Gene JAK3 (Mouse)

JAK3

Species: Mouse
Alias: JAK3, Jak3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation: Secondary Group: TK, Secondary Family: JakB,

Classification

Group: TK
Family: Jak

Sequence

Name Sequence Type Origin Length Description Download
JAK3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 276 Kinase domain by global Sugen HMM Fasta, JSON
JAK3.NA RNA Sugen 3784 None Fasta, JSON
JAK3.AA Protein Sugen 1100 None Fasta, JSON
JAK3.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 273 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of JAK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B41 JAK3.AA B41 20-254 21 8.7e-45 156.02 SMART 1-232 (232) Show / Hide 
Range on Protein: 20-254
Range on HMM: 1-232/232
Sequence Identity: 21% (56 aa)

SSEAGALHVLLPPRGPGPPQRLSFSFG-DYLAEDLCVRAAKACGILPVYHSLFALATEDF---SCWFPPSHIFCIEDVDTQ-------VLVYRLRFYFPD
|..   ..|... ..      |.| ..  . ..|||. ... |||.|..| .|.|. ||    ..| .  | . | ..|..       .|..| .||.||
SPKPRFCRVYFMDGT-----TLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLD--HWKTIMKQDVKWHKSEPWTLHFRVKFYPPD

WFGLETCHRFGLRKDLTSAILDLHVLEHLFAQHRSDLVSGRLPVGLSMKEQGEFLSLAVLDLAQMAREQAQR-------PGELLKTVSYKACLPPSLRDV
|.|           .  . ..|  .......| |.|...||.|.      . | | ||.|..  .. .. .        . ...| .||| .||....| 
WHG-----------FPNQLQEDPTRYNYFYLQCRHDILQGRHPCP----HEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWIDS

IQ---GQNFVTRRRIRRTVVLALRRVVACQADRYALMAKYILDLERLHPAATTETF
|.   .. . .. ..|. .. . ...  |.  .. .. ||.  ..|..|.  .| |
IKQSFMHYQMHHKEWRKRIMEWHKNH--CGMTPEEAKLKYLQICQRWPPMYGVEHF
Kinase JAK3.AA SH2 370-460 21 2.3e-10 41.68 SMART 1-87 (87) Show / Hide 
Range on Protein: 370-460
Range on HMM: 1-87/87
Sequence Identity: 21% (20 aa)

AELCHGPITLDFAIHKLKAAGSLPGTYILRRSPQDYDSFLLTACVQTPLGPDYKGCLIRQDPSGAFSLVG-LSQPHRSLRELLAACWNSGLR
 . .||.|. . | ..||. |  .|....| | ..  .. |. ...      .| ..||....| ... .  . .. || ||..      |.
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase JAK3.AA Jak 311-377 12 0.021618 4.5 In-house 74-144 (299) Show / Hide 
Range on Protein: 311-377
Range on HMM: 74-144/299
Sequence Identity: 12% (9 aa)

EHRLVTVTRMDGHILEAEFPGLPEALSFVA----LVDGYFRLICDSRHYFCKEVAPPRLLEEEAELCHGPI
.|..... . |..... |.  . ......     . ... ..  |. ..|.|...... ..|.  ..||..
YHGVCCHWCQDEYCMVMEYWCYGPLDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDV
Kinase JAK3.AA Jak 517-775 36 3e-133 448.96 In-house 1-299 (299) Show / Hide 
Range on Protein: 517-775
Range on HMM: 1-299/299
Sequence Identity: 36% (109 aa)

LEWHENLGHGSFTKIFRGRRREVVD-----GETHD--SEVLLKVMDSRHRNCMESFLEAASLMSQVSYPHLVLLHGVC--MAG-DSIMVQEFVYLGAIDM
|.|||.||.|.|....|.|.....|     ...|.   .|..||....|......| ...|.|||.|..|.|..||||  ... ...||.|.. .|..|.
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

YLR----KRGHLVSA--SWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGG--DGNPPFIKLSDPGVSPTVLSLEML--TDRIPWVAPECLQE-A
||.    .. . |..  .||.|..||......|||||...||.|.||..|..|||   ....||.||.||..|......||.  ..||||.|||||.. .
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

QTLGLEADKWGFG-ATTWEVF----------------SGGPAHITSLEPAKKLKFYEDQGQLPALK--WTELAGLITQCMAYDPGRRPSFRAILRDLNG
..| |..|||.|| .| ||..                ..|.... ......||.|||....||. .  |.|.. |..||..||| .|||||.|.|||| 
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase JAK3.AA Pkinase_Tyr 517-773 26 1.4e-63 215.93 Pfam 1-270 (270) Show / Hide 
Range on Protein: 517-773
Range on HMM: 1-270/270
Sequence Identity: 26% (73 aa)

LEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLKVM--DSRHRN-CMESFLEAASLMSQV-SYPHLVLLHGVCM-AGDS---IMVQEFVYLGAIDMYL
..  . ||.|.| ....|. .   |.. .. .|  |..  .. |.. |.|.|.. |..|.|  . |..| |.|||.  |..   ..| |.. .|  . ||
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RKR---GHLVSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNPPFIKLSDPGVSPTV-------LSLEMLTDRIPWVAPECLQEAQTL
||.   .. .. ...||   | | ...|||.|.. |  . || .|...      . ..| .| | . ..        . .     |.| ||||...    
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-F

GLEADKWGFGATTWEVFSGGPAH-ITSLEPAKKLKFY-EDQGQLPALK--WTELAGLITQCMAYDPGRRPSFRAILRDL
  . | | || . ||.|. |       . ..  ...  || ...|. .  . |.  |..||..||| .||.|..|...|
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase JAK3.AA TK 517-773 14 2.4e-44 146.07 In-house 1-486 (486) Show / Hide 
Range on Protein: 517-773
Range on HMM: 1-486/486
Sequence Identity: 14% (73 aa)

LEWHENLGHGSFT---KIFRGRRREVVDGETHDS-------------------EVLLKVMDSRHRNCMES--------------FLEAASLMSQVS----
..  . ||.| |    ....|. |.  ... ...                   .|  |.. . . . .|               ||| |. |.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-YPHLVLLHGVCMAGD-------------SIMVQEFVYLGA----IDMYLRKRGHL--------------------------------------------
  |..| |.|||. |.              ..| |.. .|      . ||||. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VSASWKLQVTKQLAYALNYLEDK------GLPHGNVSARKVLLAREGG-----DGNPPFIKLSDPG---
                               ..  ..|    |.| .. ||..|      .. |... || .|.....      ||..|..|..| |   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----VSPTVLSLE------------------------------MLTDRIPWVAPECLQEAQ--------TLGLEADKWGFGATTWEVFSGG----PAHI
      .  . | .                                   | | |||||.. .        .   . | | || . ||.|. |    .  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TS------LEPAKKLKFYEDQGQ-------------LPALKW------------------TELAGLITQCMAYDPGRRPSFRAILRDL
..        . . .  |  .|.             ..  .                   .|.. |..|| .||| .||.|..... |
SNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase JAK3.AA TyrKc 517-773 21 1.1e-14 14.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 517-773
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

LEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLKVMDSRHRNCMESFLEAASLMSQV--SYPHLVLLHGVCMA--------GDSIMVQEFVYLGAIDM
..  . ||.| | ....|. .          .|  |.. . .   .| |.. |..|...  . |..| |.|||.         .   .| |.. .|. . 
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRKRGHLVSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNPPFIKLSDPGVSPTVLSL-------EMLT------DR--IP--WVAP
||||... .. . .|.   | |   .||..|.. |    || .|.....       .| || | |  . .        .. .       .  .|  | ||
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

ECLQEAQTLGLEADKWGFGATTWEVFSGG--PAHI-----TSLEPAKKLKFYEDQGQLPAL--------KWTELAGLITQCMAYDPGRRPSFRAILRDL
||...      . | | || . ||.|. |  |         | . . ..    .    |.           .|.  ...|| ..||  ||.|..| ...
ECINYGKF-TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase JAK3.AA EGFR 517-714 27 1.5e-13 41.19 In-house 1-196 (258) Show / Hide 
Range on Protein: 517-714
Range on HMM: 1-196/258
Sequence Identity: 27% (56 aa)

LEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLKVM-DSRHRNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDSIMVQEFVYLGAIDMYLRKRGHLV
|     || | | ....|    . .||.    |  ||. ..  ..  | .|. |  |  |  |||| | ||||. .  .|  .  .|..  |.|.    .
LKKVKVLGSGAFGTVYKGIW--IPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNI

SASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNPPFIKLSDPGVSP--TVLSLEMLTDR----IPWVAPECLQEAQTLGLEADKWGFGA
 .   |    | |  ..|||.. . | .  || ||.        |  .|  | |..    . . |.  .     | |.| ||... .    . | | .| 
GSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKS------PNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHH-RCYTHQSDVWSYGV

TTWEV
| ||.
TCWEL
Kinase JAK3.AA UTK 517-718 22 3.1e-13 41.62 In-house 1-237 (296) Show / Hide 
Range on Protein: 517-718
Range on HMM: 1-237/296
Sequence Identity: 22% (53 aa)

LEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLKVMDSRHR--NCME---SFLEAAS---LMSQVS-YPHLVLLHGVCMAGDSIM-VQEFVYLGAIDM
..  . ||.| |  ....|.... . .. .. | .|| ....     .|    |.| |    .|.|..  |... | |||...  .| | |.   |  . 
VQLGRQLGQGAFGEVHKARFTQCSEHMY-EMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

YLRKRGH-------LVSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREG--GDGNPPFIKLSDPG---VSPTVLS-----------LEMLTDR
|||. ..       ...   .|.   . | ...||. .|. |... || .|... .  .     ..|..| |    |  | .           ..| ...
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWH-CMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

IP----WVAPECLQEAQTLGLEADKWGFGATTWEVFSGG
 .    | |||.| .. .  .  | | || . ||....|
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWG
Kinase JAK3.AA S_TKc 517-777 19 6.9e-13 12.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 517-777
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

LEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLKVMDSRHRNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDSIMVQEFVYL--GAIDMYLRKRGHL
 | .. .|.|.| | ...| ..       . .| .|...       |...   .....   |..| |..|.  ..  || |..    |    |..|||. 
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRH

-----VSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNPPFIKLSDPGVSPTVLSLEMLTDRI---PWVAPECLQEAQTLGL-EADKW
      .  .   ...|.. ||.|. ..|  |  .    .|| .         ||..| |..  .      |  .    ..||| |      |  ..| |
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWW

GFGATTWEVFSGGPAHITSLEPAKKLKFYEDQGQLPALKWTELAGLITQCMAYDPGRRPSFRAILR-----DLNGLI
 .| . .| ..| |      .... .|              |.  .| .|. .|| .||.   .|.      .   .
SCGCILYEMLCGYPPFP---QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase JAK3.AA TKL 523-773 14 1.9e-12 41.12 In-house 1-364 (364) Show / Hide 
Range on Protein: 523-773
Range on HMM: 1-364/364
Sequence Identity: 14% (54 aa)

LGHGSFTKIFRGRRR------EVVDGETHDSEVLLKVMDSRHRNC---------------------------MESFLEAASLMSQVSYPHLVLLHGVCMA
.| |.| ....|. |          .   . .|  |.. |.. ..                           .. . | . .||. . |..|.. |.|..
IGSGGFGEVYKGKWRGWGGKCP---S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCC

GDS--------------IMVQEFVYLGAIDMYLRKRGHLVSASWKLQVTKQLAYALNYLED--------KGLPHGNVSARKVLLAREGGDG--------N
...               .| |..  |    ||         . ...  .. | ..|||          ... | .   . .|. . . .         .
PPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

PPFIKLSDPGVSPTV--------------------LSLEMLTDRI---PWVAPECLQEAQ---------------TLGLEADKWGFGATTWEVFSGGPAH
. ..|..| | | ..                    .. ...  ..    | |||.|....               .    .| . ||   ||.... .  
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--

ITSLEPAKKLKFYEDQ---------------GQLPALK---------------WTELAGLITQCMAYDPGRRPSFRAILRDL
     | ....... .               |. | ..               ..... |...|...||  ||||  ||  |
-----PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase JAK3.AA Syk 517-655 28 3.2e-11 34.84 In-house 1-143 (257) Show / Hide 
Range on Protein: 517-655
Range on HMM: 1-143/257
Sequence Identity: 28% (41 aa)

LEWHENLGHGSFTKIFRGRRREV-VDGETHDSEVLLKVMDSRHRN--CMESFLEAASLMSQVSYPHLVLLHGVCMAGDSIMVQEFVYLGAIDMYLRKRGH
|.  . .|.| |  .  |  ..    ||    .| .|.    | .    . |.  |..| |   |. | . |.| |    ||.| . ||.   || . .|
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

LVSASWKLQVTK-QLAYALNYLEDKGLPHGNVSARKVLLAREG
 ..|.  | .   | |    ||| |   |    || |||  ..
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRH
Kinase JAK3.AA TK-Unique 517-716 22 6e-10 30.62 In-house 1-234 (294) Show / Hide 
Range on Protein: 517-716
Range on HMM: 1-234/294
Sequence Identity: 22% (54 aa)

LEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLKVMDSRHRNC-MESFLEAASLMSQVS-YPHLVLLHGVCMAGD--SIMVQEFVYLGAIDMYLRKRG
||  ...| |.|  ..||  ...  .. ... |..|    ...      ||  ...|...   |..| . |.|.  |    .. |... |  . |||...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

HL-------------------------VSASWKLQVTKQLAYALNYLED--KGLPHGNVSARKVLLAREGGDGNPPFIKLSDPGVSP-----TVLSLEML
                           .|    ..  .|.| ...||.   |.  |....|| |||..         .|..| | ..     .|.| .  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE------DKVCKICDFGMARDVYTNGVYSMMCS

TDRIP--WVAPECLQ-EAQTL-GLEADKWGFGATTWEVFS
  |||  | ||| |.   ..    . | | || . ||.|.
QGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase JAK3.AA Frk 517-777 21 1.6e-09 28.84 In-house 1-260 (260) Show / Hide 
Range on Protein: 517-777
Range on HMM: 1-260/260
Sequence Identity: 21% (59 aa)

LEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLKVMDSRHRNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDSI-MVQEFVYLGAIDMYLR---KRG
..    || | | ... |.    .        | .| . .   .  . ||  | .| .. .| |. |. ||   . | .. | .  |..  ||.   ..|
IQLIRRLGSGQFGEVWEGLWNNTT-------PVAVKTLKPGTMDPND-FLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKG

HLVSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNPPFIKLSDPGVSPTVLSLEM------LTDRIP--WVAPECLQEAQTLGLEADK
. .     .... |.|  . |||..   |  . || ||.      |.   .|. | |.   ..  .          |.|  | |||  .  .   . .| 
RQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLV------GEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNK-FTIKSDV

WGFGATTWEVFSGGPAHITSLEPAKKLKFYEDQGQLPALK--WTELAGLITQCMAYDPGRRPSFRAILRDLNGLI
| ||    |.   |      .  |. |.  .    .|       .|  .. .|   || .|| |  .   |.  .
WSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase JAK3.AA Ack 517-667 28 2.3e-08 24.31 In-house 1-149 (266) Show / Hide 
Range on Protein: 517-667
Range on HMM: 1-149/266
Sequence Identity: 28% (44 aa)

LEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLKVMDSR---HRNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDS-IMVQEFVYLGAIDMYLRKRG
.  .| || |.|    ||       |..   .|  |.  |      |||..||  .. | .   |||| |.||  . ..  || |.  .|.    |||  
ITLCEKLGDGCFGVVWRGEWTN-PGGKH--IQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHC

H--LVSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNPPFIKLSD
     . .  ..   |.| .. ||| |.. |  . || .||..         .| .|
RTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDD-----RKVKICD
Kinase JAK3.AA Pkinase 684-773 18 5.1e-05 18.84 Pfam 175-293 (293) Show / Hide 
Range on Protein: 684-773
Range on HMM: 175-293/293
Sequence Identity: 18% (22 aa)

IPWVAPECLQEAQTLGLEADKWGFGATTWEVFSGGPAHITS----LEPAKKLKFYEDQGQLPALKW------------------------TELAGLITQC
....||| ....|  | ..| |..| . .|...| |    .        .. ..... |  .   |                         |.  .|. |
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

MAYDPGRRPSFRAILRD--L
 ..|| .||... || .  .
LCKDPKKRPTAEQILQHPWF
Kinase JAK3.AA Ack 684-718 45 8e-05 12.21 In-house 175-208 (266) Show / Hide 
Range on Protein: 684-718
Range on HMM: 175-208/266
Sequence Identity: 45% (16 aa)

IPWVAPECLQEAQTLGLEADKWGFGATTWEVFSGG
..| |||||    .     | | || | ||.||.|
FAWCAPECLRH-RQFSHASDVWMFGVTLWEMFSYG
Kinase JAK3.AA UTK 751-773 34 0.000257 10.68 In-house 274-296 (296) Show / Hide 
Range on Protein: 751-773
Range on HMM: 274-296/296
Sequence Identity: 34% (8 aa)

LITQCMAYDPGRRPSFRAILRDL
| ..|..||| .||.|. ..  .
LMHRCWHYDPQERPDFEDLVQQM
Kinase JAK3.AA TK-Unique 751-773 43 0.000289 10.75 In-house 272-294 (294) Show / Hide 
Range on Protein: 751-773
Range on HMM: 272-294/294
Sequence Identity: 43% (10 aa)

LITQCMAYDPGRRPSFRAILRDL
|. .|  ..|  |||||.|.  |
LMKSCWQWEPEERPSFRQIKHRL
Kinase JAK3.AA Src 517-650 24 0.043017 2.85 In-house 1-129 (255) Show / Hide 
Range on Protein: 517-650
Range on HMM: 1-129/255
Sequence Identity: 24% (34 aa)

LEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLKVMDSRHRNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDSI-MVQEFVYLGAIDMYLR--KRGH
.   . || | |   . |  .  .       .|  |.. . .    | ||. | .| ... ..|| |. ||  .. |  |.|.   |    ||.  ..|.
IKLCRKLGQGQFGEVWMGYWNGNT-------KVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGR

LVSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVL
 ..    .  . | |   .||| . . |    || ||
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVL
Kinase JAK3.AA Src 751-773 34 0.046606 2.73 In-house 233-255 (255) Show / Hide 
Range on Protein: 751-773
Range on HMM: 233-255/255
Sequence Identity: 34% (8 aa)

LITQCMAYDPGRRPSFRAILRDL
...||   || .|| |  .   |
IMLQCWHKDPEQRPTFEYLQWFL
Kinase JAK3.AA Syk 703-718 62 0.091619 1.83 In-house 191-206 (257) Show / Hide 
Range on Protein: 703-718
Range on HMM: 191-206/257
Sequence Identity: 62% (10 aa)

DKWGFGATTWEVFSGG
| |.|| | || || |
DVWSFGVTMWEMFSYG
Kinase JAK3.AA Ack 751-773 39 0.288911 0.03 In-house 244-266 (266) Show / Hide 
Range on Protein: 751-773
Range on HMM: 244-266/266
Sequence Identity: 39% (9 aa)

LITQCMAYDPGRRPSFRAILRDL
.  || . .|  ||.| ||  .|
MMMQCWQHHPADRPTFSAIRDQL
Kinase JAK3.AA Jak 818-1093 39 3e-151 508.75 In-house 1-299 (299) Show / Hide 
Range on Protein: 818-1093
Range on HMM: 1-299/299
Sequence Identity: 39% (118 aa)

LKYISLLGKGNFGSVELCRYDPLG------DNTGP--LVAVKQLQHS-GPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRD
||... ||.|.||.|..||||...      |...   .|.||..||. .|....||.|||.|.. .....||||.||...........||||...|.|.|
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

FLQ----RHRARLHT--DRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAH---VKIADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNI
.|.    ||. ....  |....||.|||.||.||...|..|.|..||||||..|.|   |||..|.|.. .. .|.||.........|.|||||.|... 
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDRDERIPWYAPECLTNCK

FSR--QSDVWSFG-VVLYELF-TYCDKSCSPSAEFLSMMGPEREG-PPLCRLLELLAEGRRLPPPPTCPTEVQELMQLCWAPSPHDRPAFGTLSPQLDA
|..  ..|.|||| |.|.|.. .|||.|.||.|.|| |.|..... . .||.|... .| ||| |..|..|...|||.||...|..||.| |. ..|..
FYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ
Kinase JAK3.AA Pkinase_Tyr 818-1091 39 1.5e-119 405.55 Pfam 1-270 (270) Show / Hide 
Range on Protein: 818-1091
Range on HMM: 1-270/270
Sequence Identity: 39% (113 aa)

LKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQL-QHSGPDQ--QRDFQREIQILKAL-HSDFIVKYRGVSYGPGRQ-SLRLVMEYLPSGCLRDFLQR
.. .  ||.|.||.| ........|||.  |||| | ... ..|  ..|| ||..|.| | | . ||.. || .  |.. .. .|||| | |.|.|.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---RARLHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYY-VVREPGQSPIFWYAPESLSDNIFSRQSDVWS
|   . .| . .|| ..|||.|||||| ...|.||||||||.||... .|||.|||||...   .||| ..|. |  ||.|.|||......|. .|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVVLYELFTYCDKSCSPSAEFLSMMGPEREGPPLCRLLELL-AEGRRLPPPPTCPTEVQELMQLCWAPSPHDRPAFGTLSPQL
|||...|.|||...              . .| .  ...|..  .|.|.|.|. || |. .||..||.. | ||| |  .  ||
FGVLMWEIFTYGEQP-------------TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase JAK3.AA TyrKc 818-1091 36 1.4e-107 364.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 818-1091
Range on HMM: 1-280/280
Sequence Identity: 36% (110 aa)

LKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHSGPDQQRDFQREIQILKAL--HSDFIVKYRGVSYGPGR-----QSLRLVMEYLPSGCLRDFL
.. .  || |.|| | .....         |||| |...    ..|| ||..|.. |  | . ||.  ||   .||     . | .|||| | |.|.|.|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QRHRARLHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLG------KDYYVVRE--PGQ--SPIFWYAPESLSDNIF
..|| .| .. || |.|||..|||||  ..|.||||||||.|| .. .|||.||||.. .  .      ||||...|   |    || |.|||.. ...|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SRQSDVWSFGVVLYELFTYCDKSCSPSAEFLSMMGPEREGPPLCRLLELLAEGRRLPPPPT--------CPTEVQELMQLCWAPSPHDRPAFGTLSPQL
. .||||||||...|.|||...  .  ..   || ..       ...|.. .|.|.|.||         ||.|. ..|. ||.  |.||| | ..  ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQ-------EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase JAK3.AA TK 818-1091 21 5.5e-95 318.87 In-house 1-486 (486) Show / Hide 
Range on Protein: 818-1091
Range on HMM: 1-486/486
Sequence Identity: 21% (109 aa)

LKYISLLGKGNFG---SVELCRYDPL---------------------GDNTGPLVAVKQLQHSGPDQQRDFQR-----------------EIQILK--AL
....  ||.|.||    | .... ..                     ....   ||||.|    ...|..|.                  |.....  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HSDFIVKYRGVSYGPGR----------QSLRLVMEYLPSGC----LRDFLQRHRAR--------------------------------------------
| . ||.  ||.  ..           . . .|||| | |.    |||.|...| .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LHTDRLLLFAWQICKGMEYLGAR------RCVHRDLAARNILVESEAH-----------VKIADFG---
                               |.. .|| ..|||..||||| ..      ..|||||||||.|| .. .           .||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLLPLGKDYYVVREPG-----------------------QSPIFWYAPESLSDNI---------FSRQSDVWSFGVVLYELFTYCDKSCSP--
     ||. .. ..|||.....|                       . || |.|||.| |..         |. .||||||||...|.|||...   .  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

-------SAEFLSMMGPEREGPPLCRLLELLAEG--------------RRLPPPPTCP--------------TEVQELMQLCWAPSPHDRPAFGTLSPQL
       .            | ..  ..|.| .|               |.|.|| ||              .|...||| ||.. | ||| | .|  ||
SNQDVWKD------------G-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase JAK3.AA Syk 824-1085 35 4.2e-61 209.09 In-house 7-257 (257) Show / Hide 
Range on Protein: 824-1085
Range on HMM: 7-257/257
Sequence Identity: 35% (96 aa)

LGKGNFGSVELCRYDPL---GDNTGPLVAVKQLQ--HSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLH
.|.||||||    |      |.     ||.| |   |. | ..  | || |.   |   .||.  |.  ..   .. .|||  . | . ..|| ||    
IGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAE---MMMMVMEMAELGPMHKYLQQHRHEIT

T-DRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELF
.   | | . |.  || ||  .  |||||||||.| . .   || |||. | | .. .||. .  |  |. |||||.    .|| .|||||||| . | |
ANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMF

TYCDKSCSPSAEFLSMMGPEREGPPLCRLLELLAEGRRLPPPPTCPTEVQELMQLCWAPSPHDRPAFG
 |  |   |     .| |.|        .....  | |.. |. || |. .||..||   . ||| |.
SYGQK---P---YGEMKGQE--------VMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase JAK3.AA EGFR 818-1019 40 1.3e-58 193.21 In-house 1-199 (258) Show / Hide 
Range on Protein: 818-1019
Range on HMM: 1-199/258
Sequence Identity: 40% (82 aa)

LKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQL-QHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR
|| .  || | || |    . | |.|    ||.| | ...|| .. .. .|  ..  . .. .|.  ||  .   ....||  |.| ||| |... |. .
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMH---SQMQLVTQYMPYGCLLDYVRQHKDN

LHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
.    ||... || |||.||  .| |||||||||.|| | .||||.||||||||.  .. | . . |  || | | |...  ..  ||||||.|| . ||
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQG-GKMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL

FTY
 |.
MTF
Kinase JAK3.AA UTK 818-1019 32 6e-58 196.81 In-house 1-236 (296) Show / Hide 
Range on Protein: 818-1019
Range on HMM: 1-236/296
Sequence Identity: 32% (78 aa)

LKYISLLGKGNFGSVELCRYDPLGDNTGP-LVAVKQLQHSGPDQQR-----DFQREIQ---ILKALH-SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLR
..   .||.|.|| | ..|...  .  .  .||||..||....||      || .| .   ..|..|    ...  ||    .   . .|.|| . | ||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR

DFLQRHRARLH-------TDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESE-------AHVKIADFG---LAKLLP-------LGKDYYVVREP-
..|.|||  .         ...| .||.|  ||.||  ...|||||||||.|| .          .||||||   ......        . .||. . . 
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

GQSPIFWYAPESLSDN-IFSRQSDVWSFGVVLYELFTY
.. || |.|||.| ..  |...|||||||||..|..|.
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase JAK3.AA TK-Unique 818-1019 32 1e-54 187.11 In-house 1-235 (294) Show / Hide 
Range on Protein: 818-1019
Range on HMM: 1-235/294
Sequence Identity: 32% (76 aa)

