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLP---KN .. || || | ||.| .. | |||| ||| | |. .| |...| | ... .| . . | .| | . |||.||| .. IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTLKP--GTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVE--EPIYIITELMRHGSLQEYLQAINDK KNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKE-YYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVT ......|.. | |. || || |. |.|||||||||||. . .|| |||| . . |.| | . . |. | ||| || | |||||||. GRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGIL LHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALL | |..|| .| | | || .. ...| |.|.||||| ..|..| .||. .| .| || | .| . LTEIITYG-----------RM--PYPG-MTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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| Kinase | JAK1.AA | UTK | 874-1076 | 28 | 1.4e-59 | 202.47 | In-house | 1-236 (296) | Show / Hide |
Range on Protein: 874-1076 Range on HMM: 1-236/296 Sequence Identity: 28% (69 aa) LKRIRDLGEGHFGKVELCRYDPEGDNTGE-QVAVKSLKPESGGNHIAD----LKKEIE---ILRNLY-HENIVKYKGICMEDGGNGIKLIMEFLPSGSLK ... |.||.|.|| | ..|.... . .| .|||| ..... ... . . .| .. ... |.|... |.|. ... . ...|. . |.| VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR EYLPKNKNKIN-------LKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEH-------QVKIGDFG---LTKAIET--------DKEYYTVKDD || ... . . | |.|..| .| || || |...|||||||||.|| . . ..||.||| ..... | . .||. .. SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ RDSPVFWYAPECLIQC-KFYIASDVWSFGVTLHELLTY . |. |.|||.|.. .| ..||||||||...|..|. DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW |
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| Kinase | JAK1.AA | EGFR | 874-1076 | 38 | 3.8e-58 | 191.6 | In-house | 1-199 (258) | Show / Hide |
Range on Protein: 874-1076 Range on HMM: 1-199/258 Sequence Identity: 38% (78 aa) LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNK ||... || | ||.| . |||.| ||.| |. ..| . .. | .. . |...|. |.||.. ..|. ..| |.| .|. ..|.. LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ---MQLVTQYMPYGCLLDYVRQHKDN INLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHEL | ...| ...|| ||| || .. |||||||||||| | .||| |||| | | |.. |.... . |. | | ||. . .. .|||||.|||. || IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGK-MPIKWMALECIHHRCYTHQSDVWSYGVTCWEL LTY .|. MTF |
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| Kinase | JAK1.AA | S_TKc | 874-1152 | 23 | 4.8e-58 | 200.06 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 874-1152 Range on HMM: 1-231/231 Sequence Identity: 23% (70 aa) LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPS--GSLKEYLPKNK . .| .|.| |||| .|| ||..||.| .| ....||.||.. |.||||..... . . . ..||... |.|..|. |.. YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRG NK-----INLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYI-ASDVWS . .. . .|. |||....|. |.. .|||| |.|. . ..||.|||| . . . .. ||| | .. ..|.|| RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWS FGVTLHELLT----YCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGF-----EALL .|..| |.|. .. |.. .|.|| ..|. ...|||... |..| | . .. . CGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | JAK1.AA | Src | 874-1076 | 38 | 2.6e-57 | 193.25 | In-house | 1-196 (255) | Show / Hide |
Range on Protein: 874-1076 Range on HMM: 1-196/255 Sequence Identity: 38% (78 aa) LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLP--KNK .|..| ||.|.|| | .. .|| .||||.||| . . ... .|..|. .| ||..|. .| .. | . |. ||| .|| . IKLCRKLGQGQFGEVWMGYWN---GNT--KVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE--PIYIVTEYMSHGSLLDYLKKDGEG NKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLH ...|.|.. | |. .||.||.|..|.||||||||||| . .|..|||| . |. |.. |. . . |. | |||.. .| | |||||||. |. RHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLT ELLTY |. || EIVTY |
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| Kinase | JAK1.AA | TKL | 880-1148 | 20 | 5e-55 | 189.14 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 880-1148
Range on HMM: 1-364/364
Sequence Identity: 20% (80 aa)
LGEGHFGKVELCRYD------PEGDNTGEQVAVKSLKPESGGN--------------------------HIADLKKEIEILRNLYHENIVKYKGICMEDG
.|.|.||.| .. | . .||. |||| .| .. . ...|| ....| |.|||...|.|.. .
IGSGGFGEVYKGKWRGWGGKCP-S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP
GNG-----------IKLIMEFLPSGS-LKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQ--------YVHRDLAARNVLVESEHQ------------
... . ..||. | || | .. . | .. |..|..||.|| |.. .|||| .|.|| . .
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD
--VKIGDFGLTKAIETDKEYYTVKDD-------------RDSPV---FWYAPECLIQC----------------KFYIASDVWSFGVTLHELLTYCDSDF
.||.|||| . ...... . . . ... | |||.| . .. ..||.|||. | |.|| |
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---
SPMALFLKMIGPTHGQMTVTRL---------VNTLKEGKRLPCP------------PNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGF
| .... ... . ..|.|.|.| |.||... .|| .||. |..| .|| ... .
