Gene LCK (Mouse)

LCK

Species: Mouse
Alias: LCK, Lck
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Src
Subfamily: SrcB

Sequence

Name Sequence Type Origin Length Description Download
LCK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 251 Kinase domain by global Sugen HMM Fasta, JSON
LCK.NA RNA Sugen 1990 None Fasta, JSON
LCK.AA Protein Sugen 509 None Fasta, JSON

Protein domain

Protein domains of LCK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 LCK.AA SH3 64-120 36 1.4e-19 72.34 SMART 1-58 (58) Show / Hide 
Range on Protein: 64-120
Range on HMM: 1-58/58
Sequence Identity: 36% (21 aa)

NLVIALHSYEPSHDGDLGFEKGEQLRILEQ-SGEWWKAQSLTTGQEGFIPFNFVAKAN
  |.||..|.......| |.||. ...||. ...|||..  .|||||..| |.|.. .
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 LCK.AA SH3_1 67-113 36 1.5e-18 65.5 Pfam 1-49 (49) Show / Hide 
Range on Protein: 67-113
Range on HMM: 1-49/49
Sequence Identity: 36% (18 aa)

IALHSYEPSHDGDLGFEKGEQLRILEQSGE--WWKAQSLTTGQEGFIPF
.||. |.......| |.||... ..|.| .  |||.....|||||..| 
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 LCK.AA SH3_2 65-119 17 3.4e-11 42.08 Pfam 1-68 (68) Show / Hide 
Range on Protein: 65-119
Range on HMM: 1-68/68
Sequence Identity: 17% (12 aa)

LVIALHSYEP-SHDGD-----LGFEKGEQLRIL----EQSGEWWKA-QSLTTGQE--GFIPFNFVAKA
..... .|.| .  ..     | |.||......    . ...||..  ....|..  |..|...|.. 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 LCK.AA SH2 127-209 53 2.4e-51 152.6 Pfam 1-81 (81) Show / Hide 
Range on Protein: 127-209
Range on HMM: 1-81/81
Sequence Identity: 53% (44 aa)

WFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHY
|.....||..|||.|..|||..|.||.|||||| |...|||||...  |..||||.|...||||.||. | .|. |..|| ||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 LCK.AA SH2 125-215 44 8.6e-37 129.46 SMART 1-87 (87) Show / Hide 
Range on Protein: 125-215
Range on HMM: 1-87/87
Sequence Identity: 44% (41 aa)

EPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISP--RITFPGLHDLVRHYTNASDG
.||.. |.||..||. |..||. .|.||.|.|||..|...||||.      . ||||.|| .|.|..||    | .|| | .||.||.  ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase LCK.AA SrcB 245-495 83 1.4e-202 679.27 In-house 1-251 (251) Show / Hide 
Range on Protein: 245-495
Range on HMM: 1-251/251
Sequence Identity: 83% (210 aa)

LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDM
||||..|||||||||||||||.|.|||||..|||.|||.|||||||.||.||| ||||||||||.||||||||||..|.|.|||||..|.||...||.||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

AAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGM
.||||||||.||..|||||||||||||||.||.||||||||||.|||||||||||||||||||||||||.|.||||||||||||||.||||.||||||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

TNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLD
||||||.||||||||.||||||||||..||.|||||||.|||||||.||||
TNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase LCK.AA Src 245-494 67 8.10000000001e-195 653.5 In-house 1-255 (255) Show / Hide 
Range on Protein: 245-494
Range on HMM: 1-255/255
Sequence Identity: 67% (173 aa)

LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQE-PIYIITEYMENGSLVDFLK-TPSGIKLNVNKLL
.||...||.||||||||||.||.||||||.||.|.|||.|||.||..||.|.|..||.||||..|| ||||.||||..||| |.|| .. | .|....|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIE--DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP
|||||.|||||..|..|||||||.|.|.||.... ||.|||||||||.  |.||.||.|||||||||||||||||.|||||||||||||||||||.||.|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMTNPEVIQNLERGYRMVRPDNCPEELYH-LMMLCWKERPEDRPTFDYLRSVL
||||||.||.|..|||||| .|.|||.|||. .|. ||...||.||||.||...|
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase LCK.AA SFK-Src 245-498 59 2.9e-176 527.44 In-house 1-259 (259) Show / Hide 
Range on Protein: 245-498
Range on HMM: 1-259/259
Sequence Identity: 59% (154 aa)

LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLD
 .| ..||.||||.|| |  |. | |||| || |.|| . ||.|| .||.|.||.|..|||| |  |||||||| | .||| |.|. | |  |.. .| |
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIE-DNE-YTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPY
||||.| |||. |.||..|||| | |.|| |   ||..|||..| .. |.| |||.|||||||||||||| |. .| |||||||||||..|||| |||||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMTNPEVIQNLER--GYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFF
||||| ||.| ..|  ||||  | |||.|.| .|. ||...|.|||||. |.  ..|||
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase LCK.AA SrcA 245-494 69 8.49999999999e-167 531.49 In-house 1-250 (250) Show / Hide 
Range on Protein: 245-494
Range on HMM: 1-250/250
Sequence Identity: 69% (173 aa)

LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDM
..|  ||| |.||||||| .|| ||||.| || | |||.||| || .||.|.| .||.|||||  |||||.||||  |||.|||| . | .| . .| ||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

AAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGM
|||.|||||..|  |||||||||||||| . | |||||||||||||||||||| |||||||||||||  || ||||||||||||||||.|| ||.|||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

TNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVL
 | ||..  ||||.|  |..||| |. ||. ||.  ||.||||.|| | |
NNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase LCK.AA Pkinase_Tyr 245-494 49 8.9e-155 524.81 Pfam 1-270 (270) Show / Hide 
Range on Protein: 245-494
Range on HMM: 1-270/270
Sequence Identity: 49% (134 aa)

LKLVERLGAGQFGEVWMGYYN-----GHTKVAVKSLKQGSMSP----DAFLAEANLMKQL-QHPRLVRLYAVVT--QEP--IYIITEYMENGSLVDFLKT
... . ||.|.||||..|...     ....||||.||.|.|..    ..|..||..|||| .|| .||||.|.|  .||  |||..|||..|.| |.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

P--SGIKLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLI-EDNEY-TAREGAKFPIKWTAPEAINYGTFTIKSDVWSF
.  .. .|..  ||.|..|||.||.. |..|.|||||.| |.||.... .||.||||||.| .| .| ..|.|.|.||||.|||.|||| ||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLTEIVTHGRIP-YPGMTNPEVIQNL-ERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVL
|.|. ||.| |..| ||||.| ||.. . |.|||| .|.|||.|.|.||..||.. ||||||| .... |
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase LCK.AA Frk 245-498 60 5.1e-138 464.82 In-house 1-260 (260) Show / Hide 
Range on Protein: 245-498
Range on HMM: 1-260/260
Sequence Identity: 60% (157 aa)

LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK--TPSGIKLNVNKL
..|. |||.||||||| | .|  | |||| || |.| |. ||.|| .||.|.||.|..|||| | .|||||||| |..||| ..|.  .  | ......|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLAR-LIEDNE--YTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGR
.|||||.| |||..|.|||||||| | |.|| . ..|||||||||| |. |||  | .| ||.||||||||||.||  |||||||||||||||||.|.||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

IPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFF
.||||||| ||.| ...|||| .| |||..||..|. ||.. |. ||||. |.  |.|.|
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase LCK.AA Src-Unclassified 245-494 46 2.2e-137 462.68 In-house 1-284 (284) Show / Hide 
Range on Protein: 245-494
Range on HMM: 1-284/284
Sequence Identity: 46% (133 aa)

LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQG---SMSPDAFL--------AEANLMKQLQHPRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPS
..|.  || ||||||| | . |   ||||... |    ||| |||        .||..||...|..|| |||| .|| |.||||||| |||| ..|..  
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GIKLNVNKL------------LDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLS-----CKIADFGLA--RLIEDNEYTAREGAKFPIKWTAPEAIN
|  |    .             |.|||.| ||   |.  |.|||| | |.|. .  |      |..|||||  .|..| .| .| ||.||.||.|||.. 
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRP--DNCPEELYH-LMMLCWKERPEDRPTFDYLRSVL
||.|.|||||||.|||| || | |..||||| | ||. ..|||||| .|    ||. .|  .|  || ..|. ||||| |   .
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase LCK.AA TyrKc 245-494 43 8e-136 458.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 245-494
Range on HMM: 1-280/280
Sequence Identity: 43% (124 aa)

LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQL--QHPRLVRLYAVVTQ--------EPIYIITEYMENGSLVDFLKTPSGI
..| . || |.||||. | ..  ..||||.|| ..    .|. ||..|..|  .|| .||||.|.||        ||..|..|||..|.| |.|. . . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDN--------EYTARE--GAK--FPIKWTAPEAINYGTFTIKSD
 |.. .||... |||.||......|.||||| | |.||.. . .||.||||.| |.|          |...|  |.|  .||.|.|||.||||.||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLTEIVTHGRIPYPG-----MTNPEVIQNLERGYRMVRPDN--------CPEELYHLMMLCWKERPEDRPTFDYLRSVL
|||||... || | |  ||||     |.| |||.....|||| .|.|        ||.|.| .|  ||.| |||||||  ... .
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LCK.AA TK 245-494 27 1.4e-124 419.82 In-house 1-486 (486) Show / Hide 
Range on Protein: 245-494
Range on HMM: 1-486/486
Sequence Identity: 27% (133 aa)

LKLVERLGAGQFG---EVWMGYYNGH--------------------------TKVAVKSLKQG-SMSPDAFLA--------------EANLMKQLQ----
..|.. ||.||||   ||..| ..|.                          |.|||| || | .||...|..              ||. ||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPRLVRLYAVVTQE-------------PIYIITEYMENGS----LVDFLK--TPSGIK-----------------------------------------
 || .||||.|.||.             |..|..|||..|.    | |.|.   | ...                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LNVNKLLDMAAQIAEGMAFIEEQ------NYIHRDLRAANILVSDTLS-----------CKIADFG---
                               |..  || |..|||.||......      |..|||| | |.||.. .            |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLI-EDNEYTARE------------------------GAKFPIKWTAPEAIN---------YGTFTIKSDVWSFGILLTEIVTHGRIPYPG-M
     ||| | .| .|....                        |.|.||.|.|||..|         ||.||.||||||||.|. ||.|.|. ||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------PEVIQNLERG--------------YRMVRPDNCP--------------EELYHLMMLCWKERPEDRPTFDYLRSVL
.|          ||...|.||              .|| .|..||              ||.| ||. ||.. |||||||. |.. |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LCK.AA Src-Echino1 245-494 53 1.6e-124 420.0 In-house 1-252 (252) Show / Hide 
Range on Protein: 245-494
Range on HMM: 1-252/252
Sequence Identity: 53% (134 aa)

LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLNVNKLLD
|.. ...| |..|||| | .|| |.|||| ||...||| .||||||.||...|  .|..|||   . ||||.|| |.||.| |.||   . .. . .|.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPG
| |.|| || .....|..|||| | |.|| .   ||||||||||......| ...|||.|||||||||. || |||||||||||||.||.||.||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MTNPEVIQNLERGYRMVRPDNCPEELYHL-MMLCWKERPEDRPTFDYLRSVL
|.| ||.....||||| ....||. ||.. || ||   |  ||||..| . .
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase LCK.AA SRM 245-495 49 7.89999999999e-118 395.79 In-house 1-253 (253) Show / Hide 
Range on Protein: 245-495
Range on HMM: 1-253/253
Sequence Identity: 49% (126 aa)

LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGS-MSPDAFLAEANLMKQLQHPRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLNVNKLL
  |  .||.| ||||| |   |  .||.|  |    |    . .|   ||.| | ...||.||..  .|.||||| |  |.|  .|... .  | . .||
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYP
|.| |.||||.. |||||||||| | |.|| | . ||..|||||||| |  |    . . |.|||||||.||. . .||||||||||| |. | | .|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLD
|||| | .|  .||||| .|  || | . ||. ||.  ||.||.|  ||  | 
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase LCK.AA Tec 245-496 43 6.5e-117 394.7 In-house 1-254 (254) Show / Hide 
Range on Protein: 245-496
Range on HMM: 1-254/254
Sequence Identity: 43% (111 aa)

LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLNVNK--L
|.... || |||| | .|.. .. .||.| .| |||| . |. ||  |. |.||.||.|| | . | ||||.|||||.|.| ..|..  . ..  |   |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLRE-HKHHFQKNMAIL

LDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPY
|.|  .. ||||. |....||||| | | ||.|.   |..|||..| . | .||   |.|||.|| .||  .|  .  |||||.||.|  |. . |..||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDD
. |.| ||..   .|.|. ||. |....|  |  ||.|.||.||||  | . . .
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase LCK.AA S_TKc 245-498 23 2.7e-56 194.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 245-498
Range on HMM: 1-231/231
Sequence Identity: 23% (63 aa)

LKLVERLGAGQFGEVWMGYYNG-HTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIYIITEYMEN--GSLVDFLKTPSGIK----LN
 .... .| | ||.|. .. .. . .||.| .|      . .. | ...|. .|| .|.|| |   . .|...||...  |.| |..|   . .    ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

VNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTI-KSDVWSFGILLTEIVTH
      ...||....... ... |||||  .|||...    ||.||||||..                . ||| .    ..  |.|.||.|..| | .. 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-

GRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRS-----VLDDFF
|. |.|   ..... .. .          ..|. .... |..  ||.|||   .        .. .|
GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LCK.AA Pkinase 245-497 25 2.4e-43 154.33 Pfam 1-293 (293) Show / Hide 
Range on Protein: 245-497
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

LKLVERLGAGQFGEVWMGYYNGHTK-VAVKSLKQGSMSPDAF-----LAEANLMKQLQHPRLVRLYAVV-TQEPIYIITEYMENG----SLVDFLKTPSG
.......|.| ||.|. ..  |  | |||| .|  . ...       |.|. .|| |.||  |||| .. .   ||...||.|.|    .| |...| ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

IKL--NVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSC----KIADFGLARLIEDNEYTAREGAKFP---IKWTAPEAIN-YGTFTIKSDV
 ..    . . ... ||..|.... ... |||||  .|||....  .    ||.|||||....   |   . .. .   . . ||| |. .   . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFGILLTEIVTHGRIPYPGM----TNPEVIQNLERGYR------------------------MVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLD
||.|..| | .. || |.||     .  . .| ..|  .                        ... .| .||. ...  |..  |..|||    . .| 
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPT---AEQILQ

D--F
.  |
HPWF