Gene MLKL (Mouse)

MLKL

Species: Mouse
Alias: 9130019I15Rik, MLKL
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
MLKL.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
MLKL.AA Protein Sugen 464 None Fasta, JSON
MLKL.NA RNA Sugen 1702 None Fasta, JSON

Protein domain

Protein domains of MLKL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKL.AA TKL-Unique 194-453 34 7.70000000001e-131 440.97 In-house 1-290 (290) Show / Hide 
Range on Protein: 194-453
Range on HMM: 1-290/290
Sequence Identity: 34% (101 aa)

PWTKLKTSKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFD-SPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLD-------
.| |.........|.|.....||.||.|.. ...|  .....|..|...|||.. .|||....|.|.|..|.||...||||||..|.|...|.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

---REKDLTMSVRSLLVLRAARGLYRLHHSE--TLHRNISSSSFLVAGG-----YQVKLAGFELSKTQNSISRTAKSTK-----AERSSSTIYVSPERLK
   ....|.|..|  .....|.|.|.|||.|  ..||.. ||.|||  .     ...|...|.|||....|... ....     ..| .|.....|| |.
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

NPFCLYDIKAEIYSFGIVLWEIATGKI------PFEGCDSKKIRELVAE--DKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILERL
..||.|..|...||||||||||||.||      |..|.|.....|.|..  .....|....||. .|..|..|..|.||||||.| |..||
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKL.AA TKL 198-453 20 4.6e-62 212.5 In-house 1-364 (364) Show / Hide 
Range on Protein: 198-453
Range on HMM: 1-364/364
Sequence Identity: 20% (74 aa)

LKTSKMSTIYRGEYHR----------SPVTIKVFNNPQAESVGI-----------------------VRFTFNDEIKTMKKFDSPNILRIFGICIDQTV-
.     ...|.|...            .| .|.|.  .  .  .                        ||... ||. |.... |||... |.|.. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------KPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSE--------TLHRNISSSSFLVAGGYQ--------------VK
         .... ||||||. |.|...|       ...|  ..| .|||.. || ..         .||.. |.  ||   ..              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

LAGFELSKTQN---SISRTAKS------------TKAERSSSTIYVSPERLKNP--------------FCLYDIKAEIYSFGIVLWEIATGKIPFE--GC
.. | ||.. .   . ..|...            |.  .  .. . .|| |..               .  |. |. .||||||||||.|...|..  ..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

DSKKIR-------ELVAEDKKQEPVG------------QDCPELLREIINECRAHEPSQRPSVDGILERL
.. ...       ..|...... |.              |||. ..... .| .|.|..||| . ||.||
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLKL.AA Dicty4 236-455 28 4.1e-31 101.14 In-house 45-277 (277) Show / Hide 
Range on Protein: 236-455
Range on HMM: 45-277/277
Sequence Identity: 28% (69 aa)

FNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDR---EKDLTMSVRSLLVLR-------AARGLYRLHH--SETLHRNISSSS
|  |.. |.|   |||.   | |.    .|....||.||.  |.| .||     |.    .  . |..|       ||||.  ||   .  .|| . |. 
FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHN

FLVAGGYQVKLAGFELSK-TQNSISRTA--KSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFE--GCDSKKIRELVAEDKKQE
 ||   ..|| . | ||.  .  .. ..  ....     .. ...|| . .    |. ||  ||||||||||.|...|.   . .  .....|.. |   
LLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACG----TPCWMAPEVMMH--QPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRP

PVGQDCPELLREIINECRAHEPSQRPSVDGILER--LSA
|. ..||  ... |..|  |.|..|||  .|..|  | .
PIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKL.AA TK 204-453 15 4.6e-29 93.96 In-house 14-486 (486) Show / Hide 
Range on Protein: 204-453
Range on HMM: 14-486/486
Sequence Identity: 15% (73 aa)

S--TIYRGEYHR---------------------------SPVTIKVFNNPQAESVGIVRF-------------TFNDEIKTMK--KFDSPNILRIFGICI
|  ..|.||...                            || .|.     |.|    .               .  |.| |.  ... |||.|..|.| 
SFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCT

DQTVKP--------PEFSIVMEYCELGT----LRELLDREKD----------------------------------------------------------
..  ||        . . |||||...|     ||. | . ..                                                          
QGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLT

------------------LTMSVRSLLVLRAARGLYRLHHS------ETLHRNISSSSFLVAGGYQ-----------VKLAGFELSKT----------QN
                  |||  .    . .|.|.  ||           ||..     ||. ...           .|.| | ||..          ..
TKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSD

SISRTAK---------------STKAERSSSTI-----YVSPERLKNP-------FCLYDIKAEIYSFGIVLWEIAT-GKIPFEGCDS----------KK
.  ....               ...  |..|       . .|| |.         .  . .|  ..|||...||| | |. |. |  |          . 
DDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQE

IRELVAED-------------KKQEPVGQDCP--------------ELLREIINECRAHEPSQRPSVDGILERL
. |.. .              . . |  ..||              |.. ... .| ...|..||. . ..|.|
VMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKL.AA MLK 236-453 23 4.5e-25 84.01 In-house 52-291 (291) Show / Hide 
Range on Protein: 236-453
Range on HMM: 52-291/291
Sequence Identity: 23% (59 aa)

FNDEIKTMKKFDSPN----ILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKD--------------LTMSVRSLLVLRAARGLYRLHHSET---
|. |..  .... ||    | .. |.|...   |..| ||||||| | | ..|  ...               ....     |  |||.  ||  .    
FEMECRHLRILSHPNNHPCIIQFYGVCLQP---PCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPI

LHRNISSSSFLVA------GGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKN-PFCLYDIKAEIYSFGIVLWEIATGKIPFE-GCDSKK
 || . |.  |..      .. ..| . | .|.   .....  ...  .  . .. .|| ..  .   |..|. ..|.|.||||. |...|.. . |.  
IHRDLKSHNILIDEICHDMHHGTLKICDFGTSR---DWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMA

IRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILERL
|   ||. ..  |....||| . . ...|   .|..||| . |.. |
IAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKL.AA STE 239-447 18 3.8e-24 82.25 In-house 78-349 (359) Show / Hide 
Range on Protein: 239-447
Range on HMM: 78-349/359
Sequence Identity: 18% (53 aa)

EIKTMKKFD--SPNILRIFGICIDQ---TVKPPEFSIVMEYCELGTLRELLDR--EKDLTM------------SVRSLLVLRAARG-LYRLHHSETLHRN
|||.|||..  .||| . .| ...    .    |  |.|||.. |.|......  ..  ..            |. .  .    .| || ||     || 
EIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRD

ISSSSFLVAGGYQVKLAGFELSKTQNSISR------------TAK-STKAERSSSTIYVSPERLKNPFCL----YDIKAEIYSFGIVLWEIATGKIPFEG
| ..  |.     |||. | ...  .....            | .  ..    .   . .||....  .     ||.|. |.|.|....| |||| |.  
IKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHD

CDSKKIRELVA----------------EDKKQEPVG-----------------QDCPELLREIINECRAHEPSQRPSVD
    .   . .                ..  . |                     . . ... || |   .|..||...
MHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTAS
Kinase MLKL.AA DRK 239-455 31 5.9e-24 78.05 In-house 47-258 (258) Show / Hide 
Range on Protein: 239-455
Range on HMM: 47-258/258
Sequence Identity: 31% (71 aa)

EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTL-RELLDREKDLTMSVRSLLVLRAARGLYRLHHSE--TLHRNISSSSFLVAGGYQVKLA
||  |..   |||    | |      ||.  |.|||  .| | . |.|    .  . .  . . .|.|.  || ..   .||   |   ||   .||| |
EINLMCQLRHPNICQFMGTCNN----PPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVA

GFELSK-----TQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLRE
 | ||       |    .|.  |       .  ..|| | |    |  || .|||.|||||..| ..|. |     .   |  ..   |. | ||     
DFGLSTRFKKHKQHKFAMTMCGT-------PCWTAPEVLRNQ--RYTEKADVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQ

IINECRAHEPSQRPSVDGILERLSA
 .|.|   .|..||| . .|||| |
LMNDCWNEDPQHRPSMQECLERLEA
Kinase MLKL.AA S_TKc 195-456 16 1.1e-22 82.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 195-456
Range on HMM: 1-231/231
Sequence Identity: 16% (47 aa)

WTKLKTS---KMSTIYRGEYHR--SPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCEL--GTLRELLDRE
...|..     ... |..  ..    | ||. .            ..  ||. .|| . ||| ...... |      .. .|||||.   |.|...... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKR

KD------LTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDI-KA
.       ..  .   ..   ...|  .|    .|| .  .  |.    ..|.. | |..                  .  |..|| |      |.  |.
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL-----GYGKCKC

EIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILE------RLSAV
 ..|.|..|.| ..|. ||.  . ... ...             .. ....|. |   .|..||..  .|.          .
DWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKL.AA TK-Unique 238-453 23 2.4e-22 73.92 In-house 52-294 (294) Show / Hide 
Range on Protein: 238-453
Range on HMM: 52-294/294
Sequence Identity: 23% (58 aa)

DEIKTMKKFD-SPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLD----------------------REKDLTMSVRSLLVLRAARG----LYRLH
.||. ||. .  |||....|.|.. .     . |.||||. |.|. .|                       ..|..| .. . .... | .    .  |.
KEIQMMKELGDHPNIVQCLGCCTKSD---EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLA

H--SETLHRNISSSSFLVAGGYQVKLAGFELSK---TQNSISRTAK-STKAERSSSTIYVSPERLKNPFCLY-DIKAEIYSFGIVLWEIAT-GKIPFEGC
    .  ||.....  |.......|...| ...   | . .|.. . ..   |     . .||.||     |  .| ...|||...|||.| |. |. | 
SQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIR-----WMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGM

DSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILERL
..|.|.|.. . . ..   . |.. ..... .|  .||..||| . |. ||
PWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase MLKL.AA LZK 239-453 30 4.9e-22 71.01 In-house 37-241 (241) Show / Hide 
Range on Protein: 239-453
Range on HMM: 37-241/241
Sequence Identity: 30% (66 aa)

EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFE
.|| . | . |||  . |.|     . | . |.||||  | | | |  .. .| .     .   | |.  ||     ||   |   |..    || . | 
DIKHLRKLKHPNIIEFKGVC----TQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSKQIAQGMHYLHQHKIIHRDLKSPNILISHNDVVKICDFG

LSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAH
 |. .| .     |||           ||  .|  |    |  |.|||.||||. |. ||.   ||  |   |     . |.   ||| ..  .  |   
TSHMWNEM----DSTKMSFCGTVAWMAPEVIRNEPC--SEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKLLMKQCWSQ

EPSQRPSVDGILERL
 |  |||   ||  .
KPRNRPSFRQILMHW
Kinase MLKL.AA RIPK 212-453 22 1.8e-20 66.41 In-house 17-290 (290) Show / Hide 
Range on Protein: 212-453
Range on HMM: 17-290/290
Sequence Identity: 22% (62 aa)

HRSPVTIKVFNNPQAESV--GIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ-TVKPPE-FSIVMEYCELGTLRELLDREKD-----LTMSVRSLLVLRA
..  | .|. . .. .      .|     | | |.| .  .|..| |.|..     ... ..||||| | | | ..| .. .     .  ..|  ..   
WGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEI

ARGLYRLHHSE--TLHRNISSSSFLVAGGYQVKLAGFELSKTQN-SISRT--------AKSTKAERSSSTIYVSPERLK----NPFCLYDIKAEIYSFGI
..|   ||      .||    .  || . . ||.| | |.. .  | | .          .....|    .|  ||..     .|    . |  .|||.|
SCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAI

VLWEIATGKIPFEGCDSKKIRELVAEDKKQ---EPVGQDCPEL-----LREIINECRAHEPSQRPSVDGILERL
|.||. |.| |.|.     ..... . ..    .|| . .||      . | . .| . .| .||.  .. |. 
VMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase MLKL.AA TyrKc 198-453 23 3e-15 23.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 198-453
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

LKTSKM------STIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKF--DSPNILRIFGICIDQ---TVKPPEFSIVMEYCELGTLRELLDR
..  |.       ..|.|..   .| .|. ..         |  | .|.. |.|.  . |||.|..|.|..|    .  .   |||||...| |.. | .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

EKD-LTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSI-------SRTAKST-KAERSSSTI-YVSPERLKNPFCLY
 .. |.|.      . .|.|   ||.    || .     ||. ...|| . | ||.   .        .   |.. | ...   |   .|| .   .. .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKF

DIKAEIYSFGIVLWEIAT-GKIPFEG-----CDSKKIRELVAEDKKQEPVGQD-------CPELLREIINECRAHEPSQRPSVDGILERL
 .|  ..|||...||| | |. | .|     .. . ..|.| . .  ..   |       ||. . .|. .| ...|..||.   | |..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKL.AA Pkinase_Tyr 382-453 31 6.8e-14 47.68 Pfam 197-270 (270) Show / Hide 
Range on Protein: 382-453
Range on HMM: 197-270/270
Sequence Identity: 31% (23 aa)

IYSFGIVLWEIAT-GKIP-FEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILERL
..|||...||| | |..| ..|..   . |...||  . |  ..||. . ... .| ...|..||.   |.|.|
VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKL.AA Pkinase 363-453 19 2.1e-10 37.85 Pfam 177-293 (293) Show / Hide 
Range on Protein: 363-453
Range on HMM: 177-293/293
Sequence Identity: 19% (23 aa)

YVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGC------DSKKIRELVAEDKKQEPVGQDCP-------------------ELLREIINECRA
|..|| ..     |. |. ..|.|..|.| ..|. || |.      | ... ... . .  ..  ..|.                   | ....|. | .
YMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

HEPSQRPSVDGILER--L
  |..||. . ||.   .
KDPKKRPTAEQILQHPWF
Kinase MLKL.AA Pkinase_Tyr 236-284 41 7.3e-09 30.65 Pfam 50-98 (270) Show / Hide 
Range on Protein: 236-284
Range on HMM: 50-98/270
Sequence Identity: 41% (21 aa)

FNDEIKTMKKF-DSPNILRIFGICIDQTV-KPPEFSIVMEYCELGTLRELL
|  |.|.||.. . |||.|  |.|.||   .  .  |||||...| |.. |
FMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYL
Kinase MLKL.AA Pkinase 203-310 22 4.5e-08 29.64 Pfam 12-125 (293) Show / Hide 
Range on Protein: 203-310
Range on HMM: 12-125/293
Sequence Identity: 22% (26 aa)

MSTIYRGEYHRSP--VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELG----TLRELLD--REKDL--TM
... |..  . ..  | .|... . ..|   .. .   ||. ||....|||.|..... |    ...  .|||||| |     | ...   |.. .  ..
FGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSE

SVRSLLVLRAARGLYRLH
 .    ..  .|||. .|
WECKFYMYQILRGLEYCH