-----------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | JAK1.AA | Ack | 874-1076 | 35 | 3.4e-53 | 177.77 | In-house | 1-207 (266) | Show / Hide |
Range on Protein: 874-1076 Range on HMM: 1-207/266 Sequence Identity: 35% (74 aa) LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPE--SGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNK ... ||.| || | . .. |||||.|... . .| . |. .| |. .| |...|. |. .....|. | ||| . | | . ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPM--LMMVTELAPCGSLLDCLRKHC N--KINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESE-HQVKIGDFGLTKAIETDKEYYTVKDDR--DSPVFWYAPECLIQCKFYIASDVWSF . . . .. ||..|| ||... .||||||||.|. | |||.|||| | . ||. . | | | ||||| . .| |||||.| RTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMF GVTLHELLTY |||| | .| GVTLWEMFSY |
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| Kinase | JAK1.AA | TK-Unique | 874-1076 | 31 | 2.1e-52 | 179.01 | In-house | 1-235 (294) | Show / Hide |
Range on Protein: 874-1076 Range on HMM: 1-235/294 Sequence Identity: 31% (75 aa) LKRIRDLGEGHFGKVELCRYDP--EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLY-HENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKN |. . .||| || | . . . .... .|||| || .. . .|..|||.....| |.|||. |.|.... . .|||..| |.| || .. LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC KNK-------------------------INLKQQLKYAIQICKGMDYLGS--RQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSP . . |..|. . .|.||..|| || | .. |||||.|||||. . ...||.|||... ..|...| . . | RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP VFWYAPECLI--QCKF-YIASDVWSFGVTLHELLTY . | ||| | . . .. ||||||||.. |..|. IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL |
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| Kinase | JAK1.AA | Syk | 874-1076 | 36 | 1e-47 | 162.36 | In-house | 1-205 (257) | Show / Hide |
Range on Protein: 874-1076 Range on HMM: 1-205/257 Sequence Identity: 36% (76 aa) LKRIRDLGEGHFGKVELCRYDPE---GDNTGEQVAVKSLKPESGG-NHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPK | . . .| | || | | |. .||.| || . . . . | .. | | ||. ||| . ..|| . |.. || . LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICH---AEMMMMVMEMAELGPMHKYLQQ NKNKINLKQQLKYAI-QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGV ... | . |. |. || || ... ||||||||||| . .|. || |||. || | .||. . || |||||| || .|||||||| HRHEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGV TLHELLTY |. | . | TMWEMFSY |
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| Kinase | JAK1.AA | Pkinase | 874-1148 | 21 | 1.8e-38 | 137.1 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 874-1148 Range on HMM: 1-293/293 Sequence Identity: 21% (68 aa) LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKK-----EIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSG----SLK ....| .|.| ||.| .|. .|. .|||| .| . ... .. ||.|...| |.|||........ .. | ..||... | .|. YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLF EYLP-KNKNKI--NLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQV----KIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLI-QCK .|. ...... .. .|. ||..|..|. |. .|||| |.|. .. .. ||.|||| | .. .. ... .. ||| . . . DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQY FYIASDVWSFGVTLHELLTYCDSDFSPMALFLKM----IGPTHGQMTVTRLVNTLKEGKRLPCP---------------PNCPDEVYQLMRKCWEFQPSN ..|.||.|..|.|.|. .| .. || . .. |.. .|. .| ..| .....|... |. YGPKVDMWSCGCILYEMLCGR-------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK RTTFQNLIEG--F | |.. . . | RPTAEQILQHPWF |
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| Kinase | JAK1.AA | Syk | 1107-1142 | 47 | 9.6e-17 | 54.15 | In-house | 222-257 (257) | Show / Hide |
Range on Protein: 1107-1142 Range on HMM: 222-257/257 Sequence Identity: 47% (17 aa) LKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQ .. |.|..||. ||.|.||||.||| .. .| || IENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV |
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| Kinase | JAK1.AA | Src | 1098-1148 | 40 | 9.6e-15 | 46.47 | In-house | 204-255 (255) | Show / Hide |
Range on Protein: 1098-1148 Range on HMM: 204-255/255 Sequence Identity: 40% (21 aa) MTVTRLVNTLKEGKRLPCPPNCPDEVYQ-LMRKCWEFQPSNRTTFQNLIEGF || . .. | |.|||.|||||.|. .|..||. .| | || | . . MTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | JAK1.AA | Ack | 1108-1148 | 43 | 2.2e-14 | 44.95 | In-house | 226-266 (266) | Show / Hide |
Range on Protein: 1108-1148 Range on HMM: 226-266/266 Sequence Identity: 43% (18 aa) KEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGF ||| ||| |. || ..||.| .||...| | || .. . . KEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL |
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| Kinase | JAK1.AA | UTK | 1109-1148 | 40 | 3.8e-14 | 44.79 | In-house | 255-296 (296) | Show / Hide |
Range on Protein: 1109-1148 Range on HMM: 255-296/296 Sequence Identity: 40% (17 aa) EG--KRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGF .| |.|||. ||..||.||..||. |..| .|. | . . NGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | JAK1.AA | EGFR | 1107-1149 | 46 | 8.6e-13 | 38.63 | In-house | 216-258 (258) | Show / Hide |
Range on Protein: 1107-1149 Range on HMM: 216-258/258 Sequence Identity: 46% (20 aa) LKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFE |..|.||| ||.| ||..| ||| . | ||. |.| |. LEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK |
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| Kinase | JAK1.AA | TK-Unique | 1096-1148 | 27 | 3.6e-12 | 38.37 | In-house | 241-294 (294) | Show / Hide |
Range on Protein: 1096-1148 Range on HMM: 241-294/294 Sequence Identity: 27% (15 aa) GQMTVTRLVNTLKEGKRLPCPPNC-PDEVYQLMRKCWEFQPSNRTTFQNLIEGF ..| ..... ...|.|.| |..| ..|.|.||. || |. | .| .. . PGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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