Gene MLK4 (Mouse)

MLK4

Species: Mouse
Alias: MLK4
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK

Sequence

Name Sequence Type Origin Length Description Download
MLK4.AA Protein Sugen 1002 None Fasta, JSON
MLK4.NA RNA Sugen 5692 None Fasta, JSON
MLK4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 273 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of MLK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 MLK4.AA SH3 27-87 38 4.5e-21 77.26 SMART 1-58 (58) Show / Hide 
Range on Protein: 27-87
Range on HMM: 1-58/58
Sequence Identity: 38% (24 aa)

GMWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQ--RRLGIFPASYVAPCG
..  |||||.|...||||...|. ..||..|     |.||| |...   . |.||..||... 
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-----DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 MLK4.AA SH3_1 30-80 33 1e-12 45.96 Pfam 1-49 (49) Show / Hide 
Range on Protein: 30-80
Range on HMM: 1-49/49
Sequence Identity: 33% (18 aa)

AALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQ--RRLGIFPA
 |||||.|...||||...|  ..|.... .     .|| |...  .. |.||.
VALYDYQAQQPDELSFKKGDIIHVIEKSDD----WDWWKGRCNNTGQEGWFPS
SH3_2 MLK4.AA SH3_2 34-86 22 2.9e-11 42.34 Pfam 7-68 (68) Show / Hide 
Range on Protein: 34-86
Range on HMM: 7-68/68
Sequence Identity: 22% (15 aa)

DYEA-RGEDE-----LSLRRGQLVEVL---SQDAAVSGDEGWWAG-QV--QRRL--GIFPASYVAPC
||.. ....|     |....|....|.   ..|.      .|| .  .  ..|   | || ..|..|
DYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD-----NWWWCWETIWGGRRMRGWFPSQWVEEC
Kinase MLK4.AA MLK 110-382 69 1.6e-199 665.42 In-house 1-280 (280) Show / Hide 
Range on Protein: 110-382
Range on HMM: 1-280/280
Sequence Identity: 69% (205 aa)

LELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAA---AESVRREARLFAMLRHPNIIQLRGVCLRQPHLCLVLEFARGGALNRALAAAASDPR
|..||.||.||||.||||.|.|.||||||.|.|||||....   ||.||.|||||.||.|||||.||||||..||||||.|..|||.|||..|..     
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK-----

APGPRRARRIPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIE-----------------HDDICNKTLKITDFGLAREWHRTTRMSAA
        ||||.||||||||||||| |||.||.|||.||||||||||.||||.                 |.|.|||.|||||||||||||.|||||||
--------RIPPHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAA

GTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQL
|||||||||||..|..|||||.|||||||||||||||||||||.||||||||.||||||||||||||.||||..||.||||.||.|. |||||
GTYAWMAPEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase MLK4.AA MLK 110-382 46 4.90000000001e-160 537.97 In-house 1-291 (291) Show / Hide 
Range on Protein: 110-382
Range on HMM: 1-291/291
Sequence Identity: 46% (138 aa)

LELKELIGAGGFGQVYRATWQGQE-----VAVKAARRDPEQDAAAA---AESVRREARLFAMLRHPN----IIQLRGVCLRQPH-LCLVLEFARGGALNR
....| ||.|.||.|....|....     ||||..| ... |.. .   .. ...|.|....|.|||    |||..||||..|. .|.|.|...|| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ALAAAASDPR---APGPRRARRIPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRT-T-RMSAAGT
 |..| | .     ... ..|........|||.|.|||| |||..|..|| ||||||.|||..| |.| |....||||.|||..|.||.. | .||.|||
VLHGARSKWMDANHNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGT

YAWMAPEVI---RSSLFSKGSDIWSYGVLLWELLTGEVPYR-GIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQL
|||||||||   |.. .|. .|.||.||.|||.||.||||. ..|..|.|..||.|.|..||||||||...||||.||.|||| ||||. |.|.|
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK4.AA TKL 116-382 27 1.3e-103 350.55 In-house 1-364 (364) Show / Hide 
Range on Protein: 116-382
Range on HMM: 1-364/364
Sequence Identity: 27% (105 aa)

IGAGGFGQVYRATWQG----------QEVAVKAARRDP-----------------------EQDAAAAAESVRREARLFAMLRHPNIIQLRGVCLRQPH-
|| ||||.||...|.|          ..||||  ...                        ...|  . .  ..|...  .||||||.|. |.|.. |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCLVLEFARGGA-LNRALAAAASDPRAPGPRRARRIPPQVLVNWAVQIARGMLYLHEEAV-----VPILHRDLKSSNILLLEKIEHDD
            ||.| |.. ||  |.. .                   ......|| .||||| ||| .        ||.||||||.|||. |. ....
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS

------ICNKTLKITDFGLAREWHRT---------------------TRMSAAGTYAWMAPEVIRSS----------------LFSKGSDIWSYGVLLWE
      . . ..||.||||.|.....                     |.|.  ||..||||||.| .                 .|. .|..|.|..|||
NYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWE

LLTGEVPYRGIDGLAVA---------YGVAVNKLTLPIP------------STCPEPFAKLMKECWEQDPHIRPSFALILQQL
.||...||....   .          ..|....| .|||            ..||....|||..||..||. ||||  ||..|
ILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK4.AA TyrKc 110-382 30 1.9e-84 287.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 110-382
Range on HMM: 1-280/280
Sequence Identity: 30% (94 aa)

LELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARLFAML--RHPNIIQLRGVCLRQ-------PHLCLVLEFARGGALNRALAA
..|.. .| | ||.||..||  ..||||  . |         |  .||||.  .|  .||||..| |||. |       . |..|.|.. .|.|.  | .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

AASDPRAPGPRRARRIPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRT---------TRM----S
   .           .... |.....|||.|| |||.    .. ||||   |.|. |.         | ||.||||.|...            |.    .
HRPK-----------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

AA--GTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLT-GEVPYRGI----DGLAVAYGVAVNKLTLPIPST--------CPEPFAKLMKECWEQDPHIR
.     . |||||.|. . |.  ||.||.||..||..| |. || |.       . ..    .   .|.|          ||.   ..||.||. ||. |
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

PSFALILQQL
|.|. | ...
PTFSEIHECF
Kinase MLK4.AA Pkinase 110-382 26 2.2e-80 278.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 110-382
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)

LELKELIGAGGFGQVYRATWQGQE--VAVKAARRDPEQDAAAAAESVR-REARLFAMLRHPNIIQLRGVCLRQPHLCLVLEFARGG----ALNRALAAAA
..... ||.|.||.||.....| .  ||||  ... ...     . .| .|... ..|.||||..|.... . .|...|.|...||     | . . .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

SDPRAPGPRRARRI--PPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR---EWHRTTRMSAAGTYAWMAP
        .| ...  ..... ... ||.||. |.|..    |.|||||..|||. .. . |.    ..||.|||||.   . . .  .. .||. .|||
--------WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAP

EVIR-SSLFSKGSDIWSYGVLLWELLTGEVPYRGI------DGLAVAYGVAVNKLTLPIPSTCP-------------------EPFAKLMKECWEQDPHI
|||| ..  .. .|.||.|..|.|.|.|. |..|       | ... . .   .|  ..| .|.                   |.. ...| |...||. 
EVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK

RPSFALILQQ--L
||... |||   .
RPTAEQILQHPWF
Kinase MLK4.AA LZK 164-382 47 1.1e-77 261.43 In-house 44-241 (241) Show / Hide 
Range on Protein: 164-382
Range on HMM: 44-241/241
Sequence Identity: 47% (106 aa)

LRHPNIIQLRGVCLRQPHLCLVLEFARGGALNRALAAAASDPRAPGPRRARRIPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDD
|.|||||...||| . |  | ..|.   | |   |            |  | |.|| .|.|  ||| || |||      | |||||| |||    | |.|
LKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVL------------RERRTITPQLMVDWSKQIAQGMHYLHQHK---IIHRDLKSPNIL----ISHND

ICNKTLKITDFGLAREWHRT--TRMSAAGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLM
.    .|| |||  ..|     |.|| .|| |||||||||    |   ||||.|| |||.||.|.||. .|  |. .||  | | ||.|||||| |  ||
V----VKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKLLM

KECWEQDPHIRPSFALILQQL
| ||.| |  ||||  ||. .
KQCWSQKPRNRPSFRQILMHW
Kinase MLK4.AA Pkinase_Tyr 110-382 32 1.4e-71 243.07 Pfam 1-270 (270) Show / Hide 
Range on Protein: 110-382
Range on HMM: 1-270/270
Sequence Identity: 32% (96 aa)

LELKELIGAGGFGQVYRATWQ------GQEVAVKAARRDPEQDAAAAA---ESVRREARLFAML-RHPNIIQLRGVCL-RQPH--LCLVLEFARGGALNR
... . .|.| ||.||..||       ...||||   ..   .|   .   |.  |||..   | .||||..| |||. .. .  ...|.|.. .| |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

ALAAAASDPRAPGPRRARRIPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREW-----H-RTTRMSAAG
 | .             ...... |.....|||.|| ||..    .. ||||   |.|. |        |.. ||.||||||         |..  .   
YLRKHR--------EDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGK-L

TYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLT-GEVP-YRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQL
   |||||.|. . |.  ||.||.|||.||..| || | | |..   |   .. .   .|.|  ||..  .|||.||..||  ||.|. |..||
PIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK4.AA TKL-Unique 112-382 32 3.5e-71 242.79 In-house 1-290 (290) Show / Hide 
Range on Protein: 112-382
Range on HMM: 1-290/290
Sequence Identity: 32% (96 aa)

LKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARLFAMLR-HPNIIQLRGVCL----RQPHLCLVLEFARGGALNRALAAAASDPR
  ..||.||.||||...| | .||.|      |       .  ..| ..  .|. |||| .. |.|      .|..|.|.|.  || |.  |.   . . 
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQ--NNNN

APGPRRARRIPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTRMSAA-----------GTYAWM
    ..   ...|. |. | .||.|| ||| .    |.||||||||.|. ..     |     || ||||..   . ..|..            |.. ||
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSN---IAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APEVIRS--SLFSKGSDIWSYGVLLWELLTGEV------PYRGIDGLAVAYGVAV--NKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQL
||||.|.  ...|. ||..|.|. |||..|...      ||.|.|  ...  |..   .. .|||. ||. . .|...|| .|| .||||  |.  |
APEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK4.AA LRRK 110-384 28 9.4e-71 241.37 In-house 1-351 (351) Show / Hide 
Range on Protein: 110-384
Range on HMM: 1-351/351
Sequence Identity: 28% (104 aa)

LELKELIGAGGFG-QVYRATWQG----------------------------QEVAVKAARRDP------------------------------EQDAAAA
|.  |.|| ||||  ||||.|.|                            |.||.|   |||                              ..|.. |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

AESVRREARLFAMLRHPNIIQLRGVCLRQPHLCLVLEFARGGALNRALAAAASDPR--APGPRRARRIPPQVLVNWAVQIARGMLYLHEEAVV-PILHRD
  . |.|. .   |.||||..| |.|..  .||.|.|.|. |.|.. | . ..|..   .      .|.....   |.|||.|| |||      ||.|||
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMK-----AHISWMLKLKIALQIAKGMEYLHS--HNPPIIHRD

LKSSNILLLEKIEH-------DDICNKTLKITDFGLAR--EWHRTT-RMSAAGTYAWMAPEVIR---SSLFSKGSDIWSYGVLLWELLTGE-VPYRGIDG
||| |||| .  ..       ...|    || |||. |     ... ..   |.  |||||..|    . ..  .|. |.|..||||||..  |....|.
LKSPNILLWSSPQNHSPNYPNAHVC---AKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDF

LAVA---YGVAV---NKLTLPIPST-CPE-----PFAKLMKECWEQDPHIRPSFALILQQLTA
 ..    . .     ..|  .||.. ||.      . .|...||..||  ||.|  |...|  
FDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK4.AA TK 110-382 18 6.6e-67 223.06 In-house 1-486 (486) Show / Hide 
Range on Protein: 110-382
Range on HMM: 1-486/486
Sequence Identity: 18% (91 aa)

LELKELIGAGGFG---QVYRATWQG---------------------------QEVAVKAARRDPEQDAAAAAE-------------SVRREARLFA--ML
..| . .|.| ||   .||...|.|                           ..||||  . . ......  .             .  .|. ..   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNIIQLRGVCLRQ------------PHLCLVLEFARGGA----LNRALA--AAASDPRAPGPR-----------------------------------
.||||..| |||...            .....|.|.. .|     |   |        . ...|                                    
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------------------RARRIPPQVLVNWAVQIARGMLYLHEEAVVPI----LHRDLKSSNILLLEKIEHD---DICNKTLKITDFG--
                           . ...... |. ...|||.|| |||.  .        ||||   |.|. |.       | |  . ||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAREWHRTTRMSAAGTYA----------------------------WMAPEVIRSSL---------FSKGSDIWSYGVLLWELLT-GEVPYRGI
      |||. .. .   ....|                             |||||....           |.  ||.||.|||.||..| |..|| | 
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

DGL---------AVAYGVAVN--------------KLTLPIPSTCP--------------EPFAKLMKECWEQDPHIRPSFALILQQL
            .  .   ..              .. .| |  ||              | .. ||..||. ||  ||.|. ...||
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK4.AA UTK 110-382 28 2.5e-62 212.02 In-house 1-296 (296) Show / Hide 
Range on Protein: 110-382
Range on HMM: 1-296/296
Sequence Identity: 28% (90 aa)

LELKELIGAGGFGQVYRATWQG-------QEVAVKAARRDPEQDAAAAAE---SVRREAR---LFAMLR-HPNIIQLRGVCLRQPHLCLVLEFARGGALN
..| ...|.| ||.|..|...        . ||||...  .. ||  . |    ...|||   . .... |||...| |||...  ...|.|....| | 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ--HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

RALAAAASDPRAPGPRRARRIPPQVLVN------WAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFG---LAREWHR----
  |  .. .|.          .......      .|..||||| |||.  .|   ||||   |.|. .    .  |  . || |||   ..|. ..    
SYLRRHRPTPP----------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFV---HRDLAARNCLVHMHRM-MWHCMMVCKIADFGRGGMSRRVNTFHFS

-------TTRMSAAGT--YAWMAPEVIRSS-LFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAVNK-LTLPIPSTCPEPFAKLMKECWEQDPH
         ... ..    .|||||.. .   |.  ||.||.||..||..| | .|| |.   .|.  |     . .| |  ||.|  .||..||..|| 
NRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQ

IRPSFALILQQL
 ||.|  ..||.
ERPDFEDLVQQM
Kinase MLK4.AA ZAK 220-381 43 2.4e-60 206.81 In-house 102-257 (257) Show / Hide 
Range on Protein: 220-381
Range on HMM: 102-257/257
Sequence Identity: 43% (71 aa)

VLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR-EWHRTTRMSAAGTYAWMAPEVI-RSSLFSKGSDIWSYGVL
. . || |||.|| ||| .|.. | |||||| |.     |. . .|    || |||  |   | .| ||  || .|||||.|  |   .   |.||||| 
HIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVV----IDKNGVC----KICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVV

LWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQ
|||.|| ||||.. ... ..  .     .| ||. || ||..|| .||. ||  ||..  |   
LWEMLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase MLK4.AA S_TKc 110-389 25 1.8e-58 201.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 110-389
Range on HMM: 1-231/231
Sequence Identity: 25% (76 aa)

LELKELIGAGGFGQVYRATWQG--QEVAVKAARRDPEQDAAAAAESVRREARLFAMLRHPNIIQLRGVCLRQPHLCLVLEFARG--GALNRALAAAASDP
 |. ..|| |.||.||.... .  ..||.|  .           |..||| ..  . .||||..| .|.    ||..|.|.. |  | | . .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI-------

RAPGPRRARR------IPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTRMSAAGTYAWMAPEV
     .. .|      .|. .   .. ||.... |.|.  ..   ||||| .|||| |          ..||.||||||.      ..  ||  .|||||
-----KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGII---HRDLKPENILLDE----------HIKICDFGLARQL-----TTFCGTPWYMAPEV

IRSSLFSK-GSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQ--QLTAIEEAV
.    ..|  .|.|| |..|.|.|.|. |..    ... . . .           ....  ... |.. ||  ||.   .||  .. .. . .
L---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK4.AA Dicty4 228-384 37 3.5e-51 169.03 In-house 121-277 (277) Show / Hide 
Range on Protein: 228-384
Range on HMM: 121-277/277
Sequence Identity: 37% (62 aa)

IARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR----EWHRTT-RMSAAGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELL
.|||| .||.  .| |.||||||.|.|  .        |.. |..||||..    .   ..  |.|.|| .|||||| ..  .   .|  |.| .|||.|
AARGMNWLHCCNPV-IIHRDLKSHNLLVDK--------NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEIL

TGEVPYR--GIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQ--LTA
|.. ||   ...   .. .|.  || .|||. || ....|...||. ||  ||||. |.|.  | .
TRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK4.AA Dicty4 110-191 32 1.1e-19 62.52 In-house 1-87 (277) Show / Hide 
Range on Protein: 110-191
Range on HMM: 1-87/277
Sequence Identity: 32% (28 aa)

LELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARLFAMLRHPNIIQLRGVCL----RQPHLCLVLEFA-RG
.   ..|| |.||.||..|| |.||||| .  . . . ..  .. |.|. . . .|||||... | |.      . .| | |.  .|
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKG
Kinase MLK4.AA ZAK 110-194 31 6e-09 28.16 In-house 1-79 (257) Show / Hide 
Range on Protein: 110-194
Range on HMM: 1-79/257
Sequence Identity: 31% (29 aa)

LELKELIGAGGFGQVYRATWQGQE-----VAVKAARRDPEQDAAAAAESVRREARLFAMLRHPNIIQLRGVCLRQPH-LCLVLEFARGGAL
. . . .| | || |||| |  |      .|||                . .||     .|| ||||  |.|.  |     | |.|  | |
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVFK------------IEKEAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSL
Kinase MLK4.AA LZK 110-146 37 0.114853 1.3 In-house 2-37 (241) Show / Hide 
Range on Protein: 110-146
Range on HMM: 2-37/241
Sequence Identity: 37% (14 aa)

LELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQD
 || . .| |  | |.|  .....||||  |   | |
SEL-QWLGSGAQGAVFRGWFRNETVAVKKVRDLKETD