Gene MarkmA3 (Mouse)
MarkmA3
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| MarkmA3.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 249 | Kinase domain by global Sugen HMM | Fasta, JSON |
| MarkmA3.NA | RNA | Sugen | 2722 | None | Fasta, JSON |
| MarkmA3.AA | Protein | Sugen | 504 | None | Fasta, JSON |
Protein domains of MarkmA3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | MarkmA3.AA | MARK | 28-276 | 51 | 5.8e-166 | 546.29 | In-house | 1-262 (262) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-262/262 Sequence Identity: 51% (134 aa) YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIR---KRE-YWCNRVISEVELLMMADHPNIISLLQVIE--TKKK-VYLIMELCKGKSLYQHIRKA--GY | || |||||..|.||||.|..||..||.|.. . . |.. | .|.|.... ||||||.|..||| |... .|||||.. |..||..|... |. YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR LQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDG--KVKIIDFGLGTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFMV |.| |||..|.|..||.||||...|||||.||.||.. ..| ..||||||......|||||| ||||.|. |||..|. ||||||.|.|.||||||||| LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV TGKIPFDACS--IKKLVKRILAGKYSIPSRLSAELQDLLSLLMTANPKLRPTVAEVMVHPWV .|. |||... .|.| |.||.|||.||...|.|...|...|.|.||. |||. |.| |||. CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
|||||||||
| Kinase | MarkmA3.AA | CAMKL | 28-276 | 37 | 1.1e-138 | 445.35 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-297/297 Sequence Identity: 37% (113 aa) YVMLETIGHGGCATVKLAQH-RLTGTHVAVKTIRKREYWCNRVIS----------------EVELLMMAD---HPNIISLLQVIETKKK------VYLIM | ...|.|.|....||||.| |.||..||.| | |. |.. ... |.....| . |||||.|..||||... .||.| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM ELCKGKS--LYQHIRKAGY----LQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDG--KVKIIDFGLGTKVKP-----GQKLNLFCGTYPFS |.| | . |...|.| |. ..||||| .|.|..||.||||..||||||.||.||.. ..| ..||||||.... .| ||||. |||..|. EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM APEVLLS--TPYDGPKIDVWTLGVVLYFMVTGKIPFDACSIK---------KLVKRILAGKYSIPSRLSAELQDLLSLLMTANPKLRPTVAEVMVHPWV |||.... .||||||.|.| .||.||.||.|. |||. ... .. .... ... |....| ...||.. ... ||. |||. ..| |||. APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
|||||||||
| Kinase | MarkmA3.AA | CAMK | 33-276 | 25 | 4.7e-123 | 398.56 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 33-276
Range on HMM: 1-425/425
Sequence Identity: 25% (107 aa)
TIGHGGCATVKLAQHRLTG------------THVAVKTIRKR-----------------------------EYWCNRVISEVELLMM-------ADHPNI
|.|.|. ..|||..|..|. ..||.| | |. .... .| .|.|.... |||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
ISLLQVIE------------TKKK--------VYLIM---ELCKGK----SLYQHIRKA---------------GYLQEHEARALFKQLLSAMNYCHNQG
|.|..|.| | .| .|..| |.| | |...|.. |...|.||| .|.|..||..|||...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
IVHRDLKPDNIMVEKD-----------------GKVKIIDFGLGTKVKP------------------------GQKLNLFCGTYPFSA-PEVLLS-----
||||||||.||.. .. ...||||||. .|..| |||.. |||| .. | ||||..
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
--------TPYDGPKIDVWTLGVVLYFMVTGKIPFDAC-------------SIKKLVKRILAGKYS-IPSR-----------------------LSAELQ
||.|||.|.| .||.||.|..|. ||.. ....| ..|..|||. .|. .|.| .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK
DLLSLLMTANPKLRPTVAEVMVHPWV
||.. ... .|. |.|..... |||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
|
|||||||||
| Kinase | MarkmA3.AA | S_TKc | 28-276 | 32 | 7e-99 | 335.72 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-231/231 Sequence Identity: 32% (87 aa) YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRKREYWCNRVISEVELLMMADHPNIISLLQVIETKKKVYLIMELCKG--KSLYQHIRKAGY------L | .|..||.|. ..|....|. || .||.| |. .....|...|.. .||||. |. |... ...|..||.| | .|...|.| |. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF QEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLGTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFMVTGK | .|| ...|...|..|||..||.||||||.||.. . .||.|||| ... . |||| . ||||| .|...|.|.| .|..|| |..|. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY IPFDACSIKKLVKRILAGKYSIPSRLSAELQDLLSLLMTANPKLRPTVAEVMV-------HPWV ||. .... |.|. | |. |... ... .|. |||. |.. |||. PPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | MarkmA3.AA | AGC | 28-276 | 21 | 3.2e-92 | 238.05 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-395/395 Sequence Identity: 21% (84 aa) YVMLETIGHGGCATVKLAQHR------LTGTHVAVKTIRKRE---------YWCNR----------VISEVELLMMAD----------HPNIIS-LLQVI . .| .|| |. .| |.... || |.| ..|.. .. | .| . |.... ||.|.. | FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF ETKKK--VYLIMELCK---------GK-SLYQHIR---KAGYLQEHEARALFKQ-------LLSAMNYCHN-QGIVHRD-LKPDNIMVEKDGKVKIIDFG ..|.. .|..||... | |..|.. | |.. | .|| . . ...|. | |. .||.||| |||.||. .|| .|. ||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG LGTKVKPG---------------------------------------------------QKLNLFCG--TYPFSAPEVLLSTPYDGPKIDVWT--LGVVL | .... . .. . ||| | . |||.| |. | |. ||... LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM YFMVTGKIPFDACS----------IKKLVKRILAG------KYSIP----------SRLSAELQDLLSLLMTANPKLRPT----------VAEVMVHPWV | |.||. || . . ... ..|. | | .| . .| |..||.. |.. .|. |.. . |.. ||| YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
|||||||||
| Kinase | MarkmA3.AA | Pkinase | 28-276 | 29 | 5.6e-92 | 316.67 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-293/293 Sequence Identity: 29% (88 aa) YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRKREYWCNRVIS-----EVELLMMADHPNIISLLQVIETKKKVYLIMELCKGK----SLYQHIR--KA |. ...|| |. ..|....|. || ||||.|.||. .. .. |.... . .||||. |. . |.|...|..||.| | .|. .|. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GYL--QEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKV----KIIDFGLGTK--VKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTL | . .|.|.. ..|.|....|||..||.||||||.||.. ..| . ||.|||| . ... .. ||||... ||||... .|.|||.|.| . GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVVLYFMVTGKIPFDAC------SIKKLVKRILAGKYSIPSRLS---------------------AELQDLLSLLMTANPKLRPTVAEVMVHPWV |..|| |..|. ||. . . .....||. .... .. . |..|... . . .|| ||| .... |||. GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | MarkmA3.AA | AMPK | 28-276 | 39 | 1.3e-91 | 272.27 | In-house | 1-254 (254) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-254/254 Sequence Identity: 39% (100 aa) YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRKR----EYWCNRVISEVELLMMADHPNIISLLQVI-ETKKKVYLIMELCKGKSLYQHIRKAGYLQEH |.. .||| | ||.. | |||. ||.| . |. . .|. .|...| . ||.|| | .|| ||.. ...|| | |. | | | |||. YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER EARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLGTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFMVTGKIPF ||. .|.| .|. |||. .|||||||| |. .. ..|| |||| | |..| || |||. . .| ||..|.| ||.|| |. |. || EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF DACSIKKLVKRILAGKYSIPSRLSAELQDLLSLLMTANPKLRPTVAEVMVHPWV | .. .| |.|..|.|.||. || | .||.. . . .| | |. ... ||| DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
