Gene MarkmE1 (Mouse)

MarkmE1

Species: Mouse
Alias: MarkmE1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
MarkmE1.AA Protein Sugen 640 None Fasta, JSON
MarkmE1.NA RNA Sugen 2682 None Fasta, JSON
MarkmE1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 248 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of MarkmE1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MarkmE1.AA MARK 24-271 50 3.7e-161 530.35 In-house 1-262 (262) Show / Hide 
Range on Protein: 24-271
Range on HMM: 1-262/262
Sequence Identity: 50% (131 aa)

YEILTTLGQGTFGEVKLASHLVTQTKVAIKILPKSRKNS-----LVQPEIEIMKSLDHPHIIKLLHIID--TTRN-IFIVLEHAVGGELMSRIEEF--GY
|..|.|.|.|....|||| |. |..||||||..| ..|       |. ||||||.||||.||||.|.|.  |... |....|.| ||||...|...  |.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRG--NVKLTDFGLGTKIIMGQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLYFMA
| | |..|.|.|.|.|..|||.|.|||||.||||||.|..|  |.|..|||....|..|||| |||||.||.|||.|. . |||...|.|||||||||| 
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

TGCLPFNGYS--YEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKWL
.|..|| |..  |. ...|| .|||.. . .|.|..  | .|||||| ||||...| . .|.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase MarkmE1.AA CAMKL 24-271 39 3.1e-142 456.79 In-house 1-297 (297) Show / Hide 
Range on Protein: 24-271
Range on HMM: 1-297/297
Sequence Identity: 39% (119 aa)

YEILTTLGQGTFGEVKLASH-LVTQTKVAIKILPKSRKNSL-----------------VQPEIEIMKSLD---HPHIIKLLHIIDTTRN------IFIVL
|.|. |||.|.||.|||| | . |..||||||. |....                   .. ||.|||.|.   ||.||||...|.| ..      |..|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EHAVGGE--LMSRIEEFGY----LAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRG--NVKLTDFGLGTKIIM-----GQKLVTFCGTLPYC
|.. |||  |. .|.. |.    . | |..|.|.|.| |..|||..||||||.||||||||..|  |.|..|||......      |||| ||||..||.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APELFED--RGYDGRATDVWSLGVVLYFMATGCLPFNGYSY--------EAIKQKIIAGKYPRSF-SLSPELWEVIAKLLTVNPGERPTVHDIARFKWL
|||.|..  . |||...|.||.||.||.| .| |||.. .|        .  .....  .||. . ..| ..   | |.|.||| .|||.|.| . .|.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MarkmE1.AA CAMK 29-271 26 1.5e-119 387.08 In-house 1-425 (425) Show / Hide 
Range on Protein: 29-271
Range on HMM: 1-425/425
Sequence Identity: 26% (114 aa)

TLGQGTFGEVKLASHLVTQ------------TKVAIKILPKSR------------------------------KNSLVQPEIEIMKS-------LDHPHI
|||.|.||.|||. |  |.            .||||||..|..                              .   |. ||||||.       ||||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLLHIID------------TTRN--------IFIVL---EHAVGGEL----MSRIEEF---------------GYLAEVECHRLFKQLVYALQYCHEKG
|||.....            | ..        ...|.   |.. ||||     ..| |                |.. | |..|.|.|.. |..|||...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKPENILLDHR-----------------GNVKLTDFGLGTKIIM------------------------GQKLVTFCGTLPYCA-PELFED-----
||||||||||||||..                 .|.|..|||. .|..                         |||. |||||..|.| ||...      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------RGYDGRATDVWSLGVVLYFMATGCLPFNGY-------------SYEAIKQKIIAGKYP-RSFSLSP-----------------------ELW
        . |.|...|.||.||.||.| .|..||.|              ... ...||..|||   .. .||                       |  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

EVIAKLLTVNPGERPTVHDIARFKWL
  | |.|.|.| .|.|.... . .|.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MarkmE1.AA S_TKc 24-271 34 1.2e-99 338.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-271
Range on HMM: 1-231/231
Sequence Identity: 34% (92 aa)

YEILTTLGQGTFGEVKLASHLVTQTKVAIKILPKSRKNSLVQPEIEIMKSLDHPHIIKLLHIIDTTRNIFIVLEHAVG--GELMSRIEEFGY------LA
|||| ..|.|.||.|... |  |. .|||||..       .. ||.|.|. .||.|.||. ....  ....|.|.. |  |.|...|.. |.      . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EVECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRGNVKLTDFGLGTKIIMGQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLYFMATGCL
| .. ....|.. ||.|||..||.||||||||||||.  ..|..|||| ...       |||||. |.|||..   ||.... |.||.|..|| |..|. 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

PFNGYSYEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVNPGERPTVHDIAR-------FKWL
||    .... .||           |||... | |.|...| .|||. .. .         |.
PFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MarkmE1.AA AMPK 24-271 44 3.9e-98 291.92 In-house 1-254 (254) Show / Hide 
Range on Protein: 24-271
Range on HMM: 1-254/254
Sequence Identity: 44% (113 aa)

YEILTTLGQGTFGEVKLASHLVTQTKVAIKILPKSRKNSL-----VQPEIEIMKSLDHPHIIKLLHII-DTTRNIFIVLEHAVGGELMSRIEEFGYLAEV
| |  |.| |||| ||.. |  |..||||||| | .  ..     .| ||.|.|.. |||||.|  .| .|.. ||.|.|.. |||| . |   | | | 
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

ECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRGNVKLTDFGLGTKIIMGQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLYFMATGCLPF
|  |.|.| . .. |||. .||||||||||.||||  |.|. ||||      |..| | ||   | |||. . . | |. .|.|| ||.|| |  | |||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

NGYSYEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKWL
   .  .  .||..|.|.    ||||  . | ..|.|.| .| |.|||   .|.
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase MarkmE1.AA AGC 24-271 23 2.2e-97 251.72 In-house 1-395 (395) Show / Hide 
Range on Protein: 24-271
Range on HMM: 1-395/395
Sequence Identity: 23% (94 aa)

YEILTTLGQGTFGEVKLASHL------VTQTKVAIKILPKSR--------KNSLVQPE------------IEIMKSLD----------HPHIIK-LLHII
.|.|...|.|.||.| |. .        |.   |.|.| |..        .   .. |             .|.. ..          || |.| | .  
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DTTRN--IFIVLEHAV---------GG-ELMSRIE---EFGYLAEVECHRLFKQ-------LVYALQYCHE-KGIVHRD-LKPENILLDHRGNVKLTDFG
 . ..  ...|.| .          || ||....      |.. | ..   . .       .| ||.| |. .||.||| |||||||||..|..||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LGTKIIMG---------------------------------------------------QKLVTFCG--TLPYCAPELFEDRGYDGRATDVWS--LGVVL
| ......                                                   ..  ||||  |  | ||| .      |.| | ||  ||...
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

YFMATGCLPFNG----------YSYEAIKQKIIAG----KYPRSFS------------LSPELWEVIAKLLTVNPGERPT----------VHDIARFKWL
| | ||. ||.|          .. . . |||. |    . .  |             .|||..  | |||...| .|..          . .| . .| 
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MarkmE1.AA NuaK 24-271 42 1.3e-96 254.46 In-house 1-252 (252) Show / Hide 
Range on Protein: 24-271
Range on HMM: 1-252/252
Sequence Identity: 42% (109 aa)

YEILTTLGQGTFGEVKLASHLVTQTKVAIKILPKSR---KNSLVQ--PEIEIMKSLDHPHIIKLLHIIDTTRNIFIVLEHAVGGELMSRIEEFGYLAEVE
||.. |||.||.| ||||    |  .||||  .|..   .. .|.   ||||| ||.|||||.   .      | ||.| | ||||   |.| . | | |
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

CHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRGNVKLTDFGLGTKIIMGQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLYFMATGCLPFN
  ..| | | |. |||  .|.||||| ||||||  .|.|  ||||      .. | ||||   |  ||  . . | |   | |||||.|| |  | .|| 
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

GYSYEAIKQKIIAGKY--PRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKWL
|  .  ... |  |.|  |.  |   .|   | ..|.|||  | |. ||.   |.
GHDFKHLVKQISQGAYYEPCKPSDACML---IRWMLMVNPRRRATIYDICHHWWV
Kinase MarkmE1.AA QIK 24-271 40 1.8e-95 323.47 In-house 1-272 (272) Show / Hide 
Range on Protein: 24-271
Range on HMM: 1-272/272
Sequence Identity: 40% (110 aa)

YEILTTLGQGTFGEVKLASHLVTQTKVAIKILPKSRKNSL----VQPEIEIMKSLDHPHIIKLLHIIDTTRNIFIVLEHAVGGELMSRIEEFGY------
|.|  |.| | |. |||| | .| |||||||. ||. ..     .  |..|||.|.|||||||. .. | . ..|| | . .||.   . ..|       
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMV

--------------LAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRGNVKLTDFGLGTKIIMGQKLVTFCGTLPYCAPELFEDRGYDGRATD
              .|| |  | |.|.. | .|||...||||||| ||||||   |.|. |||..     || | |.||. || |||.|| . |||   |
NSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVD

VWSLGVVLYFMATGCLPFNGYSYEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKWL
.||.||||| . .| ||| | . .  .|... ||.   |..| .. . | . |.|.|. | |.  | . .|.
IWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase MarkmE1.AA Pkinase 24-271 31 2.1e-87 301.48 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-271
Range on HMM: 1-293/293
Sequence Identity: 31% (92 aa)

YEILTTLGQGTFGEVKLASHLVTQTKVAIKILPKSRKNSLVQP------EIEIMKSLDHPHIIKLLHIIDTTRNIFIVLEHAVGG----ELMSRIE--EF
|.|. ..|.|.||.|... |  |. .||.||..|....| ..       ||.|||.|.||.|..|...  . ..| .|.|.. ||    .|...|.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GYL--AEVECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRGNV----KLTDFGLGTK--IIMGQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSL
| .   | || . ..|.. .|.|||..||.||||||||||.|..|..    |..||||  .  .  .. . |||||..|.|||.  .. |.|.. |.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVLYFMATGCLPFNGY------SYEAIKQKIIAGKYPRSFSLS---------------------PELWEVIAKLLTVNPGERPTVHDIARFKWL
|..|| |..| .|| |       .  .. ..|  ........ .                     .|. ..| ..|...| .||| ..|   .|.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MarkmE1.AA NIM1 24-271 36 6.6e-83 243.37 In-house 1-258 (258) Show / Hide 
Range on Protein: 24-271
Range on HMM: 1-258/258
Sequence Identity: 36% (95 aa)

YEILTTLGQGTFGEVKLASHLVTQTKVAIKILP--------KSRKNSLVQPEIEIMKSLDHPHIIKLLHIIDTTRNIFIVLEHAVGGELMSRIEEFGYLA
| .   .| | |  |||. |  |. ||||||.         |  .  .   ||  |  . || |..|  .. |   .. |.| | ||||  .| . | |.
YRFCGEIGRGNFSKVKLGVHQLTKEKVAIKIMDLDKTKMDQKTQR--MLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLR

EVECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRGNVKLTDFGLGTKIIM----GQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLYFMA
| .|  .|.|.| | .  |...|||||.| ||...  .. ||. |||  . ..|    .|.| ||||  || ||||| |  | |   ||| ||. |||| 
EIHCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPELFQDEHYIGEYVDVWALGILLYFMM

TGCLPFNGYSYEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKWL
||  ||       .|  | .|.|     .|    . |   |   |..|.|. ..    |.
TGVMPFRAETVPKMKKCILKGQYQIPDYVSLPCHRLIRGMLKHIPTQRYTIDQMMNHQWM
Kinase MarkmE1.AA Ciliate-E2 24-271 25 1.1e-72 247.76 In-house 1-365 (365) Show / Hide 
Range on Protein: 24-271
Range on HMM: 1-365/365
Sequence Identity: 25% (96 aa)

YEILTTLGQGTFGEVKLASHLVTQTK-----------------------VAIKILPKSRKNSLVQPEIEIMK----------------SLDHPHIIKLLH
|...  .|||.|| |.....  .| .                       .|.||. |. .... | || ||.                .|.||.|||.  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQ-EIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

IID--TTRNIFIVLEHAVGGELMSRIEEF-----------GYLAEVECHRLFKQLVY---------------ALQYCHEKG-IVHRDLKPENILLDHRGN
     .. ||..|.| . ||.|...|...           .|. | |. ...||...               ||.|.|.|. |.|||.||||||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKLTDFGLGTK--------------------------------IIMGQKLVTFCGTLPYCAPELFEDRGYDG--------RATDVWSLGVVLYFMATGCL
.|..|||| .|                                ||  .   |.|||..| ||| ..  .||.         . |.|||||.||.| .| .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFNGYSYEAIKQKIIAGKYPR--------------SFSLSPELWEVIAK----LLTVNPGERPT-VHDIARFKWL
||    .. |||. |    |                ...|.|    | |    .| ..| .|.|   .|   .|.
PF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MarkmE1.AA Ciliate-E2-Unclassified 24-271 25 7e-70 238.48 In-house 1-352 (352) Show / Hide 
Range on Protein: 24-271
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

YEILTTLGQGTFGEVKLASHLVTQTKVAIKILPKSRKNS--LVQP---------EIE----------------IMKSLDHPHIIKLLHIIDTTRNIFIVL
|.|. ..||| ||.|... |  .. . |.|.. |.....  ...          |..                |.....||.|.|....  .. ||.||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EHAVGGELMSRIEEF-----------------GYLAEVECH-----RLFKQLVYALQYCHEKG-IVHRDLKPENILLDHRG---NVKLTDFGL-------
| . ||.|.  |...                   . | ..      ..|.|.. .|.|.|.|. |.|||.||||||.|  |   ..|..|||.       
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---------GTKIIMGQKLVTFCGTLPYC----APELFEDRGYDGR---ATDVWSLGVVLYFMATGCLPFNGYSYEA----------------IKQKIIA
          ..|.  |.. |||||. |     |||...  .||..   . |.|||||.||.| .| .||.....|                 ..|.|..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

G---KYPRSF-----SLSPELWEVIA----KLLTVNPGERPTVHDIARFKWL
.   . . ..      .||| .. |     |.| .||..|.|  .|    |.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase MarkmE1.AA Pkinase_Tyr 24-208 25 2.5e-24 83.04 Pfam 1-205 (270) Show / Hide 
Range on Protein: 24-208
Range on HMM: 1-205/270
Sequence Identity: 25% (53 aa)

YEILTTLGQGTFGEVKLASHL----VTQTKVAIKILPK---SR---KNSLVQPEIEIMKSL-DHPHIIKLLHIID-TTRN--IFIVLEHAVGGELMSRIE
 ... .||.| ||||...        |...||.|.|.    ..   . .. . |..|||.| .||.|..|. ..    .   |.||.|.. .| | .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

E----FGYLAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRGNVKLTDFGLGTKI-------IMGQKLVTFCGTLPYCAPELFEDRGYDGRAT
.     . |   .      |   ...| ..|...||||   |.|... . || .||||   |        ....   .    . .||| . .. .   ..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LP--IKWMAPECINYGKFT-TKS

DVWSLGVVLY
|||| ||...
DVWSFGVLMW
Kinase MarkmE1.AA TyrKc 24-270 21 3.8e-21 77.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-270
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YEILTTLGQGTFGEVKLASHLVTQTKVAIKILPKSRKNSLVQPEIEIMKSL--DHPHIIKLLHIIDTT-------RNIFIVLEHAVGGELMSRIEEFGY-
 . . .|| | |||| ..      ..||.| | ..        |..||..|  .||.|..|. .. .          ..||.|.. .| | ... . .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRGNVKLTDFGLGTKIIMGQ-------KLVTF----CGT--LPY--CAPELFEDRGYDGRAT
|   . .    |     .| |.|...||||   |.|..... || .|||| .. |          .  .     .|   ||.  .||| . .. .   ..
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL-SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKS

DVWSLGVVLYFMATGCLPFNGY------SYEAIKQKIIAGKYPRSFSL---------SPELWEVIAKLLTVNPGERPTVHDIARFKW
|||| ||... . | . .          | . . ... .|....             ..|. ... .    .| .|||  .| . ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
UBA_CAMKL MarkmE1.AA UBA_CAMKL 291-328 39 4.5e-13 45.02 In-house 1-41 (41) Show / Hide 
Range on Protein: 291-328
Range on HMM: 1-41/41
Sequence Identity: 39% (16 aa)

DPSIMVLMGVM--GYNPGEIRESLREKKF-DQVMATYLMLK
|..|. .|  |  |... ||.||||. |. ....|||. | 
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL