Gene NEK10 (Mouse)

NEK10

Species: Mouse
Alias: NEK10
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK10

Sequence

Name Sequence Type Origin Length Description Download
NEK10.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
NEK10.AA Protein Sugen 1151 None Fasta, JSON
NEK10.NA RNA Sugen 3453 None Fasta, JSON

Protein domain

Protein domains of NEK10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Arm NEK10.AA Arm 198-238 31 0.001299 15.93 Pfam 1-41 (41) Show / Hide 
Range on Protein: 198-238
Range on HMM: 1-41/41
Sequence Identity: 31% (13 aa)

VKDQREWVTASGAHKTLVSLLGARDTTVLLGALLALASLAE
  .|.. |  .|. . ||.||  .|. |.  |. ||  |. 
NPEQKQAVIQCGCVPPLVQLLHHPDEEVQENACWALWNLCA
Arm NEK10.AA Arm 280-320 26 1.816891 5.19 Pfam 1-41 (41) Show / Hide 
Range on Protein: 280-320
Range on HMM: 1-41/41
Sequence Identity: 26% (11 aa)

EPQIKEQVKLYEGIPILLSLLHSDHLKLLWSVIWILVQVCE
 |. |..|    ..|.|..|||... ...  . | |   | 
NPEQKQAVIQCGCVPPLVQLLHHPDEEVQENACWALWNLCA
Arm NEK10.AA Arm 239-279 24 8.743651 2.86 Pfam 1-41 (41) Show / Hide 
Range on Protein: 239-279
Range on HMM: 1-41/41
Sequence Identity: 24% (10 aa)

SSECREKISELNVVENLLMILHEYDLLSKRLTAELLRLLCA
..|... . ....|. |.  ||  |   ..  .  |. |||
NPEQKQAVIQCGCVPPLVQLLHHPDEEVQENACWALWNLCA
Kinase NEK10.AA NEK10 519-785 71 1.5e-231 770.97 In-house 1-279 (279) Show / Hide 
Range on Protein: 519-785
Range on HMM: 1-279/279
Sequence Identity: 71% (200 aa)

YAVLDHLGSGAFGCVYKVRKRSGQN------LLAMKEVNLHNPAFGKDKKDRDSSVKNIVSELTIIKEQLYHPNVVRYYKTFLE--NDRLYIVMELIEGA
|.|.||||.|||||||||||...|.      ||||||...|||||||..|.||.|.....|||.|||||..|||.||||.||.|  |.|.|||||||||.
YEVYDHLGTGAFGCVYKVRKKAQQHSENPAKLLAMKEIFMHNPAFGKNDKERDKSIEDMISELKIIKEQMRHPNIVRYYRTFVEPQNHRMYIVMELIEGC

PLGEHFNSLKEKHHHFSEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQ-ESSKLTSMVGTILYSCPEVLKSEPYGEK
||.|||||.|||||||.|||.|..|||.|||||||||||.||||||||||||.||||.||.|||||||||| ..||.||.||||||||||...|||||||
PLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLHKEKQIVHRDLTPNNIMMGDKDRVTITDFGLAKQKQPDPSKMTSVVGTILYSCPEIVQSEPYGEK

ADVWAAGCILYQMATLSPPFCSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTIRRCLTPDAEARPDIVEVSS---MISD
|||||.||.||||.||.|||.|||||.||.||||..|.||.||..|..|..||.||||||.|||||||.|||   ||.|
ADVWAFGCCLYQMCTLQPPFYSTNMLTLAMKIVEHFYDPVNEGMWSDDVRFTITRCLTPDPEARPDIVKVSSVLRMIQD
Kinase NEK10.AA NEK 519-785 34 9.40000000001e-120 404.15 In-house 1-286 (286) Show / Hide 
Range on Protein: 519-785
Range on HMM: 1-286/286
Sequence Identity: 34% (103 aa)

YAVLDHLGSGAFGCVYKVRKRSGQNL-----LAMKEVNLHNPAFGKDKKD--RDSSVKNIVSELTIIKEQLYHPNVVRYYKTFLEND--RLYIVMELIE-
| .. ..|.|.||.|||||..| ..      ...|..|  .    |.|..  .         .  .|..|| |||.|.||  |.|..  .|.||||  | 
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKIN-MGNMSEKEKQNAQN---------NEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEG

GAPLGEHFNSLKEKHH---HFSEERLWKIFIQLCLALRYLHKEK----RIVHRDLTPNNIMLGDKDK----VTVTDFGLAKQKQ-ESSKLTS-MVGTILY
|  | ....|.|.. .   .|.||  |..|||.||||.|.|..|    .|.|||. |.||.| ....    | . |||..|. . ....... .|||  |
GGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYY

SCPEVLKSEPYGEKADVWAAGCILYQMATLSP--PFCST--NMLSLATKIVEA-VYEPVPEGI-YSEKVTDTIRRCLTPDAEARPDIVEVSSMISD
 .|||....||..|.|.|. ||.||.|.||.|  || ..  ||.||..||..   |.|.|. . ||..  . |...|..| | ||.. .. .|   
MSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK10.AA S_TKc 519-791 32 1.5e-77 264.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 519-791
Range on HMM: 1-231/231
Sequence Identity: 32% (91 aa)

YAVLDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVKNIVSELTIIKEQLYHPNVVRYYKTFLENDRLYIVMELIEG--APLGEHF
| .|...|.||||.|||.|... . . |.|...                 ..| .|. | |.   |||.|..| .| . |.||.|||...|    | .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI

NSLKEKHHH--FSEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQESSKLTSMVGTILYSCPEVLKSEPYGE-KADVW
 . . .  .  |.| . .... |.|.|| |.|.  .|.|||| | ||.| .   . ..|||||.|       |...||  |  ||||   .||  |.|.|
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWW

AAGCILYQMATLSPPFCSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTIRRCLTPDAEARPDIVEVSSMISDVM-MKYL
. ||||| |..  |||.  .|  .  ||.            |. . | ||.||. | | || . |.  . .|.. . ..
SCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK10.AA Pkinase 519-783 29 2.6e-66 231.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 519-783
Range on HMM: 1-293/293
Sequence Identity: 29% (89 aa)

YAVLDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVKNIVSELTIIKEQLYHPNVVRYYKTFLENDRLYIVMELIEG--APLGEHF
| ..  .|||.|||||| .... . . |.|......   .||. .|        ||. | |.   |||.||.| .| ..|..|.|||. ||    . . |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLF

NSLK-EKHHHF--SEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKV----TVTDFGLAKQ--KQESSKLTSMVGTILYSCPEVLK-SEPY
  .. ..|  |  ||. . ... |.. .| |.|. ..|.|||| | ||.. ... .     ..|||||||     .| .|. .||. |  |||.. ...|
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

GEKADVWAAGCILYQMATLSPPFCST------NMLSLATKIVEAVYEPVPEGIYS-------------------EKVTDTIRRCLTPDAEARPDIVEVSS
| |.|.|..|||||.|..  |||..       ... .  .| .. ..   .  .|                   |   | |..||..| . || . ..  
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

M--I
   .
HPWF
Kinase NEK10.AA CAMK 524-779 20 5.2e-65 208.16 In-house 1-419 (425) Show / Hide 
Range on Protein: 524-779
Range on HMM: 1-419/425
Sequence Identity: 20% (85 aa)

HLGSGAFGCVYKVRKRSGQ------------NLLAMKEVN-----------------LHNPAFGKDKKD-RDSSVKNIVSELTIIKE------QLYHPNV
 ||.|.|| |.... .. .               |.| ..                 . .   ...... |... ||. .|. | |       .| |||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYYKTFLE-------------------NDRLYIVM---ELIEGAPLGEH-FNSLKEKHH--------------HFSEERLWKIFIQLCLALRYLHKEKR
.. | ..                     ....|.||   |...|  | .  |. ..|. .              .|.|.   ..| |.| |..|.|. . 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-

IVHRDLTPNNIMLGDKD-----------------KVTVTDFGLAKQKQESS------------------------KLTSMVGTILYSC-PEVLKS-----
|||||| | ||.| |..                 .. ..|||.|.......                        |.. ..||  | . ||||..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EPYGEKADVWAAGCILYQMATLSPPFCST-------------NMLSLATKIVEAVYEPVPEGIYS----------------------EKVT
         ..||.|.|.|..|.||| | .  ||| .              |.  |  || .. |.  |. .                        . . 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DTIRRCLTPDAEARPDIVEV
| ||..|..| | |. | ..
DLIRKMLQVDPEKRMTIEQC
Kinase NEK10.AA STE 519-778 23 4.4e-56 192.62 In-house 1-350 (359) Show / Hide 
Range on Protein: 519-778
Range on HMM: 1-350/359
Sequence Identity: 23% (84 aa)

YAVLDHLGSGAFGCVYKVRKR------SGQNL---------LAMKEVNLHN--PAFGK------DKKDRDSSVKNIVSELTIIKEQLY-HPNVVRYYKTF
.  .. .|.|||| ||| ...      . ...          |.|..|| |  .   .      .... .. ...|  |. | |.    |||.|.|| ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

LEN-------DRLYIVMELIEGAPLG---E-HFNSLKEKH------HHFSEERLWKIFIQLCLA-LRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGL
. .       | |.|.||...|  |    .  .  .|. .      |.|.|. . .|  |.. . | |||. . |.|||. | ||.|     |  .|||.
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGV

AKQKQE-----------------SSKLTSMVGTILYSCPEVLKS------EPYGEKADVWAAGCILYQMATLSPPFCS-TNM---------------LSL
..| ..                 ..| ...|||  .  |||..        .|..|.|.|  || .  |||  ||..  ..|               . .
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

ATKIVEAVYEPVPEG------------------IYSEKVTDTIRRCLTPDAEARPDIVE
  .||.    | |.                    .|..  | |..||. | . ||.  .
L-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase NEK10.AA Ciliate-E2 519-729 23 2.5e-54 184.9 In-house 1-296 (365) Show / Hide 
Range on Protein: 519-729
Range on HMM: 1-296/365
Sequence Identity: 23% (70 aa)

YAVLDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHN-----------------PAFGKDKKDRDSSVKNIVSELTI---------IKEQLYHPNVVRYYK
| ..  .|.|.||.|||..... |.. |.|  . ..                   . |...   .....|  |. .         |.||| |||....| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

TFL--ENDRLYIVMELIEGAPLGEHFN--SLKEKHH-----HFSEERLWKIFIQLCL---------------ALRYLHKEKRIVHRDLTPNNIMLGDKDK
.|    .. .|.|||...|  | .. .  ..|..|.      |.|.   .|. |..                ||.|||....|.|||. |.||..     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VTVTDFGLAKQKQES-----------SKLTSM----------------------VGTILYSCPEVLKSEP---------YGEKADVWAAGCILYQMATLS
. ..||||.|. ...            ..                         .||  | .||.|....         |..|.|.|..|.|||.| .  
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPF
|||
PPF
Kinase NEK10.AA Ciliate-E2-Unclassified 519-779 22 5.6e-54 185.62 In-house 1-346 (352) Show / Hide 
Range on Protein: 519-779
Range on HMM: 1-346/352
Sequence Identity: 22% (77 aa)

YAVLDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVKNIVSELTIIK---------------EQLYHPNVVRYYKTFLENDRLYIV
| ..  .|.|.||.|||..... . . |||. . ..    | ..  |   .|.  |. ..|                ...||..|... .|   . .|||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MELIEGAPLGEHFNSLKE------------KH-HHFSEERLW-----KIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKD---KVTVTDFGLAKQKQE
||..||  | .. .. |             |. ..|.|.        ..| |....| |||... |.|||..|.||.. ..    .. ..|||..|. |.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----------------SSKLTSMVGTILYS----CPEVLKSEPYG----EKADVWAAGCILYQMATLSPPFCSTN------------------MLSLATK
                . ......||. |      ||||... |.    .|.|.|. |.|||.| .  .|| ..|                  .|    |
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

IVEAVYEPVPE----GIYSEKVTDTIR----RCLTPDAEARPDIVEV
  .  . . |.     . |... | |.    ..|  . . |... ..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI
Kinase NEK10.AA NEK6 519-776 36 1.2e-53 174.85 In-house 1-252 (252) Show / Hide 
Range on Protein: 519-776
Range on HMM: 1-252/252
Sequence Identity: 36% (95 aa)

YAVLDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVKNIVSELTIIKEQLYHPNVVRYYKTFLENDRLYIVMELIEGAPLGEHFNS
...  ..| | |  ||. .    .   |.| | . .     |.| |.  .|    |. ..| || ||||..||  |.||  | ||.|| .   .      
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMM---DAKARQDCIK----EIDLLK-QLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKH

LKEKHHHFSEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQESSKLT---SMVGTILYSCPEVLKSEPYGEKADVWAA
 | .     |  .|| |.||| ||  .| .||..|||. | |. .  . .| . | || .    ||| |   |.|||  |  || .. . |  |.|.|. 
FKKQKRLIPERTIWKYFVQLCSALEHMH-SKRVMHRDIKPANVFITANGIVKLGDLGLGRFF--SSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSL

GCILYQMATLSPPFCS--TNMLSLATKIVEAVYEPVPEGIYSEKVTDTIRRCLTPDAEARPDI
||.|| || |  ||     |. ||  || .  | |.|  .|||.. . .  |. ||.| ||||
GCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase NEK10.AA NEK2 519-783 29 2.7e-51 170.95 In-house 1-319 (319) Show / Hide 
Range on Protein: 519-783
Range on HMM: 1-319/319
Sequence Identity: 29% (96 aa)

YAVLDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVKNIVSELTIIKEQLYHPNVVRYYKTFL--ENDRLYIVMELIEGAPLGEHF
| ||  .|.| || ..|||  |   .|. || .  .   .  ...        |||  | . || |||.||||      .| .||||||  ||  |.   
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGH--MQEKECQM------LVSECNILR-QLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMI

NSLKEKHHHFSEERLWKIFIQLCLALRYLHK-----------------EKR---IVHRDLTPNNIMLGDKDK----------------------------
   .  .  . ||  |.|. |||.||.  |.                  .    | |||. | || |  ..                             
KKCRKERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGK

-----------VTVTDFGLAKQKQ-ESSKLTSMVGTILYSCPEVLKSEPYGEKADVWAAGCILYQMATLSPPFCSTNMLSLATKIVEAVYEPVPEGIYSE
           |   |||||.  . ..|  .. |||  |  ||...  .| || |.|. ||..| |..|.|||  || . |..|| .  ....|. .||.
RGSPMDYSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPY-QYSR

KVTDTIRRCLTPDAEARPDIVEV--SSMI
   . | . .  | . || | |   .. |
HLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase NEK10.AA NEK1 519-782 29 7.4e-48 164.09 In-house 1-276 (276) Show / Hide 
Range on Protein: 519-782
Range on HMM: 1-276/276
Sequence Identity: 29% (86 aa)

YAVLDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVKNIVSELTIIKEQLYHPNVVRYYKTFLENDR--LYIVMELIEGAPLGEHF
| ..  .|.|.|| ...|....   ....|| |. .      .|.|  |..       .| . . |||.|.|.  | || .  ||||||  .|  |    
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMK----MQEKEREESMNEV-----AILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKI

NSLKEKHHHFSEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLG--DKD---------------KVTVTDFGLAKQKQESSKLTS-MVGTILYSCP
|  | |   |||      |.|.|||| . |..| | |||. . || |   ...               .| . ||| |.  ...  . .  .||  |  |
NRQKRKGKLFSEDQIMHWFCQICLALNHIHDRK-ILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSP

EVLKSEPYGEKADVWAAGCILYQMATLSPPFCSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTIRRCLTPDAEARP---DIVEVSSM
|     ||  | |.|..||.||   ||. || . |.  |  ||... | |.|   ||...   .   .  ... ||   .| |  ..
EICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPH-YSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK10.AA ULK 519-773 24 8.8e-48 164.89 In-house 1-317 (329) Show / Hide 
Range on Protein: 519-773
Range on HMM: 1-317/329
Sequence Identity: 24% (80 aa)

YAVLDHLGSGAFGCVYKVR-KRSG---QNLLAMKEVNLHNPAFGKDKKDRDSSVKN-------IVSELTIIKEQL------Y-HPNVVRYYKTFLENDR-
| . . ||.|.|| ||| | |...   . . | | .        |.|.....   .       . .|  |.|.        . |||.|..|. | . .  
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMID-------KQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHN

-LYIVMELIEGAPLGEHFNSLKEKHH---------HFSEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVT------------VTDFGLA
 .||.||. .|   |  .. .|....         ..||.   ..|.|.. ....||| ..|.|||. | ||.. ...  |            ..|||.|
NIYIIMEYCNG---GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA

KQKQES----SKLTSMV------GTILYSCPEVLK----SEPYG-EKADVWAAGCILYQMATLSPP----FCSTN---MLSLATK---------IVEAVY
|. ...      ....|      || || .|..|.     .||.  |.|.|  |||.|.| .  ||    |....   . .|  .              .
KHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQF

EPV-PEGIYSEKVTDTIRRCLTPDAEAR
... .. . |... | |||.|. | . |
PKDGNDPQISPECKDLIRRMLQYDEKDR
Kinase NEK10.AA TyrKc 519-783 20 2.5e-16 41.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 519-783
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

YAVLDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLHNPAFGKDKKDRDSSVKNIVSELTIIKEQL--YHPNVVRYYKTFLEN-------DRLYIVMELIEG
   .. ||.|||| ||| . .      | | .. .              .. . .|. | . .|   |||.|| |   ..        . |.||||. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------------REDFMREARIMC-KLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

APLGEHFNSLKEKHHHFSEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQES------SKLTSM----VGT----ILY
  | ..   |........ . | .. .| .   .|||.  ...||||   |...|..  | ..||||..   .       ..  ..     |     |  
GDLKDY---LRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

SCPEVLKSEPYGEKADVWAAGCILYQMATL-SPPFCS-----TNMLSLATKIVEAVYEPVPEG-------IYSEKVTDTIRRCLTPDAEARPDIVEVSSM
  ||...   . .| |||. |  .. . |.  .|         .   .  .. .  . | |.        . .... . ...|   |.| ||   |. . 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

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Kinase NEK10.AA Pkinase_Tyr 581-694 27 4.8e-13 44.8 Pfam 59-176 (270) Show / Hide 
Range on Protein: 581-694
Range on HMM: 59-176/270
Sequence Identity: 27% (33 aa)

QL-YHPNVVRYYKTFL-ENDR--LYIVMELIEGAPLGEHFNSLKEK---HHHFSEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTD
|| .|||.||.|   . . .   .|||||. ..  | ..   |...    .... ..| .. .| . .. ||. .|...||||   |...... .| ..|
QLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY---LRKHREDKQPLTMKDLLQMCWQIAKGMEYLE-SKNCIHRDLAARNCLVTENNVVKICD

FGLAKQKQESSKL-TSMVGTIL
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FGLARDIYNDDYYYRKRGGGKL
Kinase NEK10.AA APH 629-677 24 0.000416 14.89 Pfam 153-202 (248) Show / Hide 
Range on Protein: 629-677
Range on HMM: 153-202/248
Sequence Identity: 24% (13 aa)

ERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLG---DKDKV-TVTDFGLA
..||. ... ..|..    . ...|.|. |.|.|.    |...|  | |.. |
WWLWQRLWAWLEAHWP---PPCWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDA
Kinase NEK10.AA Pkinase_Tyr 519-535 52 0.155631 5.82 Pfam 1-17 (270) Show / Hide 
Range on Protein: 519-535
Range on HMM: 1-17/270
Sequence Identity: 52% (9 aa)

YAVLDHLGSGAFGCVYK
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ITFGKKLGEGAFGEVYK
Kinase NEK10.AA Pkinase_Tyr 755-783 24 3.250008 1.35 Pfam 242-270 (270) Show / Hide 
Range on Protein: 755-783
Range on HMM: 242-270/270
Sequence Identity: 24% (7 aa)

SEKVTDTIRRCLTPDAEARPDIVEVSSMI
.... | ...|  .|.| ||   |. ...
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL