Gene MarkmC2 (Mouse)

MarkmC2

Species: Mouse
Alias: MarkmC2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MarkmC2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 174 Kinase domain by global Sugen HMM Fasta, JSON
MarkmC2.AA Protein Sugen 259 None Fasta, JSON
MarkmC2.NA RNA Sugen 1322 None Fasta, JSON

Protein domain

Protein domains of MarkmC2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MarkmC2.AA MARK 57-231 50 1.4e-114 375.94 In-house 1-186 (262) Show / Hide 
Range on Protein: 57-231
Range on HMM: 1-186/262
Sequence Identity: 50% (94 aa)

YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQ---NTK-EYTSPICREARIMKSLSHPNIIKLFHVVQ--RRET-TYLVMEYASEGELLDCIINV--GS
|||| |.|.|....|| | |..| . ||.||..    .. .  ....||..|||.|.||||||||||..   ... .||.|||||.|||.|.|...  | 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRG--NAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGPP
|.|.|.||.| |||.||.|||...|||||||. |||||..|  |.|..|||......|||||  ||||.||.|||... ..|.||.
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPK
Kinase MarkmC2.AA CAMKL 57-231 42 1.2e-99 318.69 In-house 1-216 (297) Show / Hide 
Range on Protein: 57-231
Range on HMM: 1-216/297
Sequence Identity: 42% (92 aa)

YKMLNTLGEGNFSVVKRAFH-VPTSTSVAVKILQNTKEYTSPICR----------------EARIMKSLS---HPNIIKLFHVVQRRET------TYLVM
|... |||.|.|..|| | |   | . ||.||.   |    |...                |..|||.|.   |||||||..|.. .|.       ||||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYASEGE--LLDCIINV----GSLEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRG--NAKLCDFGLAAEVIP-----GQKLAGFCGTLPYC
||.| ||  |.| |..     |...|.|.||.| |||.||.|||.|.|||||||. |||.|..|  |.|..|||.... .|     ||||  |||..||.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APELLQA--EKYEGPP
|||..|   ..|.||.
APEIFQGNNKPYDGPK
Kinase MarkmC2.AA CAMK 62-232 27 6.3e-81 260.37 In-house 1-315 (425) Show / Hide 
Range on Protein: 62-232
Range on HMM: 1-315/425
Sequence Identity: 27% (86 aa)

TLGEGNFSVVKRAFHVPTS------------TSVAVKI-----LQN------------------------TKEYTSPICREARIMKSLS-------HPNI
|||.|.|..||...|  |             . ||.||     |..                        . .    . || .|||.|.       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLFHVVQ------------RRET--------TYLVM---EYASEGEL----LDCIINVGS---------------LEESETRRLFAQIVHAVQYCHDHH
|||..| .              ..         |.||   ||.| |||    .| |.  |.               ..|.|.||.| ||. ||.|||.|.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKASNILIDCR-----------------GNAKLCDFGLAAEVIP------------------------GQKLAGFCGTLPYCA-PELLQA-----
|||||.|  |||.| .                 .| |..|||.|....|                        |||.  ||||..|.| ||.|.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------EKYEGPPC
        ..| ||.|
MQNATDEEKPYYGPKC
Kinase MarkmC2.AA QIK 57-230 41 1.3e-67 230.93 In-house 1-197 (272) Show / Hide 
Range on Protein: 57-230
Range on HMM: 1-197/272
Sequence Identity: 41% (81 aa)

YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNT---KEYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELLDCIINVGS------
| .  |.| ||| |||.| |  | | ||.||.  .   .|.   . ||  |||.|.||.||||. |    .  |.|.||.|.||. | ... |       
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------LEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGP
              ..|.|.|| | ||. ||.|||...|||||.|| |||.|   | |. |||.     .|| |. .||. || |||... ..|.||
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGP
Kinase MarkmC2.AA NuaK 57-230 43 1.6e-65 170.97 In-house 1-178 (252) Show / Hide 
Range on Protein: 57-230
Range on HMM: 1-178/252
Sequence Identity: 43% (77 aa)

YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTK----EYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELLDCIINVGSLEESE
|... |||.| .  ||.|    |   ||.|  .  |    .    | || .|| || ||.||. . |   ..   .|||||| ||| | | . .|| | |
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

TRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGP
.|..| ||| || ||| | |.||| |  ||| |  .|||  ||||      .. |  |||   |  ||    . |.||
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGP
Kinase MarkmC2.AA AMPK 57-230 42 9.3e-65 191.2 In-house 1-179 (254) Show / Hide 
Range on Protein: 57-230
Range on HMM: 1-179/254
Sequence Identity: 42% (76 aa)

YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTK----EYTSPICREARIMKSLSHPNIIKLFHVV-QRRETTYLVMEYASEGELLDCIINVGSLEES
| .  |.||| |  || . |  |.. ||.|||  .|    .    | || .|.|.. ||.||.|. |.    .  ..||||.| ||| | |.  | |.| 
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

ETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGP
|..|.|.||. .| |||.| ||||| |  |.|.|.  | |. ||||      |..|   ||   | |||. .  .|.||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGP
Kinase MarkmC2.AA Pkinase 57-232 35 6.7e-61 213.44 Pfam 1-193 (293) Show / Hide 
Range on Protein: 57-232
Range on HMM: 1-193/293
Sequence Identity: 35% (69 aa)

YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTKEYTSPICR------EARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEG----ELLDCII--N
|. . ..|.|.|..|... |. |.  |||||.    .  |  ..      |..|||.|.||||..|.......   |.||||.  |    .| | |   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

VGSL--EESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNA----KLCDFGLAAE--VIPGQKLAGFCGTLPYCAPELLQAEKYEGPPC
 |..  .| | .. . ||. ...|||.. |.|||.| .||||| .|.     |.||||||.     ... . .||||..|.|||...  .| ||..
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV
Kinase MarkmC2.AA NIM1 57-231 40 1.9e-54 158.37 In-house 1-184 (258) Show / Hide 
Range on Protein: 57-231
Range on HMM: 1-184/258
Sequence Identity: 40% (75 aa)

YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQ--NTK---EYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELLDCIINVGSLEES
| .   .| |||| || . |  |   ||.||.    ||          ||   |  . ||||..|. ||      .||||||. |||   | . | | | 
YRFCGEIGRGNFSKVKLGVHQLTKEKVAIKIMDLDKTKMDQKTQRMLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLREI

ETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIP----GQKLAGFCGTLPYCAPELLQAEKYEGPP
.   .||||| ||.  |   |||||||| |..   ..  |. |||    ..     .|.|  |||  || |||| | | | |..
HCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPELFQDEHYIGEY
Kinase MarkmC2.AA CAMK-Unique 57-230 23 4.5e-53 173.46 In-house 1-269 (363) Show / Hide 
Range on Protein: 57-230
Range on HMM: 1-269/363
Sequence Identity: 23% (63 aa)

YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQN-TKEYTSPIC--------------------REARIMKSLSHPNIIKLFHV----VQRRE-------
|||.. .|.|||..|....   | .  |.|.... | .  . .                     ||..|.|...|||||||...    .. |.       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------TTYLVMEYASEGELLDCIIN--------------------VGSLEE--SETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGN-----
          |.||||. .|.|.| |.                      |...|  ..|........ || | |.  |||||.|. ||..  ...     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

-----------AKLCDFGLAAEVIPGQKLA---GFCGTLPYCAP--------------ELLQAEKYEGP
            |||||||....   .. .    .|||..|.||              |.. . .| ..
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQ
Kinase MarkmC2.AA SNRK 57-230 40 3.8e-49 158.91 In-house 1-179 (254) Show / Hide 
Range on Protein: 57-230
Range on HMM: 1-179/254
Sequence Identity: 40% (72 aa)

YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTK---EYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELLDCIINVGS-LEESE
| . .|||.| | ||| | || |   ||||..  ||     .. . .| | ||   ||||..|. |.      ||..|    ... | |.   . |.|. 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

TRRLFAQIVHAVQYCHDHHIVHRDIKASN-ILIDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGP
 |. |.||.||..|||  |.||||.|  | .  .  |  || ||| . .  ||.||  .|| | | |||.|  ..|. |
ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAP
Kinase MarkmC2.AA RSK 57-222 31 7.2e-46 158.71 In-house 1-180 (278) Show / Hide 
Range on Protein: 57-222
Range on HMM: 1-180/278
Sequence Identity: 31% (57 aa)

YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTKEYTSPI----CR-EARIMKSLS-HPNIIKLFHVVQRRETTYLVMEYASEGELLDCIINVGS---
 |.| ..| | ......  |  | .  |.|.|.  |  ..      .. | .|..    ||.|..|... |  . .||.||| . |||.. . . ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDC---RGNAKLCDFGLAAE-VIP-GQKLAGFCGTLPYCAPELL
. |.| .  .|.|| ||.. |...|.|||.| .||| |    .|  ||.|||.. . ..  .|..  ||.|. |.|||.|
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEML
Kinase MarkmC2.AA S_TKc 57-259 29 7.2e-44 152.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 57-259
Range on HMM: 1-231/231
Sequence Identity: 29% (74 aa)

YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTKEYTSPICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASE--GELLDCIINVGS------L
|..|...|.| |..|... |. |   ||.||.         |.|| .|.|.  ||||.||. | |  .  |.||||..   |.|.| | . |.      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

EESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEG-------------------
 | ..|....||. |..|||.|.|.|||.| .|||.|   . |.||||||...        ||||. |.|||.|   .| .                   
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

----PPCRYLEFRGPPVPHGI------WEL-------AFPKAS-------LLWT
     . . ..  |   | ..      ..        |              | 
PPFPQMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MarkmC2.AA Pkinase_Tyr 57-198 33 9.2e-32 108.19 Pfam 1-158 (270) Show / Hide 
Range on Protein: 57-198
Range on HMM: 1-158/270
Sequence Identity: 33% (53 aa)

YKMLNTLGEGNFSVVKRAFHV----PTSTSVAVKIL--QNTKEY--TSPICREARIMKSL-SHPNIIKLFHVVQ-RRET--TYLVMEYASEGELLDCIIN
 ... .||||.| .|...        | . ||||.|  . ..|        |||.|||.| .||||..|  |.  ..|    |.||||.  | |||   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----VGSLEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLA
     ..|  ..     .||  . .| ......|||. | |.|... . .| ||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase MarkmC2.AA TyrKc 57-258 21 6.3e-16 34.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 57-258
Range on HMM: 1-280/280
Sequence Identity: 21% (61 aa)

YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTKEYTSPICREARIMKSL--SHPNIIKLFHVVQRR-------ETTYLVMEYASEGELLDCIINVGS
 ... .||||.| .| ..      . |||| |.. .     ..||||||..|  .||||..|. |.          |  ..||||.. | |.| . . . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIPG--------QKLAGF--CGT--LPY--CAPELLQ---------
 |  ..      ||    .| |.....|||. | |.|.. .. .| .||||. ..  .         . .    .|   ||.  .||| ..         
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

---------------AEKYEG-----PPCRYL------EFRGPPVPH------------------GIWEL------AFPKASLLW
               .. |.|      . . .       .| |. |.                    |.        |     ..
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF