Gene MAP3K5 (Mouse)

MAP3K5

Species: Mouse
Alias: Map3k5, MAP3K5
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: ASK

Sequence

Name Sequence Type Origin Length Description Download
MAP3K5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON
MAP3K5.NA RNA Sugen 5393 None Fasta, JSON
MAP3K5.AA Protein Sugen 1380 None Fasta, JSON

Protein domain

Protein domains of MAP3K5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ASK_nterm_v5 MAP3K5.AA ASK_nterm_v5 138-192 65 1.8e-34 120.88 In-house 1-55 (55) Show / Hide 
Range on Protein: 138-192
Range on HMM: 1-55/55
Sequence Identity: 65% (36 aa)

HFGKLDFGETAVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYC
 |..||||||...|.|||||...|.||....||.||||||||.|| |.|||||||
EFMRLDFGETDMFDEFYNADVVIVDMSIDHQQPNLFYHLGVRHSFKMRNNIILYC
TPR_ASK_1 MAP3K5.AA TPR_ASK_1 318-351 50 2.3e-20 67.19 In-house 1-38 (38) Show / Hide 
Range on Protein: 318-351
Range on HMM: 1-38/38
Sequence Identity: 50% (19 aa)

ADIVINLLLSYRDIQDYDSIVKLVETLE---KLPTF-D
.|||.|...||||||||||...|||.|.   ..|.. .
GDIVHNFMHSYRDIQDYDSMIELVEDLKEGEHIPNCCK
TPR_ASK_2 MAP3K5.AA TPR_ASK_2 394-436 52 4.1e-27 85.56 In-house 1-46 (46) Show / Hide 
Range on Protein: 394-436
Range on HMM: 1-46/46
Sequence Identity: 52% (24 aa)

SDMYCLVGRIYKDMFLDSNFTD---TESRDHGASWFKKAFESEPTL
.||.|..|||||||||.|..||   .||||..  |..|.||..|..
PDMWCMCGRIYKDMFLESQYTDEAARESRDQAIHWYRKGFEIQPNH
TPR_ASK_3 MAP3K5.AA TPR_ASK_3 482-515 44 3.2e-13 48.73 In-house 1-34 (34) Show / Hide 
Range on Protein: 482-515
Range on HMM: 1-34/34
Sequence Identity: 44% (15 aa)

YWEVGFFLGASVLANDHLRVIQASEKLFRLKTPA
|| |..|...|.||.|  ...||.|..| || | 
YWDVATFFEISILACDYHKCMQACECMFKLKPPN
Kinase MAP3K5.AA ASK 692-945 84 7.50000000001e-197 660.26 In-house 1-254 (254) Show / Hide 
Range on Protein: 692-945
Range on HMM: 1-254/254
Sequence Identity: 84% (215 aa)

VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYT
|||||||||||||||...||||||||||||||||.|||||||||||.|.|.|||||||..||||..||||||||||||||||||||||.||||.|. |||
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYT

KQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYEL
|||||||||||.||||||||||||||.||||||.|||||||.|||||||||||||||||||||||.||.|.|||||.|||||.|||..|||||||||.||
KQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPPFHEL

GEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLIDEFL
||||||||||||.|.||||||..|||.|.|||.||||||.|||.|.||| |.||
GEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MAP3K5.AA STE11 687-945 44 3e-164 551.96 In-house 1-303 (303) Show / Hide 
Range on Protein: 687-945
Range on HMM: 1-303/303
Sequence Identity: 44% (135 aa)

NGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSR--------YSQP------LHEEIALHKHLKHKNIVQYLGS---FSENGFIKIFMEQVPGGSL
   . ..|||..| ||...........|.|.|......        . |.      ..|||.|.|||.|||||.|.|.    ..|....||||..|||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTET----------FTGTLQ--------
|..||.||||.|..|..| .|||||||||.|||...|.||||||.|.|......|.|..|||..||||.|..||..          .|||..        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

YMAPEIIDKGPRG-YGKAADIWSLGCTIIEMATGKPPFYELGE-PQAAMFKVGMF-KVHPEIPESMS------AEAKAFILKCFEPDPDKRACANDLLID
.||||.|....|. ||..|||||||||.|||||||||...... ..|||||.||. | ||.|||.||      .|...|...|||.|| ||. ||.|| .
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

EFL
 |.
PFI
Kinase MAP3K5.AA STE 688-945 27 3.8e-107 362.26 In-house 1-359 (359) Show / Hide 
Range on Protein: 688-945
Range on HMM: 1-359/359
Sequence Identity: 27% (101 aa)

GDR-VVLGKGTYGIVYAGRDLS---------------NQVRIAIKEIPERDS-----------------RYSQPLHEEIALHKHLK--HKNIVQYLGSFS
 ..  ..|||..| || ...                 .....|||... ...                    | . .|| ..|...  |.|||.|.|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ENG-------FIKIFMEQVPGGSLSALLRSKWGPLKDN-----------EQTIGFYTKQILEG-LKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTS
 .|        . |.|| ..||||. ....|.|..|..           |. |.....|||.| |.|||...|.|||||..|.|.       |..|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KRLAGINP----------------CTETFTGTLQYMAPEIIDKGPRG----YGKAADIWSLGCTIIEMATGKPPF---YELGEPQAAMFKVGMF------
..|. ...                 . ||.||  .||||.|... .|    |.  .||||||||||||||||||.   . .    ...|. .|.      
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----KVHPEIPE-------------------SMSAEAKAFILKCFEPDPDKRACANDLLI--DEFL
    . .| .|.                   ..| | | || ||.. ||.||. |..||    .|.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP3K5.AA STE11-Unclassified 690-945 35 3e-94 319.41 In-house 4-308 (308) Show / Hide 
Range on Protein: 690-945
Range on HMM: 4-308/308
Sequence Identity: 35% (111 aa)

RVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSR-----YSQP----LHEEIALHKHLKHKNIVQYLGSF--SENGFIKIFMEQVPGGSLSALLRSKWG
. ..|||..| || . ....   .|.|.| . |.        .     . .|... |.| |||||||.|     ....| ||||..||||....|. | |
GEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLN-KYG

PLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLA------------------GIN-PCTE------TFTGTLQ--
..  .|..|  |||||||||.||| . |.||||||.|.|| .  |. |..|||..|  .                   |  .  .      .  ||..  
CF--DEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDF-DGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQP

-YMAPEIIDKGPR-GYGKAADIWSLGCTIIEMATGKPPFYELGE--PQAAMFKVGMFKVHPEIPESMS-----------AEAKAFILKCFEPDPDKRACA
 .||||.|.     |.. ..||||||||.|||||||.|.. . .  ...|..|..| .  |.||| .|           .|.|.|. |||. || ||. |
FWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTA

NDLLIDEFL
| || . |.
NQLLQHPFI
Kinase MAP3K5.AA S_TKc 687-945 31 4.9e-94 319.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 687-945
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

NGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPG--GSLSALLRSKWGPLK---
     ..|||..| || .|. . . . |||.|.       . .  ||...|. .|.|||.....| . ... ..|| ..|  |.|  ..... .. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

DNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGK-AADIWSLGCTIIE
 .| .. ||..||...|.|.|...|.|||.| .|.|...   ..||.||| ...|        || ||. |||||..     |||| ..|.||.||...|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYE

MATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLI-------DEFL
|..|.|||.     ...|||. .           | ||| || ||.. ||.||  | ..|        ....
MLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP3K5.AA Pkinase 692-945 30 5.8e-78 270.12 Pfam 6-293 (293) Show / Hide 
Range on Protein: 692-945
Range on HMM: 6-293/293
Sequence Identity: 30% (89 aa)

VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHE----EIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGG----SLSALLR-SKWGPLKD
..|.|..| || ... ... . |.|.|. |. . ... .     ||...|.|.|.|||.....| ... | . || ..||    .|..... .. |..  
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

NEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVL----KISDFGTSKRL-AGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCT
 |... || .|||.||.|.|.. |.|||.| .|.||.   |..    ||.||| .| .    |. . ||.||. |||||.|  | ..||...|.||.||.
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCI

IIEMATGKPPFYEL-----GEPQAAMFKVGMFKVHPEIPES-------------------MSAEAKAFILKCFEPDPDKRACANDLLIDEFL
..||..|.|||..       .... ...... ..| ..|..                   .| |.| || .|...|| ||  | ..| ....
LYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MAP3K5.AA MEKK15 686-945 42 2.3e-71 243.39 In-house 2-264 (264) Show / Hide 
Range on Protein: 686-945
Range on HMM: 2-264/264
Sequence Identity: 42% (116 aa)

ENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIP------ERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGP
. |.  .|||| || || |     |. ||.| .       |.  .  . | ||. | | ||||||| |||   |.  . |||. |||||.|...  ..||
KKGN--ILGKGAYGTVYCGLTNTGQL-IAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSII-NRFGP

LKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLA--GINPCT----ETFTGTLQYMAPEIIDKGPRGYGKAADIWS
|  .|     ||||||.| .|||.| .||||||| ||..    |..|. |||  |||.  |||           ||  .||||.|     |||. .||||
L--DEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMP-TGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIME--TGYGRKSDIWS

LGCTIIEMATGKPPFYELGEPQAAMFKVGMF-KVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLIDEFL
.|||. ||||.|||. .. .. |||| .|    . |..|.  | .|. |.  |   | . |. | .||   |.
IGCTVFEMATRKPPWADM-DRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MAP3K5.AA CAMK 692-945 17 3.8e-65 208.6 In-house 1-425 (425) Show / Hide 
Range on Protein: 692-945
Range on HMM: 1-425/425
Sequence Identity: 17% (75 aa)

VLGKGTYGIVYAGRDLSNQ------------VRIAIKEIP-----------------ERDSRYS-----------QPLHEEIALHKH-------LKHKNI
.||.|..|.|. ... ...            .. ||| |.                  ..|. .           . .  ||...|.       |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYLGSFSENGF-------------------IKIFM---EQVPGG----SLSALLRSK--------------WGPLKDNEQTIGFYTKQILEGLKYLHDN
.. .  .  . .                   . ..|   | ..||     |   ....              .| .  .|.   .| .||.....|.|..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRF--TEREARRYFRQICSAVHYCHSH

QIVHRDIKGDNVLINTYS----------------GVLKISDFGTSKRLAGI-----------------------NPCTETFTGTLQYMA-PEIIDKGP--
 |||||.| .|.|... .                . .||.||| .... .                        ..  .|| ||. ||| ||.. . .  
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------RGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAA--------------MFKVGMFK-VHPEIPE-------------------SMSAEA
          ..||...|.||.|.    | .|.||||.  . .                . . | .   .|....                     |.|.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KAFILKCFEPDPDKRACANDLLIDEFL
| .| |. ..||.||. . . | ....
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MAP3K5.AA MEKK2 692-945 40 2.2e-63 216.88 In-house 6-262 (262) Show / Hide 
Range on Protein: 692-945
Range on HMM: 6-262/262
Sequence Identity: 40% (107 aa)

VLGKGTYGIVYAGRDLSNQVRIAIKEIPERD-----SRYSQPLHEEIALHKHLKHKNIVQYLGSFSENG--FIKIFMEQVPGGSLSALLRSKWGPLKDNE
.||.| .| ||   |      .|.| ..  .     ..  | |. || | | |.|. |||| |   .|.   . |||| .||||.   |.  .|.| .. 
LLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKA-YGALTET-

QTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCT---ETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEM
     ||.|||||..||||. |||||||| |.| .  || .|..||| ||||  |        . |||  .|.||.|.    |||. ||.||.|||..||
-VTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDS-SGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVING--EGYGRKADVWSIGCTVVEM

ATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLIDEFL
 | |||. |  |  ||.||.   .  |..|...| .|. |. .||      |  |..||  .| 
LTEKPPWAEY-EAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MAP3K5.AA Ciliate-E2 692-945 21 4.3e-61 208.44 In-house 6-365 (365) Show / Hide 
Range on Protein: 692-945
Range on HMM: 6-365/365
Sequence Identity: 21% (81 aa)

VLGKGTYGIVYAGRDLSNQVR-----------------------IAIKEIPERDSRYSQP-LHEEIALH------------KHLKHKNIVQYLGSFS--E
..|.|..|.|| ... ..| .                       .|.| . ... ..    .|.   ..            ..|.|.||...  .|    
KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKD

NGFIKIFMEQVPGGSLSALLRSKWGPLKDN--------EQTIGFYTKQILE---------------GLKYLHDNQ-IVHRDIKGDNVLINTYSGVLKISD
.  | . || . ||.|  ......   . .        |. |....||||.               .|.||| .  |.||||| .|.|.      .||.|
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIID

FGTSKRLAGINP-------------------------------CTETFTGTLQYMAPEIIDKGP-------RGYGKAADIWSLGCTIIEMATGKPPFYEL
||.||..   |                                 . |. ||. ||||||. ...        ||....||||||... || .|||||   
FGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---

GEPQAAMFKVGMFKVHPE--------------IPESMSAEAKAFILK----CFEPDPDKRAC-ANDLLIDEFL
        | . ..  ..              .... | |.| .| |    ... ||.||   ....|  ...
----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MAP3K5.AA STE20 689-945 34 1.3e-58 201.08 In-house 3-288 (288) Show / Hide 
Range on Protein: 689-945
Range on HMM: 3-288/288
Sequence Identity: 34% (99 aa)

DRVVLGKGTYGIVYAGRDLSNQVR----IAIKEIPERDS----RYSQPLHEEIALHKHLKHKNIVQYLGSFSEN----GFIKIFMEQVPGGSLSALLRS-
.  ..|.|.|| || ... ...      .||| .. ..        . .  ||   | .||.|||.|.||.  .      . | ||   ||||. ...  
LLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHC

-KWG------PLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAG-----INPCTETFTGTLQYMAPEIIDKGP-
 |.|      |.  ||. | . ....|.||.||| |.|.|||||.||.|... .|  |..||| .  |       ...   || ||  .||||.| .   
MKCGKNHKGHPM--NEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTE-DGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--RGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHP---EI--PESMSAEAKAFILKCFEPDPDKRACANDLLIDEFL
   ||.  .|||||| |.||||.|.||....  |  |||..   .  |   .   |.. | | . |. || . ||.||. | .||  .|.
PDKGYDYKCDIWSLGITAIEMAEGEPPYFDM-HPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP3K5.AA Ciliate-E2-Unclassified 692-945 23 8.4e-54 185.0 In-house 6-352 (352) Show / Hide 
Range on Protein: 692-945
Range on HMM: 6-352/352
Sequence Identity: 23% (82 aa)

VLGKGTYGIVYAGRDLSNQVRI-----AI-------KEIPERDSRYSQPLHEEIALH---------------KHLKHKNIVQYLGSFSENGFIKIFMEQV
..|.| .|.||  .. ...  .     ..       | | . | .... ..|.  .                ....| .|| ..  |     | | ||..
QIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYC

PGGSLSALLRSKWG---------------PLKDNEQTIG----FYTKQILEGLKYLHDNQ-IVHRDIKGDNVLINTYSG--VLKISDFGTSKRLAGINPC
.||.|.  ......                  . .|...    ||..|||.||.||| .. |.||||| .|.|..   .   .||.||| ||..   | |
EGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNC

---------------TETFTGTLQYM----APEIIDKGPRGYG--KAADIWSLGCTIIEMATGKPPFY-ELGEP----------------QAAMFKVGMF
               . ||.||..||    |||....   .    ...||||||. . || .|..||| .  |                 .   .| . .
DTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNI

KVHPEIP----ESMSAEAKAFIL----KCFEPDPDKRACANDLLIDEFL
.. .. .       | ||| ||     |... .|.||  ....|   ..
QFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase MAP3K5.AA Pkinase_Tyr 692-831 27 2.2e-18 62.86 Pfam 6-156 (270) Show / Hide 
Range on Protein: 692-831
Range on HMM: 6-156/270
Sequence Identity: 27% (42 aa)

VLGKGTYGIVYAGRDL----SNQVRIAIKEI-PERDSRY--SQPLHEEIALHKHL-KHKNIVQYLGSFS-ENGF--IKIFMEQVPGGSLSALLRSK--WG
.||.| .| || |.      ....  |.| . .  ...   .. . .|... |.| .|.|||...|  . . .   | | || .|.|.|   ||..  ..
KLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

PLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFG
.  . .. ...   || .|. ||......|||.   |.|..  ..| ||.|||
QPLTMKDLLQM-CWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFG
Kinase MAP3K5.AA TyrKc 692-944 22 6.6e-17 50.69 SMART 6-280 (280) Show / Hide 
Range on Protein: 692-944
Range on HMM: 6-280/280
Sequence Identity: 22% (66 aa)

VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHL--KHKNIVQYLGSFSEN-------GFIKIFMEQVPGGSLSALLRSKWGPLKD
.|| | .|.|| |.     .  |.| . |      . ...|. . ..|  .|.|||. .|  ..        . . | || .|.|.|   ||.. .    
KLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--L

NEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGI---------NPC----TETFTGTLQYMAPEIIDKGPRGYGKAA
. ..   .  || .|  |||.....|||.   |.|..    . |||||| |. .                    . .   .  |||| |..|   .  . 
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG--KFTTKS

DIWSLGCTIIEMAT-GKPPFYEL----GEPQAAMFKVGMFKVHPEIPES--------MSAEAKAFILKCFEPDPDKRACANDLLIDEF
|.|| | .. |. | |..| ..      ..| .. .|   .  ...|..        ...|    ...| . ||..| . ... ...|
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR-MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MAP3K5.AA Pkinase_Tyr 853-944 22 0.000345 14.81 Pfam 181-270 (270) Show / Hide 
Range on Protein: 853-944
Range on HMM: 181-270/270
Sequence Identity: 22% (21 aa)

MAPEIIDKGPRGYGKAADIWSLGCTIIEMAT-GKPP-FYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLIDEF
|||| |  |   .  . |.|| | .. |. | |. | ....  ..  . ...      ..||  ..|    ...| ..||..|    .. . ..
MAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI-HEQL
Sam7 MAP3K5.AA sam7 1315-1377 21 3.8e-11 37.53 In-house 1-70 (70) Show / Hide 
Range on Protein: 1315-1377
Range on HMM: 1-70/70
Sequence Identity: 21% (15 aa)

TEDSELPGWLRENGA--DEDTISRFLAEDY----TLVDVLYYVTRDDLKCLRL-RGGMLCTLWKAIIDFR
. ....  ||.. |   ... ...|.....    |  |.| ..|..||. .   |.|  . .|..| ..|
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR