Gene MarkmD2 (Mouse)

MarkmD2

Species: Mouse
Alias: MarkmD2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MarkmD2.NA RNA Sugen 1791 None Fasta, JSON
MarkmD2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 249 Kinase domain by global Sugen HMM Fasta, JSON
MarkmD2.AA Protein Sugen 596 None Fasta, JSON

Protein domain

Protein domains of MarkmD2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MarkmD2.AA MARK 19-267 51 2.5e-166 547.48 In-house 1-262 (262) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-262/262
Sequence Identity: 51% (136 aa)

YMILRTLGKGSFAEVKLACHLHTGVWVAVKVLERGEKND----SVIMTEIDIIKSLDHPNIIKLFHIIE--TREH-TYMVMEHAAGGDLVSHIEKV--GC
|..|.|.|.||.|.||||||.|||..||.|..|.  .||    . .| ||.| |.|||||||||||.||  |..| .|..||.| ||.| ..|...  |.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LQEEETHRIFTQMVCAVNYCHENSIAHRDIKPDNILLDGRG--SVKLCDFGLAIKVTSGQRFKGFCGTLEYCAPEIFTDVEYDAQANDIWSLGVVLYTMV
|.|||..|||.|.|.||||||...|.||||||.|||.| .|   .|..|||..|....||. . ||||..|.|||||   .||... ||||||||||.||
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

TGRFPFEAKT--YSQMKEKMLNPKYSIPPMLSPHIANLIVQLFTVDPDQRPKICDIMQHRWL
.|.|||...|  | ....|.|..||.||...|... ||| .|.||.|..||.|..||.|.|.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MarkmD2.AA CAMKL 19-267 40 1.4e-139 448.14 In-house 1-297 (297) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-297/297
Sequence Identity: 40% (120 aa)

YMILRTLGKGSFAEVKLACH-LHTGVWVAVKVLERGEKNDSVIMT----------------EIDIIKSLD---HPNIIKLFHIIETREH------TYMVM
| |..|||||||..||||.| ..||. ||.|....  ...  .|.                || | |.|.   |||||||...|||.||       |.||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EHAAGGD--LVSHIEKVGC----LQEEETHRIFTQMVCAVNYCHENSIAHRDIKPDNILLDGRGS--VKLCDFGLAIKVTS-----GQRFKGFCGTLEYC
|.. ||.  |  .|.| |.    ..|.|..|.|.|.|.||||||.. |.||||||.||||| .|.  .|..|||.... .      || .| |||...|.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEIFTD--VEYDAQANDIWSLGVVLYTMVTGRFPFEAKTY--------SQMKEKMLNPKYS-IPPMLSPHIANLIVQLFTVDPDQRPKICDIMQHRWL
||||| .   .||... ||||.||.||.||.|..||.. ||          ....|   .|  |.. .|    .|| .. .|.|..||.| .||.|.|.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MarkmD2.AA CAMK 24-267 25 4.5e-120 388.79 In-house 1-425 (425) Show / Hide 
Range on Protein: 24-267
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)

TLGKGSFAEVKLACHLHTG------------VWVAVKVLER-----------------------------GEKNDSVIMTEIDIIKS-------LDHPNI
|||.|||..|||..| .|.            . ||.|....                              .|.   .. ||.| |.       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLFHIIE------------TREH--------TYMVM---EHAAGG----DLVSHIEKVGC---------------LQEEETHRIFTQMVCAVNYCHENS
|||....|            | ..         ||||   |.. ||    || ..| . ||               ..|.|..|.| |...||.|||.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IAHRDIKPDNILLDGR-----------------GSVKLCDFGLAIKVTS------------------------GQRFKGFCGTLEYCA-PEIFTD-----
|.|||.||.||||| .                 . .|..|||.|.|...                        || .| ||||.||.| ||..       
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------VEYDAQANDIWSLGVVLYTMVTGRFPFEAK-------------TYSQMKEKMLNPKYS-IPPMLSP-----------------------HIA
         .|. .. |.||.||.||.|..|..||...             ......|| .. ||. .||..||                          
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NLIVQLFTVDPDQRPKICDIMQHRWL
.|| .. .|||..|..| ....| |.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MarkmD2.AA AGC 19-267 24 4.1e-104 269.5 In-house 1-395 (395) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-395/395
Sequence Identity: 24% (97 aa)

YMILRTLGKGSFAEVKLACHLH------TGVWVAVKVLERGE---KND----SVIMTE------------IDIIKSLD----------HPNIIK-LFHII
. .|...||||| .| |. . .      ||   |.|||.  .   ...      .|||             .| . ..          ||.|.| |..  
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETREH--TYMVME----HAA-----GG-DLVSHIE---KVGCLQEEETHRIFTQ-------MVCAVNYCHE-NSIAHRD-IKPDNILLDGRGSVKLCDFG
.. .|   |.|||     .      || .| .|.    | |.. ||..  .. .       .|.|. | |. . | ||| .||.||||| .| .||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAIKVTSG---------------------------------------------------QRFKGFCG--TLEYCAPEIFTDVEYDAQANDIWS--LGVVL
|. .. ..                                                   .| . |||  | || ||||.    |. .. |.||  ||...
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKAC-DWWSFGLGCLM

YTMVTGRFPFEAKT----------YSQMKEKML------NPKYSIP----------PMLSPHIANLIVQLFTVDPDQRPK----------ICDIMQHRWL
| |.||. || ...            .| .| .      | |  .|          . .||   .|| .|...||..|.           . .|..| | 
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MarkmD2.AA S_TKc 19-267 35 2e-101 344.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-231/231
Sequence Identity: 35% (95 aa)

YMILRTLGKGSFAEVKLACHLHTGVWVAVKVLERGEKNDSVIMTEIDIIKSLDHPNIIKLFHIIETREHTYMVMEHAAG--GDLVSHIEKVGC------L
| |||..|||.|..|... | .||  ||.|..         |. ||.| |. .||||.||. .... .| |||||.. |  ||| ..|.| |.      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QEEETHRIFTQMVCAVNYCHENSIAHRDIKPDNILLDGRGSVKLCDFGLAIKVTSGQRFKGFCGTLEYCAPEIFTDVEYDAQANDIWSLGVVLYTMVTGR
 | .. ... |..||..|||.. | |||.||.|||||    .|.|||||| ..      . ||||..|.|||..    |.  . |.||.|..|| |..|.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

FPFEAKTYSQMKEKMLNPKYSIPPMLSPHIANLIVQLFTVDPDQRPKICDIMQ-------HRWL
 ||.  .. .| .|..          ||   ..| .....||..|| . ...|       | |.
PPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MarkmD2.AA AMPK 19-267 40 6.2e-96 285.29 In-house 1-254 (254) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-254/254
Sequence Identity: 40% (104 aa)

YMILRTLGKGSFAEVKLACHLHTGVWVAVKVLER----GEKNDSVIMTEIDIIKSLDHPNIIKLFHII-ETREHTYMVMEHAAGGDLVSHIEKVGCLQEE
|.|  |.|.|.|  ||.. |  ||  ||.|.|..    ... .  |  ||.| |.. ||.||.|. .| || .  .||||...||.| . | | | |||.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

ETHRIFTQMVCAVNYCHENSIAHRDIKPDNILLDGRGSVKLCDFGLAIKVTSGQRFKGFCGTLEYCAPEIFTDVEYDAQANDIWSLGVVLYTMVTGRFPF
|. | | |.. .| |||.. |.||| || |.|||   ..|. ||||    . |.  |  ||   | |||. .   |     |||| ||.|| |. |. ||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

EAKTYSQMKEKMLNPKYSIPPMLSPHIANLIVQLFTVDPDQRPKICDIMQHRWL
.    ..   | .| .|.||  ||| ...|| .. .||| .| .| ||..| |.
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MarkmD2.AA Pkinase 19-267 32 5.8e-90 309.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-293/293
Sequence Identity: 32% (96 aa)

YMILRTLGKGSFAEVKLACHLHTGVWVAVKVLERGEKNDSVIMT-----EIDIIKSLDHPNIIKLFHIIETREHTYMVMEHAAGG----DLVSHIE--KV
| |.|..|.|||..|....|  ||  ||||.... ...... .|     || | |.|.||||..|... |.. | |||||.. ||    || ..|.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GCL--QEEETHRIFTQMVCAVNYCHENSIAHRDIKPDNILLDGRGSV----KLCDFGLAIK--VTSGQRFKGFCGTLEYCAPEIFTDVEYDAQANDIWSL
||.  .|.|  ....|......|||...| |||.||.|||.| .| .    |.|||||| .    ... ...||||..|.|||.  . .|. .. |.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVLYTMVTGRFPFEAK------TYSQMKEKMLNPKYSIPPMLS---------------------PHIANLIVQLFTVDPDQRPKICDIMQHRWL
|..|| |..||.||  .      .  || .. . |... .   .                     .    .|  ....|| .|| . .|.|| |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MarkmD2.AA QIK 19-267 38 8.6e-87 294.65 In-house 1-272 (272) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-272/272
Sequence Identity: 38% (106 aa)

YMILRTLGKGSFAEVKLACHLHTGVWVAVKVLERG---EKNDSVIMTEIDIIKSLDHPNIIKLFHIIETREHTYMVMEHAAGGDLVSHIEKVGC------
| | ||.||| || |||| |  |   ||.|.. .    |.|   .  |. |.|.|.||.||||. ..|| .  |.|.| . .|..  .. | |       
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------LQEEETHRIFTQMVCAVNYCHENSIAHRDIKPDNILLDGRGSVKLCDFGLAIKVTSGQRFKGFCGTLEYCAPEIFTDVEYDAQAND
              ..|.|. |.|.|.. || |||.  |.|||.|  |||||    .|. |||.    ..||  . .||.  | |||.|   |||    |
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

IWSLGVVLYTMVTGRFPFEAKTYSQMKEKMLNPKYSIPPMLSPHIANLIVQLFTVDPDQRPKICDIMQHRWL
|||.||||| .|.| .||  ||  ......|  |. ||. .|   . || .  .|||..|  |  |.||||.
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MarkmD2.AA RSK 22-267 30 1.3e-74 254.24 In-house 1-278 (278) Show / Hide 
Range on Protein: 22-267
Range on HMM: 1-278/278
Sequence Identity: 30% (85 aa)

LRTL---GKGSFAEVKLACHLHTGVWVAVKVLERGEKNDS-----VIMTEIDIIKSLD-HPNIIKLFHIIETREHTYMVMEHAAGGDLVSHIEKVGC---
|. |   |.|..  ..   |  ||   |.|||.. .   .       |||..| .    ||.|..|..  .| ...|..||   ||.|  |..| ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LQEEETHRIFTQMVCAVNYCHENSIAHRDIKPDNILLDG---RGSVKLCDFGLAIK-VTS-GQRFKGFCGTLEYCAPEIFT----DVEYDAQANDIWSLG
. |.|   .. . |.|| . |.  | |||.||.|||.|    .|..||.|||.. . . . .|. . ||.|.||.|||. .    .. .|... |.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKAC-DWWSLG

VVLYTMVTGRFPFEA---KTYSQMKEKMLNPK--YSIP--PMLSPHIANLIVQLFTVDPDQRPK-----ICDIMQHRWL
|..|.| ||. || .   .. ..  ..... |   ..|  . ||.   .|| .....|| .|..     . .| || |.
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MarkmD2.AA Ciliate-E2 19-267 22 7.2e-73 248.39 In-house 1-365 (365) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-365/365
Sequence Identity: 22% (83 aa)

YMILRTLGKGSFAEVKLACHLHTGVWVA---------------------VKVLERGEKNDSVIMTEIDIIK----------------SLDHPNIIKLFHI
| ... .|.|.|. |.....  ..  .|                     . .    ...   |. ||.|..                .|.||||||..  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IE--TREHTYMVMEHAAGGDLVSHIEKV-----------GCLQEEETHRIFTQMVC---------------AVNYCHENS-IAHRDIKPDNILLDGRGSV
 .  .... |.||| . |||| ..|..            ... |.|  .|..| .                |..|.|..  | ||||||.|||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLCDFGLAIKVTSG--------------------------------QRFKGFCGTLEYCAPEIFTDVEYDA--------QANDIWSLGVVLYTMVTGRFP
|..||||. |..                                  . |. .|||..| ||||.   .||          . |||||||.|| |..|..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEAKTYSQMKEKML-NPKYSIPPM----------------LSPHIANLIVQ----LFTVDPDQRPK-ICDIMQHRWL
|       .....  . ... | .                .|.   .|| .    .. .||..|.  . .|..| |.
F-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MarkmD2.AA SNRK 19-267 37 1.5e-72 236.84 In-house 1-254 (254) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-254/254
Sequence Identity: 37% (96 aa)

YMILRTLGKGSFAEVKLACHLHTGVWVAVKVLER---GEKNDSVIMTEIDIIKSLDHPNIIKLFHIIETREHTYMVMEHAAGGDLVSHIEKVG-CLQEEE
| . .|||.| || |||| |. ||  |||||...    |   . .. |.  .|   ||||..|. .|.|    |...|   |.|.  .| |    |.|. 
YDLEKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDL

THRIFTQMVCAVNYCHENSIAHRDIKPDN-ILLDGRGSVKLCDFGLAIKVTSGQRFKGFCGTLEYCAPEIFTDVEYDAQANDIWSLGVVLYTMVTGRFPF
 .. | |.. |..|||.  . |||.||.| .  .  | ||| ||| . |   |.. . .|| | | ||||    .||| | |||||||.|| .| |. ||
ARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF

EAKTYSQMKEKMLNPKYSIPPMLSPHIANLIVQLFTVDPDQRPKICDIMQHRWL
.    |    .... ||..|...| .  .|| ..   || .|  . .|  | |.
QEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV
Kinase MarkmD2.AA MELK 19-267 36 1.3e-70 240.54 In-house 1-254 (254) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-254/254
Sequence Identity: 36% (92 aa)

YMILRTLGKGSFAEVKLACHLHTGVWVAVKVLERGEKNDSV--IMTEIDIIKSLDHPNIIKLFHIIETREHTYMVMEHAAGGDLVSHIEKVGCLQEEETH
| .  ..| | || ||||||. |.  ||.|.... .  . .  . ||.| .|.| | .| .|.|.|||..  .||||. .||..  .| .   |.|||| 
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETR

RIFTQMVCAVNYCHENSIAHRDIKPDNILLDGRGSVKLCDFGLAIKVTSGQRFKG----FCGTLEYCAPEIFTDVEYDAQANDIWSLGVVLYTMVTGRFP
 .| |.| |. | |    ||||.||.|.|.|    .|| ||||  |   |.. .      || . | |||.    .|     |.||.|..||... |  |
HFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKT-KGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLP

FEAKTYSQMKEKMLNPKYSIPPMLSPHIANLIVQLFTVDPDQRPKICDIMQHRWL
|.    . |  |..  .|  |. |||.  .|. ..  |||..| .. ....| |.
FDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase MarkmD2.AA Pkinase_Tyr 19-224 26 9.2e-25 84.49 Pfam 1-227 (270) Show / Hide 
Range on Protein: 19-224
Range on HMM: 1-227/270
Sequence Identity: 26% (61 aa)

YMILRTLGKGSFAEVKLACHL----HTGVWVAVKVLERGEKNDSV-----IMTEIDIIKSL-DHPNIIKLFHIIE-TREH--TYMVMEHAAGGDLVSHIE
  ....||.|.| ||...        |.. ||||.| .    ..       | |. | |.| .||||..|  ..   .|.   |.|||....||| ..  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----VGCLQEEETHRIFTQMVCAVNYCHENSIAHRDIKPDNILLDGRGSVKLCDFGLAIKV----TS-GQRFKGFCGTLEYCAPEIFTDVEYDAQANDI
|     . |  ..   . .|  .. .| ... . |||.   |.|..  . || ||||||  .    .   .| .|       .||| . . ..  .  |.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKS-DV

WSLGVVLYTMVT-GRFP-FEAKTYSQMKEK
|| ||... ..| |. | ..  . ....|.
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEY
Kinase MarkmD2.AA TyrKc 19-267 22 2.3e-23 84.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

YMILRTLGKGSFAEVKLACHLHTGVWVAVKVLERGEKNDSVIMTEIDIIKSL--DHPNIIKLFHIIETR-------EHTYMVMEHAAGGDLVSHIEKVGC
   ...|| | | || ..      . ||||.|  .      .| |. | ..|  .||||..|. .. .        |  ..|||....||| ... | . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LQEEETHRIFTQMVCAVNYCHENSIAHRDIKPDNILLDGRGSVKLCDFGLAIKVTSG-------QRFK-----GFC--GTLEYCAPEIFTDVEYDAQAN
 |. .. . . .|  |  .| |.. . |||.   |.|.. .. || .||||. .....       .  .     |      .  .||| . . ..   . 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKS

DIWSLGVVLYTMVT-GRFPFEA-----KTYSQMKEKMLNPKYSIPPML---------SPHIANLIVQLFTVDPDQRPKICDIMQHRWL
|.|| ||... . | |  | .      .. ... |.  . ..  .|           .. . ... |    ||..||   .|  |. .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
UBA_CAMKL MarkmD2.AA UBA_CAMKL 289-325 40 7e-10 33.67 In-house 2-41 (41) Show / Hide 
Range on Protein: 289-325
Range on HMM: 2-41/41
Sequence Identity: 40% (16 aa)

PSIVVAMWAM--GYSAKDIRESLREKKF-NNIMATYLILK
..|.  | .|  |.. ..|.||||. |. | |.|||..| 
EEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL