Gene MSK1 (Mouse)

MSK1

Species: Mouse
Alias: MSK1, 3110005L17Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation: Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: MSKb,

Classification

Group: AGC
Family: RSK
Subfamily: MSK

Sequence

Name Sequence Type Origin Length Description Download
MSK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 270 Kinase domain by global Sugen HMM Fasta, JSON
MSK1.AA Protein Sugen 863 None Fasta, JSON
MSK1.NA RNA Sugen 4496 None Fasta, JSON
MSK1.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of MSK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MSK1.AA AGC 48-317 36 2.5e-194 508.18 In-house 1-395 (395) Show / Hide 
Range on Protein: 48-317
Range on HMM: 1-395/395
Sequence Identity: 36% (147 aa)

FELLKVLGTGAYGKVFLVRKISGH---DAGKLYAMKVLKKAT-IVQKAK-TTEHTRTE------------RQVLEHIRQ---------SPFLVT-LHYAF
||.|||.|.|..|||.|||| .|.   | ||.||||||||.. ||.| | . ||| ||            |..||....         .||.|  |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTETK--LHLILDYIN---------GG-ELFTHLS---QRERFTEHEVQIYVGE-------IVLALEHLHK-LGIIYRD-IKLENILLDSNGHVVLTDFG
|....  |.....|..         || |||.||    .. ||.| ....|  |       ||||||.||. .|||.|| .|.||||||..||. |||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEFVADE-------------------------------------------------TERAYSFCG--TIEYMAPDIVRGGDSGHDKAVDWWS--LGVL
|.||.. |.                                                 ..|...|||  | ||||| |.      ..||.||||  ||.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCL

MYELLTGASPFTVDG------EKNSQAEISRRIL------KSEPPYP----------QEMSTVAKDLLQRLLMKDPKKRLGCGPRD-----AEEIKEHLF
|||.||| .||. |       . ....|.  .|.      . ....|          ...|  ||||...|| |||.||||||..|     |||||.| .
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

F
|
F
Kinase MSK1.AA RSK 51-317 56 2.2e-173 582.27 In-house 1-278 (278) Show / Hide 
Range on Protein: 51-317
Range on HMM: 1-278/278
Sequence Identity: 56% (159 aa)

LKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER---
|||||.|.||||||.||. .||.|..|||||||||.|||..|.|.||.|||..||...|.||.||||||||||.||.||..|..||||||||.....   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDS---NGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRG--GDSGHDKAVDWWSLGV
|.|.|...|  |||||.||||..|||.||.|.||||.|.   .||..|||||..|.|..|.......||.||||||| ...   ...|||||.|||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMYELLTGASPFTVDGEKNSQAEISRRILKSE--PPYP--QEMSTVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFF
||||.|||..||.  ...|...||..||.| .  .. |  |..|. ||||....|..||.|||||||.||||||.| .|
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MSK1.AA MSK 51-312 53 1.5e-171 576.19 In-house 1-277 (277) Show / Hide 
Range on Protein: 51-312
Range on HMM: 1-277/277
Sequence Identity: 53% (147 aa)

LKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTE
|||||||.|||.|..||...||.|||||||.|.|||.|||.||.|||.||||.||...|.|..|.||||||......|...|.||||||||...||.|.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

HEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSN---GHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRG---GDSGHDKAVDWWSLGVLM
.|......|.|.|..|.|..|||.||.|.||||.|..   |||.|.|||....|..||..|..|.|.|..||||...|.   .|.|.|.|.|||||||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

YELLTGASPFT--VDGEK---NSQAEISRRILKSEPPYP----QEMSTVAKDLLQRLLMKDPKKRLGCGPRDAEEIK
|..|||..||.  .|...   ||..||..||.|.|...|    |.||..||||.|.||.||||||||.....|.|.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase MSK1.AA p70 48-317 47 1e-135 457.14 In-house 1-299 (299) Show / Hide 
Range on Protein: 48-317
Range on HMM: 1-299/299
Sequence Identity: 47% (146 aa)

FELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTR-------------------------TERQVLEHIRQSPFLVTLHYAFQT
|||||||| |.|||||.|||  |.|.||.||||||.||.||  .| |.|||                          || .|| . ..||.. |||||||
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEV-KHPFICDLHYAFQT

ETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETE---------RAYSFC
. || |||.|. |||||.||     . |  .. |  ||..||||||..|||||| | ||..|.. ||||||||||.|| . | .            ..||
NGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFC

GTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSE--PPYPQEMSTVAKDLLQRLLMKDPKKRLGCGPRDAEEI
|||||||| |...  .||..||||||||.|||  |||. ||| .  |    ..   |||    .  |   .  ..||...|| ..|..|.| || ||..|
GTIEYMAPEILMR--CGHNHAVDWWSLGCLMYDMLTGGPPFTGENRK----KTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADI

KEHLFF
.|| ||
QEHPFF
Kinase MSK1.AA SGK 48-317 43 1.4e-132 411.93 In-house 1-283 (283) Show / Hide 
Range on Protein: 48-317
Range on HMM: 1-283/283
Sequence Identity: 43% (127 aa)

FELLKVLGTGAYGKVFLVRKISG---------------HDAGKLYAMKVLKKATIV------QKAKTTEHTRTER-QVLEHIRQSPFLVTLHYAFQTETK
|..|||.| | .|||..|.. .                   .|.||||||.|..|.       | |   |. .||  .|  .. .||.| |||||||..|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMK-HPFIVNLHYAFQTKWK

LHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVR
| . .||.||||.| ||  . .| |... .|. |||.|||.||.. ||||| | ||||||. ||..||||||.|| ......   .|||| ||.|| . |
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDT-TFTFCGTPEYLAPEVLR

GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSTVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFF
.   .||..||||.|| ..||...|. ||    . .  ..    |....   |. ||  |.||.| || ||||||||   ||..|||.| ||
K--QPHDRTVDWWCLGCVLYEMMYGLPPF----YSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase MSK1.AA AktR 48-317 47 9.69999999999e-128 430.68 In-house 1-268 (268) Show / Hide 
Range on Protein: 48-317
Range on HMM: 1-268/268
Sequence Identity: 47% (130 aa)

FELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER
|...|.|| ||.|||.||.|    | .|.||||..|| .  .. .  .||.|||...| . . ||.| |||.|||..|| .|..|. |||||.||.....
FHVYKCLGKGAFGKVYLVQKKR--DNQKQYAMKMIKK-KKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK

FTEHEVQIYVGEIVLALEHLHKL-GIIYRDIKLENILLDSNGHVVLTDFGLSK-EFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMY
|.| ....|  .|.||||.||.   |||||.| ||||||..||| .||||||| .|. ...|.||||||| |||||....    ||.|.||||..|.. |
FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKK-KGHNKSVDWWAFGIFIY

ELLTGASPFTVDGEKNSQAEISRRILK-SEPPYPQEMSTVAKDLLQ-RLLMKDPKKRLGCGPRDAEEIKEHLFF
|..||  ||..  ... |  .. .|    ..||| . |  .|||.| .||.|.|.|||| .  ..||||.| .|
EMVTGCPPFYH--KNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase MSK1.AA RSK 48-317 41 1.8e-121 409.87 In-house 1-271 (271) Show / Hide 
Range on Protein: 48-317
Range on HMM: 1-271/271
Sequence Identity: 41% (115 aa)

FELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER
.||....|.|...||....|. . |....||||..||||.. | .    . .|| .|... ..|| |.|||.||.|.|. .|.|   ||.||..|.    
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIILRYG-HHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKM

FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSN----GHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVL
|.| || .|  || ||.|.||..||..|| | ||||.|.     ||. ..|||..|. . ||.. ...||.|..|||| ...  . |||.|.||||.|||
FSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLK--RQGHDQACDWWSFGVL

MYELLTGASPFTVDGEKNSQAEISRRILKSE----PPYPQEMSTVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFF
||| |||. || . . ...  .|  ||         ....  |  ||||| ..|  || .|||.|| ..|.||.| .|
MYEMLTGCTPF-QNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase MSK1.AA Akt 48-254 54 5e-120 385.4 In-house 1-203 (264) Show / Hide 
Range on Protein: 48-254
Range on HMM: 1-203/264
Sequence Identity: 54% (115 aa)

FELLKVLGTGAYGKVFLVRKISGHDAGKLY-AMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRE
|..||||| |..||||||.|    | .|.| |||||||  |.||    ||| ||| .|.|.. .||.| |||.|||..|| ...||.||||||.||....
FDFLKVLGKGSFGKVFLVKKK---DTQKWYYAMKVLKKDYIIQKN-QVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKR

RFTEHEVQIYVGEIVLALEHLHKLGIIYRD-IKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS-LGVLM
||.| .   |. ||.||.||||. .|||||  |.||||.|..||. ||||||.|| .  .......|||| ||.|| |  |   ||.||||||. ||..|
RFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNG--NGHTKAVDWWGSLGCVM

YELLTGASPF
||...|. ||
YEMMCGRPPF
Kinase MSK1.AA S_TKc 48-317 33 6.5e-104 352.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 48-317
Range on HMM: 1-231/231
Sequence Identity: 33% (93 aa)

FELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYING--GELFTHLSQR
.|.|...| ||.|||...|...    |...|.|..|           ||.| |.|.|..  . |..|.|...||. ..|.....|..|  |.||... .|
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

ER------FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDK-AVDWW
 |      |.| ... |. .|..|||..|..|||.||.| ||||||.  |. ..||||....        ..|||| .|||| ..     |..| ..|||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----GYGKCKCDWW

SLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSTVAKDLLQRLLMKDPKKRLGCGPRDA--EEIKEHLFF
|.|...||.|.|  ||        .... ..|.          |  |||.....| |||.||...    .  ..|| | .|
SCGCILYEMLCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MSK1.AA Pkinase 48-317 29 3.9e-86 297.26 Pfam 1-293 (293) Show / Hide 
Range on Protein: 48-317
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTR-TERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGG----ELFTHL
.......| |..|.|.. ....  .   ..|.|..|| ..  . |  .|.| .| |.. .. ..|. |.|...|...........| .||    .||...
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEK-SWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

S--QRERF--TEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHV----VLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKA
|  .. .|  .|.|.. |. .|. .||..|. |||.||.|.||||.|.|||.     ..||||.| |     . ...||||..|||| ..| |.......
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPK

VDWWSLGVLMYELLTGASPFTVDG----EKNSQAEISRRILKSEPPYPQE---------------------MSTVAKDLLQRLLMKDPKKRLGCGPRDAE
||.||.|...||.|.|  ||  .     . ..| .. .||.. ..... .                     .|  .||.. ..| ||||||..     ||
VDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AE

EIKEHLFF
.|..| .|
QILQHPWF
Kinase MSK1.AA CAMK 53-317 19 3.2e-83 267.91 In-house 1-425 (425) Show / Hide 
Range on Protein: 53-317
Range on HMM: 1-425/425
Sequence Identity: 19% (86 aa)

VLGTGAYGKVFLVRKI-SG---------HDAGKLYAMKVLKKATIVQ------------------------KAKTTEHTRTERQVLEHIR------QSPF
.||.|..|||.|.. . ..          . |. .|.|...|  .                          ..|. .  | | ... ...      . | 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

LVTLHYAFQ------------TETK--------LHLIL---DYINGGEL----FTHLSQR---------------ERFTEHEVQIYVGEIVLALEHLHKL
.. |. ...            | .|        .....   .|. ||||    | .. ..                ||||.|.. |.  |. |....|..
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GIIYRDIKLENILLDSN-----------------GHVVLTDFGLSKEFVADETER----------------------AYSFCGTIEYMA-PDIVRG-G--
.|. ||.|.||||||.|                 . . ..|||....|  .| ..                       . |||| |||| | ...| |  
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------DSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKN---------SQAEISRRILKSEPP-YPQEMSTV-----------------------A
           ......| ||.||..| .|.| .||  | ...         .. |. ..|.| .   .| ..|..                       .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFF
|||....| .||.||.      .|....| ..
KDLIRKMLQVDPEKRM-----TIEQCLNHPWM
Kinase MSK1.AA Ciliate-E2 48-317 24 9.4e-81 274.59 In-house 1-365 (365) Show / Hide 
Range on Protein: 48-317
Range on HMM: 1-365/365
Sequence Identity: 24% (96 aa)

FELLKVLGTGAYGKVFLVRK-ISGH-------------------DAGKLYAMKVLKKATIVQKAKTTEHTR---------TERQVLEHIRQSPFLVTLHY
....|..|.|..|.|.....   ..                   ...|.||||..||  | |. .     |          |...||.. ..|... ...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQL-NHPNIIKMYE

AFQ--TETKLHLILDYINGGELFTHLSQR-----------ERFTEHEVQ---------------IYVGEIVLALEHLHKLG-IIYRDIKLENILLDSNGH
.||  ..... |...|..||.|| .. ..           ..||| |..                |...|.||||.||. . ||.||||.||||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VVLTDFGLSKEFVADETERA------------------------------YSFCGTIEYMAPDIVRGGD-------SGHDKAVDWWSLGVLMYELLTGAS
. ..||||||..  |. .|                               ...||| .|||| |..|..        |.|...|.|||||..||.|.|  
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFTVDGEKNSQAEISRRILKSEPPYP------------------QEMSTVAKDLLQR----LLMKDPKKRLGCGPRDAEEIKEHLFF
||             . |.. .  .|                  .. |  .|||...    .| |||.||..    ..|.|..| .|
PF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase MSK1.AA Akt 270-317 50 1.1e-17 53.07 In-house 215-264 (264) Show / Hide 
Range on Protein: 270-317
Range on HMM: 215-264/264
Sequence Identity: 50% (25 aa)

ILKSEPPYP--QEMSTVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFF
|. ..  .|     |  .|||. .|| |||||||| || ||.|||.| .|
IKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase MSK1.AA S_TK_X 318-378 30 1.2e-15 59.21 SMART 1-79 (79) Show / Hide 
Range on Protein: 318-378
Range on HMM: 1-79/79
Sequence Identity: 30% (24 aa)

EKIKWDDLAA--KKVPAPFKPVIR----DELDVSNFAEEFTEMDPTYSPAAL--------PQSSERL-----FQGYSFVA
 .| ||.| .  |....|||| |.    .. |.||| .||||..|...|.          ..  |..     | |...|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase MSK1.AA Pkinase_C 337-380 27 9.5e-14 51.64 Pfam 1-46 (46) Show / Hide 
Range on Protein: 337-380
Range on HMM: 1-46/46
Sequence Identity: 27% (13 aa)

VIRDELDVSNFAEEFTEMDPTYSP---AALPQSSERLFQGYSFVAPS
 .....|.||| .|||...|...|     ....  ..|.|...|.|.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase MSK1.AA TyrKc 48-315 21 4.7e-13 -11.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 48-315
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

FELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHI-RQSPFLVTLHYAFQTE-------TKLHLILDYINGGELF
 .|.|.|| ||.|.|.. . .         | |.||. .        |  . | ... ..  . | .| |. .  ..         | ... |  .| | 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

THLSQRER-FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVAD----ETERAYSF----CGT----IEYMAPDIVRG
 .|  ... ..  .   .   |    |.||. ..| ||.   |.|...|..|  .|||||..   |    | .  |.     .|     |  |||     
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

GDSG-HDKAVDWWSLGVLMYELLTGASPFTVDGEK--NSQAEISRRILKS-EPPYPQE--------MSTVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEH
 . |    . | || ||.|.|..|   .   . ..   | .|. ... .   .| |..        ...   .. ..  . ||..|        .||.| 
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEIHEC

L
.
F
Kinase MSK1.AA APH 164-198 17 1.907657 2.4 Pfam 164-202 (248) Show / Hide 
Range on Protein: 164-198
Range on HMM: 164-202/248
Sequence Identity: 17% (7 aa)

LEHLHKLGIIYRDIKLENILLD--SNGHVV--LTDFGLS
..|.. .... .| .. |...|  ..|  |  . |.. .
EAHWPPPCWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDA
Kinase MSK1.AA MSK 555-751 61 4.90000000001e-136 458.22 In-house 73-277 (277) Show / Hide 
Range on Protein: 555-751
Range on HMM: 73-277/277
Sequence Identity: 61% (127 aa)

QLHTFLVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFARLKPPD-NQPLKTPCFTLHYA
|.||.||||..||||||..|....||.|.|...|||.||.||.|||..|..||||||||.||.||.|| ..|.||||||||.|.| ....|.|||||||.
QCHTYLVMEYCNGGELFTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYM

APELLT----HNG-YDESCDLWSLGVILYTMLSGQVPFQ--SHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLR
|||.|.    ..| |||.||.|||||||||||.||||||  ..||...|.|..||||.|.||.|||.|.||.|.|..||||||.|||.||.|||.|..||
APEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLR

YNEWL
..||.
AHEWK
Kinase MSK1.AA RSK 555-751 43 1.2e-111 377.16 In-house 73-278 (278) Show / Hide 
Range on Protein: 555-751
Range on HMM: 73-278/278
Sequence Identity: 43% (92 aa)

QLHTFLVMELLNGGELFERIKRKKH---FSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDN-LEIKVIDFGFARLKPPD-NQPLKTPCFT
.....|.||...|||||......||   |||.||...|...|.||.|.|. |..|||||||| |..||. |  .||..||||......| ||...|.|.|
EGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYT

LHYAAPELLT----HNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLK----
..|.|||.|.     .|.|..||.|||||..|.||.|..|||. ...    .. ||||.|.||.||.....|...||||||||...|..||.|||.    
IEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQG-PND---NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQ

-MSGLRYNEWL
 .. .. ..|.
DAEEIKQHPWF
Kinase MSK1.AA CAMK 557-751 29 2.6e-92 297.74 In-house 131-425 (425) Show / Hide 
Range on Protein: 557-751
Range on HMM: 131-425/425
Sequence Identity: 29% (87 aa)

HTFLVM---ELLNGGEL----FERIKRKKH---------------FSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDN------------
| ..||   |.  ||||    |..|.....               |.| ||....| ..||| ..|. ..|||||||||.|..| ||.            
HMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDW

--LEIKVIDFGFARLKPP-----------------------DNQPLKTPCFTLHYAA-PELLTH--------------NGYDESCDLWSLGVILYTMLSG
    ||.||||||. ..|                       ..|..||.| |..|.| ||.|                 .|...|| ||.|||||.||.|
NNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCG

QVPFQSHDRSLTCT------SAVEIMKKIKKGDFSFEGEA------------WKNVSQE--------AKDLIQGLLTVDPNKRLKMSGLRYNEWL
  ||.. ... .|       .  |...||.||...|. .             |...|.|        .||||...|.|||.||.. .     .|.
YPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MSK1.AA AGC 557-751 23 3.7e-83 214.05 In-house 107-395 (395) Show / Hide 
Range on Protein: 557-751
Range on HMM: 107-395/395
Sequence Identity: 23% (71 aa)

HTFLVMELLN---------GG-ELFERIK---RKKHFSETEASYIMRK-------LVSAVSHMHD-VGVVHRD-LKPENLLFTDENDNLEIKVIDFGFAR
. ..|||...         || ||| ...   ....|.| .| ...         .|.|. ..|.  |..||| |||||.|....     ||  |||.. 
YLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLTDFGLCK

LKPPD-----------------------------------------------------NQPLKTPCFTLHYAAPELLTHNGYDESCDLWS--LGVILYTM
  . |                                                     .. .  || | .| ||| |    |. .|| ||  ||...| |
EGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGLGCLMYEM

LSGQVPFQSHDRS---LTCTSAVEIMKKIKKGD-FSFEGEAW-----------KNVSQEAKDLIQGLLTVDPNKRLK----------MSGLRYNEWL
|.|. ||.....      ...  |...||..|. |..... .           ...|.||||||..||..||.|||            . ..  .| 
LTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MSK1.AA S_TKc 425-751 28 6.5e-78 266.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 425-751
Range on HMM: 1-231/231
Sequence Identity: 28% (98 aa)

DLKDKPLGEGSFSICRKCVHKKTNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQVAASAQPPGQVVLCSLLLLALLFNRSLTRKPVTW
  . ...|.|.|. ..||.||||.. .|.|||.     ....||  ||   .|||||||..||.|                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-----------------------------------

TWLVHSTSQLPPLPPPMPEIVLFILLSDNGQLHTFLVMELLNG--GELFERIKRKKH------FSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLF
                                | ..|||...|  |.||..||....      |.| .| ..|. ...|. ..|. |..||||||||.|.
-------------------------------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILL

TDENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDE-SCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGE
..     .||..|||.||.        .| | |..| |||.|   ||.  .|| ||.|.||| ||.|. ||.            ...|||.         
DE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG---------

AWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRY-------NEWL
     |.||||.|...|..||.||.    .          .|.
-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MSK1.AA RSK 559-740 42 6.8e-70 238.51 In-house 77-255 (271) Show / Hide 
Range on Protein: 559-740
Range on HMM: 77-255/271
Sequence Identity: 42% (78 aa)

FLVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDE-NDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPEL
...|... ||.|| |. ..| ||| |.. .|. . .|. . |  |.||||||||| |. ||  .   ||. |||||     .|  |.|.| |  | ||| 
YMIMDFMRGGDLFDRLLKQKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEV

LTHNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRL
|   |.|..|| ||.||..|.||.|  |||. .|  .     .| ..|| | ||. .  | ..|.|||||. ..|..||..||
LKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTP----MNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRL
Kinase MSK1.AA Ciliate-E2 557-751 28 1.7e-64 220.29 In-house 108-365 (365) Show / Hide 
Range on Protein: 557-751
Range on HMM: 108-365/365
Sequence Identity: 28% (80 aa)

HTFLVMELLNGGELFERIK--RKKH---------FSETEASYIMRKLVS---------------AVSHMHDVG-VVHRDLKPENLLFTDENDNLEIKVID
. .||||...||.||..||  .||.         |.| |..|||.....               |. ..|  . ..|||.||||.||        ||.||
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIID

FGFARLKPPDNQ--------PLKTPCF------------------------TLHYAAPELLT---------HNGYDESCDLWSLGVILYTMLSGQVPFQS
||...   .|||         ...  .                        |..| ||| |          ..|||..||.|||||||| ||.|. ||  
FGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--

HDRSLTCTSAVEIMKKIKKGDFSFEGE--------------AWKNVSQEAKDLIQG----LLTVDPNKRLK-MSGLRYNEWL
             ...||.....|  .               ||..|||.||||.     .| .||.||.  .. .  ..|.
-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MSK1.AA Pkinase 557-740 31 2.8e-62 218.03 Pfam 74-282 (293) Show / Hide 
Range on Protein: 557-740
Range on HMM: 74-282/293
Sequence Identity: 31% (67 aa)

HTFLVMELLNGG----ELFERIK--RKKHF--SETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNL--EIKVIDFGFARLK-PPDNQPLKT
|  .|||...||    .||..|.  |.. |  || |.  .|. ..... ..|. |..||||||||.|.  .|...   .|..|||.|...    |. ..|
HIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTT

PCFTLHYAAPELLT-HNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVS-----------------QEAKDL
.| |..|.|||..  ...|. ..| ||.|.||| ||.|. ||..|. . .  .  .....|......|. . | ..|                 .|.||.
FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF

IQGLLTVDPNKRL
| ..|..||.||.
IKWCLCKDPKKRP
Kinase MSK1.AA SGK 559-740 35 5.1e-39 117.81 In-house 101-268 (283) Show / Hide 
Range on Protein: 559-740
Range on HMM: 101-268/283
Sequence Identity: 35% (64 aa)

FLVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELL
..||. .||||.|  ..| |||.| .|   .  .|.|  . |.  ...|||||||.|  |   .  ..  ||| . ..  .|.  .| | |. | ||| |
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILL-DHQGH--CCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVL

THNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRL
 . ..| . | |.|| .|| |..|  || | ...       .   .| ...  .     ...| .|.|||||||. || |||
RKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQ-------QMYDNIINQPLQIP----PQMSNDAWDLIQGLLQKDPKKRL
Kinase MSK1.AA MSK 426-490 43 4.1e-36 119.57 In-house 1-73 (277) Show / Hide 
Range on Protein: 426-490
Range on HMM: 1-73/277
Sequence Identity: 43% (32 aa)

LKDK-PLGEGSFSICRKCVHKKTNQAFAVKIIS-------KRMEANTQKEITALKLCEGHPNIVKLHEVFHDQ
||.. ..|.|.|.|||||||..|....|.||.|       ......||.|...|..|..|||||.||..|.||
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQ
Kinase MSK1.AA Akt 559-740 37 8e-35 108.69 In-house 76-248 (264) Show / Hide 
Range on Protein: 559-740
Range on HMM: 76-248/264
Sequence Identity: 37% (70 aa)

FLVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRD-LKPENLLFTDE-NDNLEIKVIDFGFARLK-PPDNQPLKTPCFTLHYAAP
..||.  ||||||  ..||. ||| .| .    ...|  | |  ... || |||||.|   . .    |.. ||| ..     |..  || | |  | ||
YFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGH----ICLTDFGLCKENIIKDHDKTKTFCGTPEYLAP

ELLTHNGYDESCDLWS-LGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRL
| |  ||.. ..| |. ||...| |. |. || . |.        . .|||| ..  |     ...|.|.|||| |||. ||.|||
EILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHH-------QMFKKIKNQPVKFPDK--DWISPECKDLISGLLNKDPKKRL
Kinase MSK1.AA RSK 426-490 35 6.7e-29 102.33 In-house 1-73 (278) Show / Hide 
Range on Protein: 426-490
Range on HMM: 1-73/278
Sequence Identity: 35% (26 aa)

LKDK-PLGEGSFSICRKCVHKKTNQAFAVKIISKRMEANTQK-------EITALKLCEGHPNIVKLHEVFHDQ
||.. ..| |....||||.|..|.| .|.|...|.. ...||       |.. |..|..||.||.||..|...
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTE
Kinase MSK1.AA AktR 559-741 33 8.2e-29 102.05 In-house 77-253 (268) Show / Hide 
Range on Protein: 559-741
Range on HMM: 77-253/268
Sequence Identity: 33% (63 aa)

FLVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDV-GVVHRDLKPENLLFTDE-NDNLEIKVIDFGFARLKPP--DNQPLKTPCFTLHYAA
|..||   |||||  .|.||.||| .|  ..   . |. . |.   .. |||||||.|   . .    .| .||| ..| .   .... .. | | .| |
FFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGH----VKITDFGLSKLQFMMHYDEKAYSFCGTPEYMA

PELLTH-NGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ-GLLTVDPNKRLK
|| .|   |.. |.|.|..|. .| |..|. ||.....        .. .|||. .  .. .  ...|...||||| .||  .|||||.
PEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQN-------QMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLG
Kinase MSK1.AA p70 559-740 30 1.4e-26 93.34 In-house 104-283 (299) Show / Hide 
Range on Protein: 559-740
Range on HMM: 104-283/299
Sequence Identity: 30% (60 aa)

FLVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFGFARLKPPDNQP----------LKTPCF
.|. | | |||||   .|.  . |. |.. .   . |  | |  |.. ||||||| .    |    ..  |||    .  | .           . | | 
YLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCML---NQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TLHYAAPELLTHNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGD--FSFEGEAWKNVSQEAKDLIQGLLTVDPNKRL
|  | |||.|.  |..  .| ||||. .| || |. ||       |     ....|| ||    .         ..|..|||. ||  .| .|.
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPF-------TGENRKKTIDKILKGKQGLKL----PPYLTHEMRDLIKKLLKRHPTQRW
Kinase MSK1.AA CAMK 430-489 26 1.2e-22 69.17 In-house 1-109 (425) Show / Hide 
Range on Protein: 430-489
Range on HMM: 1-109/425
Sequence Identity: 26% (29 aa)

PLGEGSFSICRKCVHKKTN------------QAFAVKIISKR-------------------------------MEANTQKEITALKLCEG------HPNI
 ||.|||.. ..|.||.|.            | .|.|||.|.                               ...| ..||  .|.. |      ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLHEVFHD
.||.||. |
IKLYEVYED
Kinase MSK1.AA AGC 429-490 23 5.4e-22 52.26 In-house 5-103 (395) Show / Hide 
Range on Protein: 429-490
Range on HMM: 5-103/395
Sequence Identity: 23% (23 aa)

KPLGEGSFSICRKCVHK------KTNQAFAVKIISKRM---------EANTQKE------------ITALKLCEG---------HPNIVK-LHEVFHDQ
|..|.|||. .. . .|       |.. .|.|...|.          ...|. |               |..| .         ||.||| ||  |.|.
KVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDK
Kinase MSK1.AA RSK 422-490 40 7.6e-18 60.43 In-house 1-73 (271) Show / Hide 
Range on Protein: 422-490
Range on HMM: 1-73/271
Sequence Identity: 40% (31 aa)

YDLDLKDKPLGEGSFS---ICRKCVHKKTNQAFAVKIISKRMEANT----QKEITALKLCEGHPNIVKLHEVFHDQ
|.|    . .|.||||   .|.||.|| ||| .|.||| |   ...     .|.  .     ||.|||||.|| |.
YEL---HECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDE
Kinase MSK1.AA Pkinase 426-489 39 5.5e-16 57.61 Pfam 2-71 (293) Show / Hide 
Range on Protein: 426-489
Range on HMM: 2-71/293
Sequence Identity: 39% (28 aa)

LKDKPLGEGSFSICRKCVHKKTNQAFAVKIISKRMEANTQK-------EITALKLCEGHPNIVKLHEVFHD
 . ...|.|||. ..||.||.|.. .|||||.|| |   ..       ||  .| . .|||||.|...|.|
HIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED
Kinase MSK1.AA Ciliate-E2 425-490 20 8.6e-13 40.23 In-house 1-106 (365) Show / Hide 
Range on Protein: 425-490
Range on HMM: 1-106/365
Sequence Identity: 20% (22 aa)

DLKDKPLGEGSFSICRKCVHKKTNQAFA-----------------------VKIISKRMEANTQKEITALKLCE---------------GHPNIVKLHEV
  . | .|.|.|.. .|| ..|... ||                       .||..|..  .. .||  ..  .                ||||.|..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FH--DQ
|   |.
FQEKDD
Kinase MSK1.AA AktR 427-487 30 0.000148 13.94 In-house 3-70 (268) Show / Hide 
Range on Protein: 427-487
Range on HMM: 3-70/268
Sequence Identity: 30% (21 aa)

KDKPLGEGSFSICRKCVHK-KTNQAFAVKIISK------RMEANTQKEITALKLCEGHPNIVKLHEVF
  |.||.| |.    . .| .... .| |.|.|      ...  |. | . .. |  || |||||. |
VYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCF
Kinase MSK1.AA APH 597-638 22 0.001257 13.25 Pfam 165-207 (248) Show / Hide 
Range on Protein: 597-638
Range on HMM: 165-207/248
Sequence Identity: 22% (10 aa)

SHMHDVGVVHRDLKPENLLFTDENDNLEIK--VIDFGFARLKPP
.|... ...|.|..| |..... ... .    |||...|.. .|
AHWPPPCWCHGDFHPGNVMWDP-RPDGGRVTGVIDWDDACWGDP