Gene LIMK1 (Mouse)

LIMK1

Species: Mouse
Alias: LIMK1, Limk1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: LISK
Subfamily: LIMK

Sequence

Name Sequence Type Origin Length Description Download
LIMK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 266 Kinase domain by global Sugen HMM Fasta, JSON
LIMK1.AA Protein Sugen 647 None Fasta, JSON
LIMK1.NA RNA Sugen 3323 None Fasta, JSON

Protein domain

Protein domains of LIMK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LIM LIMK1.AA LIM 25-80 41 1.1e-22 83.23 Pfam 1-60 (60) Show / Hide 
Range on Protein: 25-80
Range on HMM: 1-60/60
Sequence Identity: 41% (25 aa)

CASCGQRIYDGQYL-QALNADWHADCFRCCECSVSLSHQ--YYEKDG-QLFCKKDYWARY
||.|...||| .|. .|.|  || .||.||.|. .|..   .||.|| .| ||..|. ..
CAGCNKPIYDRYYVMRAMNKVWHPECFCCCHCQKPLTPGDECYEHDGNKLYCKHCYHKLF
LIM LIMK1.AA LIM 24-75 42 3.3e-21 77.72 SMART 1-52 (52) Show / Hide 
Range on Protein: 24-75
Range on HMM: 1-52/52
Sequence Identity: 42% (22 aa)

VCASCGQRIYDGQYLQALNADWHADCFRCCECSVSLSHQYYEKDGQLFCKKD
.|| |.. ||. |...|..  || .||.||.|. .|.. .|||||...||..
KCARCNKPIYGDQVMRAMGKHWHPECFCCCHCNKPLGGTFYEKDGKPYCKHC
LIM LIMK1.AA LIM 84-142 36 2.9e-19 71.1 Pfam 1-60 (60) Show / Hide 
Range on Protein: 84-142
Range on HMM: 1-60/60
Sequence Identity: 36% (22 aa)

CHGCSEHIT-KGLVMVAGELKYHPECFICLACGNFIGDGDTYTLVEHSKLYCGQCYYQTV
|.|| . |. . .||.| . ..|||||.|  |. ....||.. .....|||| .||..  
CAGCNKPIYDRYYVMRAMNKVWHPECFCCCHCQKPLTPGDECYEHDGNKLYCKHCYHKLF
LIM LIMK1.AA LIM 83-137 32 1.1e-11 46.09 SMART 1-52 (52) Show / Hide 
Range on Protein: 83-137
Range on HMM: 1-52/52
Sequence Identity: 32% (18 aa)

SCHGCSEHITKGLVMVAGELKYHPECFICLACGNFIGDGDTYTLVEHSKLYCGQC
 |..|...|.   ||.|.. ..||||| |  |.. .|.   .  ... |.||  |
KCARCNKPIYGDQVMRAMGKHWHPECFCCCHCNKPLGG---TFYEKDGKPYCKHC
PDZ LIMK1.AA PDZ 165-255 23 4.3e-20 71.41 Pfam 1-86 (86) Show / Hide 
Range on Protein: 165-255
Range on HMM: 1-86/86
Sequence Identity: 23% (22 aa)

LVSIPAS-AHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSR-LLQLTLE
.|... .  .|..|.|..  .....        ... .  | ||.........||.||.|..|||..|||...|.. ..|....   ..||..
QVTLEKQDKRGGLGFSIKGGNDQRH-------DQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ
PDZ LIMK1.AA PDZ 176-258 22 8.4e-12 46.46 SMART 1-80 (80) Show / Hide 
Range on Protein: 176-258
Range on HMM: 1-80/80
Sequence Identity: 22% (21 aa)

RGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNS------IHVGDRILEING-TPIRNVPLDEIDLLIQETSR-----LLQLTLEHDP
 || .||                . . .| ||  .|  |        ...||||||.|| .|..|.. ... ........      ..||.....
GGLGFSIVG-------------GIFISSVVPG--GPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
Kinase LIMK1.AA LIMK 339-604 73 1.3e-242 812.29 In-house 1-287 (287) Show / Hide 
Range on Protein: 339-604
Range on HMM: 1-287/287
Sequence Identity: 73% (210 aa)

LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQYPWSQRV
||||||||||.||||||||||.||||||||||.|.||||||||||||||||||.||.|||||||||||||||..|||||||.|..||..||...||.|||
LIHGEVLGKGFFGQAIKVTHRQTGEVMVMKELHRCDEETQRTFLKEVKVMRCLDHPHVLKFIGVLYKDKRLNMVTEYIKGGCLKNIIHDMDQPFPWQQRV

SFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKNQS------------------EDLRSLKKP---DRKKRYTVVGNPYWMA
.||.|||.||.|||||.|||||||||||||||.|.|||||||||||||||..||                  |..|.|.||   ||||||||||||||||
RFARDIACGMSYLHSMCIIHRDLNSHNCLVREDRSVVVADFGLARLMIDERKQSCNMTPGGYGSGANMDNPMEPKRTLHKPKSRDRKKRYTVVGNPYWMA

PEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWL
|||.||.||||||||||||||.|||||||.|.||..|||||||||...|....||..|||.||||...|||.||..||.|.||.|||
PEMMNGKSYDEKVDVFSFGIVMCEIIGRVYACPDCMPRTMDFGLNQQEFWEKCCPDQCPPPFFPIMFMCCDMDPDMRPCFDKLHQWL
Kinase LIMK1.AA LISK 344-604 49 7.4e-182 595.88 In-house 1-296 (296) Show / Hide 
Range on Protein: 344-604
Range on HMM: 1-296/296
Sequence Identity: 49% (147 aa)

VLGKGCFGQAIKVTHRETGEVMVMKELIR-----FDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYK-DKRLNFITEYIKGGTLRGIIKNMDS---QYPW
..|||.||...|.|||.||.||..|...|     .|.|.|...|.||..|..|.|||...|.||.|. |..|...||||.||.|. ..|.||.   ..||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

SQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVREN----RNVVVADFGLARLMIDEKNQS-----------------EDLRSLKKP---DRKKRYTVV
.|||..|.|||.||.||||||||||||.|.|||||||    ....|.|||.||.|..|.|..                 ...|...|.   .||.|.|..
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTIC

GNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTM--DFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWL
|.||||||||..|.||||..|||||||||||||.||.|||||.|||.  ||||... |....|| .|||.|......||..||..|||| ...|||
GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEFWQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase LIMK1.AA TESK 343-606 42 3.6e-103 326.72 In-house 1-292 (292) Show / Hide 
Range on Protein: 343-606
Range on HMM: 1-292/292
Sequence Identity: 42% (124 aa)

EVLGKGCFGQAIKVTHRETGEVMVMKELI-RFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFA
| .| | |    ||.|| .| |||.|    .     .   |.||. |  |.|||.|.| ||  .. .|  .|||| ||.|  .  . .   .| |..  |
EKIGSGFFSEVYKVRHRASGQVMVLKMNKQKIWRANRHNMLREVQLMNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLADSELHLSWTQKIHLA

KDIASGMAYLHSMNIIHRDLNSHNCLVR--ENRNV--VVADFGLA---------------------RLMIDEKNQSEDLRSLKKP--DRKK-RYTVVGNP
 ||| || |||| .. |||| | |||||  .|.    ||.|||||                       .||  |    |        |..| .  ||| |
YDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLEKIPVYCMDSRKEKMAVVGSP

YWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLET
||||||   |  ||||.||||||||||||| |..|||||.||| .||| .  |    ||  ||. |  ... || .|| .||.|. . . || 
YWMAPEVLRGEWYDEKADVFSFGIVLCEIIARIQADPDYMPRTEKFGLDYQAF-KEMCPMDCPEPFLQLAFHCCNMDPKDRPVFHEITKHLEW
Kinase LIMK1.AA TKL 345-604 28 3.1e-89 302.78 In-house 1-364 (364) Show / Hide 
Range on Protein: 345-604
Range on HMM: 1-364/364
Sequence Identity: 28% (105 aa)

LGKGCFGQAIKVTHRE--------TGEVMVMKELIR------------------------FDEETQRTFLKEVKVMRCLE---HPNVLKFIG--------
.|.| ||.  | ..|         ||.....| . .                         |.|... . .|.......    |||...|.|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VLYK----DKRLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFAKDIASGMAYLHSMN--------IIHRDLNSHNCLVRENRN--------------V
 | ..    .. | ...||..||.|. ..        |.||...|.|||.||.||||||        ||||||.|.|.|| || .              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

VVADFGLARLMIDEKNQSEDLRS------LKKPDRKKRYTVVGNPYWMAPEMINGR----------------SYDEKVDVFSFGIVLCEIIG--RVNADP
 ..||||.| |  ..|..    .      ..   ||...|..|.|.|||||...|                 .|.||.||.||||||.||.   |. .|.
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

DYLPRT------MDFGLNVRGFLDRYCP------------PNCPPSFFPITVRCCDLDPEKRPSFVKLEQWL
.| |.       ..| ...  .|   .|            |.||||.  .  .|.| |||||||| .. ..|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LIMK1.AA LISK-DD1 384-604 36 2.8e-75 256.43 In-house 44-290 (290) Show / Hide 
Range on Protein: 384-604
Range on HMM: 44-290/290
Sequence Identity: 36% (94 aa)

EVKVMRC---LEHPNVLKFIGVLYK-------------DKRLNFITEYIKGGTLRGIIKNM------------DSQYPWSQRVSFAKDIASGMAYLHSMN
|.|. .    . |||. .|||. ..             . .|  .||.|.|| |. ..||             ... ||. ||. |.|||..|||||| |
EIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWYLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKN

IIHRDLNSHNCLVREN----RNVVVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPD
|||||| | | || ||    .   | |||.|| .   |||.          .....| .| . |||||.| | |||. .||||||.|| |.| |.. |..
IIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQ----------NNRHMTICGTDNWMAPEVILGMSYDWSCDVFSFGMVLLELITRKKPDKR

YLPRTM--DFGLNVRGFLDRYCPPN--CPPSFFPITVRCCDLDPEKRPSFVKLEQWL
...|.   .|....  |. .  |    ||..|   .. ||  ||. |||| .  | |
MWQRSPMNCFDIDQEEFRQQKIPKDNDCPREFMDLCMWCCKYDPNNRPSFKEIVQTL
Kinase LIMK1.AA S_TKc 339-604 24 2.4e-58 201.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 339-604
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKG--GTLRGIIKNMDSQ-----
   ....||| ||.  |..|..||... .|..        .....|.....   |||. |...| .  ..| ...||. |  |.|. .||.. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

YPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDE-KV
.|  .  .... |.....|.||..||||||   | |. |  .. ..||||||..                     .|..| |..||||..   .|.  |.
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------TTFCGTPWYMAPEVL---GYGKCKC

DVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQ---------WL
|. |.|..| | . .    |  . ....  .              .|..  .  .|.. ||||||.  .. |         |.
DWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LIMK1.AA TK 339-604 16 1.4e-53 177.62 In-house 1-486 (486) Show / Hide 
Range on Protein: 339-604
Range on HMM: 1-486/486
Sequence Identity: 16% (83 aa)

LIHGEVLGKGCFG---QAIKVTHRETG----------------------------EVMVMKELIRFDEETQRT--------------FLKEVKVMRC--L
.. |..||.| ||   .  | . |. .                             | ..||    ..| ..               .. | |.|..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

EHPNVLKFIGVLYKD------------KRLNFITEYIKGGT----LRGIIKNM-----------------------------------------------
.|||.....||  ..            . .  ..|| ..|     ||   ..                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------DSQYPWSQRVSFAKDIASGMAYLHSM------NIIHRDLNSHNCLVRENRN-----------VVVADFGLAR
                            ..| .  |.. .. .||.||.||||.      |..||||  .|||| || .           . .|||||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

---LMIDEKNQSEDLRSLKKPDRKKRYTVVGNPY----------------------------WMAPEMINGRS---------YDEKVDVFSFGIVLCEII
   .              .. .... |.......                            ||||| .|.|          . .| ||.|||... || 
QGSG-----------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF

GRVNADPDY-LPR---------TMDFGLNVRG-------------FLDRYCPPNCPP-------------SFFPI-TVRCCDLDPEKRPSFVKLEQWL
 .  . .   ..          .  . . .||              . . .||.||.              .. .   .|...|||.||.|  | . |
TYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LIMK1.AA TKL-Unique 341-543 31 3.7e-52 179.6 In-house 1-222 (290) Show / Hide 
Range on Protein: 341-543
Range on HMM: 1-222/290
Sequence Identity: 31% (72 aa)

HGEVLGKGCFGQAIKVTHRETGEVMVMKE-LIRFDEETQRTFLKEVKVMRCLE-HPNVLKFIGVLY----KDKRLNFITEYIKGGTLRGIIK--------
 ....| | .|| .|...| .   .. .. .  .  |  ..| .||..| .|. |||.....|.      . .......||. ||.|.  .         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-NMDSQYPWSQRVSFAKDIASGMAYLHSMN--IIHRDLNSHNCLVREN-----RNVVVADFGLARLMI--DEKNQSED--LRSLKKPDRKKRYTVVGNPY
 |  .  ...|||..|.|||.|| |||. .  |||||| | | || .|      |. ..||||...    .... .|    |           |..|.. 
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR---------NQTRCGSFR

WMAPEMING--RSYDEKVDVFSFGIVLCEII
|||||....    |.||.||.|||||| ||.
WMAPEVLRMNFCQYSEKSDVYSFGIVLWEIA
Kinase LIMK1.AA Pkinase 339-539 27 3.2e-49 174.62 Pfam 1-202 (293) Show / Hide 
Range on Protein: 339-539
Range on HMM: 1-202/293
Sequence Identity: 27% (60 aa)

LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEET--QRTFLK--EVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGG----TLRGIIK-NMD
.  |...|.| ||.  | .|. ||.. ..|.. . .|.   ..| ..  |...|. | |||....... . .... ...||  ||     |  .|.  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SQY--PWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRNV----VVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMIN-
  .  .. .  .... |..|..|.|||.|||||| . |.|. .| ..     ..|||||...                     .|..| |..|||| |. 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------Y-NNS-MTTFCGTPWYMAPEVIRG

GRSYDEKVDVFSFGIVL
|. |. |||..|.|..|
GQYYGPKVDMWSCGCIL
Kinase LIMK1.AA STE 339-604 23 7.1e-49 168.69 In-house 1-359 (359) Show / Hide 
Range on Protein: 339-604
Range on HMM: 1-359/359
Sequence Identity: 23% (87 aa)

LIHGEVLGKGCFGQAIKVTHRE---------------TGEVMVMKELIRFDE-----------------ETQRTFLKEVKVMRCLE--HPNVLKFIGVLY
. . |..||| ||.  |  ...               |||.| .|..   ..                 | .  .|||.|.|...   |||. |..|  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------KRLNFITEYIKGGTLRGIIK-NMDSQYP------------WSQRVSFAKDIASG-MAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGLAR
|.         |. . ||. ||.|. ||| ..  . |             ||   ....|  | ..||||..|||||. . | |.     |  .|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

LMID---EKNQSEDLRSLKKPD---------RKKRYTVVGNPYWMAPEMING------RSYDEKVDVFSFGIVLCEIIGRVNA----DPDYLPRTMDFG-
 ..|   .. | .        .          .||.|.|| | |||||.|..        ||.|.|. |.|....| .          | .    . |. 
QLTDSMANI-Q-S--------NNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNY

-------------LNVRGFLDRYC--------------PPNCPPSFFPITVRCCDLDPEKRPSFVKLEQ----WL
              .   . |. .              | .. |.|     .|.. ||.|||.  .| .    ..
HMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase LIMK1.AA TyrKc 339-604 27 3.4e-48 167.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 339-604
Range on HMM: 1-280/280
Sequence Identity: 27% (85 aa)

LIHGEVLGKGCFGQ----------AIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCL--EHPNVLKFIGVLYKD-------KRLNFITEYIKGG
.  |..|| |.||.          |.|. . ..                .. |..| ..|. |  .|||.....||  ..       . |  ..|| ..|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

TLRGIIKNMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDE-KNQSEDLRSLKKPDRKKRYTV----VGNP-
 |.  ...   . .... .||. .||.||.||||.|.|||||   |||| ||. | ..||||.|   |. ..            .|. |..     |.  
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----------ESKDYYRKKEHKGGKTM

---YWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLP---RTMDFGLNVRGFLDRY----CPPN--------CPPSFFPITVRCCDLDPEKRP
    ||||| || . . .| ||.|||... ||  .   .. |     . |     |. ....     .|||        ||.  . |  .|.. |||.||
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

SFVKLEQWL
.|  . . .
TFSEIHECF
Kinase LIMK1.AA Dicty5 381-545 35 3.9e-44 149.81 In-house 43-199 (260) Show / Hide 
Range on Protein: 381-545
Range on HMM: 43-199/260
Sequence Identity: 35% (62 aa)

FLKEVKVMRCLE--HPNVLKFIGVLYKDKRLNFI-TEYIKGGTLRGIIKNMDS----QYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRN
| .|| .|   .  |||. .. |   ....  |. |||.. |.|.   .           . |....| ||| .| .||||||||||| | | |. ||  
FYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWK

VVVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYTV-VGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGR
. . |||  |                  | .. .|. || . |||.|. ||. |..|.||.|||||| |.. |
IKIIDFGTSRFV----------------DNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTR
Kinase LIMK1.AA Pkinase_Tyr 339-488 31 3.2e-36 123.3 Pfam 1-164 (270) Show / Hide 
Range on Protein: 339-488
Range on HMM: 1-164/270
Sequence Identity: 31% (52 aa)

LIHGEVLGKGCFGQAIKVTHR----ETGEVMVMKEL-IRFDEET--QRTFLKEVKVMRCL-EHPNVLKFIGVLY-KDKR--LNFITEYIKGGTLRGIIKN
.. |..||.|.||.  | | .    .|.     | |    ..|   .. |..|.|.|. |  |||.....|| . ...   .  ..|| ..| |.   ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

M---DSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDE
    . . . .. .... .||.||.||.|.|.|||||   |||| ||. | ..||||||.. ..
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYND
Kinase LIMK1.AA MLK 339-483 28 1.7e-33 113.61 In-house 1-181 (291) Show / Hide 
Range on Protein: 339-483
Range on HMM: 1-181/291
Sequence Identity: 28% (52 aa)

LIHGEVLGKGCFGQAIKVTHRETG----EVMVMKELIRF-----DEETQRTFLKEVKVMRCLEHPN----VLKFIGVLYKD-KRLNFITEYIKGGTLRGI
.   |..|.| ||.  | . | .     .| | .  .|.      .. |. | .|..  | | |||    . .| ||  .. . .  ..||. || |  .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IKNMDS-------------QYPWSQRVSFAKDIASGMAYLHSMN---IIHRDLNSHNCLVRE------NRNVVVADFGLAR
... .|              |. .. ...|...|.||.|||||    ||||||.||| |. |      .......|||..|
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase LIMK1.AA MLK 511-545 47 1.8e-12 39.73 In-house 195-232 (291) Show / Hide 
Range on Protein: 511-545
Range on HMM: 195-232/291
Sequence Identity: 47% (18 aa)

GNPYWMAPEMI---NGRSYDEKVDVFSFGIVLCEIIGR
|.. |||||.|    .  |.||.||.|.|.|| |.. |
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase LIMK1.AA Pkinase_Tyr 515-543 51 3.9e-07 24.78 Pfam 180-208 (270) Show / Hide 
Range on Protein: 515-543
Range on HMM: 180-208/270
Sequence Identity: 51% (15 aa)

WMAPEMINGRSYDEKVDVFSFGIVLCEII
||||| || . . .| || |||... ||.
WMAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase LIMK1.AA Pkinase_Tyr 571-604 38 5.7e-05 17.47 Pfam 237-270 (270) Show / Hide 
Range on Protein: 571-604
Range on HMM: 237-270/270
Sequence Identity: 38% (13 aa)

CPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWL
||.|||.    .  .| . |||.||.|  . . |
CPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase LIMK1.AA MLK 572-604 39 0.001051 8.88 In-house 259-291 (291) Show / Hide 
Range on Protein: 572-604
Range on HMM: 259-291/291
Sequence Identity: 39% (13 aa)

PPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWL
|..||...     .| . ||.|||||    | |
PSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase LIMK1.AA TKL-Unique 572-597 38 0.017165 4.82 In-house 258-283 (290) Show / Hide 
Range on Protein: 572-597
Range on HMM: 258-283/290
Sequence Identity: 38% (10 aa)

PPNCPPSFFPITVRCCDLDPEKRPSF
|..||...  .  .|.. ||..||||
PNHCPKEYRDLIQQCWHHDPSQRPSF
Kinase LIMK1.AA Dicty5 572-608 27 0.172122 0.89 In-house 224-260 (260) Show / Hide 
Range on Protein: 572-608
Range on HMM: 224-260/260
Sequence Identity: 27% (10 aa)

PPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETLR
|. || ..  .   |    | .|||| .  . .| . 
PKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase LIMK1.AA Pkinase 585-607 36 1.773904 2.77 Pfam 272-293 (293) Show / Hide 
Range on Protein: 585-607
Range on HMM: 272-293/293
Sequence Identity: 36% (9 aa)

RCCDLDPEKRPSFVKLEQWLET--L
.|...||.|||.    || |.   .
WCLCKDPKKRPT---AEQILQHPWF