LKYISLLGKGNFGSVELCRYDPLG--DNTGPLVAVKQLQ-HSGPDQQRDFQREIQILKALH-SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRH
|.  ...|.|.|| |  . . ..   ..    ||||.|. .. . ...|| .|||..|.|     ||.  |..  .. ..  ..|||.| |.|...|.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

RAR-------------------------LHTDRLLLFAWQICKGMEYLGA--RRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYYVVREPGQSP
|                           .   .|. |||||..|||||    ...|||||.|||.|. .   .||.|||.|. .  ...|   .. |  |
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

IFWYAPESLS--DNIF-SRQSDVWSFGVVLYELFTY
| | |||||.  .... . .||||||||...|.||.
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL
Kinase JAK3.AA TKL 824-1091 21 2.7e-54 186.68 In-house 1-364 (364) Show / Hide 
Range on Protein: 824-1091
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

LGKGNFGSVELCRYD------PLGDNTGPLVAVKQLQHS------------------------GPDQQRDFQREIQILKALH---SDFIVKYRGVSYGPG
.|.| || |   ..       | . .||  ||||..                            |.... ...|.. .. ..    . ||.. |..  |.
IGSGGFGEVYKGKWRGWGGKCP-S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

-----------RQSLRLVMEYLPSGCLRDFLQRHRARLHTDRLLLFAWQICKGMEYLGARR--------CVHRDLAARNILVESEAH-------------
              | .|||| | |.|...|.        .... .| .|..||.|| ...         .||||  .|||| .  .             
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-VKIADFGLAKLLPLGKD---------------YYVVREPGQS-PIFWYAPESLSDN----------------IFSRQSDVWSFGVVLYELFTYCDKSCS
 .||.||||.. .   ..                .  .   |   . | ||| | ..                 .| ..||.|||.||.|..| |     
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

PSAEFLSMMGPEREGPPL--------CRLLELLA-EGRRLPPP------------PTCPTEVQELMQLCWAPSPHDRPAFGTLSPQL
          |... |.            ... . .|.|.|.|            |.||... .||| ||.. |..|| | ..  .|
----------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase JAK3.AA Frk 818-1095 36 5e-52 178.52 In-house 1-260 (260) Show / Hide 
Range on Protein: 818-1095
Range on HMM: 1-260/260
Sequence Identity: 36% (102 aa)

LKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHSGPDQQRDFQREIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ---RH
...|  || | || |    .. | .|| | ||||.|. .|    .|| || ||.| | |.  |  |         . . .. | .  | | ..||   ..
IQLIRRLGSGQFGEV----WEGLWNNTTP-VAVKTLK-PGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTV---EEPIYIITELMRHGSLQEYLQAINDK

RARLHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAK-LLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVV
  ...   |.  | |.  || ||  .  .||||||||.||. .  .||||||||. |.   .| |  |   . || | |||    | |. .|||||||..
GRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGIL

LYELFTYCDKSCSPSAEFLSMMGPEREGPPLCRLLELLAEGRRLPPPPTCPTEVQELMQLCWAPSPHDRPAFGTLSPQLDALW
|.|. ||          .  | . |         |. ...| |.| || || .. |.|. ||   |. || | ||  .|.  .
LTEIITYG------RMPYPGMTNAE--------VLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase JAK3.AA Src 818-1019 38 1.4e-51 173.53 In-house 1-196 (255) Show / Hide 
Range on Protein: 818-1019
Range on HMM: 1-196/255
Sequence Identity: 38% (79 aa)

LKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVK-YRGVSYG-PGRQSLRLVMEYLPSGCLRDFLQ--RH
.| .  ||.|.|| |    ..   .||   |||| |      .. .|..|.||.| |  . .|. |  .| . |       | ||   |.| |.|.  . 
IKLCRKLGQGQFGEVWMGYWN---GNT--KVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEP----IYIVTEYMSHGSLLDYLKKDGE

RARLHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVL
  .||  .|. .|.|. .||.||.... .||||||||.||  .  .|.||||||.|.  ..| |. |.    || | ||| .. . |.  |||||||. |
GRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILL

YELFTY
.|..||
TEIVTY
Kinase JAK3.AA Ack 818-1019 38 7.4e-51 169.78 In-house 1-207 (266) Show / Hide 
Range on Protein: 818-1019
Range on HMM: 1-207/266
Sequence Identity: 38% (81 aa)

LKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHS---GPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHR
..   .|| | ||.|     .    ..   |||| |       |  . || || .|. .|    .|.  ||  .     |..|.|  | | | | |  | 
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPM--LMMVTELAPCGSLLDCLRKHC

A--RLHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESE-AHVKIADFGLAKLLPLGKDYYVVREPG--QSPIFWYAPESLSDNIFSRQSDVWSF
    .   .|. |. ||..|| ||...||.||||||||||. |    |||.||||   |....|||.  ..     |. | |||.|    ||  ||||.|
RTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMF

GVVLYELFTY
|| | | |.|
GVTLWEMFSY
Kinase JAK3.AA S_TKc 818-1094 24 3.1e-50 174.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 818-1094
Range on HMM: 1-231/231
Sequence Identity: 24% (71 aa)

LKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPS--GCLRDFLQRHRA
 . . ..||| ||.| .||       || .||.|..        ....|||||||  | ..|||. .| .    ..| .||||..   | |.|...... 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

R-----LHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSR-QSDVWSF
.     ..  .   ...|||...||.  .. .||||   |||. .  |.||.|||||..|                 .. ||| |    ...  .|.||.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVVLYELFT----YCDKSCSPSAEFLSMMGPEREGPPLCRLLELLAEGRRLPPPPTCPTEVQELMQLCWAPSPHDRPAFGTLSP------QLDAL
|..|||...    ..     . . |  ..                            . |. .... |.   | .||    .        .   .
GCILYEMLCGYPPFP----QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase JAK3.AA Pkinase 818-1082 21 2.3e-38 136.73 Pfam 1-282 (293) Show / Hide 
Range on Protein: 818-1082
Range on HMM: 1-282/293
Sequence Identity: 21% (68 aa)

LKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHSGPDQQRD--FQR--EIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSG----CLRDF
.. .. .|.|.||.| .|.    |.    .||||..  .. . . |    |  ||||.| |....||..... .   .... .||||.. |     | |.
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDY

LQ-RHRARL--HTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHV----KIADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLS-DNIFS
.. . . ..    . .  ...||..|.||. .....||||   |||. .. |.    ||.||||||..      ..        ... ||| .  ..  .
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

RQSDVWSFGVVLYELFTYCDKSCSPSAEFLSMMGPEREGPPLCRL--------LELLAEGRRLPPPPTCP-----------------------TEVQELM
. .|.||.|..|||...                      || .          ...... .. |..  .|                        | ....
PKVDMWSCGCILYEMLCGR--------------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI

QLCWAPSPHDRP
  |... |..||
KWCLCKDPKKRP
Kinase JAK3.AA UTK 1045-1091 34 7.2e-14 43.83 In-house 248-296 (296) Show / Hide 
Range on Protein: 1045-1091
Range on HMM: 248-296/296
Sequence Identity: 34% (17 aa)

RLLELLAEG--RRLPPPPTCPTEVQELMQLCWAPSPHDRPAFGTLSPQL
.... . .|  .|.|.|. || .| .||. ||...| .|| | .|  |.
QVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase JAK3.AA Ack 1047-1091 41 3.5e-13 40.83 In-house 221-266 (266) Show / Hide 
Range on Protein: 1047-1091
Range on HMM: 221-266/266
Sequence Identity: 41% (19 aa)

LELLA-EGRRLPPPPTCPTEVQELMQLCWAPSPHDRPAFGTLSPQL
|...  || ||| |. || .. ..|  ||.. | ||| |. .  ||
LQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase JAK3.AA Src 1047-1091 39 2.7e-11 34.59 In-house 210-255 (255) Show / Hide 
Range on Protein: 1047-1091
Range on HMM: 210-255/255
Sequence Identity: 39% (18 aa)

LELLAEGRRLPPPPTCPTEVQE-LMQLCWAPSPHDRPAFGTLSPQL
|. .  | |.| |..|| |. | .|. ||  .| .|| | .|   |
LQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase JAK3.AA TK-Unique 1044-1091 32 3.5e-10 31.44 In-house 246-294 (294) Show / Hide 
Range on Protein: 1044-1091
Range on HMM: 246-294/294
Sequence Identity: 32% (16 aa)

CRLLELLAEGRRLPPPPTC-PTEVQELMQLCWAPSPHDRPAFGTLSPQL
....|.. .| |.| |. | . |. .||. ||  .|..|| | ..  .|
KDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase JAK3.AA EGFR 1048-1092 37 4e-07 19.51 In-house 214-258 (258) Show / Hide 
Range on Protein: 1048-1092
Range on HMM: 214-258/258
Sequence Identity: 37% (17 aa)

ELLAEGRRLPPPPTCPTEVQELMQLCWAPSPHDRPAFGTLSPQLD
.|| .| ||| || |   |  .|  ||   .  || |  |  ...
DLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK