Gene LRRK2 (Mouse)

LRRK2

Species: Mouse
Alias: LRRK2, 4921513O20Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
LRRK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 246 Kinase domain by global Sugen HMM Fasta, JSON
LRRK2.NA RNA Sugen 8230 None Fasta, JSON
LRRK2.AA Protein Sugen 2527 None Fasta, JSON

Protein domain

Protein domains of LRRK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 LRRK2.AA LRR_1 796-821 26 50.93473 0.69 Pfam 5-26 (26) Show / Hide 
Range on Protein: 796-821
Range on HMM: 5-26/26
Sequence Identity: 26% (8 aa)

LDLAN-N--SIC-LGGFGIGKIDPSWLGPL
||| . |  ...         | ||..  |
LDLSGCNCCNLTGH-------IPPSCF-NL
LRR_1 LRRK2.AA LRR_1 983-1004 25 4.215854 4.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 983-1004
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

HITSLDLSA-N--EL-KDIDAL-SQKC
....||||  |   | ..|      ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK2.AA LRR_TYP 1010-1033 33 0.002595 18.25 SMART 1-24 (24) Show / Hide 
Range on Protein: 1010-1033
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LEHLTKLELHQNSLTSFPQQLCET
| .|..| |. | ||. |..... 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP LRRK2.AA LRR_TYP 1034-1057 33 0.021848 13.46 SMART 1-24 (24) Show / Hide 
Range on Protein: 1034-1057
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LKCLIHLDLHSNKFTSFPSFVLKM
|  | .|||..|..|. |. ..  
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRRK2.AA LRR_1 1012-1034 29 0.120858 10.0 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1012-1034
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

HLTKLELHQ-N--SLT-SFPQQLCETL
.|..| |   |  .|| ..|   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRK2.AA LRR_1 1036-1057 29 0.195422 9.26 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1036-1057
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

CLIHLDLHS-N--KFT-SFPSF-VLKM
 | |||| . |  ..| ..|.    ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC LRRK2.AA LRR_BAC 1010-1029 35 0.250072 5.82 SMART 1-20 (20) Show / Hide 
Range on Protein: 1010-1029
Range on HMM: 1-20/20
Sequence Identity: 35% (7 aa)

LEHLTKLELHQNSLTSFPQQ
 .||..|    |.||..|. 
PPHLKWLNVSNNQLTELPEL
LRR_BAC LRRK2.AA LRR_BAC 1082-1101 55 0.000485 20.67 SMART 1-20 (20) Show / Hide 
Range on Protein: 1082-1101
Range on HMM: 1-20/20
Sequence Identity: 55% (11 aa)

CPSLKQLNLSYNQLSSIPEN
 |.|| || |.|||.. ||.
PPHLKWLNVSNNQLTELPEL
LRR_1 LRRK2.AA LRR_1 1084-1105 29 0.000892 17.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1084-1105
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLKQLNLSY-N--QLS-SIPEN-LAQV
.|. |.||. |  .|. .||.. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK2.AA LRR_TYP 1082-1105 41 0.006661 16.89 SMART 1-24 (24) Show / Hide 
Range on Protein: 1082-1105
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

CPSLKQLNLSYNQLSSIPENLAQV
 |.|. |.||.|||...|... | 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP LRRK2.AA LRR_TYP 1128-1151 33 0.002472 18.32 SMART 1-24 (24) Show / Hide 
Range on Protein: 1128-1151
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LKELKILNLSKNHIPSLPGDFLEA
| .|. |.|| |.. .|| . .. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRRK2.AA LRR_1 1130-1152 22 0.01221 13.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1130-1152
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

ELKILNLSK-N--HI-PSLPGDFLEAC
 |..|.||  |  .. ...| . . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC LRRK2.AA LRR_BAC 1128-1148 38 1.112571 0.87 SMART 1-20 (20) Show / Hide 
Range on Protein: 1128-1148
Range on HMM: 1-20/20
Sequence Identity: 38% (8 aa)

LKELKILNLSKNHIPSLPGDF
  .||.|| | |.. .|| ..
PPHLKWLNVSNNQLTELP-EL
LRR_1 LRRK2.AA LRR_1 1108-1128 25 10.806966 3.08 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1108-1128
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

KLEQLLLEG-N--KIS-GICS--PLSL
.|. | | | |  ...  | .    .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK2.AA LRR_TYP 1195-1219 44 0.00849 16.54 SMART 1-24 (24) Show / Hide 
Range on Protein: 1195-1219
Range on HMM: 1-24/24
Sequence Identity: 44% (11 aa)

LPHLRSLDMSHNNIECLPGPAHWKS
||.||.|| |.|... || |  . .
LPNLRELDLSNNQLTHLP-PGAFQG
LRR_1 LRRK2.AA LRR_1 1197-1217 25 0.011443 13.63 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1197-1217
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

HLRSLDMSH-N--NIE-CLPG--PAHW
.|..||.|. |  |.. ..|     . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC LRRK2.AA LRR_BAC 1172-1191 35 0.043217 11.64 SMART 1-20 (20) Show / Hide 
Range on Protein: 1172-1191
Range on HMM: 1-20/20
Sequence Identity: 35% (7 aa)

PSSITSLKLSQNSFTCIPEA
|.....|  | |. |. || 
PPHLKWLNVSNNQLTELPEL
LRR_1 LRRK2.AA LRR_1 1174-1195 29 0.056533 11.17 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1174-1195
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SITSLKLSQ-N--SFT-CIPEA-IFSL
....| ||  |  ..| .||.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC LRRK2.AA LRR_BAC 1195-1214 40 0.061507 10.47 SMART 1-20 (20) Show / Hide 
Range on Protein: 1195-1214
Range on HMM: 1-20/20
Sequence Identity: 40% (8 aa)

LPHLRSLDMSHNNIECLPGP
 |||..|. |.|....||  
PPHLKWLNVSNNQLTELPEL
LRR_1 LRRK2.AA LRR_1 1246-1267 33 0.004824 14.96 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1246-1267
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

RVEKLHLSH-N--KL-KEIPPE-IGCL
. ..|.||. |  .| ..|||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRK2.AA LRR_1 1269-1291 33 0.046829 11.46 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1269-1291
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLTSLDVSY-N-LEL-RSFPNE-MGKL
||..||.|. |   | ...|..   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRRK2.AA LRR_TYP 1244-1266 29 0.103648 7.92 SMART 1-24 (24) Show / Hide 
Range on Protein: 1244-1266
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

WSRVEKLHLSHNKLKEIPPEI-GC
 .  ..|.||.|.|...||.. ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP LRRK2.AA LRR_TYP 1267-1291 36 0.134227 7.0 SMART 1-24 (24) Show / Hide 
Range on Protein: 1267-1291
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LENLTSLDVSYNLELRSFPNEMGKL
| ||..|| |.|  |.. |...   
LPNLRELDLSNNQ-LTHLPPGAFQG
LRR_BAC LRRK2.AA LRR_BAC 1267-1287 33 0.234017 6.04 SMART 1-20 (20) Show / Hide 
Range on Protein: 1267-1287
Range on HMM: 1-20/20
Sequence Identity: 33% (7 aa)

LENLTSLDVSYNLELRSFPNE
 ..|..|.||.|  |...|  
PPHLKWLNVSNNQ-LTELPEL
LRR_1 LRRK2.AA LRR_1 1221-1243 22 3.337122 4.89 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1221-1243
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

NLRELIFSK-N--QIS-TLDFSENPHV
||..| .|  |  ... ..  |   . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
COR LRRK2.AA COR 1504-1854 20 1.6e-106 346.59 In-house 1-434 (434) Show / Hide 
Range on Protein: 1504-1854
Range on HMM: 1-434/434
Sequence Identity: 20% (91 aa)

IINESLNFKIRDQPV--VGQLIPDCYVELEKIILSER--KAVPTEFPVINRKHLLQLVNEHQ---------LQLDENELPHAVHFLNESGVLLHFQ--DP
|.......|.... .  ..| .| ......... ..|  . ...|.|.. .| ..|.. ||.         ...||.|| .....|...|...||.  |.
IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWDH

ALQLSDLYFVEPKWLCKVMAQILTVKVDGCLK--HPKGI-ISRRDVEKFLSKK---------KRFPKNYMMQYFKLLEKFQIALPIGE----------EY
. .|.|.....|.|.|..|..|...|   |..  |.||| ....|.||.....         .|.|.... ....|.|||....||..          ..
DPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQETTT

LLVPSSLSDHRPVIE-LPHC-------ENSEIIIRLYEM------PYFPMGFWSRLINRLLEISPFMLS-GRERALRPNRMYWRQGIYLNWSPE--AYCL
.|.|. |.|.|| .  ....       .... . | |..      ...|.|||.|.. ||....  |.. ..||.. ...||||.|..|.|. .  ...|
YLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFYERSC-CEWMYWRNGMVLKWEGHNKNEAL

VGSEVLDNRPESFLKITVPSCRK-----GCILLGRVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFN---DGE-EHQ--KILLDELMKKAEEG-
| ...     .. ..||| .|..     .| |.... .||......|.|.   ...|...  ....| ..  .   . .  ..   . .|......|.| 
VKCDN----HDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHW--VCREWIPCPHCIQDHWDTCCDICYYQYDWCIRAEEMGM

DLLINPDQPR-----------------------LTI-PISQ
| ...| . .                        .| .||.
DSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD
ROC LRRK2.AA ROC 1332-1503 29 9.6e-69 228.86 In-house 1-215 (215) Show / Hide 
Range on Protein: 1332-1503
Range on HMM: 1-215/215
Sequence Identity: 29% (64 aa)

YNRMKLMIVGNTGSGKTTLLQQLMKMKKP-------ELGMQGATVGID-VRDWSIQIRGK----RRKDLVLNVWDFAGREEFYSTHPHFMTQ-RALYLAV
.|.||||..|. |.|||.|..|||. |..        .|.. .|.||. . .|.......    . ... .|||||.|.|....|| .|.|. |..||.|
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMFRKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYLLV

YDLSK----GQAE----VDA--MKPWLFNIKARASS--------SPVILVGTHLDVSDEKQ-----RKACISKITKELLNKRGFPTIR---------DYH
.|...    || |      .  ...|| .||.|..         ||||.||||.|......     .|.|. .....|  .  || |.         ...
WDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCC-RMWQKL--RNKFPNICHSWMQIEHYQGF

FVNATEES-DALAKLRKT
|. ..|..   . |||..
FHVDCETGCKGIDKLRHH
Miro LRRK2.AA Miro 1336-1455 23 2.6e-41 148.37 Pfam 1-140 (140) Show / Hide 
Range on Protein: 1336-1455
Range on HMM: 1-140/140
Sequence Identity: 23% (34 aa)

KLMIVGNTGSGKTTLLQQLMKMKKP------------ELGMQGATVGIDVRDWSIQIRGKRRKDLV-------LNVWDFAGREEFYSTHPHF--MTQRAL
|....|..|.||.....|......|            .. |.| |...|    ..|.........|       ...||..|||.....|.||  |...  
KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPREMHGHTYYVD----TMQVDWDTQSENVDRVKMCYFHIWDCGGREYWKFEHMHFACMKWADA

YLAVYDLSKGQ--AEVDAMKPWLFNIKARASS-SPVILVGTHLD
.. |||.....  ..|.....||......... .|||.||...|
ICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
RAB LRRK2.AA RAB 1335-1504 22 6.1e-08 -43.53 SMART 1-172 (172) Show / Hide 
Range on Protein: 1335-1504
Range on HMM: 1-172/172
Sequence Identity: 22% (42 aa)

MKLMIVGNTGSGKTTLLQQLMKMKKPELGMQGATVGIDVRDWSIQIRGKRRKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPW
.|....|. | ||. ||.. .. | .|   . .|.|.| .  .|...||| |   | .|| || | | |  ...    .  . |||... .      . |
FKIILIGDSGVGKSCLLHRFTDDKFSE--QYKHTIGVDFKTKTIEVDGKRVK---LQIWDTAGQERFRSITSSYYRGAHGCILVYDITNRESFENVKN-W

LFNIKARASS----SPVILVGTHLDVSDEKQRKACISKITKEL----LNKRGFPTI-----RDYHFVNATEESDALAKLRKTI
|  |.  |..     ...|||   | ..     .  ..  ...      | |.| .     ..  .|.      .||.  . .
LKEIRMHANPPPENVVIMLVGNKCDLEH---QRQVSTEEAQKFCCDCAEKHGMPFMFETSAKTNTNVEE--AFQCLARKIYQR
Kinase LRRK2.AA LRRK 1875-2134 29 1.7e-123 416.58 In-house 1-351 (351) Show / Hide 
Range on Protein: 1875-2134
Range on HMM: 1-351/351
Sequence Identity: 29% (104 aa)

LEFEEAPEFLLGDGSFG-SVYRAAYEG----------------------------EEVAVKIFNKH----------------------------------
|..||     .|.|.|| .|||| ..|                            ..||.|..|..                                  
LKIEEQ----IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHED

--TSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQ---QDK-----ASLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHN
  ...|..|.|.....||.||...||.  .|.|...|||.|. |.|...|.   ||.     |.....|...|||..|.|..||||..  ||.||||..|
CCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPN

VLLFTL-------YPNAAIIAKIADYGIAQ--YCCRMG-IKTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLHDIWTTGSRIMEGLRFP-----NE
.||...       ||||...|||||.|| .  .|..|| .|...|.||..|||. |  |.. |....|.||||..|....|......... |.     .|
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWME

FDELAIQGKLPDPVK---EYGCAPWPMVEKLITKCLKENPQERPTSAQVFDILNS
..|..|...|.....   ...|.||.|...||..| ...|..||.. |....| .
QIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase LRRK2.AA TKL 1885-2132 21 1e-68 234.57 In-house 1-364 (364) Show / Hide 
Range on Protein: 1885-2132
Range on HMM: 1-364/364
Sequence Identity: 21% (80 aa)

LGDGSFGSVYRAAYEG----------EEVAVKIFNKHTSL-----------------------------RLLRQELVVLCHLHHPSLISLLAAGIRPR--
.| |.|| ||.. . |          ..||||.|..| .                                ...|....  |.|| ....... ..|.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------------MLVMELASKGS-LDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM--------IIYRDLKPHNVLLFTL---------YPNAAII
             ..|||....|| |..|.          . .|.|| .| |. ||||          ||.||||..|.|..           .||| . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKIADYGIAQYCCRMG--------------------IKTSEG-TPGFRAPEVARGN---------------VIYNQQADVYSFGLLLHDIWTTGSRIMEG
.||.|.|...  ...|                     . ... ||.. |||| ||.                 |....||||||..|  | |      . 
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

LRFPNEFD-------ELAIQGKLPDPVK---------EYGCAPWPMVEKLITKCLKENPQERPTSAQVFDIL
  .| .|        ..... .|. |..               .| . ||...| ...|..||.  .. ..|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRRK2.AA TK 1879-2132 15 1.1e-41 136.99 In-house 1-486 (486) Show / Hide 
Range on Protein: 1879-2132
Range on HMM: 1-486/486
Sequence Identity: 15% (74 aa)

EAPEFLLGDGSFG---SVYRAAYEG---------------------------EEVAVKIFNK--HTSLRL-----------------LRQELVVLCH--L
   .  || | ||    ||.. ..|                           ..||||.  .  ..| .                  . .|. ..||  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPSLISLLA--------------AGIRPRMLVMELASKGS----LDRLLQQDKA---------------------------------------------
||| ...|..               . .| |.|||....|.    |.  |.. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------SLTRTLQHR-------------------IALHVADGLRYLHSA------MIIYRDLKPHNVLLFTLYPNAAI------IAKIADYGIA--
          .|| . ...                   ... .|.|..||||        .. |||  .|.|..  .... .      ..||||.| .  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

------------QYCCRMGIKTSEGTPGF-----------------------RAPEVARGNV--------IYNQQADVYSFGLLLHDIWTTG-SRIMEGL
            .. .|.. ..  . .                          |||. ...|        ..  . ||.||| |.. |.| |     .|.
GSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

RF--------PNEFDELAIQG-------------KLPDPVKEYGC-----------APWPMVEKLITKCLKENPQERPTSAQVFDIL
          . |. |.  .|             ... |  .. .           .| .... |...| ...|..||| .|. . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LRRK2.AA S_TKc 1879-2137 24 5.2e-38 133.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 1879-2137
Range on HMM: 1-231/231
Sequence Identity: 24% (66 aa)

EAPEFLLGDGSFGSVYRAAYEG--EEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGI-RPRMLVMELASK--GSLDRLLQQDKAS-----LTR
     ..| |.||.||..   .  ..||.|| .     . .|.|. .| . ||| .. |. .       .|||...   |.| ..... .       .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

TLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-QADVYSFGLLLHDIW
    ...  ....| |.||  ||.||||| |.|| .         ||.| |.|        .|  ||| ..||||      |.   .|..|.| .|    
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

TTGSRIMEGLRFPNEFDELAIQGKLPDPVKEYGCAPWPMVEKLITKCLKENPQERPTSAQVFD----ILNSAEL
. |    .     ...  . . |              | .  .| |||. .|..|||  ...     | .   .
C-GYPPFP-----QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRRK2.AA Dicty4 1880-2068 32 8.1e-35 113.67 In-house 2-212 (277) Show / Hide 
Range on Protein: 1880-2068
Range on HMM: 2-212/277
Sequence Identity: 32% (71 aa)

APEFLLGDGSFGSVYRAAYEGEEVAVKIF--NKHTS----LRLLRQELVVLCHLHHPSLISLLAAGI----RP--RMLVMELASKGSLDRLLQQ------
. | ..|.||||.||..   | |||||..  .. ..    |  .|.|   .| . || .. .. | .     |   . |.|. .||.| .||        
NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQ

DKASLTRTLQHR---IALHVADGLRYLHS--AMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG-----IKTSEGTPGFRAPEVARGNVIYN
.. .|  .|  |   .|. .| |. .||.    || ||||.|| |       .   .|..| |..||  .        .|  |||.  |||| ...  ||
QSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV-----DKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQP-YN

QQADVYSFGLLLHDIWT
. |||||||..|  | |
EKADVYSFGIVLWEILT
Kinase LRRK2.AA Pkinase 1885-2132 24 9.1e-35 124.02 Pfam 7-293 (293) Show / Hide 
Range on Protein: 1885-2132
Range on HMM: 7-293/293
Sequence Identity: 24% (74 aa)

LGDGSFGSVYRAAYEGEE--VAVKIFNKHTSLRLLRQ------ELVVLCHLHHPSLISLLAAGIRPRMLV--MELASKG----SLDRLLQ-QDKASL--T
.| ||||.||..   |..  |||||..|..     .|      |. .. .|.||  . |. .  ... .   ||.. .|    .| .... ... ..  .
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFS

RTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF-TLYPNAAIIAKIADYGIAQ---YCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL
     .... .. || |.||  ||.||||| |.|.  . ...|  . ||.| |.|    |      .|  |||...|||| ||.  | . .|..|.|..|
EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL

HDIWTTGSRIMEG-LRFPNE-----FDELAIQGKLPDPVKEYGCAPW---------------------PMVEKLITKCLKENPQERPTSAQVFDI--L
.   .       | . ||..      |....  .  .|  .. .  |                     .   ..|..||. .|..||| .|..    .
YEMLC-------GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LRRK2.AA MLK 1875-2063 27 1.2e-34 117.68 In-house 1-226 (291) Show / Hide 
Range on Protein: 1875-2063
Range on HMM: 1-226/291
Sequence Identity: 27% (63 aa)

LEFEEAPEFLLGDGSFGSVYRAAYEGEE-----VAVKIFN--------KHTSLRLLRQELVVLCHLHHPS----LISLLAAGIRP-RM--LVMELASKGS
..|.|     .| ||||.|... . ...     ||||...        . .. . ...|   | .| ||      | .... ..|     .||| ...||
IQFHE----WIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGS

LDRLL--QQDKAS-----------LTRTLQHRIALHVADGLRYLHS-A--MIIYRDLKPHNVLLFT--LYPNAAIIAKIADYGIAQYCCRMGI-KTS-EG
| ..|  ...| .            .  .  ..|| .| |. |||| |  .|| ||||.||.|.      . .  ..||.| |..   ..|.  ..|  |
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAG

TPGFRAPEV-AR-GNVIYNQQADVYSFGLLL
|. ..||||  .  .  |.  .||.|.|..|
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVL
Kinase LRRK2.AA TKL-Unique 1881-2063 27 2.4e-29 100.7 In-house 1-218 (290) Show / Hide 
Range on Protein: 1881-2063
Range on HMM: 1-218/290
Sequence Identity: 27% (59 aa)

PEFLLGDGSFGSVYRAAYEGEEVAVKIFNK-----HTSLRLLRQELVVLCHLH-HPSLISLLAAGI----RPR--MLVMELASKGSLDRLLQ--------
.  ..| |..|.||.. . |..||.|.|..      .... .. |. ..  || || .  . .. .     |    .|||  . |||. .|.        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-QDKASLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSE-----------GTPGFRAPEVARG
  ..  |.  .. ..|. .|.|. |||.    || ||||. |.|.    . | . .||.| |..    ..  .|.            |..  .|||| |.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

N-VIYNQQADVYSFGLLL
|   |....||||||  |
NFCQYSEKSDVYSFGIVL
Kinase LRRK2.AA CAMK 1884-2063 18 1.8e-28 88.3 In-house 1-324 (425) Show / Hide 
Range on Protein: 1884-2063
Range on HMM: 1-324/425
Sequence Identity: 18% (59 aa)

LLGDGSFGSVYRAAYE-G-------------EEVAVKIFNK------------------------------HTSLRLLRQELVVLCH-------LHHPSL
 || |||| |...                  ..||.|| .|                                ... .|.|. .. .       |.|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ISLLAAGI------------RPRM----------LVM---ELASKG----S-LDRLLQQDK-------------ASLTRTLQHRIALHVADGLRYLHSAM
|.|. .                ..          .||   |..| |      .|.. .. .               .|    .|.   ......|.||  
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIYRDLKPHNVLLFTLYPNAA------------IIAKIADYGIAQYCCRMG-------------------------IKTSEGTPGFRA-PEVARG-----
|. ||||| |.|| . ...                 ||.| | |... .                            ||. |||.. | ||| .|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------NVIYNQQADVYSFGLLL
        .  |....|. | | .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase LRRK2.AA Dicty4-Unclassified 1884-2068 29 4.7e-28 93.16 In-house 6-203 (263) Show / Hide 
Range on Protein: 1884-2068
Range on HMM: 6-203/263
Sequence Identity: 29% (60 aa)

LLGDGSFGSVYRAAYEGEEVAVKIFNK-HTSLR-----LLRQELVVLCHLHHPSLISLLAAGIRP------RMLVMELASKGSLDRLLQ-----QDKA-S
 .| | |  |..    | .||||.||    . |       . |  .|  . || |. .  . | |       . |||.  || |  .       |..  .
FIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIK

LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEG-TPGFRAPEVARGNVIYNQQADVYSFGLLLH
|  ||  ..|. .| |. .||.  .| ||.|  |.|.          .|||| ||.         |  . ||   .||. ..   ||| .||||....| 
LDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILM-----DKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHES-YNQKSDVYSYAMMLY

DIWT
   |
ELAT
Kinase LRRK2.AA TyrKc 1875-2132 23 1.4e-25 92.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 1875-2132
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

LEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHL--HHPSLISLLAAGI---------RPRMLVMELASKGSLDRLLQQDK
.....     || | || ||.. .  ..||||  .... .. ...|. ..|.|  ||| .. |... .          | |.|||....|.|.  |.  .
ITLGK----KLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

ASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRM-------GIKTSEGTPGFR--------APEVARGNV
  |.    . ... .|.| .||||  .| |||   |.|.   .     ..||.| | . .             ... .. | .        |||. . . 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG-

IYNQQADVYSFGLLLHDIWTTGSRIMEGL----RFPNEFDELAIQGKLPDPVKE-----YGCAPWPMVEKLITKCLKENPQERPTSAQVFDIL
... . ||.||| ..  | | |    .|       . |  |.  ||. ... ..     . |.|  | . ....| .|.| .||| ... ...
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase LRRK2.AA STE 1885-2063 20 3.4e-25 85.99 In-house 7-258 (359) Show / Hide 
Range on Protein: 1885-2063
Range on HMM: 7-258/359
Sequence Identity: 20% (55 aa)

LGDGSFGSVYRAAYE-----------------GEEVAVKIFNKHTS-------------------LRLLRQELVVLCHLH--HPSLISLLAAGIRP----
.| |.||.||.|..                  || .|.|. |. ..                   .  . .|. .. ...  ||  .  . . ..     
IGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNH

-----RMLVMELASKGSLDRLLQ---QDKASLT----------RTLQHRIALHVADG-LRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQY
       ..||. . |||| ...     . .|.           ..  .|.  .  | | ||||  || ||.|| |.||          .|..| |..  
KNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCDFGVCGQ

CCR----------------MGIK--TSEGTPGFRAPEVARG-----NVIYNQQADVYSFGLLL
                   |. |  |  ||| . |||| ..     .  |. ..|..|.|...
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase LRRK2.AA Pkinase_Tyr 1875-1987 24 1.8e-24 83.52 Pfam 1-129 (270) Show / Hide 
Range on Protein: 1875-1987
Range on HMM: 1-129/270
Sequence Identity: 24% (33 aa)

LEFEEAPEFLLGDGSFGSVYRAAYE------GEEVAVKIFNKHTSLRL-----LRQELVVLCHL-HHPSLISLLAAGI---RP--RMLVMELASKGSLDR
..| .     || |.||.||.. .       . .||||. . ... .      . .|. ....| ||| ...|... .   .|   ..|||.. .|.|. 
ITFGKK----LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

LLQQD---KASLTRTLQHRIALHVADGLRYLHS
 |..    | .||      ... .|.|. ||.|
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase LRRK2.AA DRK 1886-2068 32 2e-19 62.5 In-house 8-197 (258) Show / Hide 
Range on Protein: 1886-2068
Range on HMM: 8-197/258
Sequence Identity: 32% (63 aa)

GDGSFGSVYRAAYEGEEVAVK-IFNKHTS----LRLLRQELVVLCHLHHPSLISLLAAGIRPR--MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHV
| |..| |.|    | .||||  ||        |  ...|  ..| | ||  .  . .   |     .||  ..||| . |  .. ..   |  .... .
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDC

ADGLRYLHSA--MIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQ----YCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLHDIWT
| |. |||.    || |||| || |    .       |.||.| .        .   .|  |||.  |||| | |  |   ||||||.  |  . |
AKGMIYLHCCNPIIIHRDLKSHNLLVDEHW-----QVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLR-NQRYTEKADVYSFAIVLWECVT
Kinase LRRK2.AA DRK 2109-2134 30 1.5e-07 21.67 In-house 233-258 (258) Show / Hide 
Range on Protein: 2109-2134
Range on HMM: 233-258/258
Sequence Identity: 30% (8 aa)

KLITKCLKENPQERPTSAQVFDILNS
.|.. |. |.|| ||.  ..  .| .
QLMNDCWNEDPQHRPSMQECLERLEA
Kinase LRRK2.AA Dicty4 2109-2134 28 8.5e-07 18.88 In-house 250-277 (277) Show / Hide 
Range on Protein: 2109-2134
Range on HMM: 250-277/277
Sequence Identity: 28% (8 aa)

KLITKCLKENPQERPTSAQVFDI--LNS
.||..|. ..|| ||. ...  .  |..
HLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase LRRK2.AA MLK 2108-2132 32 2e-06 18.2 In-house 267-291 (291) Show / Hide 
Range on Protein: 2108-2132
Range on HMM: 267-291/291
Sequence Identity: 32% (8 aa)

EKLITKCLKENPQERPTSAQVFDIL
.||...| ...| .||...|.  .|
KKLMKQCWNQDPHKRPSFRQIVQHL
Kinase LRRK2.AA Dicty4-Unclassified 2105-2132 35 0.000122 11.77 In-house 236-263 (263) Show / Hide 
Range on Protein: 2105-2132
Range on HMM: 236-263/263
Sequence Identity: 35% (10 aa)

PMVEKLITKCLKENPQERPTSAQVFDIL
. . |||  |. . |. |||  |. . |
NFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase LRRK2.AA TKL-Unique 2109-2132 29 0.001245 8.89 In-house 267-290 (290) Show / Hide 
Range on Protein: 2109-2132
Range on HMM: 267-290/290
Sequence Identity: 29% (7 aa)

KLITKCLKENPQERPTSAQVFDIL
.||..| . .|..||.  ..   |
DLIQQCWHHDPSQRPSFDEIIHRL
Kinase LRRK2.AA CAMK 2110-2128 42 0.007189 4.28 In-house 401-419 (425) Show / Hide 
Range on Protein: 2110-2128
Range on HMM: 401-419/425
Sequence Identity: 42% (8 aa)

LITKCLKENPQERPTSAQV
|| |.|. .|..|.| .|.
LIRKMLQVDPEKRMTIEQC
Kinase LRRK2.AA STE 2111-2127 52 0.015613 4.91 In-house 334-350 (359) Show / Hide 
Range on Protein: 2111-2127
Range on HMM: 334-350/359
Sequence Identity: 52% (9 aa)

ITKCLKENPQERPTSAQ
| |||. .|..|||. |
INKCLQKDPNKRPTASQ
Kinase LRRK2.AA Pkinase_Tyr 2040-2063 37 0.03128 8.18 Pfam 182-204 (270) Show / Hide 
Range on Protein: 2040-2063
Range on HMM: 182-204/270
Sequence Identity: 37% (9 aa)

APEVARGNVIYNQQADVYSFGLLL
|||. . .. .. . ||.||| |.
APECINYGK-FTTKSDVWSFGVLM
Kinase LRRK2.AA Pkinase_Tyr 2104-2132 24 0.29488 4.88 Pfam 242-270 (270) Show / Hide 
Range on Protein: 2104-2132
Range on HMM: 242-270/270
Sequence Identity: 24% (7 aa)

WPMVEKLITKCLKENPQERPTSAQVFDIL
.. . .|...| ...|..||| ...  .|
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
WD40 LRRK2.AA WD40 2231-2276 25 0.00122 18.75 SMART 1-46 (46) Show / Hide 
Range on Protein: 2231-2276
Range on HMM: 1-46/46
Sequence Identity: 25% (12 aa)

EETKRHTLEKMTD--SVTCLHCNSLAKQSKQSNFLLVGTADGNLMIFE
. .  ||..  |.  .|||.  ..  . ....|.|..|  ||.. |..
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 LRRK2.AA WD40 2401-2438 18 0.539947 2.05 SMART 1-46 (46) Show / Hide 
Range on Protein: 2401-2438
Range on HMM: 1-46/46
Sequence Identity: 18% (9 aa)

NKESKHQLS-YSG--RVKALCLQKN-------TALWIGTGGGHILLLD
. .  | ..  .|  .| ..|   .       . |  |   |.| . |
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD