Gene MSSK1 (Mouse)

MSSK1

Species: Mouse
Alias: Stk23, MSSK1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
MSSK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 486 Kinase domain by global Sugen HMM Fasta, JSON
MSSK1.AA Protein Sugen 565 None Fasta, JSON
MSSK1.NA RNA Sugen 1963 None Fasta, JSON

Protein domain

Protein domains of MSSK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MSSK1.AA SRPK 78-563 52 0.0 1072.99 In-house 1-554 (554) Show / Hide 
Range on Protein: 78-563
Range on HMM: 1-554/554
Sequence Identity: 52% (291 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPS---------------------DPKRETIVQLIDDFRISGVNG
|||.||||||||||||||||.|..|.||.|.|||| |||||||||||||.|||..||.                     ||.|...|||.|.|...|.||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

VHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQSGAQPPSRSTVSTAPQ--
.|.|||.|||||.|||||...||||.|..|||.|.||||.||||||.||.||||||||||.|||| ..||.|.|||.||||..|.|.||.| |.||||  
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQDYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQ

-EVLIGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLE---------AMEAAVQAEDSSSR-----------LERGSGSTSSSGCHPEGTRAGPSPASSS
 .....|.||||.|||..|.|||....|......|..|         ..|.. ...|. ..           .|... ..... .. .... .. .....
TQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDNEDNNQEDNDNEQDNKNNQNQENNMENEQEEKENTNKQKKNQKKKEQHKDKKEQECQ

PV------PGGERSLSPSSQTSGFSGSLFS-----------TASCSILSGSSNQRETGGLLSPSTPFG-------ASNLLVNPLEPQNAD---KIKIKIA
.|      |..| | . .||......|...           ..|... ... .|...| . |.....        |...||....|.|||   |||||||
NVQKQNNDPNFE-SQN-DSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNKQ-DQQKEGQKQSEESECESEDMQEQAGKFLVWWKNPRNADLDHKIKIKIA

DLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGE
|||||||||.||||||||||||..||.|||.|..||||||||||||||||||||||||||||||||.||||||.||.|.||. |||||.|||||||..||
DLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGE

LRHIPNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL
|||||.||.|.|..||.|||||. |.|.||..||.||..|.|||||.|..|||||||
LRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase MSSK1.AA CMGC 78-563 16 9.5e-116 382.05 In-house 1-513 (513) Show / Hide 
Range on Protein: 78-563
Range on HMM: 1-513/513
Sequence Identity: 16% (111 aa)

YHVVRKLGWGHFSTVWLCWD--------------IQRKRFVALKVVKSAGHYTETAV-------------DEIKLLKCVR----------DSDPSDPKRE
|....|.|.|....|. |.|              .. ...||.| .|..  |.|.|              .|||.||...          | ||......
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

TIVQLIDDFRISGVNGV-------------HVCMVLEVLGHQLLKWIIKSN--YQG------------------------LPVPCVKSIVRQVLHGLD--
 ||.|.| |. .. .|              |...| | ..| |.. | . .  |||                        ... ... . .|.| ||.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YLHTKCK-IIHTDIKPENILLCVGDAYIRRLAAEATEWQQSGAQPPSRSTVSTAPQEVLIGKLSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAAVQ
|.| ... |||.|.||||||..    .|.|. .    | .|  .                                                        
YCHSHWGNIIHRDLKPENILINHNCELITRM-M----W-KS--E--------------------------------------------------------

AEDSSSRLERGSGSTSSSGCHPEGTRAGPSPASSSPVPGGERSLSPSSQTSGFSGSLFSTASCSILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNA
                                                                                        . . ||.    .
----------------------------------------------------------------------------------------D-W-NPC----Q

DKIKIKIADLGNACWVHKH------------------------FTEDIQTRQYRAVEVLIGAE----------YGPPADIWSTACMAFELATG-------
.. ..||.| |.|.|.|.|                        .|....|| ||| |.|.|..          |..| |.|| .|. .|. ||       
KNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFR

-DYLFEPHSGE-----DYSRDEDHIAHIVELLGDIPPAFALSGR-------YSREFFNRRGELRHIPNLK-------------------------HWGLY
 ..|| .||..     ..... |....|...|| ..  .. .|.       ...|..|. . .......|                          |  .
GKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPP

EVLMEKYEWPLE--------------------------------QATQFSAFLLPMMEYIPEKRASAADCLQHPWL
  . ... |  .                                .  |.  .|  |..| |.|| .|...||||..
KPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase MSSK1.AA CLK 78-507 17 2e-52 155.11 In-house 1-291 (350) Show / Hide 
Range on Protein: 78-507
Range on HMM: 1-291/350
Sequence Identity: 17% (81 aa)

YHVVRKLGWGHFSTVWLCWDIQR-KRFVALKVVKSAGHYTETAVDEIK-LLKCVRDS-DPSDPKRETIVQLIDDFRI-SGVNGVHVCMVLEVLGHQLLKW
| .| .|| | |..|  ||| .. |..||||...... |.| |  ||.  .| .    ||   ..| .....| |    |    |.|.| | .|  .   
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHG----HICIVFELYGLSIYDF

IIKSN------YQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVG----DAYIRRLAAEAT-EWQQSGAQPPSRSTVSTAPQEVLIGKLS
. . |      |...|   .... .| .. .  || . |..||| |||||...      ...   .  .   .                           
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKIN---------------------------

KNKRKKMRRKRKQQKRLLEERLRDLQRLEAMEAAVQAEDSSSRLERGSGSTSSSGCHPEGTRAGPSPASSSPVPGGERSLSPSSQTSGFSGSLFSTASCS
                                                                                                    
----------------------------------------------------------------------------------------------------

ILSGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNAC---WVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDY
                      .     .  . .      |.. | |.|      | | .. ..||.||| ||  |  .  | |.|| .|  ||| ||. 
----------------------KKS-NNCVCHYWHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFT

LFEPHSGEDYSRDEDHIAHIVELLG-DIPPAFALSGR---YSREFFNRRGEL
||  |.        .| | . ...| .|| . . . |    ....|......
LFQTHD------NREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLD
Kinase MSSK1.AA S_TKc 78-563 15 1.8e-49 171.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 78-563
Range on HMM: 1-231/231
Sequence Identity: 15% (77 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGH---QLLKWI
|...||.| | |..|..|...  .| ||.|..|      |..  ||..||          . . ||.|.| |.       |..||.| ...    |.. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYI

IKSNYQG----LPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYI------RRLAAEATEWQQSGAQPPSRSTVSTAPQEVLIGKLSKN
 | ...|    .|   ......|.. .|.|.| . .||| |.|||||||.     |      |.|                                   
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL-----------------------------------

KRKKMRRKRKQQKRLLEERLRDLQRLEAMEAAVQAEDSSSRLERGSGSTSSSGCHPEGTRAGPSPASSSPVPGGERSLSPSSQTSGFSGSLFSTASCSIL
                                                                                                    
----------------------------------------------------------------------------------------------------

SGSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGP-PADIWSTACMAFELATGDYLFEP
                                                      |  . |. |.| |||    ||. ..|.||  |. .|...|  .|. 
------------------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-

HSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIPNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQ----
        ... . ...                                                      ..  |.  .... |||| .| ..||    
--------QMQMMFKKIG---------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPWL
   |||.
IKCHPWF
Kinase MSSK1.AA Pkinase 78-563 16 3.1e-40 143.36 Pfam 1-293 (293) Show / Hide 
Range on Protein: 78-563
Range on HMM: 1-293/293
Sequence Identity: 16% (85 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVD-----EIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGH----
||..||.| | |..|..| ..   . ||.|..|  .   .  .      ||...| ..         . ||.|.| |.     . |..||.| ...    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFED----KDHIYMVMEYCEGGLYV

-QLLKWIIKSNYQGL--PVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIRRLAAEATEWQQSGAQPPSRSTVSTAPQEVLIGKLSKNK
  |  .|  ... ..  .   .|....|.| ||.|.|  ..||| |.||||||.   . .|                                       
MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID-NNGHIDA-------------------------------------

RKKMRRKRKQQKRLLEERLRDLQRLEAMEAAVQAEDSSSRLERGSGSTSSSGCHPEGTRAGPSPASSSPVPGGERSLSPSSQTSGFSGSLFSTASCSILS
                                                                                                    
----------------------------------------------------------------------------------------------------

GSSNQRETGGLLSPSTPFGASNLLVNPLEPQNADKIKIKIADLGNAC---WVHKHFTEDIQ-TRQYRAVEVLI-GAEYGPPADIWSTACMAFELATGDYL
                                    ..||.| | |.   . ... . ..  |. |.| ||.  | .|||..|.||  |. .|...|  .
------------------------------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP

FEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIPNLKHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQH
|  ... .  .  |... |.. .| ...      .  . || .|    |          . ......|. |    .  |.  . .. |.|| .|...|||
FP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------F-HWTFHNWSEE----CKDFIKWCLCKDPKKRPTAEQILQH

PWL
||.
PWF
Kinase MSSK1.AA DYRK 78-220 31 9.2e-28 98.56 In-house 1-138 (320) Show / Hide 
Range on Protein: 78-220
Range on HMM: 1-138/320
Sequence Identity: 31% (46 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKS
| ..  .| | |. |  ||| ...  ||.|....   .  .| .|||.|.. .. || | ..  .|.. | |   .    |.|.| | |   |   . . 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYH--CVHMYDYFYHRN----HLCIVFELLSMNLYEFLKNN

NYQGL-PVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLC
. ||. ..  |... .|.|..|..||.. .||| |.|||||.|.
HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLK
Kinase MSSK1.AA DYRK2 78-219 32 1.2e-24 76.84 In-house 1-135 (318) Show / Hide 
Range on Protein: 78-219
Range on HMM: 1-135/318
Sequence Identity: 32% (46 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKS
| ..  .| | |  |  | |  .| .||.|..     . ..|. ||. |.  |  |.       .| . | |   .    |.|...| |.  | . | | 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDN--TMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKN

NYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILL
..||. .  |    ...|..|. || | .||| | |||||||
HFQGFSLQLVRRFAHSILQCLRFLH-KNNIIHCDLKPENILL
Kinase MSSK1.AA DYRK 396-563 27 8.8e-22 78.35 In-house 138-320 (320) Show / Hide 
Range on Protein: 396-563
Range on HMM: 138-320/320
Sequence Identity: 27% (52 aa)

QNA-DKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSG
... .|  ||..| | .| .|....  || | ||| ||..|  |. . |.||  |   || ||  ||   .||..    | .| |.|.|| .|. .  .|
KQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKG

--RYSREFFNR------------RG------ELRHIPNLKHWGLYEVLME--KYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL
  |. ..||..            .       ... .|...    .   ..  ...    .  ||  |.. . .. |.|| .... |||||.
RCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase MSSK1.AA CAMKL 78-219 22 1.3e-20 62.36 In-house 1-160 (297) Show / Hide 
Range on Protein: 78-219
Range on HMM: 1-160/297
Sequence Identity: 22% (38 aa)

YHVVRKLGWGHFSTVWLCWDIQR-KRFVALKVVKSAGHYTETAVD----------------EIKLLKCVRDS-DPSDPKRETIVQLIDDFRISGV---NG
| ... || |.|..| |...|.  .. || |...  .   .. ..                ||...| .. .  |       |..| . .  .     . 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPN------IIKLYEVIETPEHDIET-

VHVCMVLEVLGHQ---LLKWIIKSNYQG--LPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILL
 ....|.|  .     |. .|.|  . .  .| .  . . ||......|.| .. |.| |||||||||
KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILL
Kinase MSSK1.AA DYRK2 403-563 27 2.2e-20 62.7 In-house 143-318 (318) Show / Hide 
Range on Protein: 403-563
Range on HMM: 143-318/318
Sequence Identity: 27% (51 aa)

IKIADLGNACWVHK-HFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPAFALSG------R
||..| |  | .|  ..  .||.| ||| || .|  || . |.||  | . || ||  ||    ||..    | .| . |.|| .||.  ..       .
IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLG-MPPKKFFDTWFYIHCF

YSREFFNR-------------RGELRHIPNLKHWGLYEVLMEKYEWPLE--QATQFSAFLLPMMEYIPEKRASAADCLQHPWL
. . |||.             . |.  . .  |   .     .    |.  .   |  |..  .|  |..| .... |.|||.
RRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase MSSK1.AA DYRK1 78-220 29 1.1e-18 61.82 In-house 1-138 (321) Show / Hide 
Range on Protein: 78-220
Range on HMM: 1-138/321
Sequence Identity: 29% (43 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVHVCMVLEVLGHQLLKWIIKS
| .   .| | |  |   .| |.. .||.|..|    . . |  ||.||  .   |. .  .  ||.|   |        |.|.|.|.|   |   .   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEM--KYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNT

NYQGLPVPCVKSIVRQVLHGLDYLHT-KCKIIHTDIKPENILLC
...|  .  .. . .|..  | .. |   .||| |.||||||||
HFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLC
Kinase MSSK1.AA CAMK 83-220 15 5e-17 50.72 In-house 1-213 (425) Show / Hide 
Range on Protein: 83-220
Range on HMM: 1-213/425
Sequence Identity: 15% (35 aa)

KLGWGHFSTVWLCWDIQRK------------RFVALKVVKSA-----------------------------GHYTETAVDEIKLLKCVRD-----SDPSD
.|| | |..| || ... .            . || |...                               ..  .    ||...| ...     . |  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN-

PKRETIVQLIDDFRISGV--------NGVH--------VCMVL---EVLGHQ-----LLKWIIKSNY-------------QGLPVPCVKSIVRQVLHGLD
     |..|.. .  . .        .  .        ..||.   |          |. .|..  .               ..   .. ..||.. ...
-----IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVH

YLHTKCKIIHTDIKPENILLC
|.| .  |.| |.|||||||.
YCHSHN-IVHRDLKPENILLD
Kinase MSSK1.AA DyrkP 400-461 45 2.6e-16 49.56 In-house 144-205 (323) Show / Hide 
Range on Protein: 400-461
Range on HMM: 144-205/323
Sequence Identity: 45% (28 aa)

KIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLF
| ..|| | | .|..| |    .| | ||| ||.||  |    |.||  |.  || ||  ||
KCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF
Kinase MSSK1.AA DYRK1 397-489 40 4.8e-14 45.26 In-house 139-224 (321) Show / Hide 
Range on Protein: 397-489
Range on HMM: 139-224/321
Sequence Identity: 40% (38 aa)

NADKIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIVELLGDIPPA
|. . .||| | | .| . .   . || | ||. |||.| ||    |.||  |.  |. ||. ||   ||   | . | . .||| || .||.
NPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SG---SNEVDQMNKIVEVLG-MPPK
Kinase MSSK1.AA CDK4 142-219 33 8.5e-13 40.02 In-house 65-143 (290) Show / Hide 
Range on Protein: 142-219
Range on HMM: 65-143/290
Sequence Identity: 33% (27 aa)

IVQLIDDFRISGVNG--VHVCMVLEVLGHQLLKWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILL
||.|.| .  . . .  . . ||.|     |  .. |    |.| . .| . .| | |.|.||. . ||| | ||.|||.
IVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHR-IIHRDLKPQNILV
Kinase MSSK1.AA CAMK 543-563 47 2.3e-09 25.56 In-house 405-425 (425) Show / Hide 
Range on Protein: 543-563
Range on HMM: 405-425/425
Sequence Identity: 47% (10 aa)

MMEYIPEKRASAADCLQHPWL
|... ||||.....||.|||.
MLQVDPEKRMTIEQCLNHPWM
Kinase MSSK1.AA DyrkP 78-127 32 1.3e-07 20.46 In-house 1-50 (323) Show / Hide 
Range on Protein: 78-127
Range on HMM: 1-50/323
Sequence Identity: 32% (16 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLK
| ..  ||   ||    | | |  . . .|..     | . ..||||||.
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLR
Kinase MSSK1.AA CAMKL 543-563 38 8.6e-07 17.54 In-house 277-297 (297) Show / Hide 
Range on Protein: 543-563
Range on HMM: 277-297/297
Sequence Identity: 38% (8 aa)

MMEYIPEKRASAADCLQHPWL
|..  ||||... . ..|||.
MLQVNPEKRPTIHQIMNHPWM
Kinase MSSK1.AA CDK4 539-563 48 1e-06 18.87 In-house 266-290 (290) Show / Hide 
Range on Protein: 539-563
Range on HMM: 266-290/290
Sequence Identity: 48% (12 aa)

FLLPMMEYIPEKRASAADCLQHPWL
.|. |  | ..|| ||  |||||..
LLQKMLCYNHHKRMSAYQCLQHPYF
Kinase MSSK1.AA DyrkP 190-219 53 2e-06 16.32 In-house 111-139 (323) Show / Hide 
Range on Protein: 190-219
Range on HMM: 111-139/323
Sequence Identity: 53% (16 aa)

IVRQVLHGLDYLHTKCKIIHTDIKPENILL
|  |.| .|||.|   ..|| |.||||||.
ITQQILIALDYIHS-LRLIHCDLKPENILM
Kinase MSSK1.AA CLK 543-563 52 2e-06 14.88 In-house 330-350 (350) Show / Hide 
Range on Protein: 543-563
Range on HMM: 330-350/350
Sequence Identity: 52% (11 aa)

MMEYIPEKRASAADCLQHPWL
|.|| | || ...| ||||. 
MLEYDPSKRITCKDALQHPFF
Kinase MSSK1.AA CDK4 427-454 46 5e-06 16.49 In-house 175-202 (290) Show / Hide 
Range on Protein: 427-454
Range on HMM: 175-202/290
Sequence Identity: 46% (13 aa)

YRAVEVLIGAEYGPPADIWSTACMAFEL
||| |||  . |  | |.|| .|  .|.
YRAPEVLLQSYYNTPVDMWSVGCIFAEM
Kinase MSSK1.AA TyrKc 78-284 15 1.3e-05 -132.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 78-284
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAGHYTETAVDEIKLLKCV--RDSDPSDPKRETIVQLIDDFRISGVNGV----HVCMVLEVLGHQLL
 .  .||| |.| .|...  .   . || |..|.     |   .|..... .  .         . ||.|.   . .| |       ...|.|   |  |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHH--------PNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDL

KWIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGD-----------------------AYI-------RR-------LAAEAT
|  ....   |...   |.  |.  | .||| | ..|| |.   |.|.  .                         |.       ..       .| |. 
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

EWQQS---------------------GAQPPSR---STVSTAPQEVLIGKLSKNKRKKMRRK----------------------RKQQKRL----LEERL
  . .                     |.||..          . . .| .. . .| .                          ..  .|     . |..
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MSSK1.AA DyrkP 550-563 50 0.001084 7.27 In-house 310-323 (323) Show / Hide 
Range on Protein: 550-563
Range on HMM: 310-323/323
Sequence Identity: 50% (7 aa)

KRASAADCLQHPWL
.| .| . |||||.
RRPTAKEALQHPWF
Kinase MSSK1.AA DYRK1 530-563 26 0.002211 7.17 In-house 288-321 (321) Show / Hide 
Range on Protein: 530-563
Range on HMM: 288-321/321
Sequence Identity: 26% (9 aa)

LEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL
.|   .|   .. |..| |..| .  . |||...
VEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase MSSK1.AA CAMK 402-446 22 0.011505 3.61 In-house 234-319 (425) Show / Hide 
Range on Protein: 402-446
Range on HMM: 234-319/425
Sequence Identity: 22% (19 aa)

KIKIADLGNACWVHKH--------------------------FTEDIQTRQYRA-VEVLIG--------------AEYGPPADIWS
.|||.| | |. . .                           ...   |  | |  ||| |                |||..|.||
NIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWS
Kinase MSSK1.AA CDK4 78-110 39 0.039939 2.84 In-house 1-33 (290) Show / Hide 
Range on Protein: 78-110
Range on HMM: 1-33/290
Sequence Identity: 39% (13 aa)

YHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVK
|  |  .| | . ||.   |..  .||||| |.
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVR
Kinase MSSK1.AA CAMKL 438-446 66 0.165003 0.41 In-house 213-221 (297) Show / Hide 
Range on Protein: 438-446
Range on HMM: 213-221/297
Sequence Identity: 66% (6 aa)

YGPPADIWS
.||..||||
DGPKVDIWS