|||||||||
| Kinase | MarkmA3.AA | QIK | 28-276 | 37 | 3.8e-90 | 305.81 | In-house | 1-272 (272) | Show / Hide |
Range on Protein: 28-276
Range on HMM: 1-272/272
Sequence Identity: 37% (103 aa)
YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRKR---EYWCNRVISEVELLMMADHPNIISLLQVIETKKKVYLIMELCKGKSLYQHIRKAGY------
| . ||| | |.||||.|| | | ||.| | | | ... ||... | .||.|| |.||.||.. |...| |.. .. .. | |
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV
--------------LQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLGTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKID
..| ||| |.|..|| |||...||||||| ||. .. .||.|||.. |.|| |. .||. |. |||... |||||.|
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD
VWTLGVVLYFMVTGKIPFDACSIKKLVKRILAGKYSIPSRLSAELQDLLSLLMTANPKLRPTVAEVMVHPWV
.| .||||| .|.|..||| ....| .|.| ||. || .| ....| .. .|. | |.. .. |.|
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
|
|||||||||
| Kinase | MarkmA3.AA | SNRK | 28-276 | 42 | 6.6e-81 | 264.63 | In-house | 1-254 (254) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-254/254 Sequence Identity: 42% (107 aa) YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRKR---EYWCNRVISEVELLMMADHPNIISLLQVIETKKKVYLIMELCKGKSLYQHIRKAGY-LQEHE | . .|.|.| | ||||.| || .|||| | | | ... || . . ||||. | ||.|. |.|||.|| | .| .| | |.| YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL ARALFKQLLSAMNYCHNQGIVHRDLKPDN-IMVEKDGKVKIIDFGLGTKVKPGQKLNLFCGTYPFSAPEVLLSTPYDGPKIDVWTLGVVLYFMVTGKIPF || |.|.. |..||| .|||||||.| . || | ||. ||| | .||.||. .|| .||||.|| || | .|.| |||.|| .| |. || ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF DACSIKKLVKRILAGKYSIPSRLSAELQDLLSLLMTANPKLRPTVAEVMVHPWV . . .|. ||..|...|.| .||. .. .|| | .. |. |.|| QEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV |
|||||||||
| Kinase | MarkmA3.AA | Ciliate-E2 | 28-276 | 22 | 7.2e-79 | 268.32 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 28-276 Range on HMM: 1-365/365 Sequence Identity: 22% (84 aa) YVMLETIGHGGCATVKLAQHRLTGTH-----------------------VAVKTIRKR--EYWCN--RVISEVE----------LLMMADHPNIISLLQV | .. || |. ..|......... .|.|...|. |.. . ... |.. .| .||||| . . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC IE--TKKKVYLIMELCKGKSLYQHIR------------KAGYLQEHEARALFKQLLS---------------AMNYCHNQG-IVHRDLKPDNIMVEKDGK . .....||.||.|.|..|...|. . .|. | |.. ..||.|. |..|.|... |.|||.||.||.. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- VKIIDFGLGTKVKPGQKLNL--------------------------------FCGTYPFSAPEVLLSTPYDG--------PKIDVWTLGVVLYFMVTGKI .||||||| .|... .. .. .|||... |||.| . .||. |.|.| |||.||.|..|| IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP PFDACSIKKLVKRILAGKYSIP------------------SRLSAELQDLLSL----LMTANPKLRPT-VAEVMVHPWV || . |. .|...| .| | .||.. .. .|. |.| ... ||| PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
|||||||||
| Kinase | MarkmA3.AA | Ciliate-E2-Unclassified | 28-276 | 24 | 2.9e-71 | 243.05 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 28-276
Range on HMM: 1-352/352
Sequence Identity: 24% (85 aa)
YVMLETIGHGGCATVKLAQHRLTGTHV------------AVKTIRKREYWCNRVISEVE----------------LLMMADHPNIISLLQVIETKKKVYL
| ....||.|| ..|...||. .. . ..| |.. . .. . |.. .| . .||.|. .. . ..|...|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI
IMELCKGKSLYQHIRK-----------------AGYLQEHEAR-----ALFKQLLSAMNYCHNQG-IVHRDLKPDNIMVEKDG---KVKIIDFGLGTKVK
.||.|.|..| |.|.| ..| .|. .|.|.|.. .|.| .. |.|||.||.||.. ..| ..||||||. | .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ
----------------PGQKLNLFCGTYPFS----APEVLLSTPYDGP---KIDVWTLGVVLYFMVTGKIPFDACSIKK----------------LVKRI
. |... ||||. . ||||| . ||.. |.|.|.|||.||.|..|. ||.. . .. | . |
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI
LAGKYSIPS--------RLSAELQDLLS----LLMTANPKLRPTVAEVMVHPWV
.......|. ..| | .|... .. ||. |.| ... |||
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
|
|||||||||
| Kinase | MarkmA3.AA | RSK | 30-276 | 30 | 1e-70 | 241.28 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 30-276 Range on HMM: 1-278/278 Sequence Identity: 30% (85 aa) MLET--IGHGGCATVKLAQHRLTGTHVAVKTIRKREYWCN-----RVISEVELLMMAD-HPNIISLLQVIETKKKVYLIMELCKGKSLYQHIRKAGY--- . . .| | ... .|. ||.. |.| ..|.. . .. |.. |.. ||.|..| . .|..|.|||||.|.| |. |..| .. LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC LQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEK---DGKVKIIDFGLGTK--VKPGQKLNLFCGTYPFSAPEVLL---STP-YDGPKIDVWTLG . |.||.. . .. .|. . | |||.||||||.||. . .| .|..|||. . . .|... ||.| . |||.| .| |.|.|| FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHD-KACDWWSLG VVLYFMVTGKIPFDA---CSIKKLVKRILAGK--YSIP--SRLSAELQDLLSLLMTANPKLRPT-----VAEVMVHPWV |..| | ||. || . . |.. |||. || ..| . ||.| .||.. ... .|. |.. ..|. ||| VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
|||||||||
| Kinase | MarkmA3.AA | TyrKc | 28-275 | 20 | 7.7e-17 | 49.6 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 28-275 Range on HMM: 1-280/280 Sequence Identity: 20% (59 aa) YVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRKREYWCNRVISEVELLMMA--DHPNIISLLQVIETK-------KKVYLIMELCKGKSLYQHIRKAGY ......|.| .| ... . . ||||.... ..| ..... .||||. |. |. .. . ....||.... .| ...|| . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP -LQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLGTKVKPG------QKLNLF----CGT--YPF--SAPEVLLSTPYDGPKI |. . | . |.| | ....|||| |..| ... ||| |||| ... . .. .| | |||.. . .| KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKS DVWTLGVVLYFMVT-GKIPFDA-----CSIKKLVKRILAGKYSIPSRL---------SAELQDLLSLLMTANPKLRPTVAEVMVHPW ||| ||... . | |. | .| . ..... .|.. . ..|. .. . ..|. ||| .|. .. . DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF |
|||||||||
| Kinase | MarkmA3.AA | Pkinase_Tyr | 28-168 | 24 | 3.6e-16 | 55.38 | Pfam | 1-157 (270) | Show / Hide |
Range on Protein: 28-168 Range on HMM: 1-157/270 Sequence Identity: 24% (39 aa) YVMLETIGHGGCATVKLAQHR----LTGTHVAVKTIRKREYWCNR-----VISEVELLMMA-DHPNIISLLQVIE-TKKK--VYLIMELCKGKSLYQHIR ......|.| .|... . |...||||.. | . ..|..... .||||..|. |. .. .|..||.... .|. . | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR K----AGYLQEHEARALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGL | . | .. | ..|.| ......|||| |..|.....||| |||| KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL |
|||||||||
| Kinase | MarkmA3.AA | APH | 114-167 | 14 | 0.000138 | 16.52 | Pfam | 142-200 (248) | Show / Hide |
Range on Protein: 114-167 Range on HMM: 142-200/248 Sequence Identity: 14% (9 aa) RKAGYLQ---EHEARA-LFKQLLSAMNYCHNQGIVHRDLKPDNIMVE-KDGKVK---IIDFG ....... ..... |. .|.... ...|.|..|.|.|. ... . .||.. VDPEWFDEDRQWWLWQRLWAWLEAHWP---PPCWCHGDFHPGNVMWDPRPDGGRVTGVIDWD |
|||||||||
| Kinase | MarkmA3.AA | Pkinase_Tyr | 204-237 | 29 | 3.87831 | 1.09 | Pfam | 196-232 (270) | Show / Hide |
Range on Protein: 204-237 Range on HMM: 196-232/270 Sequence Identity: 29% (11 aa) DVWTLGVVLYFMVT-GKIP-FDACSIKKLVKRI-LAG ||| ||... ..| |..| . .| ....| | DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG |
|||||||||
| UBA_CAMKL | MarkmA3.AA | UBA_CAMKL | 296-333 | 36 | 3.4e-13 | 45.45 | In-house | 1-41 (41) | Show / Hide |
Range on Protein: 296-333 Range on HMM: 1-41/41 Sequence Identity: 36% (15 aa) DPAIVKAMGHI--GFQAQDIEDSLRQRKF-NQTMASYCLLK |. |.. | .. ||. ..|..|||..|. |. .| |.|| DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL |
|||||||||