Gene LZK (Mouse)

LZK

Species: Mouse
Alias: C130026N12Rik, LZK
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: LZK

Sequence

Name Sequence Type Origin Length Description Download
LZK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 240 Kinase domain by global Sugen HMM Fasta, JSON
LZK.AA Protein Sugen 959 None Fasta, JSON
LZK.NA RNA Sugen 3192 None Fasta, JSON

Protein domain

Protein domains of LZK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LZK.AA LZK 167-406 80 8.49999999999e-214 716.55 In-house 1-241 (241) Show / Hide 
Range on Protein: 167-406
Range on HMM: 1-241/241
Sequence Identity: 80% (194 aa)

ISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGM
||||||||||||||||.|.||.|.||.||||...||||||||||||||||.|||||||.||||||||||.|||||||||..|.|||.|.||||..||.||
ISELQWLGSGAQGAVFRGWFRNETVAVKKVRDLKETDIKHLRKLKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSKQIAQGM

NYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK-STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVG
.|||.||||||||||||.|..|.|.|||.|||||...... ||||||.|||||||||||||||.|||||||||||||||.||.|||||||||.|||||||
HYLHQHKIIHRDLKSPNILISHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVG

SNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHL
|||||||.|||||.|||.||||.|..||||||||||.|||.
SNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW
Kinase LZK.AA MLK 167-406 43 8.9e-147 493.91 In-house 1-291 (291) Show / Hide 
Range on Protein: 167-406
Range on HMM: 1-291/291
Sequence Identity: 43% (128 aa)

ISELQWLGSGAQGAVFLGKFRAEE-----VAIKKVR-------------EQNETDIKHLRKLKHPN----IIAFKGVCTQAPC-YCIIMEYCAHGQLYEV
| ...|.|||..|.|..|..|...     ||.|.||             .. |....|||.|.|||    ||.|.|||.| || .||.||||..|.||.|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LRAGRK--------------ITPRLLVDWSTGIASGMNYLHLHK---IIHRDLKSPNVLVTH------TDAVKISDFGTSKELSDK-STKMSFAGTVAWM
|...|.              ... ....|.. .|.||.||| ..   ||||||||.|.|...       . .||.|||||...... ...||.|||.|||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEVI---RNEPVSEKVDIWSFGVVLWELLTGEIPYK-DVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHL
|||||   |.|..|||.|.||.||||||.||.|.||| ..|..||.|.|. |.|..|.|||||...| |||| |...|..|||||| ..||
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase LZK.AA TKL 173-406 28 1e-100 340.94 In-house 1-364 (364) Show / Hide 
Range on Protein: 173-406
Range on HMM: 1-364/364
Sequence Identity: 28% (104 aa)

LGSGAQGAVFLGKFRA----------EEVAIKKVR----------------------------------EQNETDIKHLRKLKHPNIIAFKGVCTQAPC-
.|||. | |. ||.|           ..||.|| .                                  .. |  |.....|.||||. |.|.|.. || 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHK--------IIHRDLKSPNVLVTHTDA--------------VK
            .||.|||| .| |...|       . ....|. .||.|||||| ..        ||||||||.|.||                   .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ISDFGTSKELSDKS--------------------TKMSFAGTVAWMAPEVIRNE----------------PVSEKVDIWSFGVVLWELLTGEIPYKDVDS
|.|||.|...| ..                    |.|.  || .||||||.|..                . |||.|..|||.||||.||...||.| ..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

S---------AIIWGVGSNSLHLPVP------------STCPDGFKILMKQTWQSKPRNRPSFRQTLMHL
.         .....|....|..|.|            ..||...| ||.. |...|..|||| . | .|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LZK.AA TKL-Unique 170-406 34 1.9e-76 260.3 In-house 2-290 (290) Show / Hide 
Range on Protein: 170-406
Range on HMM: 2-290/290
Sequence Identity: 34% (99 aa)

LQWLGSGAQGAVFLGKFRAEEVAIKKVRE---QN----ETDIKHL---RKLK-HPNIIAFKGVCT----QAPCYCIIMEYCAHGQLYEVLR---------
.  .|.|..|.|. ||.| ..||||.  .   ..    .. ....    ||. ||||  . |.|.    ..| .||.|||| .| ||.||          
WNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

-AGRKITPRLLVDWSTGIASGMNYLHLHK--IIHRDLKSPNVLVTHT-----DAVKISDFGTSKELSDKSTKMSFA-----------GTVAWMAPEVIRN
    |... . |.    ||.||.|||  .  ||||||||.|.||.         .||.|||.|| ...|..||..            |.  ||||||.|.
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK-FNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--EPVSEKVDIWSFGVVLWELLTGEI------PYKDVDSSAIIWGVGS--NSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHL
  .  |||.|..|||.||||..|..|      ||...|. ...  | .   ....|.|. ||  .. |..| | . | .|||| . .  |
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase LZK.AA Pkinase 167-406 25 2.5e-72 251.38 Pfam 1-293 (293) Show / Hide 
Range on Protein: 167-406
Range on HMM: 1-293/293
Sequence Identity: 25% (76 aa)

ISELQWLGSGAQGAVFLGKFRAEE--VAIKKVREQNETD-----------IKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHG----QLYEVLR--AG
.  .. .|||. | |.... . ..  ||.|... ..| .           |. ...|.||||. ......  . ....|||| .|     |.....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RKI--TPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAV----KISDFGTSKE--LSDKSTKMSFAGTVAWMAPEVIR-NEPVSEKVDIWSF
...  ... . .. . |..|..|.| ..|||||||. |.|. ... .    ||.||| .|   .  .|  ..|.||  .||||||| ... . |||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVLWELLTGEIPYKDV------DSSAIIWGVGSNSLHLPVPSTCP-------------------DGFKILMKQTWQSKPRNRPSFRQTLMH--L
|..|.|.|.|. |...       |  ..|  ...  || . | .|.                   . .| ..|  .. .|  ||...| | |  .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LZK.AA Pkinase_Tyr 167-406 33 1.1e-71 243.43 Pfam 1-270 (270) Show / Hide 
Range on Protein: 167-406
Range on HMM: 1-270/270
Sequence Identity: 33% (90 aa)

ISELQWLGSGAQGAVFLGKFR------AEEVAIKKVREQNETD----------IKHLRKL-KHPNIIAFKGVCT-QAPC--YCIIMEYCAHGQLYEVLRA
|. .. ||.|| | |..|. .        .||.|...|.   .          .| ...| .||||. . |||| |     ..|.|||..|| |.. ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----GRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKEL----SD-KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWS
    ....|.  |..... ||.||.||. ...|||||   |.|||..  |||.||| .. .       .... .    . |||||.|..   ..| |.||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWS

FGVVLWELLT-GEIP-YKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHL
|||..||..| ||.| |.... . ..  .. .   .| |  |||    |||| |. .| .||.|.. . .|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase LZK.AA ZAK 167-405 40 1.7e-70 240.55 In-house 1-257 (257) Show / Hide 
Range on Protein: 167-405
Range on HMM: 1-257/257
Sequence Identity: 40% (104 aa)

ISELQWLGSGAQGAVFLGKFRAEE-----VAIKKV-REQNETDIKHLRKLKHPNIIAFKGVCTQAPC-YCIIMEYCAHGQLYEVLRAGRKITPR------
|      | |  |.|. ..          .|.|||     |  |  | |..| ||| | |.|   |  | |. ||   | ||      |           
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVFKIEKEAEI--LSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSSSGGN

---LLVDWSTGIASGMNYLHLH---KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI-RNEPVSEKVDIWSFGVVLWELL
     . | | ||.|| |||     ||||||||| || .     .|| |||||... .  | ||. || .|||||.|   |||.|  |.||.||||||.|
SMDHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDKNGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVVLWEML

TGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH
| |.|||| .   | | .      | .|. ||  || || | |.  |. ||..||    
TREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase LZK.AA S_TKc 167-414 27 5.3e-68 233.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 167-414
Range on HMM: 1-231/231
Sequence Identity: 27% (71 aa)

ISELQWLGSGAQGAVFLGKFRA--EEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAH--GQLYEVLRAGRK------ITPRLLV
   |. .|.|| | |.... .   ..||||...|. .  |. |.| .||||. ...|.    .....|||| .  | |.....  ..      ...    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

DWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSE-KVDIWSFGVVLWELLTGEIPYKDV
 .   |.....|.| |.|||||||  |.|...   .||.||| ...|      ..| ||  .|||||.   . .  |.|.||.|..|.|.|.|. |.   
FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--

DSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLM-HLDIASADVL
.  ...  .|            .. .| .... .|  |..||.  . |   .||..   .
QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LZK.AA Dicty4 167-408 35 1.3e-65 217.86 In-house 1-277 (277) Show / Hide 
Range on Protein: 167-408
Range on HMM: 1-277/277
Sequence Identity: 35% (99 aa)

ISELQWLGSGAQGAVFLGKFRAEEVAIKKV--REQN--ETDIKHLRK-------LKHPNIIAFKGVCT----QAPCYCIIMEYCAHGQLYEVLRA-----
|   | .|.|. | |..|. |  |||.||   . ||  |  .. .||       . ||||. |.| ||    . .  || .||.  | ||..|..     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

GRKITPR--LLVD---WSTGIASGMNYLHL--HKIIHRDLKSPNVLVTHTDAVKISDFGTSK---ELSDKST-KMSFAGTVAWMAPEVIRNEPVSEKVDI
  .|..   |          .| |||.||     |||||||| | ||     ||..||| |.   . .|...  |. .||..|||||| ...|  ||.| 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

WSFGVVLWELLTGEIPYK--DVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMH--LDI
 ||| ||||.||...||     .   .. .|..  | .|.|. ||. .| |..  |   | .|||| . .    |. 
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase LZK.AA TyrKc 167-406 32 2.4e-64 220.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 167-406
Range on HMM: 1-280/280
Sequence Identity: 32% (92 aa)

ISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETD-----IKHLRKL--KHPNIIAFKGVCTQA-------PCYCIIMEYCAHGQLYEVLRAGRK-IT
|. .. ||.|| | |..|. . ..||.|...|          .. ..||  .||||... |||||        . ..|.|||..|| | . ||. |. ..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

PRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDK--------STKMSF--AGT----VAWMAPEVIRNEPVSEKVDIWS
.. |..... ||.||.||| ...|||||   |.||..   ||||||| |... |.          ...    |     . |||||.|.    ..| |.||
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS

FGVVLWELLT-GEIPYKD-----VDSSAIIWGVGSNSLHLPVPS-------TCPDGFKILMKQTWQSKPRNRPSFRQTLMHL
|||..||..| |. || .     .. . .|  | .     . |.       .|||    .||| |. .| .||.|..    .
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LZK.AA TK 167-406 18 8.4e-62 205.65 In-house 1-486 (486) Show / Hide 
Range on Protein: 167-406
Range on HMM: 1-486/486
Sequence Identity: 18% (88 aa)

ISELQWLGSGAQG---AVFLGKFRA---------------------------EEVAIKKVREQNETDIK---------------------HLRKLK----
|  .. ||.|. |    |..|. |                            ..||.| ..| .... .                      . ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIIAFKGVCTQAPC------------YCIIMEYCAHGQ----LYEVLRAGRK---------------------------------------------
 ||||. . |||||  .            ..|.|||..||     | . ||. |.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------ITPRLLVDWSTGIASGMNYLHLH------KIIHRDLKSPNVLVTHTDA-----------VKISDFG---
                               .|.. |. ..  ||.|| ||| .      ...||||   |.||.. .            .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TSKELSD--KSTKMSFAGT-------------------------VAWMAPEVIR---------NEPVSEKVDIWSFGVVLWELLT-GEIPYKDVD
      .... .    ...|  ||                         . |||||...         .   ..| |.|||||..||..| |. ||    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SS---------AIIWGVGSN--------------SLHLPVPSTCP--------------DGFKILMKQTWQSKPRNRPSFRQTLMHL
|.         . .     .               . .| |  ||              . . .||.| |. .|. ||.|.| .  |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LZK.AA DRK 174-408 36 1.3e-58 197.15 In-house 8-258 (258) Show / Hide 
Range on Protein: 174-408
Range on HMM: 8-258/258
Sequence Identity: 36% (91 aa)

GSGAQGAVFLGKFRAEEVAIKKVREQNET----------DIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGR-KITPRLLVDWSTGI
| |  | ||.|  |  .||.|.    |.            |  . .| ||||. | | |.  |  ||.|||   | || .|     ..   |.      .
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDC

ASGMNYLHLHK--IIHRDLKSPNVLVTHTDAVKISDFGTSK---ELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDS
| ||.|||     |||||||| | ||     ||..||| |       .. . |   ||  | |||| ||..  || |..||..||||..| ..||  .  
AKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDPYFGMPT

SAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDI
  ..  ||   . .|.|  ||  .  ||.  |   |  |||. . |  |. 
FQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase LZK.AA TK-Unique 167-406 30 3.6e-57 195.65 In-house 1-294 (294) Show / Hide 
Range on Protein: 167-406
Range on HMM: 1-294/294
Sequence Identity: 30% (90 aa)

ISELQWLGSGAQGAVFLGKFRA--------EEVAIKKVR-EQNETD-------IKHLRKLK-HPNIIAFKGVCTQAP-CYCIIMEYCAHGQLYEVLRAGR
.  .. .|.|| | |. |...           ||.|... . ..||       |.....|. ||||. . |.||      .||||||. | |   ||  |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

K--------------------------ITPRLLVDWSTGIASGMNYLHL--HKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSD----KSTKMSFAGTV
.                          |.|..|. .  .||.||.||.   .||.|||| . |||.|.   .||.||| ......     ... ..   .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

AWMAPEVIR--NEPV-SEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSTC-PDGFKILMKQTWQSKPRNRPSFRQTLMHL
.|||||...   ..  ..| |.|||||..||..| |. || ..... |.  .  .   .|.|. | .. .  |||..||..|  |||||| .  |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECI-RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase LZK.AA MLK 293-406 50 7e-53 173.0 In-house 168-280 (280) Show / Hide 
Range on Protein: 293-406
Range on HMM: 168-280/280
Sequence Identity: 50% (57 aa)

KISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSK
|| |||   |.     .|| ||| ||||||||.    |.  |.||.||.|||||||| ||. .|  |. .||  | | ||.|||||. .. ||.  |.  
KITDFGLAREWHKTT-RMSAAGTYAWMAPEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQD

PRNRPSFRQTLMHL
|  ||.| . |  |
PHKRPKFSEILQQL
Kinase LZK.AA MLK 166-286 42 5.3e-36 116.33 In-house 2-136 (280) Show / Hide 
Range on Protein: 166-286
Range on HMM: 2-136/280
Sequence Identity: 42% (59 aa)

EISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHL--------------RKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKIT
.| |.  .|.|  | |. . ...||||.|  |.. | |.                   |||||||| .||| . |  |..||||. | |  |. ||..| 
KIKEI--IGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVC-AGKRIP

PRLLVDWSTGIASGMNYLHLHK---IIHRDLKSPNVLV
|  ||.| . || ||||||      |||||||| |.|.
PHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILI