Gene NEK11 (Mouse)

NEK11

Species: Mouse
Alias: NEK11, 4932416N14Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK11

Sequence

Name Sequence Type Origin Length Description Download
NEK11.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
NEK11.AA Protein Sugen 628 None Fasta, JSON
NEK11.NA RNA Sugen 2625 None Fasta, JSON

Protein domain

Protein domains of NEK11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK11.AA NEK11 30-288 93 6.8e-238 796.6 In-house 1-259 (259) Show / Hide 
Range on Protein: 30-288
Range on HMM: 1-259/259
Sequence Identity: 93% (243 aa)

YVLQQKLGSGSFGTVYLVSDKKAKPGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQETFCIITEYCEGRDLDYRIQEYKEAGK
||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||..|||||||||||||||||||||.|||
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGK

VFAENQIVEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCELATTLTGTPHYMSPEALKHQGYDAKSDIWSLACILYEMCCL
.|.||||.||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||.||||||||||||||||.
IFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCM

DHAFAGSSFLSVVLNIVEGKTPSLPDRYPRELNTIMERMLNKSPSLRPSAADILKAPYM
|||||||.|||.|||||||.||||||||||||||||||||||.|||||||.||||.|||
DHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase NEK11.AA NEK 30-288 41 1.3e-142 480.12 In-house 1-286 (286) Show / Hide 
Range on Protein: 30-288
Range on HMM: 1-286/286
Sequence Identity: 41% (118 aa)

YVLQQKLGSGSFGTVYLVSDKKAKPG--EELKVLKEISVGELNPNETVQAN-VEAQLLSRLHHPAIVRFHASFMEQE--TFCIITEYCE-GRDLDYR---
| ...|.|.||||.||.| .|. .    |.| |.|.|..|.... |. .|   |...|..|.|| ||... ||.|..  ..||. |||| | ||. .   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IQEYKEAGKVFAENQIVEWFIQLLLGVDYMHER-----RILHRDLKSKNIFLKNN-----LLKIGDFGVSRLLMGSCELATT-LTGTPHYMSPEALKHQG
|...|..|| | |.||..||||..|...|||.|     .|||||.|..|||| .|     ..||||||.|..|. ....|.| ..|||.||||| .....
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDAKSDIWSLACILYEMCCL--DHAFAGS--SFLSVVLNIVEG-KTPSLPDR--YPRELNTIMERMLNKSPSLRPSAADILKAPYM
|. ||||||| |.|||||.|   |.| ..  ...| ...|..| . | .|..  | ..|. ....||.|.|..|||. .||. |..
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK11.AA NEK1 30-288 39 4.5e-99 335.44 In-house 1-276 (276) Show / Hide 
Range on Protein: 30-288
Range on HMM: 1-276/276
Sequence Identity: 39% (109 aa)

YVLQQKLGSGSFGTVYLVSDKKAKPGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQET--FCIITEYCEGRDLDYRIQEYKEA
|. ....|.|||| ..||   | |    . |.|||.| .  . |. ..  |. .|... || ||..  || |       |. |||.| ||  .|.. |  
YHYIKQIGEGSFGKAWLV---KHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRK

GKVFAENQIVEWFIQLLLGVDYMHERRILHRDLKSKNIFLK---NN---------------LLKIGDFGVSRLLMGSCELATTLTGTPHYMSPEALKHQG
|| | | ||  ||.|. |.. ..| |.|||||.||.||||    |                |.|.||||..|.|  . |.| |  ||| | |||    ..
GKLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKP

YDAKSDIWSLACILYEMCCLDHAFAGSSFLSVVLNIVEGKTPSLPDRYPRELNTIMERMLNKSPSLRPSAADILKAPYM
|. ||||||| |.||| | | |.| . ..   || |..|  | .| .| .||      |....|..|||. .||. | .
YNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK11.AA NEK4 30-288 42 4.6e-92 312.15 In-house 1-257 (257) Show / Hide 
Range on Protein: 30-288
Range on HMM: 1-257/257
Sequence Identity: 42% (111 aa)

YVLQQKLGSGSFGTVYLVSDKKAKPGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQET--FCIITEYCEGRDLDYRIQEYKEA
|   .  | ||.| |.||  .. |      |.| .   .    |.  |  ||||||.| || || .  |.   .    .|.  .||| ||  . .. |  
YCHMKVVGKGSYGEVWLVRHRRDK---KQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQK--

GKVFAENQIVEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCELATTLTGTPHYMSPEALKHQGYDAKSDIWSLACILYEM
...  |.|.||||.|  ..  ||||..|||||||  |||| | |..||||||.|| |  .|..| |. ||| |||||    . || ||||||| | .|||
NQFLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEM

CCLDHAFAGSSFLSVVLNIVEGKTPSLPDRYPRELNTIMERMLNKSPSLRPSAADILKAPYM
  | |||      | .  |..|. | .|  |  .|  ..  ||.| |  |||  ||.. ||.
ITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK11.AA S_TKc 30-288 30 2.3e-82 280.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 30-288
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

YVLQQKLGSGSFGTVYLVSDKKAKPGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQETFCIITEYCEG--RDLDYRIQEYKEA
| . .|.|.|.||.||.. .||     ..  .|.|.          ..  | |.|.. ||| ||... .| . . .....|||.|   ||  .|....  
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G--KVFAENQIVEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCELATTLTGTPHYMSPEALKHQGYDA-KSDIWSLACILY
|  ..| | ..  .. |......|.|...|.|||||  ||.| .  .||.|||..|.|       ||. |||.||.|| |   ||.  |.|.||. ||||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMCCLDHAFAGSSFLSVVLNIVEGKTPSLPDRYPRELNTIMERMLNKSPSLRPSAADILK-------APYM
||.|    |     . ......           ..|.  .....|.| |. ||.| ..|.        |..
EMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK11.AA Pkinase 30-288 30 4.9e-79 273.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 30-288
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

YVLQQKLGSGSFGTVYLVSDKKA-KPGEELKVLKEISVGELNPNETVQANV--EAQLLSRLHHPAIVRFHASFMEQETFCIITEYCEGR----DLDYRIQ
|.. .|.||||||.||.  .|.  |    . ..|.|.. . .... ...    |.|.. ||.|| |||.. .|..    ....|||||     ||  .|.
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

EYKEAGKVF--AENQIVEWFIQLLLGVDYMHERRILHRDLKSKNIFLK-NNLL----KIGDFGVSRLL-MGSCELATTLTGTPHYMSPEALK-HQGYDAK
   .....|   |...  .. |.| |..|.|...|.|||||. ||... |. .    ||.|||.....   . . .||..|||.||.|| .. .|.|. |
T--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDIWSLACILYEMCCLDHAFAGS----SFLSVVLNIVEGKTPSLPDRYP-----------------------RELNTIMERMLNKSPSLRPSAADILKAP
.|.||. ||||||.|    | |.    . ..    |.. . | |.  .|                       .|.  .....|.| |. ||.|..||. |
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YM
..
WF
Kinase NEK11.AA NEK8 60-288 35 1.8e-77 220.71 In-house 30-278 (278) Show / Hide 
Range on Protein: 60-288
Range on HMM: 30-278/278
Sequence Identity: 35% (89 aa)

VLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQETFCIITEYCEGRDLDYRIQEYKEAGKVFAEN-----------------QIVEWFIQ
..|.| . .. ..|   |  | |.||.|.|| |.    .|||  |  |  ||..|  |   ||. .  .| | |                  .|.  |.|
IWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQ--NKLFEEERQLKQVNHCFNIYFNEQMILWYFFQ

LLLGVDYMHERRILHRDLKSKNIFL-KN-NLLKIGDFGVSRLLMGSCELAT--TLTGTPHYMSPEALKHQGYDAKSDIWSLACILYEMCCLDHAFAGSSF
 ...| .||.  |||||||  |||. .  ...|||||| |  .      .|  |. ||| |||||  . . |..|||.|.| |.|||||||  ||..|  
MCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNL

LSVVLNIVEG-KTPSLPDRYPRELNTIMERMLNKSPSLRPSAADILKAPYM
. .|. |. . .   ..|.|  |.   ..  | . |  ||||. |.. |  
PALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK11.AA NEK-Unclassified 83-288 37 1.1e-64 212.95 In-house 46-258 (258) Show / Hide 
Range on Protein: 83-288
Range on HMM: 46-258/258
Sequence Identity: 37% (82 aa)

LLSRLHHPAIVRFHASFMEQETFCIITEYCEGRDLDYRIQEYKEAGK--VFAENQIVEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGV
.|| | || || .| || |        .||.| .|| |||  |  .|   | |  |  |.||.   | | | |.|.|||||  |||| .  .. .||||.
ILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQ--KHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGI

SRLLMGSCELATTLTGTPHYMSPEALKHQGYDAKSDIWSLACILYEMCCLDHAFAGSSFLSVVLNIVEGKT-------PSLPDRYPRELNTIMERMLNKS
|| .    . | |  ||. .|||| .. | |. .||.||| ||.||||  . .|   . ..|   |. .         |     |   |  ..  || . 
SRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEP-VSKTYSTDLQQVIRFMLRRN

PSLRPSAADILKAPYM
.  |||| .|.  .| 
FQQRPSATEIVEQDYI
Kinase NEK11.AA Ciliate-E2 30-288 21 5.4e-62 211.6 In-house 1-365 (365) Show / Hide 
Range on Protein: 30-288
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

YVLQQKLGSGSFGTVYLVSDKKAKPGEELK---------------VLKEISVGELNPNETVQANVEAQLLSRLH----------------HPAIVRFHAS
| ...|.|.|.||.||.....| .  . .|                 |.. .  ...|.  | . | ... ...                || |.... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FM--EQETFCIITEYCEGRDLDYRIQEY---------KEAGKVFAENQIVEWFIQLLL---------------GVDYMHERR-ILHRDLKSKNIFLKNNL
|    .... ...|||.| || ..|..          | . | | |..| . . |.|                .. |.|..  |.|||.|  ||..    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

LKIGDFGVSR----------------LLMGSC----------------ELATTLTGTPHYMSPEALK---------HQGYDAKSDIWSLACILYEMCCLD
.|| ||| |.                ..|                   ... |. |||.||.|| |.         ..||| |.||||| .|||||..  
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

HAFAGSSFLSVVLNIVEGKTPSLP------------------DRYPRELNTIMER----MLNKSPSLRPS-AADILKAPYM
. |         ... . .  ..|                  .  . |   .. .    ||.| |. |.. . .||. |..
PPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK11.AA TKL 36-286 20 7.8e-60 205.1 In-house 1-364 (364) Show / Hide 
Range on Protein: 36-286
Range on HMM: 1-364/364
Sequence Identity: 20% (77 aa)

LGSGSFGTVYLVSDK----------------KAKPGEELKVLKEISVGELNPN--------------ETVQANVEAQLLSRLHHPAIVRFHASFMEQET-
.|||.||.||    .                |  . .. .   ..|  ....|              .  . ..|. ..|||.|| ||.| .. .. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FCIITEYCEGRDLDYRIQEYKEAGKVFAENQIVEWFIQLLLGVDYMHERR--------ILHRDLKSKNIFLKNNL-------------
            .||..|||.| .| ....           .|.. | ..  .|..|.| ..        |.|||||||||....|.             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--LKIGDFGVSRLLMGSCE-------------------LATTLTGTPHYMSPEALKHQ----------------GYDAKSDIWSLACILYEMCCLDHAFA
  .||.||| || . .| .                      |  ||| .|.||.|. |                 |. |.|..| . .|.|...  . ..
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

GSSFLSV----------VLNIVEGKTPSLP------------DRYPRELNTIMERMLNKSPSLRPSAADILKAP
.  . ..          ......|. | .|            .  |...  .|..  .  |. |||. .|||  
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase NEK11.AA Ciliate-E2-Unclassified 30-288 24 1.2e-58 201.14 In-house 1-352 (352) Show / Hide 
Range on Protein: 30-288
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)

YVLQQKLGSGSFGTVYLVSDKKAKPGE----ELKVLKEISVGELNPNETVQANVEAQLLSR------------------LHHPAIVRFHASFMEQETFCI
| .....|.|.||.||.. .|| |       ..|. .....   . ..    | . .. ..                  . || ||...  |  .....|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ITEYCEGRDLDYRIQEYKE-------------AGKVFAENQIV-----EWFIQLLLGVDYMHER-RILHRDLKSKNIFLKNN----LLKIGDFGVSR---
..||||| || . |...|               .| | |.|..      .| |.|.| .|.|.   |.|||.|  ||...||     .|| ||| |.   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

------------LLMGSCELATTLTGTPHYM----SPEALKHQGYD----AKSDIWSLACILYEMCCLDHAFAGSSFLS----------------VVLNI
            . . . ....| .||| ||    .|| |. |.||     |.||||| .|||||.   . | . .  .                .  ||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

VEGKTPSLP-------DRYPRELNTIME----RMLNKSPSLRPSAADILKAPYM
 ....   .       .. . |   . .    .||.| |. |... .||. |..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase NEK11.AA STE 30-288 24 1.3e-58 201.02 In-house 1-359 (359) Show / Hide 
Range on Protein: 30-288
Range on HMM: 1-359/359
Sequence Identity: 24% (90 aa)

YVLQQKLGSGSFGTVYLVSDKKA----KPGEE--------LKVLKEISVGELNP---------------NETVQANVEAQLLSRLH--HPAIVRFHASFM
. ...|.|.|.|||||.  ..|     | ||.        .   |.... . |.               .|  |   | .......  || ||... ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EQ-------ETFCIITEYCEGRDLDYRIQEYKEAGK----------VFAENQIVEWFIQLLLG-VDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRL
         .. .|. ||..|  ||  |..... ||          .| |.||     |.| |  .| |. .| |||.|. ||.|     |. ||||.  
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

LMGS----------------CELATTLTGTPHYMSPEALKH------QGYDAKSDIWSLACILYEMCCLDHAFAGSSFLS----------------VVLN
|  |                 .  .|..||| .|.|| ..       .|||.|.||||| | . ||..  . ..  . ..                .. .
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-C

IVEGKTPSLPD-------------------RYPRELNTIMERMLNKSPSLRPSAADILK--APYM
||.|. |.|||                   ..  |..  ... |.| |. ||.| . ||   |  
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK11.AA Pkinase_Tyr 80-229 26 5.8e-25 85.17 Pfam 53-210 (270) Show / Hide 
Range on Protein: 80-229
Range on HMM: 53-210/270
Sequence Identity: 26% (42 aa)

EAQLLSRL-HHPAIVRFHASFM-EQET--FCIITEYCEGRDLDYRIQEYKEAGKVFAENQIVEWFIQLLLGVDYMHERRILHRDLKSKNIFLK-NNLLKI
||.... | ||| |||...  . ..|    .|..||... ||.   .. .| .. .   ..... .|   | .| ..... ||||  .|. .. ||  ||
EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKI

GDFGVSRLL-MGSCE-LATTLTGTP-HYMSPEALKHQGYDAKSDIWSLACILYEMCCL
.||| .|..   .    ... .  |   |.||....  .  |||.||    ..|.. .
CDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase NEK11.AA TyrKc 30-292 22 3.8e-21 77.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 30-292
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

YVLQQKLGSGSFGTVYLVSDKKAKPGEEL---KVLKEISVGELNPNETVQANV--EAQLLSRL--HHPAIVRFHASFMEQ-------ETFCIITEYCEGR
 .| .|||.| ||.||.   |      .    |.||| .          ..    ||.....|  ||| |||...  ..|       |  .|..||... 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

DLDYRIQEYKEAGKVFAENQIVEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNL-LKIGDFGVSRLLMGS------CELATTLT--GTP-----HYMS
||. .......    .   . ... .|   | .| |.... ||||   |. ...|.  ||.||| || .          .  .. .  |.        |.
DLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEALKHQGYDAKSDIWSLACILYEMCCLDHAFAGS------SFLSVVLNIVEGKTPSLPDR--------YPRELNTIMERMLNKSPSLRPSAADILKAPY
||....  .  |||.||    ..|.. .             |   |. .. .|. .  |.          | |. .||..  .  |. ||. ..|     
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----

MEEQL
  |..
-HECF
Kinase NEK11.AA Pkinase_Tyr 30-46 47 0.002362 11.98 Pfam 1-17 (270) Show / Hide 
Range on Protein: 30-46
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

YVLQQKLGSGSFGTVYL
 .. .|||.|.||.||.
ITFGKKLGEGAFGEVYK