Gene NEK2 (Mouse)

NEK2

Species: Mouse
Alias: Nek2, NEK2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK2

Sequence

Name Sequence Type Origin Length Description Download
NEK2.AA Protein Sugen 443 None Fasta, JSON
NEK2.NA RNA Sugen 3218 None Fasta, JSON
NEK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of NEK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK2.AA NEK2 8-271 58 7.4e-218 730.04 In-house 1-319 (319) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-319/319
Sequence Identity: 58% (188 aa)

YEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEVEKQMLVSEVNLLRELKHPNIVSYYDRIIDRTNTTLYIVMEYCEGGDLASVISKGTKDRQY
||||..||.||.|||.|.|||||||||||||..||.|.|.|.||||||.|.||.||||||| |||.||||.|.||||||||||||||...|.|..|.|||
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

LEEEFVLRVMTQLTLALKECHR----------------RSDGGHTVLHRDLKPANVFLDSKHN-------------------------------------
.||||..|.|.||..||.|||.                |.||.||.||||.||||.|||..||                                     
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMSCLSYNEKSDIWSLGCLLYELCALMPPFTAFNQKELAGKIREGRFRRIPYRYSDGLNDLITRML
  ||||||||||.||||||||.||||||||||||||....|||||||||.|||.||.|||.|||.|.||..|..||..|.||||||.||..||..|..|.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

NLKDYHRPSVEEILESPLI
|...|||||.||||..|.|
NVDHYHRPSIEEILQHPQI
Kinase NEK2.AA NEK 8-271 48 7.89999999999e-156 523.98 In-house 1-286 (286) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-286/286
Sequence Identity: 48% (140 aa)

YEVLHSIGTGSYGRCQKIRRKSDGKI-----LVWKELDYGSMTEVEKQMLV-SEVNLLRELKHPNIVSYYDRIIDRTNTTLYIVMEYCE-GGDLASV---
||..  || ||.|.. |.|||||||.     .|||. ..|.|.| |||... .||..|..|||||||.|||..|.. | .|.||||||| ||||.     
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ISKGTKDRQYLEEEFVLRVMTQLTLALKECHRRSDGG-HTVLHRDLKPANVFLDSKHN----VKLGDFGLARILNHDTSFAKT-FVGTPYYMSPEQMSCL
| |... ..|.||| ......|. ||||..| |. |. . .||||.||.|.||....|    ||.||||....|||.|..|.| .||||||||||...  
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

SYNEKSDIWSLGCLLYELCALMP--PFTAF--NQKELAGKIREG-RFRRIP-YR-YSDGLNDLITRMLNLKDYHRPSVEEILESPLI
.||.|||||||||.|||.|.|.|  || |   |...|. ||..|  . .|| .| ||. |..||..||.    .|||...||| |.|
PYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK2.AA NEK8 8-271 36 2.9e-98 281.13 In-house 1-278 (278) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-278/278
Sequence Identity: 36% (104 aa)

YEVLHSIGTGSYGRCQKIRRKSDG--KILVWKELDYGSMTEVEKQMLVSEVNLLRELKHPNIVSYYDRIIDRTNTTLYIVMEYCEGGDLASVISKGTKDR
||    .| |. | |   |||.|.  .  .||. .   |.| | ||  .|...|  | ||||.||||  ..  ..|| |.|||..|| |.  |.. ... 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFME--DNTLMIEMEYADGGTLYQMIQH-QQNK

QYLEEE----------------FVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDSK-HNVKLGDFGLARILNHDTSFA--KTFVGTPYYMSPE
  .||.                 .| ...|  .|.   |      | .||||||..|.|..     ||.||||.. |.| ... .  || ||||||||||
LFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQ-----HNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPE

QMSCLSYNEKSDIWSLGCLLYELCALMPPFTAFNQKELAGKIREG-RFRRIPYRYSDGLNDLITRMLNLKDYHRPSVEEILESPLI
  .  .||.|||.|.||| |||.| |   | | |. .|  ||  .  .  |. .|| ..  |..  | .    |||. .|.  ||.
MCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK2.AA NEK1 8-271 41 6.4e-95 321.64 In-house 1-276 (276) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-276/276
Sequence Identity: 41% (118 aa)

YEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEVEKQMLVSEVNLLRELKHPNIVSYYDRIIDRTNTTLYIVMEYCEGGDLASVISKGTKDRQY
|...  || ||.|.  . ..|.||. .| ||     | | |..  . ||..|. .||||||.|..  . . .  ||||||||.||||.  | . .   . 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LEEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD--SKH---------------NVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMSC
  |   .   .|. |||.  | |      .||||.|. |.||   ..                 ||||||| ||.||| ...|.| .||||| |||    
FSEDQIMHWFCQICLALNHIHDR-----KILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQN

LSYNEKSDIWSLGCLLYELCALMPPFTAFNQKELAGKIREGRFRRIPYRYSDGLNDLITRMLNLKDYHRPSVEEILESPLI
. || ||||||||| |||||.|  || | | | |  || .|..  || .||  |  |.. |..    |||||  |||.| |
KPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK2.AA S_TKc 8-271 34 3.4e-88 300.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-231/231
Sequence Identity: 34% (94 aa)

YEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEVEKQMLVSEVNLLRELKHPNIVSYYDRIIDRTNTTLYIVMEYCEG--GDLASVISKGTKDR
||.|  || |..|.. | | |..|.|   |...         ... .|...|.. .||||| .|| . |   . ||.|||||.|  ||| ..| |  . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--QYLEEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDSKHNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMSCLSYNE-KSDIWSL
  ... |  . ..| |. .||. ||.     | ..||||||.|..||.  ..|..||||||.|       .||.|||.||.|| .   .|.  |.|.||.
LRFPFPE-HARFYMYQICCALEYCHS-----HGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GCLLYELCALMPPFTAFNQKELAGKIREGRFRRIPYRYSDGLNDLITRMLNLKDYHRPSVEEILE-------SPLI
||.|||...  |||   .....  ||.           |. . |.| ..|.    .||.. |.|.        | .
GCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK2.AA NEK4 8-271 39 1.9e-76 260.29 In-house 1-257 (257) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-257/257
Sequence Identity: 39% (104 aa)

YEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEVEKQMLVSEVNLLRELKHPNIVSYYDRIIDRTNTTLYIVMEYCEGGDLASVISKGTKDRQY
|. .  .| ||||    .| . |.|  | | ..       |..    |..||  |||||||.| .      .  ||||| .||||||     .  .  | 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQ--QKNQF

LEEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDSKHNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMSCLSYNEKSDIWSLGCLLY
|||. |.    |  .||   |..      .||||||  |.||  |  .|.||||..|.||    .||| .|||||||||  .   |. ||||||||| .|
LEEYQVVEWFVQIAMALQYMHEK-----HILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVY

ELCALMPPFTAFNQKELAGKIREGRFRRIPYRYSDGLNDLITRMLNLKDYHRPSVEEILESPLI
|.  |   | | .   |  .| .|.   .|  ||  | .|.  ||. .   |||. .|.  | |
EMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK2.AA Pkinase 8-271 30 1.9e-74 258.4 Pfam 1-293 (293) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

YEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEVEKQMLVS--EVNLLRELKHPNIVSYYDRIIDRTNTTLYIVMEYCEGG----DLASVISKG
|...  || ||.|.. | ..|..||| . |.... .  . ..| ..   |. ....|.||||| .||   |  .. .|.||||||||    ||...||  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

TKDRQYL--EEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDSKHNV----KLGDFGLARIL-NHDTSFAKTFVGTPYYMSPEQMS-CLSY
 ...  .  .|. . ..|.|.  .|. ||..      ..||||||.|...|.. ..    |..|||||. . .   | ..||.|||.||.||    .  |
-WRHGCFYFSEWECKFYMYQILRGLEYCHSM-----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

NEKSDIWSLGCLLYELCALMPPFTAF------NQKELAGKIREGRFRRI-PYRYS-------------------DGLNDLITRMLNLKDYHRPSVEEILE
  |.|.||.||.|||..   |||         .|...  .|.......  |. .|                   . . |.|...|... . ||. |.||.
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

SPLI
.| .
HPWF
Kinase NEK2.AA STE 8-271 22 5.9e-69 235.39 In-house 1-359 (359) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-359/359
Sequence Identity: 22% (83 aa)

YEVLHSIGTGSYG-RCQKIRRKSD--------------GKILVWKELDYGSMT---------------EVEKQMLVSEVNLLRELK--HPNIVSYYDRII
.| .  || |..|  ......| .              |.|   |.... . .               . |.| .  |........  ||||| ||.  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DRT-----NTTLYIVMEYCEGGDLASVIS-K-GTKDR--------QYLEEEFVLRVMTQLTLA-LKECHRRSDGGHTVLHRDLKPANVFLDSKHNVKLGD
.       ...|.|.|||..|| | ..|  | |....        ....|. . ..  |.  . |.  |.       . |||.||||..|     ||| |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-----IIHRDIKPANILL-----VKLCD

FGLARILNH---------------DTS-FAKTFVGTPYYMSPEQMSC------LSYNEKSDIWSLGCLLYELCALMPPFTAFNQK---------------
||.. .|..               ...   .|||||| .|.|| ...        |..|.|||||||.. |..   ||.  ..                 
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ

-ELAGKIREGRFRRIPY-------------------RYSDGLNDLITRMLNLKDYHRPSVEEILE--SPLI
 |.  .| .|   ..|                    ..|. ..| | . |.    .||.... |.   | |
FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK2.AA CAMK 13-271 20 4.3e-65 208.42 In-house 1-425 (425) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-425/425
Sequence Identity: 20% (89 aa)

SIGTGSYGRCQKIRRKSDG------------KILVWKELDYGSMT--------------------------EVEKQMLVSEVNLLRE-------LKHPNI
 .|.||.|   . ..|...            .    | .|   ..                          .. .... .|.....        |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSYYDRIIDR----------TNTT--------LYIVM---EYCEGG----DLASVISKG------------TKDRQYLEEEFVLRVMTQLTLALKECHRR
.. |. . |.          | ..        .|.||   |||.||    || . | .               .| ...|. . |.. |.  |.. ||  
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHS-

SDGGHTVLHRDLKPANVFLDSKH-----------------NVKLGDFGLARILNH-----------------------DTSFAKTFVGTPYYMS-PEQMS
    | . |||||| |. ||...                 |.|. |||.|.....                       ..   |||.|||.||. ||  .
----HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN

C--------------LSYNEKSDIWSLGCLLYELCALMPPFTAF-------------NQKELAGKIREGRFRRIPYR---------------YSDG----
                 |..|.|.||.|..|| .    ||| .              |..||  ||..|... .|.                 ||     
GKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHF

----LNDLITRMLNLKDYHRPSVEEILESPLI
      ||| .||.    .|...|..|. | .
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK2.AA Ciliate-E2 8-271 21 1e-57 196.71 In-house 1-365 (365) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-365/365
Sequence Identity: 21% (83 aa)

YEVLHSIGTGSYGRCQKIRRKSDGK--ILVWKELDY-----------------GSMTEVEKQMLVSEVNLLRELK----------------HPNIVSYYD
|...  ||.|..|   | ......|  ... .. ..                  .| . ..... .| ...||..                ||||. .|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

RIIDRTNTTLYIVMEYCEGGDLASVISKG-TKDRQYLE------EEFVLRVMTQLTL---------------ALKECHRRSDGGHTVLHRDLKPANVFLD
  .. .....|.|||||.|||| . | .  .|  . .|      |. ....|.|..                ||...| .   .. ..|||.|| |... 
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK---NN-IIHRDIKPENILF-

SKHNVKLGDFGLARILNHDTS-------------------------------FAKTFVGTPYYMSPEQMSCLS---------YNEKSDIWSLGCLLYELC
    .|. ||||..... |                                  ..|..|||.||.||  .  .         |..|.||||||..|||..
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

ALMPPFTAFNQKELAGKIREGRFRR------------IPYRYSDGLNDLITR----MLNLKDYHRPS-VEEILESPLI
   |||    |. . .||.   .              ..   |.   ||| .    ||. .   |..  |.||. | .
FGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK2.AA ULK 8-271 26 4.4e-57 195.96 In-house 1-329 (329) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-329/329
Sequence Identity: 26% (90 aa)

YEVLHSIGTGSYG-RCQKIRRKSD---GKILVWKELDYGSMTEVEKQ--------MLVSEVNLLRELK--------HPNIVSYYDRIIDRTNTTLYIVME
|.. | .| ||.|  .. .  |..   ... . | .|  .| . ...        .| .|. ....||        ||||| .||   . ... .||.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCEGGDLASVISKGTK------DRQYLEEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDSKHN------------VKLGDFGLARILNHD
||.|||| . |.|  |        ..|.|. .. .. |.  ..|| | .      . |||.||.|. .. .              .|..|||.|. .. |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN-----IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDND

---TSFAKTFV------GTPYYMSPEQMS----CLSYN-EKSDIWSLGCLLYELCALMPPFTA-FNQKELAGKIREGR----------FRRIPYR-----
      ..|.|      |||.||.|.  .    .  |.  |.|||||||..||.    ||| | ||.  | ..... .           . . ..     
NMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

--YSDGLNDLITRMLNLKDYHRPSVEEILESPLI
   |. . ||| |||  .   | | ||... |..
PQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase NEK2.AA Ciliate-E2-Unclassified 8-271 21 1.7e-56 194.03 In-house 1-352 (352) Show / Hide 
Range on Protein: 8-271
Range on HMM: 1-352/352
Sequence Identity: 21% (77 aa)

YEVLHSIGTGSYGRCQKIRRKSDGKI------LVWKELDYGSM----------TEVEKQMLVSEVN----LLRE--LKHPNIVSYYDRIIDRTNTTLYIV
|.... ||.|..|  .| ..|.....       . .. .  ..          .|.....  . ..    .. .  | ||... ...  ....  ..|||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYCEGGDLASVISKGTK-------------DRQYLEEEFVL-----RVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDSKH---NVKLGDFGLAR
|||||||||   |.|  |              |. ..|. ..     . . |. ..|. .|.  .    ..|||.|| |...|...   ..|. |||...
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN----IIHRDIKPENILFDNNGKNYYIKIIDFGISK

ILNHD---------------TSFAKTFVGTPYYM----SPEQMSCLSYN----EKSDIWSLGCLLYELCALMPPFTAFNQKE----------------LA
 .. .                  ..||.|||.||    .|| .    |.    .|.||||||..|||..   .|| . |...                | 
KYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLY

GKIREGRFRRIP-------YRYSDGLNDLIT----RMLNLKDYHRPSVEEILESPLI
 .| .. .   .       .. |.   |.|.    .||. .   |.. |.||. |..
QNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase NEK2.AA TyrKc 8-269 21 6.8e-16 34.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-269
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEVEKQMLVSEVNLLREL--KHPNIVSYYDRIIDR-----TNTTLYIVMEYCEGGDLASVISK
 . .. .| | .|.  | . |   .  | .  ..       .... .| .....|  .|||||  |  ...          |.|||||...||| . . |
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

GTKDRQYLEEEFVLRVMTQLTLALK--ECHRRSDGGHTVLHRDLKPANVFLDSKHNVKLGDFGLARILNHD-------TSFAKTF-VGTP-----YYMSP
  ..   |  .  |  ..|        . .        . ||||   |. ....| || .||||.| . .|           |.   |.        |.|
HRPK---LCMKDLLSFCWQIACGMEYLHSK-------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EQMSCLSYNEKSDIWSLGCLLYELCAL-MPPFTA-----FNQKELAGKIREGRFRRIPYR--------YSDGLNDLITRMLNLKDYHRPSVEEILESP
| .    ...|||.|| | ...|.. . ..|         . .|.  ....|. ...|           .| . .....  . .   ||. .|| |  
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase NEK2.AA Pkinase_Tyr 43-94 31 7e-09 30.7 Pfam 39-94 (270) Show / Hide 
Range on Protein: 43-94
Range on HMM: 39-94/270
Sequence Identity: 31% (18 aa)

SMTEVE--KQMLVSEVNLLREL-KHPNIVSYYDRII--DRTNTTLYIVMEYCEGGDL
. .. .  .... .|......| .|||||..|  ..  .. |  .||||||...|||
GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDL
Kinase NEK2.AA Pkinase_Tyr 135-169 40 0.000869 13.45 Pfam 130-164 (270) Show / Hide 
Range on Protein: 135-169
Range on HMM: 130-164/270
Sequence Identity: 40% (14 aa)

HTVLHRDLKPANVFLDSKHNVKLGDFGLARILNHD
.   ||||   |. ..... || .|||||| . .|
KNCIHRDLAARNCLVTENNVVKICDFGLARDIYND
Kinase NEK2.AA Pkinase_Tyr 183-212 36 0.002048 12.19 Pfam 181-210 (270) Show / Hide 
Range on Protein: 183-212
Range on HMM: 181-210/270
Sequence Identity: 36% (11 aa)

MSPEQMSCLSYNEKSDIWSLGCLLYELCAL
|.|| ..   ...|||.|| | |..|.. .
MAPECINYGKFTTKSDVWSFGVLMWEIFTY