Gene MASTL (Mouse)

MASTL

Species: Mouse
Alias: 2700091H24Rik, MASTL
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: MAST
Subfamily: MASTL

Sequence

Name Sequence Type Origin Length Description Download
MASTL.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 275 Kinase domain by global Sugen HMM Fasta, JSON
MASTL.AA Protein Sugen 865 None Fasta, JSON
MASTL.NA RNA Sugen 4652 None Fasta, JSON

Protein domain

Protein domains of MASTL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MASTL.AA MASTL 34-308 70 3.7e-216 724.39 In-house 1-283 (283) Show / Hide 
Range on Protein: 34-308
Range on HMM: 1-283/283
Sequence Identity: 70% (200 aa)

FTIVKPISRGAFGKVYLG---QKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFVVHLYYSLQSASNIYLIMEYLIGGDVKSLLHIYGYFDEE
|.||||||||||||||||   |||.|||||||.||||||||||||||||||||||||||.|.|||||||||||..||.|||.||||||||||.|||||||
FVIVKPISRGAFGKVYLGYKNQKGKKLYAVKVMKKADMINKNMTHQVQAERDALALSKSQFCVHLYYSLQSASYVYLVMEYMIGGDVKSLLHMYGYFDEE

MAIKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDIN----MMDILTTPSMSKPKQDYSRTPGQVLSLISSLGFFTPVGEK
||||||||...||||||||||||||.||||||||||||||||||||||||.|||||    |||||.||...||.|||..|.|||.....|||.......|
MAIKYISEMVMALDYLHRHGIIHRDIKPDNMLISNEGHIKLTDFGLSKVTMNRDINARVSMMDILGTPDYLKPEQDYQQTHGQVVDWWASLGVCFYEFMK

DQDSANMFSAPKS-AAQLSRGFICPMSVDQKEPTSYSSKLLKSCFETLSSNPEIPVKCLTSNLLQCRKRLGTSSTSSQSHTFV
........|..|. ...|||....||...||..|.||||||||||||..||||.||.||..||||.|.|...|.|..|.|||.
GIPPFCDESPCKVFQNILSRDLEWPMGDEQKSTTPYSSKLLKSCFETVASNPEVPVMCLIENLLQMRPRDRPSATDVQQHTFI
Kinase MASTL.AA AGC 34-821 13 6.4e-155 403.91 In-house 1-395 (395) Show / Hide 
Range on Protein: 34-821
Range on HMM: 1-395/395
Sequence Identity: 13% (121 aa)

FTIVKPISRGAFGKVYLGQKG--------GKLYAVKVVKKAD---MINKNMTHQVQAE------------RDALALSK----------SPFVVH-LYYSL
| ..|.|..|.|||||| .|         ||.||.||.||..   ...||| .....|            |. |.. .          .||.|. |.|| 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QSASN--IYLIMEYLI--------GGDVKSLLHIYG-----YFDEEMAIKYISE-------VALALDYLHR-HGIIHRD-LKPDNMLISNEGHIKLTDFG
|. ..  .|..|||..        ||.  ..||..|     .||||.|  |..|       ..|||.|||. .|||||| |||.|.|. ..|||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKVTLNR------------------------------------DINMMDILTTPSMSKPKQDYSRTPGQVLSLISSLGFFTPVGEKDQDSANMFSAPKS
|.|.  |.                                    . | |.                                                  
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNN-MS--------------------------------------------------

AAQLSRGFICPMSVDQKEPTSYSSKLLKSCFETLSSNPEIPVKCLTSNLLQCRKRLGTSSTSSQSHTFVSSVESECHSNPKWERDCQSTESSGCAMSWNA
                                                                                                    
----------------------------------------------------------------------------------------------------

VEMLYAKSTSAIKTKTELELALSPIHDSSAIPAAGSNQVTLPRKCFREISWEARDPDNENMTIDKGQSGFCQSSQRSVNSSATSEEHLGKRNYKRNFHLV
                                                                                                    
----------------------------------------------------------------------------------------------------

DSSPCQEIMQSKKNCTEYEANKERQGCRANQSTGLTTEVQNLKLSGCESQQLDYANKENIVTYLTDRQTPEKLHIPTIAKNLMSELDEDCELSSKKDCLS
                                                                                                    
----------------------------------------------------------------------------------------------------

SNSVCSDEDRALKTTCVDSDSSFPGVSMMESSLEIQALEPDKSIRDYSFEEPNTEDLFVLPKCQENSLPQDDCHACIQDSSQVSAHPSKAPKALTSKINV
                                                                                                    
----------------------------------------------------------------------------------------------------

VAFRSFNSHINASTNSEPSKISITSLDAMDISCDYSGSYPMAVSPTEKGRHYTSHQTPNQVKLGTSYRTPKSVRRGAAPVDDGRILG--TPDYLAPELLL
                                                                    .  .  |    .    . |  ||.|.||| | 
------------------------------------------------------------------Q-E-DDTTR-KKRDRTWTFCGPCTPEYMAPEIL-

GTAHGPAVDWWA--LGVCLFEFLTGIPPFNDETPQ----------QVFQNILKR------DIPWP-------EGEEKLSDNAQSAMDMLLTIDDSKRAG-
   .|.|.|||.  ||....|.|||.|||....||          ..||.|...      ....|       ......|..|.. . .||. | .|| | 
---YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGC

---------MRELKQHPLF
           |.|.|| |
GGNDFGDKGAEEIKNHPWF
Kinase MASTL.AA MAST 34-308 36 1.2e-151 492.37 In-house 1-334 (334) Show / Hide 
Range on Protein: 34-308
Range on HMM: 1-334/334
Sequence Identity: 36% (125 aa)

FTIVKPISRGAFGKVYL--GQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFVVHLYYSLQSASNIYLIMEYLIGGDVKSLLHIYGYFDEEM
|...||||.||.|||||  ..|.....|.||.||.|||||||..|||.||..||....||||...||.|........|||..|||..||||.||||||.|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

AIKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTP---------SMSKPKQDYSRTPG--------------
| .||.|..|.|.|||.|||.|||||||||||...|||||||||||||....|.|||....||         .|.|..||||..||              
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

-------------------QVLSLISSLGFFTPVGEKDQDSANMFSAPKS-AAQLSRGFICPMSVDQKEPT-SYSSKLLKSCFETLSSN-----------
                   |............|. ...|........  |   ................|.  ....| ..|      |           
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNC------NEIEWPEGGDIN

----PEIPVKCLTSNLLQC--RKRLGTS--STSSQSHTFV
    .. ....|...|||.  |||||..  ......|.|.
DDEAMSPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase MASTL.AA MAST 34-204 42 1.8e-82 251.64 In-house 1-185 (337) Show / Hide 
Range on Protein: 34-204
Range on HMM: 1-185/337
Sequence Identity: 42% (78 aa)

FTIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFVVHLYYSLQS--ASNIYLIMEYLIGGDVKSLLHIYG-YFD
| ..|.||.||.|.||| ..   ....| || .. |.| ||.  ||..||. |.  . |||| ..|| |.      ...|||..|||. |||. ||  ..
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EEMAIKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDIL---------TTPSMSKPKQDYS
|.||  || |  |.|.||| .||.|||||||||||   ||||||||||||| .. . .. ..          ..   .. ...|.
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQ
Kinase MASTL.AA NDR 34-183 46 3.7e-81 249.95 In-house 1-157 (350) Show / Hide 
Range on Protein: 34-183
Range on HMM: 1-157/350
Sequence Identity: 46% (73 aa)

FTIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSK--SPFVVHLYYSLQSASNIYLIMEYLIGGDVKS---LLHIYGY
|.|.|.|..||||.|.| .|   |..||.|...|..|..|| . .|.|||| .| ..  .|.|| |||| | ....||.|||..||| ..   ||  ...
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

FDEEMAIKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNR
|.|..|  ||.| ..|....|. |.||||.|||| || . ||||||||||.. .. |
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIR
Kinase MASTL.AA S_TKc 34-821 10 1.3e-66 228.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 34-821
Range on HMM: 1-231/231
Sequence Identity: 10% (88 aa)

FTIVKPISRGAFGKVYLGQKGG--KLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFVVHLYYSLQSASNIYLIMEYLIG--GDVKSLLHIYGY---
..|...| .|||||||.... .  ...|.|..|           ... |.. |   . |..|.||.. |. ...|..|||. |  ||...... .|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDEEMAIKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMSKPKQDYSRTPGQVLSLISSLGFFTPV
   |.| .| .|. ....||.|.|.||||||||||.| |...  |||..||||...                                            
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

GEKDQDSANMFSAPKSAAQLSRGFICPMSVDQKEPTSYSSKLLKSCFETLSSNPEIPVKCLTSNLLQCRKRLGTSSTSSQSHTFVSSVESECHSNPKWER
                                                                                                    
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DCQSTESSGCAMSWNAVEMLYAKSTSAIKTKTELELALSPIHDSSAIPAAGSNQVTLPRKCFREISWEARDPDNENMTIDKGQSGFCQSSQRSVNSSATS
                                                                                                    
----------------------------------------------------------------------------------------------------

EEHLGKRNYKRNFHLVDSSPCQEIMQSKKNCTEYEANKERQGCRANQSTGLTTEVQNLKLSGCESQQLDYANKENIVTYLTDRQTPEKLHIPTIAKNLMS
                                                                                                    
----------------------------------------------------------------------------------------------------

ELDEDCELSSKKDCLSSNSVCSDEDRALKTTCVDSDSSFPGVSMMESSLEIQALEPDKSIRDYSFEEPNTEDLFVLPKCQENSLPQDDCHACIQDSSQVS
                                                                                                    
----------------------------------------------------------------------------------------------------

AHPSKAPKALTSKINVVAFRSFNSHINASTNSEPSKISITSLDAMDISCDYSGSYPMAVSPTEKGRHYTSHQTPNQVKLGTSYRTPKSVRRGAAPVDDGR
                                                                                                    
--------------------------------------------------------------------------------------------------TT

ILGTPDYLAPELLLGTAHGP-AVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAMDMLLTIDDSKRAGMRELKQ-----
. |||.|.|||.|    .|. ..|||..|..|.|.|.| |||   ..|..|..|.             |. | . .. .|. | .|| .  |. |     
FCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--HPLF
  || |
KCHPWF
Kinase MASTL.AA Akt 34-178 42 7.3e-57 180.27 In-house 1-149 (264) Show / Hide 
Range on Protein: 34-178
Range on HMM: 1-149/264
Sequence Identity: 42% (63 aa)

FTIVKPISRGAFGKVYLGQKGG--KLY-AVKVVKKADMINKNMTHQVQAERDALALSKSPFVVHLYYSLQSASNIYLIMEYLIGGDVKSLLHIYGYFDEE
|...| . .|.||||.| .|    |.| | || ||   |.||   ....||  |   ..||.| |.|| |.. ..|..|.|  ||.  ..|.  ..|.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MAIKYISEVALALDYLHRHGIIHRD-LKPDNMLISNEGHIKLTDFGLSK
 |  |..|. ||...|| ..|| || ||| | |....|||.||||||.|
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCK
Kinase MASTL.AA AktR 34-178 44 1.9e-55 190.49 In-house 1-150 (268) Show / Hide 
Range on Protein: 34-178
Range on HMM: 1-150/268
Sequence Identity: 44% (67 aa)

FTIVKPISRGAFGKVYLGQKG---GKLYAVKVVKKADMINKNMTHQVQAERDALA-LSKSPFVVHLYYSLQSASNIYLIMEYLIGGDVKSLLHIYGYFDE
|.. |.. .|||||||| ||.   .|.|| |..|| ..|..|. |... ||. .. ... || | |.|. |. .....||||  ||.  . |   . |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EMAIKYISEVALALDYLHRH-GIIHRDLKPDNMLISNEGHIKLTDFGLSK
|.| .|.... |||.||| |  || |||||.| |.  .||.|.|||||||
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK
Kinase MASTL.AA RSK-Unclassified 34-178 43 1.9e-54 169.18 In-house 1-149 (283) Show / Hide 
Range on Protein: 34-178
Range on HMM: 1-149/283
Sequence Identity: 43% (65 aa)

FTIVKPISRGAFGKVYLGQKGG--KLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFVVHLYYSLQSASNIYLIMEYLIGGDVKSLLH--IYGYFDE
|   . | .| |||||| .| .  ..|| || .|  || .| .  |  |.. .|... ||.| ||.| |.    ||.|||  |||    |       | |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

EMAIKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSK
. .  |.||| .|| |||. ..| ||||||| .   |||..||||.||.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSI
Kinase MASTL.AA MAST 723-821 49 5.6e-54 172.24 In-house 223-334 (334) Show / Hide 
Range on Protein: 723-821
Range on HMM: 223-334/334
Sequence Identity: 49% (55 aa)

RILGTPDYLAPELLLGTA-HGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRD---IPWPEG-----EEKLSDNAQSAMDMLLTIDDSKRAGMR
...|||||.|||..||.  ||..||||..|....|||.|.|||||.||. .|||||.|.   | ||||     .|..|  ||  .. ||. | .|| | .
QCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGAN

----ELKQHPLF
    | |||| |
NGADEVKQHPFF
Kinase MASTL.AA MAST 723-821 44 5.7e-54 162.94 In-house 227-337 (337) Show / Hide 
Range on Protein: 723-821
Range on HMM: 227-337/337
Sequence Identity: 44% (49 aa)

RILGTPDYLAPELLLGTA-HGPAVDWWALGVCLFEFLTGIPPFNDETPQQ-VFQNILK--RDIPWPEG-----EEKLSDNAQSAMDMLLTIDDSKRAGMR
...|||||.||| .||.  .|..||||..|. ..|||.|.||||..||.  .||||..  |.| |||.     ....|. ||  .. ||. . .|| | .
QCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGAN

---ELKQHPLF
   | |||| |
GADEIKQHPFF
Kinase MASTL.AA RSK 37-178 41 1.8e-53 183.97 In-house 1-155 (278) Show / Hide 
Range on Protein: 37-178
Range on HMM: 1-155/278
Sequence Identity: 41% (65 aa)

VKPISRGAFGKVYLGQKG-----GKLYAVKVVKKADMINKNM-THQVQAERDALALSK-SPFVVHLYYSLQSASNIYLIMEYLIGGDVKSLLHIYGY---
.|   .|..|||.| .|      |..||.||.||| .....  |  . .||. |.... .||.|.|.|. |  . .||||||. ||.    |   ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEEMAIKYISEVALALDYLHRHGIIHRDLKPDNMLISN---EGHIKLTDFGLSK
|.|. |  |..|..||...|| .|||||||||.|.|  .   ||||||||||..|
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCK
Kinase MASTL.AA SGK 34-178 35 4.2e-53 162.08 In-house 1-173 (283) Show / Hide 
Range on Protein: 34-178
Range on HMM: 1-173/283
Sequence Identity: 35% (61 aa)

FTIVKPISRGAFGKVYLGQKGGK--------------------LYAVKVVKKADMI-------NKNMTHQVQAER-DALALSKSPFVVHLYYSLQSASNI
| . | |  | |||||. .. ..                    .||.|| .|.  |       .|.    ..||| ..| . |.|| | | |. | .   
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLIMEYLIGGDVKSLLHIYGYFDEEMAIKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSK
|. |.|. ||.  . |   ..| |  |  | .|...||.|||   ||.|||||.| |   .||..||||||.|
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK
Kinase MASTL.AA Pkinase 34-182 34 3.1e-43 153.97 Pfam 1-165 (293) Show / Hide 
Range on Protein: 34-182
Range on HMM: 1-165/293
Sequence Identity: 34% (57 aa)

FTIVKPISRGAFGKVYLG--QKGGKLYAVKVVKKADMINKNMTHQVQ-AERDALALSKSPFVVHLYYSLQSASNIYLIMEYLIGG----DVKSLLH--IY
..|...| .|.||.||..  .. ||..|||..|| .   .   . .  .|   ..  ..|..| ||.. .. ..||..|||. ||    | .....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GYF--DEEMAIKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHI----KLTDFGLSKV--TLN
| |  .|. ...|. ... .|.|.|..|||||||||.| ||.|.|||    |..||||.|.  . |
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-N
Kinase MASTL.AA MASTL 717-821 40 4.7e-38 127.8 In-house 157-283 (283) Show / Hide 
Range on Protein: 717-821
Range on HMM: 157-283/283
Sequence Identity: 40% (51 aa)

APVDDGRILGTPDYLAPELLLGTAHGPAVDWWA-LGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLS---------------------DNA
| |   .||||||||.||...   ||..||||| ||||..||..|||||.||.|. |||||| ||. ||.| | .|                       .
ARVSMMDILGTPDYLKPEQDYQQTHGQVVDWWASLGVCFYEFMKGIPPFCDESPCKVFQNILSRDLEWPMGDEQKSTTPYSSKLLKSCFETVASNPEVPV

QSAMDMLLTIDDSKRAGMRELKQHPLF
. ... ||...   |    . .||   
MCLIENLLQMRPRDRPSATDVQQHTFI
Kinase MASTL.AA NDR 726-821 35 6.8e-35 104.57 In-house 243-350 (350) Show / Hide 
Range on Protein: 726-821
Range on HMM: 243-350/350
Sequence Identity: 35% (38 aa)

GTPDYLAPELLLG-TAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPW-----PEGEEK-LSDNAQSAMDMLLTIDDSKRAG-----MR
|||||.||| ... | .....||| ||. ..|.|.|.|||...||| ....|..  . |       ..|  ||. |.     |.. | ..| |       
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

ELKQHPLF
| |.|| |
EIKSHPFF
Kinase MASTL.AA SGK 726-821 40 2.6e-31 93.56 In-house 187-283 (283) Show / Hide 
Range on Protein: 726-821
Range on HMM: 187-283/283
Sequence Identity: 40% (40 aa)

GTPDYLAPELLLGTAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAMDMLLTIDDSKRAGMR----ELKQHPLF
||| ||||| |..  |. .|||| ||  |.|...|.||| .   || ..||.. ..  | .    |  | . .  ||. | .|| | .    | |.|| |
GTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ---MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase MASTL.AA Akt 726-821 38 4.1e-29 90.16 In-house 164-264 (264) Show / Hide 
Range on Protein: 726-821
Range on HMM: 164-264/264
Sequence Identity: 38% (39 aa)

GTPDYLAPELLLGTAHGPAVDWWA-LGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAMDMLLTIDDSKRAG-----MRELKQHP
||| ||||| |.|. |. |||||. ||. ..|...| ||| ..  .| |..|.  ..  |.  ...|.....    ||. | .|| |      .|.|.||
GTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHP

LF
 |
WF
Kinase MASTL.AA RSK-Unclassified 726-821 35 7.6e-29 87.33 In-house 184-283 (283) Show / Hide 
Range on Protein: 726-821
Range on HMM: 184-283/283
Sequence Identity: 35% (36 aa)

GTPDYLAPELLLGTAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAMDMLLTIDDSKR----AG-MRELKQHPL
|| .|||||.. .  |. ||||| ||. ..| | |.||.  .    .|.||.| ..  |. .. .| |... .  ||.  ..||     |   . |.|| 
GTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSY-ISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPF

F
|
F
Kinase MASTL.AA RSK 726-821 33 8e-28 98.76 In-house 170-278 (278) Show / Hide 
Range on Protein: 726-821
Range on HMM: 170-278/278
Sequence Identity: 33% (37 aa)

GTPDYLAPELLL----GTAHGPAVDWWALGVCLFEFLTGIPPFND---ETPQQVFQNILKRDIPWPEGE--EKLSDNAQSAMDMLLTIDDSKRAG-----
.| .|.|||.|     . .|. |.||| ||| ..| ||| |||     .........|.| ..  ....  ..||..|..   ..|. | .|| |     
YTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFS-LTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQD

MRELKQHPLF
. |.|||| |
AEEIKQHPWF
Kinase MASTL.AA Pkinase 726-821 26 2.5e-27 97.73 Pfam 173-293 (293) Show / Hide 
Range on Protein: 726-821
Range on HMM: 173-293/293
Sequence Identity: 26% (32 aa)

GTPDYLAPELLL-GTAHGPAVDWWALGVCLFEFLTGIPPFNDE------TPQQVFQNILKRDIPWPEGEE------------------KLSDNAQSAMDM
|||.|.|||... |. .||.||.|..|. |.|.|.| ||| ..      ...|....|......... ..                  ..|..... .. 
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

LLTIDDSKRAGMRELKQHPLF
.|. | .|| . ....||| |
CLCKDPKKRPTAEQILQHPWF
Kinase MASTL.AA AktR 724-821 33 3.5e-21 76.71 In-house 164-268 (268) Show / Hide 
Range on Protein: 724-821
Range on HMM: 164-268/268
Sequence Identity: 33% (36 aa)

ILGTPDYLAPELLLG-TAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRD-IPWPEGEEKLSDNAQSAMD-MLLTIDDSKRAG-----MREL
..||| |.||| ..    |. .|||||.|. ..| .||.|||...  .| ||.|.. . .. |.  ...|.....     ||  .  || |       |.
FCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPY-PSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEI

KQHPLF
| || |
KSHPWF
Kinase MASTL.AA Pkinase_Tyr 34-184 27 2e-15 52.85 Pfam 1-165 (270) Show / Hide 
Range on Protein: 34-184
Range on HMM: 1-165/270
Sequence Identity: 27% (45 aa)

FTIVKPISRGAFGKVYLGQKG------GKLYAVKVVKKADMINKNMTHQVQAERDALALS-KSPFVVHLYYSLQ-SASN--IYLIMEYLIGGDVKSLLHI
 |. | . .||||.||.|         .   |||..|   |   |.     .|   .    . | .| ||           ||..|||  .|| .. |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

Y----GYFDEEMAIKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRD
     . .. .. ...  ..| ...||.....|||||   | |.......| .||||..   | |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDD
Kinase MASTL.AA TyrKc 34-247 17 1.9e-12 -21.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 34-247
Range on HMM: 1-280/280
Sequence Identity: 17% (49 aa)

FTIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALS--KSPFVVHLYYSLQSA-------SNIYLIMEYLIGGDVKSLLHIY
 |  | . .||||.||.|.      |||..|.              |   .     . | .| ||    .          ....|||  .|| |. |. .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GY-FDEEMAIKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNR-------DINMMD---ILTTPS------------------
.  .  .  ...   .|   .|||....|||||   | |.......| .|||||.   .        |  ..       |.                   
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

-------------MSKPKQDYS------RTPGQVLSLISSLGFFTPVGE--------KDQDSANM-----FSAPK---SAAQLSRGF
             ..  .| |.       .. .|. .. . .   .  .          ..  ..        |.   . ... . |
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MASTL.AA S_TK_X 822-864 13 0.000699 9.1 SMART 1-79 (79) Show / Hide 
Range on Protein: 822-864
Range on HMM: 1-79/79
Sequence Identity: 13% (11 aa)

SEVDWENLQH--QTM--PFVPQPD----DETDTSYFE---------ARNNAQ-------------------HLTISGFS
...||..|..  ...  ||.|..     ..||||.|.         . .  .                    .  . . 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase MASTL.AA Pkinase_Tyr 748-776 29 2.895313 1.52 Pfam 198-228 (270) Show / Hide 
Range on Protein: 748-776
Range on HMM: 198-228/270
Sequence Identity: 29% (9 aa)

WALGVCLFEFLT-GIPP-FNDETPQQVFQNI
|. ||...| .| |  | . . ....|.. |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI