Gene LIMK2 (Mouse)

LIMK2

Species: Mouse
Alias: LIMK2, Limk2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: LISK
Subfamily: LIMK

Sequence

Name Sequence Type Origin Length Description Download
LIMK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
LIMK2.AA Protein Sugen 617 None Fasta, JSON
LIMK2.NA RNA Sugen 4668 None Fasta, JSON

Protein domain

Protein domains of LIMK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LIM LIMK2.AA LIM 17-47 47 1.2e-12 47.65 Pfam 27-60 (60) Show / Hide 
Range on Protein: 17-47
Range on HMM: 27-60/60
Sequence Identity: 47% (16 aa)

FRCSECQESLTNW--YYEKDG-KLYCHKDYWAKF
|.|..||..||..  .||.|| ||||...|. .|
FCCCHCQKPLTPGDECYEHDGNKLYCKHCYHKLF
LIM LIMK2.AA LIM 50-103 27 2.9e-12 47.99 SMART 1-52 (52) Show / Hide 
Range on Protein: 50-103
Range on HMM: 1-52/52
Sequence Identity: 27% (15 aa)

FCHGCSLLMTG-PAMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKC
 |..|.   .|   |.|.. ..||||| |  |.  ...   .  ... ..|| .|
KCARCNKPIYGDQVMRAMGKHWHPECFCCCHCNKPLGG---TFYEKDGKPYCKHC
LIM LIMK2.AA LIM 51-108 30 7.5e-09 34.22 Pfam 1-60 (60) Show / Hide 
Range on Protein: 51-108
Range on HMM: 1-60/60
Sequence Identity: 30% (18 aa)

CHGCSLLMTGPAMV--AGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVV
|.||    ..  .|  | . ..||||| |. |.  ...|| . .. .. ||| .|. .  
CAGCNKPIYDRYYVMRAMNKVWHPECFCCCHCQKPLTPGDECYEHDGNKLYCKHCYHKLF
PDZ LIMK2.AA PDZ 131-215 21 6.8e-21 74.15 Pfam 1-86 (86) Show / Hide 
Range on Protein: 131-215
Range on HMM: 1-86/86
Sequence Identity: 21% (19 aa)

LISMPAT-TECRRGFSVTVESASSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAIKQTSQ-TLQLLIE
.....   .  ..|||. .... .  .... ..||.... ...  ..||.||.|..|||...| ...... .|||.... ...|.|.
QVTLEKQDKRGGLGFSIKGGNDQRH-DQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ
PDZ LIMK2.AA PDZ 140-218 23 3.8e-12 47.6 SMART 1-80 (80) Show / Hide 
Range on Protein: 140-218
Range on HMM: 1-80/80
Sequence Identity: 23% (21 aa)

CRRGFSVTVESASSNYATTVQVKEVNRMHISPNNRNA------IHPGDRILEING-TPVRTLRVEEVEDAIKQTSQ-----TLQLLIEHDP
   |||..           . ...| .   .|  .        ..|||||||.|| .||.... |.. |..||...     ...|......
GGLGFSIVG---------GIFISSVVPG--GPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
Kinase LIMK2.AA LIMK 310-580 67 1.1e-239 802.54 In-house 1-287 (287) Show / Hide 
Range on Protein: 310-580
Range on HMM: 1-287/287
Sequence Identity: 67% (195 aa)

LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSVD-PFPWQQKV
||||||||||||||||||||..||.|||||||.|||||||.|||.||||||.||||.||||||||||||.||..||||.||.||......| ||||||.|
LIHGEVLGKGFFGQAIKVTHRQTGEVMVMKELHRCDEETQRTFLKEVKVMRCLDHPHVLKFIGVLYKDKRLNMVTEYIKGGCLKNIIHDMDQPFPWQQRV

RFAKGISSGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPP------------VEKATTKKRTLRKS---DRKKRYTVVGNPYWMA
|||..|..||.||||||||||||||||||...|..||||||||.||...|||...            .......||||.|.   ||||||||||||||||
RFARDIACGMSYLHSMCIIHRDLNSHNCLVREDRSVVVADFGLARLMIDERKQSCNMTPGGYGSGANMDNPMEPKRTLHKPKSRDRKKRYTVVGNPYWMA

PEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCKLEPESRPAFSKLEDSF
|||.|||||||.|||||||||.|||||.|||.|||.|||.|||||...||||..|..|||.|||....||...|..||.|.||....
PEMMNGKSYDEKVDVFSFGIVMCEIIGRVYACPDCMPRTMDFGLNQQEFWEKCCPDQCPPPFFPIMFMCCDMDPDMRPCFDKLHQWL
Kinase LIMK2.AA LISK 315-580 46 1.2e-176 578.66 In-house 1-296 (296) Show / Hide 
Range on Protein: 315-580
Range on HMM: 1-296/296
Sequence Identity: 46% (137 aa)

VLGKGFFGQAIKVTHKATGKVMVMKELIR-----CDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYK-DKKLNLLTEYIEGGTLKDFLRSVD----PFPW
..||||||...|.||..||.||..|...|     .|.|.||..| ||..|..|.|||...|.||.|. |..|...||||.||.|...|...|    |.||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

QQKVRFAKGISSGMAYLHSMCIIHRDLNSHNCLIK----LDKTVVVADFGLSRLIVEERKRPP-----------VEKATTKKRTLRKS---DRKKRYTVV
.|.|..|..|..||.|||||.||||||.|.|||..     .....|.|||. |....|...|.           .......||...|.   .||.|.|..
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTIC

GNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTL--DFGLNVKLFWEKFVPTDCPPAFFPLAAICCKLEPESRPAFSKLEDSF
|.|||||||||.|.||||..|||||||||||||..|.||||..|||   ||||....||.|..|.||||.|..|.  |||..|..|| |..... .
GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEFWQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase LIMK2.AA TESK 314-582 42 8.60000000001e-102 322.28 In-house 1-292 (292) Show / Hide 
Range on Protein: 314-582
Range on HMM: 1-292/292
Sequence Identity: 42% (124 aa)

EVLGKGFFGQAIKVTHKATGKVMVMKELI-RCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLR-SVDPFPWQQKVRFA
| .| |||    ||.|.|.|.|||.|    .     ..  | ||. |  | |||.|.| ||  .. .|  ||||| ||.| . |  |  . .|.||.. |
EKIGSGFFSEVYKVRHRASGQVMVLKMNKQKIWRANRHNMLREVQLMNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLADSELHLSWTQKIHLA

KGISSGMAYLHSMCIIHRDLNSHNCLIK-LDKTV---VVADFGLSRLIVEERKRPPVEKAT------------------TKKRTLRKSDRKKRYTVVGNP
 .|  || ||||  . |||| | |||.. .|  .   ||.|||| |..      ||    |                   |    .   ||..  ||| |
YDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLEKIPVYCMDSRKEKMAVVGSP

YWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCKLEPESRPAFSKLEDSFEA
|||||| | |  |||..|||||||||||||  . |||| .||| .||| ...| |. .| |||. |  ||  || ..| .|| |  .   .| 
YWMAPEVLRGEWYDEKADVFSFGIVLCEIIARIQADPDYMPRTEKFGLDYQAFKEM-CPMDCPEPFLQLAFHCCNMDPKDRPVFHEITKHLEW
Kinase LIMK2.AA TKL 316-580 25 3.1e-84 286.15 In-house 1-364 (364) Show / Hide 
Range on Protein: 316-580
Range on HMM: 1-364/364
Sequence Identity: 25% (94 aa)

LGKGFFGQAIKVTHKA--------TGKVMVMKELIR--CDEETQ-------------------------KTFLTEVKVMRSLDHPNVLKFIG--------
.|.|.||.  | ...         |||....| . .  .||.|                          ...  |...|..|.|||...|.|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VLYK----DKKLNLLTEYIEGGT-LKDFLRSVDPFPWQQKVRFAKGISSGMAYLHS--------MCIIHRDLNSHNCLIKLDKT--------------V
 | ..    ...| . .||..||. | ...       |.|..|.|..|..||.||||        . ||||||.|.|.|.. . |              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

VVADFGLSRLIVEERKRPPVEKATT---KKRTLRKSDRKKRYTVVGNPYWMAPEMLNGK----------------SYDETVDVFSFGIVLCEIIG--QVY
 ..|||||| . .. .    ....        .. . ||...|..|.|.|||||.|.|.                .|.| .||.||||||.||.   ..|
KICDFGLSRFMSQSGNMNDTMTTMMESAE---HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

ADPDCLPRT------LDFGLNVKLFWEKFVP------------TDCPPAFFPLAAICCKLEPESRPAFSKLEDSF
.|... |.       ..| .... .    .|            .|||| .  |.  |.. .||.|| |... . .
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LIMK2.AA LISK-DD1 355-580 30 2.6e-65 223.3 In-house 44-290 (290) Show / Hide 
Range on Protein: 355-580
Range on HMM: 44-290/290
Sequence Identity: 30% (82 aa)

EVKVMRS---LDHPNVLKFIGVLYK-------------DKKLNLLTEYIEGGTLKDFLRSVD-------------PFPWQQKVRFAKGISSGMAYLHSMC
|.|. ..   . |||. .|||. ..             .  | ..||.|||| | ..| ..              |.||  .|. |..|...||||||  
EIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWYLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKN

IIHRDLNSHNCLIKLD----KTVVVADFGLSRLIVEER--KRPPVEKATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEII
|||||| | | |.        .  | |||. | ..|..   .                 .....| .| . |||||.. | |||. .||||||.|| |.|
IIHRDLKSKNILVDENGDSQWRIKVCDFGFAR-MFEQKKNQQ-----------------NNRHMTICGTDNWMAPEVILGMSYDWSCDVFSFGMVLLELI

GQVYADPDCLPRTL--DFGLNVKLFWEKFVPTD--CPPAFFPLAAICCKLEPESRPAFSKLEDSF
  .  |.. ..|..  .|..... |  . .|.|  ||..|  |.  ||| .|. || |..  .  
TRKKPDKRMWQRSPMNCFDIDQEEFRQQKIPKDNDCPREFMDLCMWCCKYDPNNRPSFKEIVQTL
Kinase LIMK2.AA S_TKc 310-586 21 3.8e-52 180.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 310-586
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEG--GTLKDFLRSVDP------
   ....||| ||.  |..|| ||... .|..        .... |...... .|||. |...| .  ..| . .||..|  |.|.|....  .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FPWQQKVRFAKGISSGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEKATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKS
||  .  .... | ....|.||. ||||||   | |.    .. ..||||.|..                           .|..| |..||||.|   .
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------TTFCGTPWYMAPEVL---G

YDE-TVDVFSFGIVLCEIIG--QVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCKLEPESRPAFSKLED---SFEALSLF
|.   .|. |.|..| | .     .     . ....  .              .| .  .   |.. .|| ||   ..        .   |
YGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LIMK2.AA STE 310-519 23 8.6e-49 168.41 In-house 1-262 (359) Show / Hide 
Range on Protein: 310-519
Range on HMM: 1-262/359
Sequence Identity: 23% (68 aa)

LIHGEVLGKGFFGQAIKVTHK------ATGKV---------MVMKELIRCDE-----------------ETQKTFLTEVKVMRSLD--HPNVLKFIGVLY
. . |..||| ||.  |  ..       ||.|         | .|..  ...                 | .. .| |.|.|. ..  |||. |..|  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------KKLNLLTEYIEGGTLKDFLRSV--------------DPFPWQQKVRFAKGISSG-MAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSR
|.        .|..  ||..||.| |.....              ..|| .|  .... |  | ..||||. |||||. . | |.     |  .|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

LIVEE------------RKRPPVEKATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNG------KSYDETVDVFSFGIVLCEII
 ....                             ..  .||.|.|| | |||||....      | ||. .|. |.|....| .
QLTDSMANIQSNNIIDCI----------------ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase LIMK2.AA Pkinase 310-515 27 1.8e-48 172.17 Pfam 1-202 (293) Show / Hide 
Range on Protein: 310-515
Range on HMM: 1-202/293
Sequence Identity: 27% (61 aa)

LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQK---TFL-TEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGG----TLKDFLR--SV
.  |...|.| ||.  | .|| |||. ..|.. ...|. .|    .. .|...|..|.|||....... . .... . .|| |||     |.|...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DPF--PWQQKVRFAKGISSGMAYLHSMCIIHRDLNSHNCLIKLDKTV----VVADFGLSRLIVEERKRPPVEKATTKKRTLRKSDRKKRYTVVGNPYWMA
 .|  ....  .... | .|..|.||| |||||| . |.||. . ..     ..||||....                           .|..| |..||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------------Y-NNS-MTTFCGTPWYMA

PEMLN-GKSYDETVDVFSFGIVL
|| .. |. |.  ||..|.|..|
PEVIRGGQYYGPKVDMWSCGCIL
Kinase LIMK2.AA TKL-Unique 312-519 29 8e-48 165.19 In-house 1-222 (290) Show / Hide 
Range on Protein: 312-519
Range on HMM: 1-222/290
Sequence Identity: 29% (69 aa)

HGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ--KTFLTEVKVMRSLD-HPNVLKFIGVLY----KDKKLNLLTEYIEGGTLKDFLR-------
 ....| | .|| .|.... . . .. ...   | . .  ..|  ||..|  |. |||.....|.      . ..... .||..||.| | |        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

---SVDPFPWQQKVRFAKGISSGMAYLHSMC--IIHRDLNSHNCLIKLD-----KTVVVADFGLSRLIVEERKRPPVEKATTKKRTLRKSDRKKRYTVVG
   .  ....||.|..|. |..|| |||.    |||||| | | |.  .       . ..|||||..   . | .  |.  |.             |..|
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR-----------NQTRCG

NPYWMAPEMLNG--KSYDETVDVFSFGIVLCEII
.. |||||.|..  . |.| .||.|||||| ||.
SFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIA
Kinase LIMK2.AA TK 310-518 16 1.1e-45 150.63 In-house 1-387 (486) Show / Hide 
Range on Protein: 310-518
Range on HMM: 1-387/486
Sequence Identity: 16% (65 aa)

LIHGEVLGKGFFG---QAIKVTHKATG----------------------------KVMVMKELIRCDEETQKT--------------FLTEVKVMRS--L
.. |..||.| ||   .  | . .  .                             | ..||    ..| ..               .. | |.|..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPNVLKFIGVLYKDKK------------LNLLTEYIEGGT----LKDFLRSVDP---------------------------------------------
.|||.....||  ...             . ...|| ..|     |.|.||. .|                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FPWQQKVRFAKGISSGMAYLHSM------CIIHRDLNSHNCLIKLDKT-----------VVVADFGLSR
                               .. .|.. ..  |..||.||||.       ..||||  .|||.  ...           . .|||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

---LIVEERKRPPVEKATTKKRTLRKSDRKKRYTVVGNPY----------------------------WMAPEMLNGKS---------YDETVDVFSFGI
   .                    |. .... |.......                            ||||| ||..          . .  ||.|||.
QGSG-----------------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV

VLCEI
.. ||
LMWEI
Kinase LIMK2.AA TyrKc 310-580 25 6.4e-44 153.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 310-580
Range on HMM: 1-280/280
Sequence Identity: 25% (81 aa)

LIHGEVLGKGFFGQ----------AIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSL--DHPNVLKFIGVLYKD-------KKLNLLTEYIEGG
.  |..|| |.||.          |.|. .. .                .. |. | ..|..|  .|||.....||  ..       . | ...|| ..|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

TLKDFLRSVDP-FPWQQKVRFAKGISSGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEE-RKRPPVEKATTKKRTLRKSDRKKRYTV---
 |||.||.  | ....... |.  |..||.||||...|||||   |||.. ..|| ..|||||| | .. ..                  .|. |..   
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----------------ESKDYYRKKEH

-VGNP----YWMAPEMLNGKSYDETVDVFSFGIVLCEII--GQVYADPD----CLPRTLDFGLNVKLFWEKFVPTD--------CPPAFFPLAAICCKLE
  |.      ||||| .| . . .  ||.|||... ||   ||     .    . .. .   .      ..  | .        ||.. . .   |.. .
KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQ--PPNDYPMSFVCCPDEMYQIMKQCWHED

PESRPAFSKLEDSF
||.|| || . . |
PEDRPTFSEIHECF
Kinase LIMK2.AA Ciliate-E2 310-515 21 6.3e-41 138.22 In-house 1-286 (365) Show / Hide 
Range on Protein: 310-515
Range on HMM: 1-286/365
Sequence Identity: 21% (64 aa)

LIHGEVLGKGFFG-----QAIKVTH------------------KATGKVMVMKELIRCDEETQKTFLTEVK-------------VMRSLDHPNVLKFIGV
 .  ...|.| ||     . .|| .                  |...|   || ..  . | .|  . . .             ....|.|||..|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LY--KDKKLNLLTEYIEGGTLKDFLRSVD-----------PFPWQQKVRFAKGISS---------------GMAYLHSMC-IIHRDLNSHNCLIKLDKTV
 .  .|... | .||..||.|.|.... .           .| ...  .. | | .               .. ||||   |||||.   | |.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

VVADFGLSRLIVEERKRPPVEKATTKKRTLRKSDRKKRYT-------------VVGNPYWMAPEMLNGKS---------YDETVDVFSFGIVL
 ..|||||. . .....    |   |. .  |.|... ..             ..|.|. ||||.||||.         ||. .|..|.|..|
KIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase LIMK2.AA Pkinase_Tyr 310-455 32 7.8e-40 135.53 Pfam 1-161 (270) Show / Hide 
Range on Protein: 310-455
Range on HMM: 1-161/270
Sequence Identity: 32% (52 aa)

LIHGEVLGKGFFGQAIKVTHK----ATGKVMVMKEL-IRCDEET--QKTFLTEVKVMRSL-DHPNVLKFIGVLY-KDKK--LNLLTEYIEGGTLKDFLRS
.. |..||.| ||.  | | |     |.     | |   ...|   .. |. |.|.|..| .|||.....|| . ...   . . .|| ..| |.|.||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----VDPFPWQQKVRFAKGISSGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLI
     .|.. .... ..  |..||.||.|. .|||||   |||.. ...| ..||||.|.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase LIMK2.AA MLK 310-453 28 8.3e-35 118.21 In-house 1-181 (291) Show / Hide 
Range on Protein: 310-453
Range on HMM: 1-181/291
Sequence Identity: 28% (52 aa)

LIHGEVLGKGFFGQAIKVTHKATG---KVMVMKE-LIRC-----DEETQKTFLTEVKVMRSLDHPN----VLKFIGVLYKD-KKLNLLTEYIEGGTLKDF
.   |..|.| ||.  | . ...    |.   |.  .|       .. |. | .|..  | |.|||    . .| ||  .. ... ...||.||| | ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LRSVDP--------------FPWQQKVRFAKGISSGMAYLHSMC---IIHRDLNSHNCLIKL------DKTVVVADFGLSR
|.. ..               . ......|. ...||.|||||    ||||||.||| ||        ..|....|||.||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase LIMK2.AA Dicty5 352-453 34 6e-23 75.83 In-house 43-152 (260) Show / Hide 
Range on Protein: 352-453
Range on HMM: 43-152/260
Sequence Identity: 34% (38 aa)

FLTEVKVMRSLD--HPNVLKFIGVLYKDKKL-NLLTEYIEGGTLKDFLRSVDP-----FPWQQKVRFAKGISSGMAYLHSMCIIHRDLNSHNCLIKLDKT
|  || .|   .  |||. .. |   ...|    .|||.  |.| . |.           . |.. .| .|  .| .|||| |||||| | | ||  . .
FYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWK

VVVADFGLSR
. . ||| ||
IKIIDFGTSR
Kinase LIMK2.AA Dicty5 478-521 44 1.1e-17 57.38 In-house 155-199 (260) Show / Hide 
Range on Protein: 478-521
Range on HMM: 155-199/260
Sequence Identity: 44% (20 aa)

DRKKRYTV-VGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQ
| .. .|. || . |||.|. ||. |....||.|||||| |.. .
DNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTR
Kinase LIMK2.AA MLK 487-519 41 7.6e-11 33.99 In-house 195-230 (291) Show / Hide 
Range on Protein: 487-519
Range on HMM: 195-230/291
Sequence Identity: 41% (15 aa)

GNPYWMAPEML---NGKSYDETVDVFSFGIVLCEII
|.. |||||..    .  |.| .||.|.|.|| |..
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase LIMK2.AA TK 548-580 23 2.6e-05 12.91 In-house 440-486 (486) Show / Hide 
Range on Protein: 548-580
Range on HMM: 440-486/486
Sequence Identity: 23% (11 aa)

PTDCPP-------------AFFPL-AAICCKLEPESRPAFSKLEDSF
| .||.             ... .    |....|| || || | . .
PPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LIMK2.AA Pkinase_Tyr 491-519 44 4e-05 17.99 Pfam 180-208 (270) Show / Hide 
Range on Protein: 491-519
Range on HMM: 180-208/270
Sequence Identity: 44% (13 aa)

WMAPEMLNGKSYDETVDVFSFGIVLCEII
||||| .| . . .  || |||... ||.
WMAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase LIMK2.AA MLK 547-580 26 0.000959 9.02 In-house 258-291 (291) Show / Hide 
Range on Protein: 547-580
Range on HMM: 258-291/291
Sequence Identity: 26% (9 aa)

VPTDCPPAFFPLAAICCKLEPESRPAFSKLEDSF
.| .||. .  |  .| . .|..|| |.     .
IPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase LIMK2.AA Pkinase_Tyr 548-580 33 0.107808 6.36 Pfam 238-270 (270) Show / Hide 
Range on Protein: 548-580
Range on HMM: 238-270/270
Sequence Identity: 33% (11 aa)

PTDCPPAFFPLAAICCKLEPESRPAFSKLEDSF
| .||.    |   | . .|| || || .   .
PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase LIMK2.AA Dicty5 547-584 31 0.212548 0.57 In-house 223-260 (260) Show / Hide 
Range on Protein: 547-584
Range on HMM: 223-260/260
Sequence Identity: 31% (12 aa)

VPTDCPPAFFPLAAICCKLEPESRPAFSKLEDSFEALS
.| |||  .  |   |    |  || | .  . || ..
IPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII