Gene MarkmC1 (Mouse)

MarkmC1

Species: Mouse
Alias: MarkmC1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MarkmC1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 245 Kinase domain by global Sugen HMM Fasta, JSON
MarkmC1.AA Protein Sugen 301 None Fasta, JSON
MarkmC1.NA RNA Sugen 1718 None Fasta, JSON

Protein domain

Protein domains of MarkmC1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MarkmC1.AA MARK 27-275 49 1.3e-154 508.67 In-house 1-262 (262) Show / Hide 
Range on Protein: 27-275
Range on HMM: 1-262/262
Sequence Identity: 49% (130 aa)

YKMLNTLGEGKFSVVKRAFHVPTSTSVAVKILQ---NTK-EYTSPICREARIMKSLSHPNIIKLFHVVQ--RRET-TYLVMEYASEGELQDRIIKV--GS
|||| |.|.| ...|| | |..| . ||.||..    .. .  ....||..|||.|.||||||||||..   ... .||.|||||.||| |.|...  | 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDYRG--NAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGPPVDIWSLGVLLFLMV
|.|.|.||.| |||.||.|||...|||||||. ||||| .|  |.|..|||......|||||  ||||.||.|||... ..|.||.||||||||.|. ||
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

SGNLPFQGRY--FVDLKQEIISANFSIPSHVSIDILNVIIELLMINPSRRPTIHQIMRHPMI
.|..|| |    ...|...| . ...||.||| .. | |  ||..||..||||..||.|| .
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MarkmC1.AA CAMKL 27-275 42 1.1e-131 422.61 In-house 1-297 (297) Show / Hide 
Range on Protein: 27-275
Range on HMM: 1-297/297
Sequence Identity: 42% (128 aa)

YKMLNTLGEGKFSVVKRAFH-VPTSTSVAVKILQNTKEYTSPICR----------------EARIMKSLS---HPNIIKLFHVVQRRET------TYLVM
|... |||.| |..|| | |   | . ||.||.   |    |...                |..|||.|.   |||||||..|.. .|.       ||||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYASEGE--LQDRIIKV----GSLEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDYRG--NAKLCDFGLAAEVIP-----GQKLAGFCGTLPYC
||.| ||  |.|.|.|     |...|.|.||.| |||.||.|||.|.|||||||. |||.|..|  |.|..|||.... .|     ||||  |||..||.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APELLQA--EKYEGPPVDIWSLGVLLFLMVSGNLPFQGR--------YFVDLKQEIISANFSIP--SHVSIDILNVIIELLMINPSRRPTIHQIMRHPMI
|||..|   ..|.||.|||||.||.|. || |.||| .          .  |. .|..  . .|  .||| |  . |  .|. ||..||||||||.||  
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MarkmC1.AA CAMK 32-275 25 7.29999999999e-113 365.15 In-house 1-425 (425) Show / Hide 
Range on Protein: 32-275
Range on HMM: 1-425/425
Sequence Identity: 25% (109 aa)

TLGEGKFSVVKRAFHVPTS------------TSVAVKI-----LQN------------------------TKEYTSPICREARIMKSLS-------HPNI
|||.| |..||...|  |             . ||.||     |..                        . .    . || .|||.|.       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLFHVVQ------------RRET--------TYLVM---EYASEGEL----QDRIIKVGS---------------LEESETRRLFAQIVHAVQYCHDHH
|||..| .              ..         |.||   ||.| |||     |.|.. |.               ..|.|.||.| ||. ||.|||.|.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKASNILIDYR-----------------GNAKLCDFGLAAEVIP------------------------GQKLAGFCGTLPYCA-PELLQA-----
|||||.|  |||.|..                 .| |..|||.|....|                        |||.  ||||..|.| ||.|.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------EKYEGPPVDIWSLGVLLFLMVSGNLPFQGR-------------YFVDLKQEIISANFS-IPSHVSI-----------------------DIL
        ..| ||..|.||.||.|. |..| .||.|                 .|.. |...... .|...|.                       .  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NVIIELLMINPSRRPTIHQIMRHPMI
. |  .|  .|..|.||.|...|| .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MarkmC1.AA QIK 27-275 41 9.6e-96 324.39 In-house 1-272 (272) Show / Hide 
Range on Protein: 27-275
Range on HMM: 1-272/272
Sequence Identity: 41% (112 aa)

YKMLNTLGEGKFSVVKRAFHVPTSTSVAVKILQNT---KEYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELQDRIIKVGS------
| .  |.| | | |||.| |  | | ||.||.  .   .|.   . ||  |||.|.||.||||. |    .  |.|.||.|.||. | ..| |       
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------LEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDYRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGPPVD
              ..|.|.|| | ||. ||.|||...|||||.|| |||.|   | |. |||.     .|| |. .||. || |||... ..|.|| ||
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

IWSLGVLLFLMVSGNLPFQGRYFVDLKQEIISANFSIPSHVSIDILNVIIELLMINPSRRPTIHQIMRHPMI
|||.||.|. .|.| ||| |     |.| ..|  | ||  .| |    |   | ..|..| || ||..|. .
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MarkmC1.AA NuaK 27-275 43 2.1e-94 248.53 In-house 1-252 (252) Show / Hide 
Range on Protein: 27-275
Range on HMM: 1-252/252
Sequence Identity: 43% (109 aa)

YKMLNTLGEGKFSVVKRAFHVPTSTSVAVKILQNTK----EYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELQDRIIKVGSLEESE
|... |||.| .  ||.|    |   ||.|  .  |    .    | || .|| || ||.||. . |   ..   .|||||| ||| | | . .|| | |
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

TRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDYRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGPPVDIWSLGVLLFLMVSGNLPFQ
.|..| ||| || ||| | |.||| |  ||| |  .|||  ||||      .. |  |||   |  ||    . |.|| || |||||||. || | .|| 
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

GRYFVDLKQEIISANFSIPSHVSIDILNVIIELLMINPSRRPTIHQIMRHPMI
|. |  |.. | . ..  | . | |    | ..||.|| || || .|  |. .
GHDFKHLVKQISQGAYYEPCKPS-DACMLIRWMLMVNPRRRATIYDICHHWWV
Kinase MarkmC1.AA AMPK 27-275 41 5.6e-93 276.38 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-275
Range on HMM: 1-254/254
Sequence Identity: 41% (105 aa)

YKMLNTLGEGKFSVVKRAFHVPTSTSVAVKILQNTK----EYTSPICREARIMKSLSHPNIIKLFHVV-QRRETTYLVMEYASEGELQDRIIKVGSLEES
| .  |.||| |  || . |  |.. ||.|||  .|    .    | || .|.|.. ||.||.|. |.    .  ..||||.| ||| | |.| | |.| 
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

ETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDYRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGPPVDIWSLGVLLFLMVSGNLPF
|..|.|.||. .| |||.| ||||| |  |.|.|.  | |. ||||      |..|   ||   | |||. .  .|.|| ||||| || |. |. | |||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

QGRYFVDLKQEIISANFSIPSHVSIDILNVIIELLMINPSRRPTIHQIMRHPMI
      .| . |..  ..||...| .. . | ..|  .|  | |||.|. ||  
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MarkmC1.AA S_TKc 27-275 34 3.5e-92 313.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-275
Range on HMM: 1-231/231
Sequence Identity: 34% (90 aa)

YKMLNTLGEGKFSVVKRAFHVPTSTSVAVKILQNTKEYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASE--GELQDRIIKVGS------L
|..|...|.| |..|... |. |   ||.||.         |.|| .|.|.  ||||.||. | |  .  |.||||..   |.| |.| | |.      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

EESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDYRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGPPVDIWSLGVLLFLMVSGN
 | ..|....||. |..|||.|.|.|||.| .|||.|   . |.||||||...        ||||. |.|||.|   .| ....|.||.|..|. |..| 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

LPFQGRYFVDLKQEIISANFSIPSHVSIDILNVIIELLMINPSRRPTIHQIMR-------HPMI
 ||.    ...  ..|          | . .. |  .|  .|..|||. ....       || .
PPFP---QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MarkmC1.AA Pkinase 27-275 30 1.8e-85 295.04 Pfam 1-293 (293) Show / Hide 
Range on Protein: 27-275
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

YKMLNTLGEGKFSVVKRAFHVPTSTSVAVKILQNTKEYTSPICR------EARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEG----ELQDRII--K
|. . ..|.| |..|... |. |.  |||||.    .  |  ..      |..|||.|.||||..|.......   |.||||.  |    .| |.|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

VGSL--EESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDYRGNA----KLCDFGLAAE--VIPGQKLAGFCGTLPYCAPELLQAEKYEGPPVDIWS
 |..  .| | .. . ||. ...|||.. |.|||.| .||||| .|.     |.||||||.     ... . .||||..|.|||...  .| ||.||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLLFLMVSGNLPFQGR---------YFVDLKQE-IISANFSIPSHVS-----------------IDILNVIIELLMINPSRRPTIHQIMRHPMI
.|..|. |..|..||.|.         . .... . ... ... .. .|                  . . .|  .|  .|..|||..||. || .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MarkmC1.AA NIM1 27-275 38 3.6e-80 235.2 In-house 1-258 (258) Show / Hide 
Range on Protein: 27-275
Range on HMM: 1-258/258
Sequence Identity: 38% (100 aa)

YKMLNTLGEGKFSVVKRAFHVPTSTSVAVKILQ--NTK---EYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELQDRIIKVGSLEES
| .   .| | || || . |  |   ||.||.    ||          ||   |  . ||||..|. ||      .||||||. |||  .| . | | | 
YRFCGEIGRGNFSKVKLGVHQLTKEKVAIKIMDLDKTKMDQKTQRMLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLREI

ETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDYRGNAKLCDFGLAAEVIP----GQKLAGFCGTLPYCAPELLQAEKYEGPPVDIWSLGVLLFLMVSG
.   .||||| ||.  |   |||||||| |..   ..  |. |||    ..     .|.|  |||  || |||| | | | |..||.| ||.||. |. |
HCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPELFQDEHYIGEYVDVWALGILLYFMMTG

NLPFQGRYFVDLKQEIISANFSIPSHVSIDILNVIIELLMINPSRRPTIHQIMRHPMI
. ||      ..|  |    ..||..||      |   |   |  |.|| |.| |  .
VMPFRAETVPKMKKCILKGQYQIPDYVSLPCHRLIRGMLKHIPTQRYTIDQMMNHQWM
Kinase MarkmC1.AA SNRK 27-275 38 2.5e-74 242.71 In-house 1-254 (254) Show / Hide 
Range on Protein: 27-275
Range on HMM: 1-254/254
Sequence Identity: 38% (98 aa)

YKMLNTLGEGKFSVVKRAFHVPTSTSVAVKILQNTK---EYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELQDRIIKVGS-LEESE
| . .|||.| | ||| | || |   ||||..  ||     .. . .| | ||   ||||..|. |.      ||..|    ... | |.|  . |.|. 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

TRRLFAQIVHAVQYCHDHHIVHRDIKASN-ILIDYRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGPPVDIWSLGVLLFLMVSGNLPF
 |. |.||.||..|||  |.||||.|  | .  .  |  || ||| . .  ||.||  .|| | | |||.|  ..|. | ||||||||.|...| | .||
ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF

QGRYFVDLKQEIISANFSIPSHVSIDILNVIIELLMINPSRRPTIHQIMRHPMI
|     .    |.   ...|.||| .  ..| ..|. .| .| .. .|  |. .
QEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase MarkmC1.AA RSK 27-275 29 5.4e-69 235.53 In-house 1-278 (278) Show / Hide 
Range on Protein: 27-275
Range on HMM: 1-278/278
Sequence Identity: 29% (83 aa)

YKMLNTLGEGKFSVVKRAFHVPTSTSVAVKILQNTKEYTSPI----CR-EARIMKSLS-HPNIIKLFHVVQRRETTYLVMEYASEGELQDRIIKVGS---
 |.| ..| ||......  |  | .  |.|.|.  |  ..      .. | .|..    ||.|..|... |  . .||.||| . ||| ... | ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDY---RGNAKLCDFGLAAE-VIP-GQKLAGFCGTLPYCAPELLQ-AEKYE--GPPVDIWSLGV
. |.| .  .|.|| ||.. |...|.|||.| .||| |    .|  ||.|||.. . ..  .|..  ||.|. |.|||.|  |.. .  .  .|.|||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLFLMVSGNLPFQG---RYFVDLKQEIISAN--FSIP--SHVSIDILNVIIELLMINPSRRPT-----IHQIMRHPMI
|.. | .|..||||       .. . | ...  ...|  . .| .  . |  .|. .|..|..     . .| .|| .
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MarkmC1.AA Ciliate-E2-Unclassified 27-275 25 2.6e-68 233.23 In-house 1-352 (352) Show / Hide 
Range on Protein: 27-275
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)

YKMLNTLGEGKFSVVKRAFHVPTSTSV-----AVKILQNTKEYTSP---ICREARIMKSLS-------------------HPNIIKLFHVVQRRETTYLV
||.. ..|.| |..|... |  .   .     . || .. . .      | .|. .|....                   ||.|.|.|.. | ... |.|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYASEGELQDRIIKVGS-----------------LEESETR-----RLFAQIVHAVQYCHDHH-IVHRDIKASNILIDYRG---NAKLCDFGLAA----
|||.  |.|.. | | ..                 ..| ...     ..||||. . .|.|  . |.||||| .|||.|  |   . |..|||..     
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

------------EVIPGQKLAGFCGTLPYC----APELLQAEKYEGP---PVDIWSLGVLLFLMVSGNLPFQGRYFVD----------------LKQEII
             ... |..  ||||. |     |||.|| ..|...    .|||||||.|. |. |..||...   .                |.|.|.
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

SANFSIPS--------HVS---IDILN-VIIELLMINPSRRPTIHQIMRHPMI
  |...|.        |.|   .|..|  .  .|  ||. |.|. ||. || .
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase MarkmC1.AA Pkinase_Tyr 27-168 33 3.9e-29 99.28 Pfam 1-158 (270) Show / Hide 
Range on Protein: 27-168
Range on HMM: 1-158/270
Sequence Identity: 33% (53 aa)

YKMLNTLGEGKFSVVKRAFHV----PTSTSVAVKIL--QNTKEY--TSPICREARIMKSL-SHPNIIKLFHVVQ-RRET--TYLVMEYASEGELQDRIIK
 ... .|||| | .|...        | . ||||.|  . ..|        |||.|||.| .||||..|  |.  ..|    |.||||.  | | |   |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----VGSLEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDYRGNAKLCDFGLA
     ..|  ..     .||  . .| ......|||. | |.|..  . .| ||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase MarkmC1.AA TyrKc 27-275 24 7.5e-28 99.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-275
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

YKMLNTLGEGKFSVVKRAFHVPTSTSVAVKILQNTKEYTSPICREARIMKSL--SHPNIIKLFHVVQRR-------ETTYLVMEYASEGELQDRIIKVGS
 ... .|||| | .| ..      . |||| |.. .     ..||||||..|  .||||..|. |.          |  ..||||.. | |.|.. | . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDYRGNAKLCDFGLAAEVIPG--------QKLAGF--CGT--LPY--CAPELLQAEKYEGPPV
 |  ..      ||    .| |.....|||. | |.|.. .. .| .||||. ..  .         . .    .|   ||.  .||| ..  |.  .  
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF-TTKS

DIWSLGVLLFLMVS-GNLPFQG-----RYFVDLKQEIISANF-SIPSH--------VSIDILNVIIELLMINPSRRPTIHQIMRHPMI
|.|| ||... . . |  |  |         .. . . . .   .| .         . .. ... .  . .|. |||  .|  |  .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF