Gene LATS1 (Mouse)

LATS1

Species: Mouse
Alias: LATS1, Lats1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP ,
Annotation:

Classification

Group: AGC
Family: NDR
Subfamily: LATS

Sequence

Name Sequence Type Origin Length Description Download
LATS1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 306 Kinase domain by global Sugen HMM Fasta, JSON
LATS1.NA RNA Sugen 3703 None Fasta, JSON
LATS1.AA Protein Sugen 1129 None Fasta, JSON

Protein domain

Protein domains of LATS1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
UBA LATS1.AA UBA 101-138 30 1.2e-09 38.39 Pfam 1-38 (38) Show / Hide 
Range on Protein: 101-138
Range on HMM: 1-38/38
Sequence Identity: 30% (12 aa)

VNPQMFQDLQAA-GFDEDMVIQALQKTNNRSIEAAVEFI
....| . |..  ||... ...||...|| ..|.|||..
IDEEMVKQLMEMTGFSMMQCKKALRACNN-NVERAVEWL
UBA LATS1.AA UBA 102-140 25 0.000662 19.13 SMART 1-38 (38) Show / Hide 
Range on Protein: 102-140
Range on HMM: 1-38/38
Sequence Identity: 25% (10 aa)

NPQMFQDLQAAGFDEDMVIQALQKTNNRSIEAAVEFISK
. .  . |   |||.. ..|||...|.  .|.|....  
YEEKIDQLMEMGFDREECVQALRACNWN-VEMAMNWLFS
Kinase LATS1.AA NDR 704-1009 55 6.7e-236 736.14 In-house 1-350 (350) Show / Hide 
Range on Protein: 704-1009
Range on HMM: 1-350/350
Sequence Identity: 55% (194 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEAD--NEWVVRLYYSFQDKDNLYFVMDYIPGGDMMS---LLIRMGI
|..||..|.||||||.|.|| ||...|| |..||.... .||||||.|||||.||||  |.|||.||||||||..||.||.|.||||||.   ||..|.|
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

FPENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTG---------------------FRWTHDSKYYQ-SGDHPRQDSMDFSN
|.|..|||||||..||.|||||||.|||||||||.|||.||||||||||||||                     |.|||.|.||| ...| .||.||..|
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

EWGDPSNCRCGD-----R---LKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLR-TGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTS
.......|.|.      .   .|.|..|. .|..||||.|.||||.|.||||... |||.|.|||||.|.|..|||||.|||.. || ||.||..||.. 
SNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQT

L-----HIPPQAKLSPEASDLIIKLCR-GPEDRLGKNG--ADEIKAHPFF
.     |.||.|.||||| ||| .||   |. |||..|  .||||.||||
WDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase LATS1.AA AGC 704-1009 33 5.4e-186 486.12 In-house 1-395 (395) Show / Hide 
Range on Protein: 704-1009
Range on HMM: 1-395/395
Sequence Identity: 33% (140 aa)

FVKIKTLGIGAFGEVCLARKV------DTKALYATKTLRKKD-VLLRN--QVAHVKAE------------RDILAEAD----------NEWVVR-LYYSF
|  .|..| |.||.|.|.||.      ||. .|| | |.||. .....  .|.|...|            |.||....          . ..|. |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKDN--LYFVMDYIP--------GGDMMSLLIRMG-----IFPENLARFYIAE-------LTCAVESVHK-MGFIHRD-IKPDNILIDRDGHIKLTDFG
||||.  |||||.|.|        ||.....|. .|     .|.|. ||||.||       ...|.|. |. ||.|||| .||.|||.|.||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCTG----------------FRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSNCRCGDRLKPLERRAARQHQ-----------RCLAHSLVG--TPNYIAP
||.                 |.| |..|| |..      .||       . |       | .... .....           | ......|  ||.|.||
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-QKS------NMD-------T-N-------K-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAP

EVLLRTGYTQLCDWWS--VGVILFEMLVGQPPFLAQTPL----------ETQMKVI------NWQTSL------HIPPQAKLSPEASDLIIKLCR-GPED
|.|    |.. |||||  .|....|||.|.||| ...|           |.  |..      ||.  .      ..|.. ..|||| ||| ||.   ||.
EIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEK

RLGKN-------GADEIKAHPFF
||| .       ||.|||.||.|
RLGCGGNDFGDKGAEEIKNHPWF
Kinase LATS1.AA DMPK 704-849 48 2.2e-106 263.85 In-house 1-147 (270) Show / Hide 
Range on Protein: 704-849
Range on HMM: 1-147/270
Sequence Identity: 48% (71 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMG-IFPEN
|  .|  | |.||||.. |   |.  || | . |.. | | ..| .. ||||.. .. .|...|.| |||...||.||.| ||||. .|. | .  .||.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

LARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLC
.||||.||.. |. |.|.||..||||||||.|.|| ||||| ||| |
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSC
Kinase LATS1.AA S_TKc 704-1009 32 4.3e-101 343.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 704-1009
Range on HMM: 1-231/231
Sequence Identity: 32% (103 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPG--GDMMSLLIRMGI---
. .....| ||||.|...|...|. ..| | ..           |.. |..|| . . ...|.||..||| |.||.||.|..|  ||..... ..|    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSNCRCGDRLKPLER
   |||  ||||.... ||.|  |..|.||||.||.|||.|.  |||..||||.. .                                           
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

RAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQ-LCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GPED
           ....|||.|.|||||   ||.   |||||.|.||.|||.|.|||     ... .|.|              |||| |.| |...  ||.
-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEK

RLGKNGADE----IKAHPFF
|..   | .    ||.||.|
RPTA-EALQDEWDIKCHPWF
Kinase LATS1.AA RSK 707-1009 35 1.4e-98 333.85 In-house 1-278 (278) Show / Hide 
Range on Protein: 707-1009
Range on HMM: 1-278/278
Sequence Identity: 35% (114 aa)

IKTLGIGAFGEVCLARKV---DTKALYATKTLRKKDVLLRNQ-VAHVKAERDILAEAD-NEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGI---
.| || |..|.| | ||.   ||. .|| | |.|. .  |.  ..|...||.||..      .|.|.|.||... || .|.|..||..   | . ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FPENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDR---DGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSNCRCGDRLKPLER
| |. |.||.||...|||  |. |.||||.||.||| |    .|||||||||.|  |                                           
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------------

RAARQHQRCLAHSLVGTPNYIAPEVLL----RTGYTQLCDWWSVGVILFEMLVGQPPFLA---QTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIK-L
   | ..  .... ..| .|.|||.|     . |... ||||| ||...|||.|.||| .   ... |.  .. . . || .|  ..||.|| ||| | |
---RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKML

CRGPEDRLG--KNGADEIKAHPFF
.| |..|||  ...|.|||.||.|
HRDPHKRLGCGPQDAEEIKQHPWF
Kinase LATS1.AA AktR 704-1009 33 2.1e-89 303.34 In-house 1-268 (268) Show / Hide 
Range on Protein: 704-1009
Range on HMM: 1-268/268
Sequence Identity: 33% (108 aa)

FVKIKTLGIGAFGEVCLARKV-DTKALYATKTLRKKDVLLRNQVAHVKAERDILA-EADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPE
|. .| || ||||.| |..|  |.. .|| | ..||.   |||  |.  ||.|.. ....   |.|.|.||.|..|.|.|.|.|||.. . | . . | |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

NLARFYIAELTCAVESVHKM-GFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSNCRCGDRLKPLERRAARQ
. ||||.|.   |.|  |.    | ||.||.|||.| |||.|.|||||                                                   |
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK------------------------------------------------LQ

HQ---RCLAHSLVGTPNYIAPEVLLR-TGYTQLCDWWSVGVILFEMLVGQPPFLA-QTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIK--LCRGPED
 .   . .|.|..||| |.|||....  |..  .|||..|. ..||..|.||| . ..  . |.. |     . .|. ...|... |||    ||. |. 
FMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ--QNKFPYPSYFSSQCKDLIQRKLLCKNPNK

RLG--KNGADEIKAHPFF
|||  .||..||| ||.|
RLGYYCNGWEEIKSHPWF
Kinase LATS1.AA MAST 704-848 46 6.8e-81 246.73 In-house 169-316 (337) Show / Hide 
Range on Protein: 704-848
Range on HMM: 169-316/337
Sequence Identity: 46% (69 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQD--KDNLYFVMDYIPGGDMMSLLIRMG-IFP
|  || .. ||.| |.|... .|. ..| |.... | ...||| .|..||.||....|..|| ..||||   |. |..||.|  |||  |||  .|  .|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGL
|..|..||||.  ..|  |..| .|||.||||.||| .||||||||||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase LATS1.AA MAST 704-848 48 3.9e-79 254.7 In-house 157-301 (334) Show / Hide 
Range on Protein: 704-848
Range on HMM: 157-301/334
Sequence Identity: 48% (70 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENL
|  || .. ||.| |.|... .|. ..| |...| | ...|.| .|..||.|||...|..|| ..|||| |..|..||.|  |||  |||  .| |.|..
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGL
|..||||.  ..|  |..| .|||.||||.||| .||||||||||
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase LATS1.AA CRIK 706-847 53 3.3e-73 232.64 In-house 2-145 (272) Show / Hide 
Range on Protein: 706-847
Range on HMM: 2-145/272
Sequence Identity: 53% (77 aa)

KIKTL-GIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMG-IFPENL
 .|.| | | ||.| . |   |   || | ..|| || . ||. .. ||||.. .  .|. .| | |||.|||| .| | ||||  ||. | .  | ||.
EVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDENM

ARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFG
|||| |||. || |.|.||..||||||.|||||| ||||| |||
ARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFG
Kinase LATS1.AA Akt 704-849 50 1.3e-68 218.38 In-house 231-378 (264) Show / Hide 
Range on Protein: 704-849
Range on HMM: 231-378/264
Sequence Identity: 50% (75 aa)

FVKIKTLGIGAFGEVCLARKVDTKALY-ATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPEN
|  .| || |.|| | |..| ||. .| | | |.|.  . .|||.|.|.|| ||   ..  .| |.||||..|.|||||||..||.  ..| | ..|.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

LARFYIAELTCAVESVHKMGFIHRD-IKPDNILIDRDGHIKLTDFGLC
 ||||.||. .| |  |... | ||  || |||.|.||||.|||||||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase LATS1.AA ROCK 704-849 51 9.1e-60 202.17 In-house 1-145 (263) Show / Hide 
Range on Protein: 704-849
Range on HMM: 1-145/263
Sequence Identity: 51% (75 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENL
|  || .| |||||| | |.  .|  || | | | ... |   |    ||||.| |  ||.|.|.| |||.  || ||||.||||...|.    . ||  
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDV-PEKW

ARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLC
|||| .|.  |....| |||||||.||||.|.|. ||.|| ||| |
ARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTC
Kinase LATS1.AA DMPK 910-1009 46 2e-54 132.44 In-house 162-270 (270) Show / Hide 
Range on Protein: 910-1009
Range on HMM: 162-270/270
Sequence Identity: 46% (51 aa)

VGTPNYIAPEVL--LRTG----YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINW-QTSLHIPPQAK--LSPEASDLIIKLCRGPEDRLGKNGA
|||| ||.||||  . ..    |   ||||||||...|||.|. || | .  ||  |  |  ...|  |.. |  .|.|| ||| .|   .|.|||.||.
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGY

DEIKAHPFF
...|.||||
EDFKCHPFF
Kinase LATS1.AA Pkinase 704-849 35 1.6e-45 162.02 Pfam 1-159 (293) Show / Hide 
Range on Protein: 704-849
Range on HMM: 1-159/293
Sequence Identity: 35% (56 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVK-AERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGG----DMMSLLI--RM
.......| |.||.|.......|  ..| |...|..     ...|.. .|  |... . . .||||..|.|||..|.||.| .||    | ....   | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GIF--PENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHI----KLTDFGLC
| |  .|. ..||. .. ...|  |.||.||||.||.|||||..|||    |..||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase LATS1.AA MAST 910-1009 50 2.8e-45 135.89 In-house 229-337 (337) Show / Hide 
Range on Protein: 910-1009
Range on HMM: 229-337/337
Sequence Identity: 50% (55 aa)

VGTPNYIAPEVLLRTG-YTQLCDWWSVGVILFEMLVGQPPFLAQTPLE-TQMKVINWQTSLHIPPQ------AKLSPEASDLIIK-LCRGPEDRLGKNGA
.||| ||||||.|..| | .  ||||.|.|..| ||| ||| . || | .  ..|| .  .  |.        ..|||| |||.| |   | .||| |||
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGA

DEIKAHPFF
|||| ||||
DEIKQHPFF
Kinase LATS1.AA MAST 908-1009 46 1.2e-41 131.85 In-house 223-334 (334) Show / Hide 
Range on Protein: 908-1009
Range on HMM: 223-334/334
Sequence Identity: 46% (52 aa)

SLVGTPNYIAPEVLLRTG-YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTS-LHIPPQ------AKLSPEASDLIIKLCRG-PEDRLGKN
...||| ||||||.|..| . .  ||||.|.|..| ||| |||   || |.  ...|       .|.        ..|||| |||.||    |..||| |
QCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGAN

-GADEIKAHPFF
 ||||.| ||||
NGADEVKQHPFF
Kinase LATS1.AA ROCK 910-1009 49 7.2e-36 119.46 In-house 160-263 (263) Show / Hide 
Range on Protein: 910-1009
Range on HMM: 160-263/263
Sequence Identity: 49% (51 aa)

VGTPNYIAPEVLLRTG----YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKA
|||| ||.||||   |    | . |||||||| ..|||||. || |..   |  |... ..||. |.....| .| ||| |     |.|||.|| |.||.
VGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQ

HPFF
|.||
HKFF
Kinase LATS1.AA Pkinase 906-1009 27 3.7e-26 93.58 Pfam 168-293 (293) Show / Hide 
Range on Protein: 906-1009
Range on HMM: 168-293/293
Sequence Identity: 27% (36 aa)

AHSLVGTPNYIAPEVLL-RTGYTQLCDWWSVGVILFEMLVGQPPFLAQ------TPLETQMKVINWQTSLHIPPQAKLS-----------------PEAS
.....|||.|.||||.. ...|.. .|.||.|.||.||| |.|||  .      ....   ..   ... ..|     |                 .|. 
MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

DLIIK-LCRGPEDRLGKNGADEIKAHPFF
|.| . ||. |..|..   |..|. ||.|
DFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase LATS1.AA CRIK 910-1009 35 1.1e-24 75.3 In-house 162-272 (272) Show / Hide 
Range on Protein: 910-1009
Range on HMM: 162-272/272
Sequence Identity: 35% (41 aa)

VGTPNYIAPEVL--LRT------GYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVIN------WQTSLHIPPQAKLSPEASDLIIKLCRGPEDRL
|||| |.|||||  . .       |   |||||.|.| .|| .|. ||   .  .|  ...|       |  |  |   |.||.. |||  |  ..  ||
VGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAYEMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRL

GKNGADEIKAHPFF
.  .   .. ||||
KYEQ---LCCHPFF
Kinase LATS1.AA Akt 906-949 44 7.9e-23 69.74 In-house 159-203 (264) Show / Hide 
Range on Protein: 906-949
Range on HMM: 159-203/264
Sequence Identity: 44% (20 aa)

AHSLVGTPNYIAPEVLLRTGYTQLCDWWS-VGVILFEMLVGQPPF
. .. ||| |.|||.|. .|.|. .|||. .|....||. |.|||
TKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase LATS1.AA Akt 968-1009 44 1.4e-14 42.91 In-house 220-264 (264) Show / Hide 
Range on Protein: 968-1009
Range on HMM: 220-264/264
Sequence Identity: 44% (20 aa)

LHIPPQAKLSPEASDLIIKLC-RGPEDRLG--KNGADEIKAHPFF
. .|.  ..|||. |||..|. . |. |||  .|.|.|||.||.|
VKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase LATS1.AA TyrKc 704-1009 21 6.2e-11 -45.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 704-1009
Range on HMM: 1-280/280
Sequence Identity: 21% (73 aa)

FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEA--DNEWVVRLYYSFQDK-------DNLYFVMDYIPGGDMMSLLI
 ...|.|| ||||||....        | |.|..        ..    |  |. .   ... .||||    ..       . |. || | |.||  . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RMGI-FPENLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSNCRCGDRLKP-
. .  ..      .     |  |  |....||||.   |.|.......| .||||         |..  ..|           ..|       .|  .. 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL---------SRDIYDDD-----------QQG-----ESKDYYRKK

---LER--RAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML-VGQPPFLA-----QTPLETQMKVINWQTSLHIPPQAKL-----
    ..     |                 |||..    .|   | || || ..|..  ||.|         .. |    ||..  . . .|| .      
EHKGGKTMLPIR---------------WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE----VIEYVKQGYRMPQPPNDYPMS

---SPEASDLIIKLC--RGPEDRLGKNGADEIKAHPFF
    |..   |.| |  . ||||   .       | .|
FVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase LATS1.AA Pkinase_C 1028-1083 28 3.9e-09 35.44 Pfam 1-46 (46) Show / Hide 
Range on Protein: 1028-1083
Range on HMM: 1-46/46
Sequence Identity: 28% (16 aa)

KITHPTDTSNFDPVDPDKLWSDGSEEENISDTLNGWYKNGKHPEHAFYEFTFRRFF
....||||||||| .         ..|  .|| . |    .   ..|  ||.....
QVKSPTDTSNFDPEF---------TDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase LATS1.AA Pkinase_Tyr 819-849 35 1.8e-05 19.13 Pfam 128-158 (270) Show / Hide 
Range on Protein: 819-849
Range on HMM: 128-158/270
Sequence Identity: 35% (11 aa)

HKMGFIHRDIKPDNILIDRDGHIKLTDFGLC
. ...||||.   |.|.......| .||||.
ESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase LATS1.AA S_TK_X 1010-1081 22 4.6e-05 20.03 SMART 1-79 (79) Show / Hide 
Range on Protein: 1010-1081
Range on HMM: 1-79/79
Sequence Identity: 22% (19 aa)

KTIDFSSDL---RQQSASYIPKIT----HPTDTSNFDPVDPDKLWSDGSEEENISDTLNGWYKNGKHPEHA-----FYEFTFRR
. ||.   .   ..  . ..|||.    .|||||||||  ... ..    . .....| .   . . .|       | .||...
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM----LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase LATS1.AA Pkinase_Tyr 704-722 47 0.010831 9.74 Pfam 1-19 (270) Show / Hide 
Range on Protein: 704-722
Range on HMM: 1-19/270
Sequence Identity: 47% (9 aa)

FVKIKTLGIGAFGEVCLAR
 ...|.|| ||||||....
ITFGKKLGEGAFGEVYKGT