Gene MRCKa (Mouse)

MRCKa

Species: Mouse
Alias: MRCKa, A930014J19Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: DMPK
Subfamily: GEK

Sequence

Name Sequence Type Origin Length Description Download
MRCKa.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
MRCKa.NA RNA Sugen 5791 None Fasta, JSON
MRCKa.AA Protein Sugen 1770 None Fasta, JSON

Protein domain

Protein domains of MRCKa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MRCKa.AA DMPK 77-343 74 8.49999999999e-308 773.23 In-house 1-270 (270) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-270/270
Sequence Identity: 74% (200 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEE
||||||||||.||||.||. |....|.|||..||||||||||||||.||||..|.|.|.|||.|||||||.|.||.||.|..|||||||.|..|||.||.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDG-KGRYGPECDWWSLGVCMYEM
||||||||||.||.|.||..||||||||||.|.|..|||.|||||||.|...||.|.|.||||||||||||.||||||. ||||||||||||.|||||||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LYGETPFYAESLVETYGKIMNH-KERFQFPAQVT-DVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF
|||||||||.|||||||||||| |....||.... ||||.|||||..|.|.||.|||.||.||||.||||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase MRCKa.AA GEK 77-343 88 5.3e-214 717.22 In-house 1-269 (269) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-269/269
Sequence Identity: 88% (238 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEE
|||||||||||||||||||.||.|.|.||||||||||||||||||||||||||||||..|||.|||||||.|.||||||||||||||||||||||||||.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML
|||||.||||.|||||||||||||||||||.|.|||||||||||||||....||.|||.|||||||||||||||||||||||||||||||||||||||||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

YGETPFYAESLVETYGKIMNHKERFQFPAQVT--DVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF
||||||||||||||||||||||..||||.|.|  ||||.||||||.||||.|||||.|||.||||||||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase MRCKa.AA AGC 77-343 31 1.2e-177 464.05 In-house 1-395 (395) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-395/395
Sequence Identity: 31% (127 aa)

FEILKVIGRGAFGEVAVVKLK------NADKVFAMKILNKWE--------MLKRAETAC-------FREERDVLVNGD----------SKWITT-LHYAF
||.|||||.|.||.|  |. |        .|..|||.|.|..        |.... |..       ..|||..|.. .          . .|.  |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDDNN--LYLVMDYYV---------GG-DLLTLLSK--FEDRLPEEMARFYLAE-------MVIAIDSVHQ-LHYVHRD-IKPDNILMDMNGHIRLADFG
||...  ||.||.|.          || .|.. | .   | |..||.||||.||       .| |... |. ....||| .||.|||.| .|||.|.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SCLKLMEDG-------------------------------------------------TVQSSVAVG--TPDYISPEILQAMEDGKGRYGPECDWWS--L
.| ..| ||                                                 ... .  .|  ||.|..||||         ||..|||||  |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------YGKACDWWSFGL

GVCMYEMLYGETPFYAESLV----------ETYGKIM------NHKERFQFP-----AQVTDVSENAKDLIRRLIC-SREHRLGQN-------GIEDFKK
|..|||||.| .|||... .          |.. |||      |.|..| ||       .  .|..|||||..|.|  .|.||| .       |.|. |.
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPFF
||.|
HPWF
Kinase MRCKa.AA ROCK 77-343 55 7.6e-136 457.6 In-house 1-263 (263) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-263/263
Sequence Identity: 55% (149 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEE
|...||||||||||| .|. | . ||.|||.|.| ||.||.. | | ||||..    |.||  ||||||||  ||.||||  ||||  |.|...  .|| 
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYD--VPEK

MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML
 |||| .|.| |.|..| . ..|||.||||.|.|  ||..||||| |.|. ..| |... |||||||||||.|..   . |.|| |||||| || .||||
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQG-QDGEYGRECDWWSVGVFIYEML

YGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF
 |.|||||.||| ||.|||.||.  .|| .| ..|..|||||.. .  ||.|||.||..| |.|.||
VGDTPFYADSLVGTYSKIMDHKNSLKFPDDV-EISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase MRCKa.AA CRIK 77-343 46 3.9e-132 423.7 In-house 1-272 (272) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-272/272
Sequence Identity: 46% (128 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEE
||.  .||.| ||.| ||  |    ..|||.. | ..| . . . | ||||..    | |.. | |||||..||||.| |  ||||| |.. ..| . |.
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED---GKGRYGPECDWWSLGVCMY
|||||||| ..|. |.|.  ||||||||.||| |  ||| ||||||  |. ....|.|   ||||||. ||.|| |     .|| || .|||||.|.  |
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMLYGETPFYAESLVETYGKIMN------HKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF
|| .| |||   . ..|| .|||       ..   ||.    || |. |||. |.| .  ||   . |  . ||||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDP-KVSPNYRDLIQSLLCNQSKRL---KYEQLCCHPFF
Kinase MRCKa.AA S_TKc 77-343 32 6.4e-89 302.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-231/231
Sequence Identity: 32% (91 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVG--GDLLTLLSKFEDR--
.|||..||.||||.|  .. |. ....|.||..            .| |...| . . ..| .|...||| ..||.||.|  |  |||.... |   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGP-ECDWWSL
   .|| .||||..... |..  |... .|||.||.|||.|   || ..|||.. .|        .  .|||.|..||.|         ||. .|||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--------GYGKCKCDWWSC

GVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLIC-SREHRLGQNGIED----FKKHPFF
|...||||.|..||.   . ... ||.               |. |||.||.. .   |.|..   .       |.||.|
GCILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MRCKa.AA RSK 80-343 37 1.1e-85 291.01 In-house 1-278 (278) Show / Hide 
Range on Protein: 80-343
Range on HMM: 1-278/278
Sequence Identity: 37% (105 aa)

LKVIGRGAFGEVAVVKLK---NADKVFAMKILNKWEMLKRAE-TACFREERDVLVNGD-SKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDR--
||| |.|..|.| ... .   ......|||.|.| .. .|.  |.  ..||..|     .. | |||||||..  |||.|.|  ||.|.| |.| .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDM---NGHIRLADFGSCLK-LMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSL
. |. |.||.|| | |..  ||.. .|||.||.||| |    .|||.| ||| | .   ...    .  ..| .|. ||.|   . ..| ..  ||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT-FCYTIEYMAPEMLKRAN-QQGGHDKACDWWSL

GVCMYEMLYGETPFYA---ESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREH-RLG--QNGIEDFKKHPFF
|| ||||| | .||..   ..  |.  .|.. |  . .|.    .|..||||||.. .  .| |||   ...|. |.||.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNW-QYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MRCKa.AA NDR 77-221 52 4e-85 262.4 In-house 1-149 (350) Show / Hide 
Range on Protein: 77-221
Range on HMM: 1-149/350
Sequence Identity: 52% (79 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD--SKWITTLHYAFQDDNNLYLVMDYYVGGDLLT---LLSKFED
|||.|.||.|||||| .|. |. ....||||..| ||... ..|  | |||...  |  ..|.. | |.|||...|||||.|  |||. |   ||.|. |
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKM-D

RLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFG
 ..|..|||| |||| ||.|||.. |.||||||||.|.|  ||| | |||
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase MRCKa.AA AktR 77-343 35 5e-81 275.49 In-house 1-268 (268) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-268/268
Sequence Identity: 35% (98 aa)

FEILKVIGRGAFGEVAVVKLK-NADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLP
|...|..|.||||.|  |. | . .|..|||.. | .. .|      . ||...    .   |  |||.||....|...|.|. ||.|.. | |.. .. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHL-KKKKKFS

EEMARFYLAEMVIAIDSVHQL-HYVHRDIKPDNILMDMNGHIRLADFG-SC-LKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVC
||.|||| |....|..  ||  . . ||.||.|||.|..||....||| |  .. |..  .. |. .||| |..||...     || ..  .|||..|. 
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSF-CGTPEYMAPEMITKK---KG-HNKSVDWWAFGIF

MYEMLYGETPFYAESLVETYGKIMNHK-ERFQFPAQVTDVSENAKDLIR-RLICSR-EHRLG--QNGIEDFKKHPFF
 |||..| .|||...  . . || ..   .|..|...   |...||||  .| | . ..|||   ||.|. |.||.|
IYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYF---SSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase MRCKa.AA Pkinase 77-343 26 7.1e-63 220.0 Pfam 1-293 (293) Show / Hide 
Range on Protein: 77-343
Range on HMM: 1-293/293
Sequence Identity: 26% (82 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFR-EERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGG----DLLTLLS-KFE
..|...||.|.||.|   . |.  |..|.||..| .  .  . . .|  |  .. . ... | .|...|.|....|.||.|  ||    || ...| . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DRL--PEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHI----RLADFGSCLKL-MEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPEC
 ..  .|. ..||. ... ...  |.   .|||.||.|||.| ||||    ...|||.. ..    ..   .. .|||.|..||...    |   |||..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIR----GGQYYGPKV

DWWSLGVCMYEMLYGETPFYAE----SLVETYGKIMNHKE-RFQFP-AQVTDVS-----------------ENAKDLIRRLICSREH-RLGQNGIEDFKK
|.||.|. .|||| |..||. .    . .. . .| . .. .. |.  .  ..|                 |..||.|....|   . |..   .|. ..
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQ

HPFF
||.|
HPWF
Kinase MRCKa.AA MAST 77-221 40 3.8e-57 182.61 In-house 1-144 (334) Show / Hide 
Range on Protein: 77-221
Range on HMM: 1-144/334
Sequence Identity: 40% (59 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEE
||. |.|..||.| |  || |.  . ||||...| .|...  .   . ||..| . .. ..  . |.|| .|.|..||.| .|||. .||. .  ...|.
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG-YFDEW

MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFG
||..|.||.|....  |.   ||||.||||.| | |||| |.|||
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase MRCKa.AA MAST 77-221 39 7.5e-56 168.79 In-house 1-147 (337) Show / Hide 
Range on Protein: 77-221
Range on HMM: 1-147/337
Sequence Identity: 39% (58 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQD--DNNLYLVMDYYVGGDLLTLLSKFEDRLP
||..|.|..||.| |  || |.  . ||||..|.  ....      . ||..|.. .  ..  . |.||   .. |..||.|  |||  .||. .  ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFG
|.||..|.|| |....  |    ||||.||||.| | |||| |.|||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase MRCKa.AA NDR 237-343 46 8.7e-54 163.94 In-house 241-350 (350) Show / Hide 
Range on Protein: 237-343
Range on HMM: 241-350/350
Sequence Identity: 46% (54 aa)

AVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF-----QFPAQVTDVSENAKDLIRRLIC-SREHRLG
.||||||. ||..|  . |   |...|||||||. ||||| | .||....  ||. |||| |. .     .||...  .|. |.||||||.|  ..||||
TVGTPDYMAPEVFQQ-KTG---YNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEAN-LSPEAWDLIRRLCCPDPDHRLG

QNG--IEDFKKHPFF
 .|  ....|.||||
SHGKGVDEIKSHPFF
Kinase MRCKa.AA MAST 238-343 39 2.1e-35 105.11 In-house 229-337 (337) Show / Hide 
Range on Protein: 238-343
Range on HMM: 229-337/337
Sequence Identity: 39% (45 aa)

VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVE-TYGKIMNHKERFQFPAQ-----VTDVSENAKDLIRRLI-CSREHRLG
.||||||.||..     |.| ||.  ||||.|. ||| | |..|| ...  | . ..| ||...  .|          .|. |.|||..|       |||
CGTPDYIAPEVIL----GQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLG

QNGIEDFKKHPFF
 || .. |.||||
ANGADEIKQHPFF
Kinase MRCKa.AA MAST 238-343 37 8.4e-31 96.26 In-house 225-334 (334) Show / Hide 
Range on Protein: 238-343
Range on HMM: 225-334/334
Sequence Identity: 37% (43 aa)

VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK-ERFQFPAQ-----VTDVSENAKDLIRRLICS-REHRLG
.||||||.||..     |.| .|.  ||||.|..||| | | .||  ..  |....| |..     .|           |. |.|||..|     . |||
CGTPDYIAPEVIL----GQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLG

QN-GIEDFKKHPFF
 | | .. |.||||
ANNGADEVKQHPFF
Kinase MRCKa.AA S_TK_X 344-406 32 6.3e-18 66.81 SMART 1-79 (79) Show / Hide 
Range on Protein: 344-406
Range on HMM: 1-79/79
Sequence Identity: 32% (26 aa)

SGIDWDNIRN----CEAPYIPEVS----SPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHH--------LPFVGFTYTS
.|||||...|     |.|..|...    ||||||||| . .  . ..|...|. .. ..          .|| ||||  
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase MRCKa.AA Pkinase_C 361-408 41 5.1e-15 56.09 Pfam 1-46 (46) Show / Hide 
Range on Protein: 361-408
Range on HMM: 1-46/46
Sequence Identity: 41% (20 aa)

EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSC
.|.|||||||||..... . ..|. |..   .||...||.||||... 
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
Kinase MRCKa.AA TyrKc 77-321 19 2.8e-11 -40.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 77-321
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG--DSKWITTLHYAFQDD-------NNLYLVMDYYVGGDLLTLLS
 . .|..|.||||||   ..|      | | |..         . |..|  .. .   . . |  |. .  ..         |..|| |  .|||.  | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KFEDRLPEEMARF----------YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMED---GTVQSSVAV----GTPD-----YIS
| ...|. .              ||...          ...|||.   |.| . |.... .||| . .. .|   |  ..   .    |. .       .
KHRPKLCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEILQAMEDGKGRYGPECDWWSLGVCMYEML-YGETPFYA-----ESLVETYGKIMNHKERFQFPA--------QVTDVSE--------------NAKDL
|| .      .|.. .. | || ||||.|.. ||..| .       |  | . .... . . | |           ... .              . ...
PECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

IRRL
....
HECF
Kinase MRCKa.AA Pkinase_Tyr 77-91 53 0.004181 11.14 Pfam 1-15 (270) Show / Hide 
Range on Protein: 77-91
Range on HMM: 1-15/270
Sequence Identity: 53% (8 aa)

FEILKVIGRGAFGEV
 ...|..|.||||||
ITFGKKLGEGAFGEV
Kinase MRCKa.AA Pkinase_Tyr 266-296 38 0.012324 9.55 Pfam 198-231 (270) Show / Hide 
Range on Protein: 266-296
Range on HMM: 198-231/270
Sequence Identity: 38% (13 aa)

WSLGVCMYEMLY-GETP-FYAESLVETYGKI-MN
|| ||.|.|..  ||.| ..  |  | | .|  .
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase MRCKa.AA Pkinase_Tyr 193-221 31 3.22799 1.36 Pfam 128-156 (270) Show / Hide 
Range on Protein: 193-221
Range on HMM: 128-156/270
Sequence Identity: 31% (9 aa)

HQLHYVHRDIKPDNILMDMNGHIRLADFG
.. ...|||.   |.| . |.... .|||
ESKNCIHRDLAARNCLVTENNVVKICDFG
BZIP_1 MRCKa.AA bZIP_1 441-477 27 6.299856 2.92 Pfam 28-64 (64) Show / Hide 
Range on Protein: 441-477
Range on HMM: 28-64/64
Sequence Identity: 27% (10 aa)

TEAYERRIKRLEQEKLELTRKLQESTQTVQALQYSTV
.| .|.|.. || |  .|  .|.. ....| |   . 
CEQLEERVEELEAENMMLRKELERLKKMCQKLKSENH
M MRCKa.AA M 453-473 28 32.633622 1.66 Pfam 1-21 (21) Show / Hide 
Range on Protein: 453-473
Range on HMM: 1-21/21
Sequence Identity: 28% (6 aa)

QEKLELTRKLQESTQTVQALQ
..| .|. ..|| ..  |.|.
EAKKQLEAEHQELEEQNQKLE
BZIP_1 MRCKa.AA bZIP_1 488-504 29 0.420478 7.15 Pfam 48-64 (64) Show / Hide 
Range on Protein: 488-504
Range on HMM: 48-64/64
Sequence Identity: 29% (5 aa)

EIKSLKEEIEKLRKQVA
|...||....||.... 
ELERLKKMCQKLKSENH
M MRCKa.AA M 494-514 28 2.444976 5.46 Pfam 1-21 (21) Show / Hide 
Range on Protein: 494-514
Range on HMM: 1-21/21
Sequence Identity: 28% (6 aa)

EEIEKLRKQVAEVNHLEQQLE
|. ..| ....| ..  |.||
EAKKQLEAEHQELEEQNQKLE
DMPK_coil MRCKa.AA DMPK_coil 488-502 46 2.508811 3.69 Pfam 47-61 (61) Show / Hide 
Range on Protein: 488-502
Range on HMM: 47-61/61
Sequence Identity: 46% (7 aa)

EIKSLKEEIEKLRKQ
|...||.|.| || .
EMEQLKKEMEMLRAR
DMPK_coil MRCKa.AA DMPK_coil 528-555 33 9.550468 1.7 Pfam 32-61 (61) Show / Hide 
Range on Protein: 528-555
Range on HMM: 32-61/61
Sequence Identity: 33% (10 aa)

RQIKASEKQIKTLQQEREELNKEL--VQAS
.. . .||. . |.|| |.| ||.   .| 
CKLQEAEKKNRELEQEMEQLKKEMEMLRAR
M MRCKa.AA M 528-548 19 27.149656 1.93 Pfam 1-21 (21) Show / Hide 
Range on Protein: 528-548
Range on HMM: 1-21/21
Sequence Identity: 19% (4 aa)

RQIKASEKQIKTLQQEREELN
 . |. |.. . |... ..| 
EAKKQLEAEHQELEEQNQKLE
DMPK_coil MRCKa.AA DMPK_coil 722-749 28 0.318916 6.76 Pfam 34-61 (61) Show / Hide 
Range on Protein: 722-749
Range on HMM: 34-61/61
Sequence Identity: 28% (8 aa)

LHDSEGQQLALNKEILVLKDKLEKTRRE
| ..| .  .| .|.  ||  .|  | .
LQEAEKKNRELEQEMEQLKKEMEMLRAR
M MRCKa.AA M 713-733 28 44.038145 1.22 Pfam 1-21 (21) Show / Hide 
Range on Protein: 713-733
Range on HMM: 1-21/21
Sequence Identity: 28% (6 aa)

SEIKNLKKELHDSEGQQLALN
.. |.| .|. . | |. .| 
EAKKQLEAEHQELEEQNQKLE
M MRCKa.AA M 774-794 28 0.009407 13.61 Pfam 1-21 (21) Show / Hide 
Range on Protein: 774-794
Range on HMM: 1-21/21
Sequence Identity: 28% (6 aa)

EENKKLTSELDKLTSLYESLS
|..|.|..|. .|.  .. |.
EAKKQLEAEHQELEEQNQKLE
BZIP_1 MRCKa.AA bZIP_1 763-798 30 0.077126 9.8 Pfam 29-64 (64) Show / Hide 
Range on Protein: 763-798
Range on HMM: 29-64/64
Sequence Identity: 30% (11 aa)

QQYEREKVLLTEENKKLTSELDKLTSLYESLSLRNQ
.|.|..   |..||..| .||..|. ....|   | 
EQLEERVEELEAENMMLRKELERLKKMCQKLKSENH
M MRCKa.AA M 797-815 21 66.704862 0.61 Pfam 3-21 (21) Show / Hide 
Range on Protein: 797-815
Range on HMM: 3-21/21
Sequence Identity: 21% (4 aa)

NQHLEEEVKDLADKKESVA
.. || |...|  ... . 
KKQLEAEHQELEEQNQKLE
DMPK_coil MRCKa.AA DMPK_coil 881-941 68 3.9e-33 116.11 Pfam 1-61 (61) Show / Hide 
Range on Protein: 881-941
Range on HMM: 1-61/61
Sequence Identity: 68% (42 aa)

ELQSALDAEIRAKQAIQEELNKVKASNILTECKLKDSEKKNLELLSEIEQLIKDTEELRSE
||||||.|||||||.|.||||||||.|| .||||...|||| ||..|.|||.|..|.||..
ELQSALEAEIRAKQSIHEELNKVKAANIQFECKLQEAEKKNRELEQEMEQLKKEMEMLRAR
BZIP_1 MRCKa.AA bZIP_1 918-943 38 2.831173 4.17 Pfam 39-64 (64) Show / Hide 
Range on Protein: 918-943
Range on HMM: 39-64/64
Sequence Identity: 38% (10 aa)

EKKNLELLSEIEQLIKDTEELRSEKG
|..| .| .|.|.| |  ..|.||. 
EAENMMLRKELERLKKMCQKLKSENH
C1_1 MRCKa.AA C1_1 1051-1103 32 1.2e-13 53.71 Pfam 1-55 (55) Show / Hide 
Range on Protein: 1051-1103
Range on HMM: 1-55/55
Sequence Identity: 32% (18 aa)

HQFFVK-SFTAPTKCHQCTSLMVG-LIRQGCSCEVCGFSCHITCVNKAPTVCPVP
|.. .. .|  ||.| .| ... | |..||..|..|.. ||  |..|.|. |.  
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 MRCKa.AA C1 1051-1100 27 2.1e-09 38.47 SMART 1-61 (61) Show / Hide 
Range on Protein: 1051-1100
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HQFFVKSFTAPTKCHQCTSLMVGLIRQ-----GCSCEVCGFSCHITCVNKAPT-------VC
|..  ..|  ||.|..| ... |. .|     | .|..|.. ||  |. |.|         |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
PH MRCKa.AA PH 1121-1241 11 1.7e-10 42.14 SMART 1-82 (82) Show / Hide 
Range on Protein: 1121-1241
Range on HMM: 1-82/82
Sequence Identity: 11% (14 aa)

TAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPTSVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSNKCSILML
. .||.... .    | .|..  .|...  |..|.             . .|...| ....                   |...  .        .... 
VIKEGWLYKKS----K-RWKKRWFVLFNDCLYYYKDK---------KPKGSIPLSDCTVRE-P----------------CFEIHH-DR-------TYYFQ

ADSENERSKWVGVLSELHKIL
..|| |. .|.  . .. . .
CESEEEMQEWMQAIQKAIHNN
PH MRCKa.AA PH 1121-1239 13 4.5e-07 28.15 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1121-1239
Range on HMM: 1-92/92
Sequence Identity: 13% (16 aa)

TAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPTSVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSNKCSILML
  .||...  .    .|.|..  .|... .|..|.          .    .|...| ..   .            . |..|...  .        ...  
VIKEGWLHKKG---KRKSWKKRWFVLFNNCLYYYKDDK-------YRPKGSIPLSDCQVTKVPDN----------KRPHCFQIRT-DR------RTYYFQ

ADSENERSKWVGVLSELHK
|.|| |.  |.  ......
AESEEEMNDWMQAIQSACR
CNH MRCKa.AA CNH 1270-1534 24 1.1e-96 332.3 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1270-1534
Range on HMM: 1-336/336
Sequence Identity: 24% (81 aa)

AAAIIDHERIALG-NEEGLFVVHV--TKDEIVRVGDNKK----IHQIELIPSDQLVAVI--SGRNRHVRLFPMSALDGRETDFY----------------
............| ..|||.|...  |.|.. ......|    ..||..|.  .....|  ...|.|....|...||..|. .                 
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIERI

---------KLAETKGCQTIAAGKVRHGALSCLCVAMKR-----QVLCYELFQSKTRH-------------RKFKE-IQVP----CNVQWMAIF---SEH
         || .||.|.... . ...    |||.|.||     ...|||  . . ..             |||.| ...|     ....|...    . 
MPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEKPK

LCVGFQSGFLRYPLNGEGGPCNMLHSNDHT--LSF-ISHQPMDALCAVEISNK-EYLLCFNSIGIYTDCQGR-RSR--QQELMWPANPSSCCYNAPYLSV
||||.|.||  ..|.|.| |.  .. .||.  ..|  . . ....|...|... |.|||.. ...|.. ||. |||  ..|.||...| |.... ||| .
LCVGCQKGFHIVNLDGTGQPWWLHDPADHSVQQDFMARRENCKPICMHRINDDEEFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSFACCYPYLLA

YSENAVDIFDVNSM-EW---IQTLPLKKVRPLNTEG
...|...|..|... ||   .|..|....|.|. ..
FHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS
CNH MRCKa.AA CNH 1266-1543 17 1.8e-19 71.94 SMART 1-375 (375) Show / Hide 
Range on Protein: 1266-1543
Range on HMM: 1-375/375
Sequence Identity: 17% (64 aa)

KTTQAAAIIDHE-----RIALGNEEGLFVVHVTK-------DEIVRVGDNKKIHQIELIPSDQLVAVISGRNRHVRLFPMSAL-----------------
 |..  ..|. .      . .| |.|...  . .       .  ..    . . .....   .... |||...|.. .| ..|                 
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

-----DGRETDF-YKLAETKG-CQTIAA-GKVRHGALSCLCVAMKRQVLCY-ELFQSKTRHRKFK--------EIQVPCNVQWMAIFSEHLCVGF-QSGF
     ..|      | ..||| |   .. ..   . . .||.||.  |  | . ...  .. ..|        ||  . ...  .||   ..|.| ...|
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

----LRYPLNG----EGGPCNMLHS-----------------NDHTLSFISHQPM------DALCAVEISN------KEYLLCFNSIGIYTDCQG---RR
    . .. ..    ..| . ..|.                 ||| | | . |.       ...... . .       .||||.. .|....|.|   ||
ERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWRR

SRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEW-IQTLP------LKKVRPLNT---EGSLNLLGLET
.| ..|.|.  | .  |  ||. . ..|...|... . || .|..       ..| | | |     .  .. .. 
WRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
PBD MRCKa.AA PBD 1609-1644 39 8.2e-13 49.81 SMART 1-38 (38) Show / Hide 
Range on Protein: 1609-1644
Range on HMM: 1-38/38
Sequence Identity: 39% (15 aa)

ISNPT-NFNHIAHMGPGDG-IQILKDLPMNPRPQESRT
||.|| ||.||.|.||.||  . . .||.. . .....
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC