Gene NEK3 (Mouse)

NEK3

Species: Mouse
Alias: NEK3, Nek3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK1

Sequence

Name Sequence Type Origin Length Description Download
NEK3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
NEK3.AA Protein Sugen 509 None Fasta, JSON
NEK3.NA RNA Sugen 2044 None Fasta, JSON

Protein domain

Protein domains of NEK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK3.AA NEK1 4-255 57 2.3e-193 648.66 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-276/276
Sequence Identity: 57% (160 aa)

YTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLLK---SDTQTSRKEAVLLAKMKHPNIVAFKESFEAEGY--LYIVMEYCDGGDLMQRIKQQ--KGKL
|.....||.||||.|.|| .....|....|||.. |   .....|..|...||||||||||..|||||..|.  |||||||||||||||.|..|  ||||
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FPEDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLT--HNG---------------KVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENLPYNN
|.||.|..||.||||..||||.|..|||||||.|.|||  .||               .|||||||.||.|...|..|||..|||||..|||..|.||||
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWSLGCILYELCALKHPFQANSWKNLILKICQGPIHPLPALYSCKLQGLVKQMLKRNPSHRPSATTLLCRGSL
|||||||||.|||||.|||||.||.||||.||||||...|.|. ||..|| ||.||.||||.||||....|.|...
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK3.AA NEK 4-255 43 1.3e-153 516.6 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-286/286
Sequence Identity: 43% (124 aa)

YTVLRVIGQGSFGRALLVLQESSNQT-----FAMKEIRLLK---SDTQTSR-KEAVLLAKMKHPNIVAFKESFEAEG--YLYIVMEYCD-GGDLMQR---
|.....|||||||.. .|   | ..      ...|.| . .    ..| .  .|. .|...||||||....||. |.  .|.||||||. ||||.|.   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKQQK--GKLFPEDTILNWFIQICLGVNHIHKR-----RVLHRDIKSKNVFLTHNGK----VKLGDFGSARLLSSPMAFACT-YVGTPYYVPPEIWENLP
||.||  ||.|.|..|..||||.||.....|.|     ..||||||..|.||| |..    ||.|||| ...|.. . .|.| .||||||  ||...| |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNNKSDIWSLGCILYELCAL--KHPFQAN--SWKNLILKICQG-PIHPLPAL--YSCKLQGLVKQMLKRNPSHRPSATTLLCRGSL
||||||||||||.|||.|.|  ||||.|.  ....|..||..|    |.|    || .|| |. |||...|..|||.. .| .  .
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK3.AA NEK4 4-255 43 9.40000000001e-102 344.35 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-257/257
Sequence Identity: 43% (111 aa)

YTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLL---KSDTQTSRKEAVLLAKMKHPNIVAFKESFEAE-G-YLYIVMEYCDGGDLMQRIKQQKGKLFP
|  ..|.|.||.|   || .      . || . |.   . ...   .|| || ..|||||| .|||.| | | .||||| .|.|||| .. ||||... .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCALKH
|  ...||.|| ..   .|....|||| |  |.|||    .|.|||| .| |     .| | .|||||  ||.. | ||. ||||||||| .||.  |||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFQANSWKNLILKICQGPIHPLPALYSCKLQGLVKQMLKRNPSHRPSATTLLCRGSL
 |.|     || .| ||   |.|  ||  || ||.|||.. |  |||   ..    .
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK3.AA NEK8 4-259 36 5.3e-97 277.47 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-278/278
Sequence Identity: 36% (103 aa)

YTVLRVIGQGSFGRALLVLQESSN--QTFAMKEI---RLLKSDTQTSRKEAVLLAKMKHPNIVAFKESFEAEGYLYIVMEYCDGGDLMQRIKQQKGKLFP
|.  ||.|.|.|| . | .  . .  .    |.|   |. ..  |    | ..|..  ||||..  ..|. .. | |.|||.||| | | |  |..||| 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

EDT-----------------ILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHN-GKVKLGDFGSARLLSSP--MAFACTYVGTPYYVPPEIWENLPYN
| .                 ||  |.|.|..|.|.|.  .||||.|  |.|.|   . ||.|||| .  ...   |. . | ||||||  ||. |  |||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

NKSDIWSLGCILYELCALKHPFQANSWKNLILKICQG-PIHPLPALYSCKLQGLVKQMLKRNPSHRPSATTLLCRGSLAPLV
.|||.|.|||.|||.| ||  | |    .|..|| |.    |..  ||  .  || . |.  |  ||||  .. .    ||.
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAM----PLC
Kinase NEK3.AA S_TKc 4-259 31 6.9e-92 312.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

YTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLLKSDTQTSRKEAVLLAKMKHPNIVAFKESFEAEGYLYIVMEYCDG--GDLMQRIKQQKG----KLF
|..||.||.|.||.  ..   .... .|.|.|.      .. |.|  .| | .||||| ....|.  ..||.|||||||  |||...||....    . |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PEDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENLPYNN-KSDIWSLGCILYELCAL
|| ..  .. |||......|.....|||.|  |..|..   .|..|||.||.|        |..|||.|..||.    .|.  |.|.||.||||||... 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

KHPFQANSWKNLILKICQGPIHPLPALYSCKLQGLVKQMLKRNPSHRPSATTLLCRGSL---APLV
. ||.    . .. ||.           |  .  .....|...|..||.|  .| ....    | .
YPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK3.AA Pkinase 4-253 27 5.2e-83 286.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-253
Range on HMM: 1-293/293
Sequence Identity: 27% (80 aa)

YTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLLKSDTQTSRK-----EAVLLAKMKHPNIVAFKESFEAEGYLYIVMEYCDGG----DLMQRIK-QQK
|...|.||.||||.  .    ......|.|.|.. . . .  .      |. ......||||| ....|| ....|.|||||.||    ||. .|. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKL-FPEDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKV----KLGDFGSARLL-SSPMAFACTYVGTPYYVPPEIWE-NLPYNNKSDIWSL
|.. |.|... ... ||. |....|.....|||.|. |... .|| .    |..|||.|...   .   . |..|||.|..||.   . .|  |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILYELCALKHPFQAN----SWKNLILKICQGPI----HPLPALYS-------------------CKLQGLVKQMLKRNPSHRPSATTLLCR--G
||||||..  . ||.      .  . . .||.        . | ..|                     .. ..| .|...|. ||.|. .|.    
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK3.AA NEK2 4-255 33 4.9e-72 241.83 In-house 1-319 (319) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-319/319
Sequence Identity: 33% (108 aa)

YTVLRVIGQGSFGRALLVLQESSNQTFAMKEI---RLLKSDTQTSRKEAVLLAKMKHPNIVAFKESF--EAEGYLYIVMEYCDGGDLMQRIKQQKG--KL
| || .||.|||||   |   |    .. |||    .     |    |  .| . |||||| .      ...  |||||||| |||| | ||  .   . 
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FPEDTILNWFIQICLGVNHIHK---------------------RRVLHRDIKSKNVFLTHNGK-------------------------------------
..|  |.  . |.|.    .|.                     . .||||||  |.||  ..                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCALKHPFQANSWKNLILKICQGPIHPLPALYSCKLQGLVKQML
  ||||||| || |     || |.||||||  ||  . ..|| ||||||.||..||.|||. |||| . . |  || ||   ..|. ||  |. ..  |.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

KRNPSHRPSATTLLCRGSL
. ...||||   .|    .
NVDHYHRPSIEEILQHPQI
Kinase NEK3.AA NEK-Unclassified 50-255 37 5.9e-70 230.72 In-house 45-258 (258) Show / Hide 
Range on Protein: 50-255
Range on HMM: 45-258/258
Sequence Identity: 37% (81 aa)

VLLAKMKHPNIVAFKESFEAEGYLYIVMEYCDGGDLMQRIKQQKGK--LFPEDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKVKLGDFGSA
..|....|| || . .||     |.   .|||||.| .||. . .|   | |  |  |.||.   |  || |...||| |  |.|||    | .|||| .
IILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGIS

RLLSSPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCALKHPFQANSWKNLILKICQGPI------HPLPALYSCKLQGLVKQMLKRNPS
| .      | | |||. .  ||. .  ||||.||.||||||.||.|.    | . .   .  || |..        |    ||  || ... ||.||. 
RIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQ

HRPSATTLLCRGSL
 |||||...     
QRPSATEIVEQDYI
Kinase NEK3.AA NEK11 4-255 42 1.7e-68 233.89 In-house 1-259 (259) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-259/259
Sequence Identity: 42% (110 aa)

YTVLRVIGQGSFGRALLVLQESSNQT---FAMKEI---RLLKSDTQTSRKEAVLLAKMKHPNIVAFKESFEAEGYLYIVMEYCDGGDLMQRIKQQK--GK
| .   .| ||||   ||      .      .|||    |   .|     || ||....|| || |  ||       |. |||.| || .||.  |  ||
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGK

LFPEDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCA
.|||  |. ||||. |||  .| ||.||||.||||.||  |  .|.|||| .|||      | |  ||| |. ||      |  ||||||| |||||.| 
IFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNN-LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCC

LKHPFQANSWKNLILKICQGPIHPLPALYSCKLQGLVKQMLKRNPSHRPSATTLLCRGSL
. | |   ..  ..|.|  |    ||  |   |  .. .|| .||| ||||  .|    .
MDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase NEK3.AA Ciliate-E2 4-255 22 9.8e-68 231.34 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-365/365
Sequence Identity: 22% (84 aa)

YTVLRVIGQGSFG-----RALLVLQES------------------SNQTFAMKEI-----RLLKSDTQTSR---------KEAVLLAKMKHPNIVAFKES
| ....||||.||     .  .| ...                   .. .||| .     . .|.  .  |         .|  .| ...||||. ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--AEGYLYIVMEYCDGGDLMQRIKQQKGKL---------FPEDTILNWFIQICL---------------GVNHIHKRR-VLHRDIKSKNVFLTHNGKV
|.   . ..|.|||||.||||...||..| |          | |  |.. . ||.                .....|..  ..|||||  |...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGSARLLSSP-----------MAFACT---------------------YVGTPYYVPPEIWENLP---------YNNKSDIWSLGCILYELCALKH
|. ||| .. .. .           .                          ..|||.|..||| .. .         |. |.||||||.||||..  |.
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFQANSWKNLILKICQGPIHPLPAL-----------------YSCKLQGLVKQ----MLKRNPSHRPS-ATTLLCRGSL
||        . .|.|..|   ..                   | . . | |.    ||...|. |.. .  .|    .
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK3.AA CAMK 9-250 19 6.5e-67 214.39 In-house 1-420 (425) Show / Hide 
Range on Protein: 9-250
Range on HMM: 1-420/425
Sequence Identity: 19% (84 aa)

VIGQGSFGRALLVLQESSN------------QTFAMKEIR-----------------LLKS------------DTQTSRKEAVLLAK-------MKHPNI
..|.||||   |. . ...            | .|.| |                  . ||            | .  |.|  .. |       ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAFKESFE--------AEGY------------LYIVM---EYCDGG----DLMQRIKQQKG-------------KLFPEDTILNWFIQICLGVNHIHKRR
. . | .|         . |            .|.||   |||.||    || ..|.....             . |.|.    .| ||| .|...|.. 
IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VLHRDIKSKNVFLTHN-----------------GKVKLGDFGSARLLSS-----------------------PMAFACTYVGTPYYVP-PEIWEN-----
. |||.|  |. |..|                 ...|. ||| |. . .                       .     |..|||.|.. ||. .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------LPYNNKSDIWSLGCILYELCALKHPFQAN-------------SWKNLILKICQGPIH-PLPALYS----------------------CKLQ
          .|. |.|.||.|.||| .   . ||..              . ..|  ||..|  . | | .                           .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

GLVKQMLKRNPSHRPSATTLL
 |...||...|..|....  |
DLIRKMLQVDPEKRMTIEQCL
Kinase NEK3.AA Ciliate-E2-Unclassified 4-255 24 2.5e-64 220.0 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)

YTVLRVIGQGSFGRALLVLQESSNQTFAMKEIR---------LLKSDTQTSRKEAVLLAK------------------MKHPNIVAFKESFEAEGYLYIV
|.....||||.||   .. ... .| .|||..           ...| . ....  .  |                  ..||.|| . . |. . ..|||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYCDGGDLMQRIKQQKG---------------KLFPEDTIL-----NWFIQICLGVNHIHKR-RVLHRDIKSKNVFLTHNG---KVKLGDFGSARLLSS
||||.||||.| ||..|.               | |.|  ..     ..| ||..| ...|.   ..|||||  |.... ||   ..|. |||... . .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

P---------------MAFACTYVGTPYYV----PPEIWENLPYNNK----SDIWSLGCILYELCALKHPFQANS----------------WKNLILKIC
.                  ..| .|||.|     .||. ..  |...    .||||||.||||..  ..||..|.                 |.|. .|.
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

QGPIHPLPALY-------SCKLQGLVK----QMLKRNPSHRPSATTLLCRGSL
|..|   ..         | . . ...    .||| ||. |...  .|.   .
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase NEK3.AA TyrKc 4-255 21 1.2e-21 79.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-255
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

YTVLRVIGQGSFG---RALLVLQESSNQTFAMKEIRLLKSDTQTSRKEAVLLAKM--KHPNIVAFKESFEAE-------GYLYIVMEYCDGGDLMQRIKQ
 | ....| | ||   .. .       .. | | ..  .   .  ..|| .. |   .|||||..      .       . |.|||||...||| .... 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QKGKLFPEDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKVKLGDFGSARLLSSP--------MAFA-----CTYVGTPYYVPPEIWENLPYN
 ..| .. .. |.. .||. | ...|.... |||.   |. ...|. || .||| .| . .         .  .     . ..      .|| .    ..
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

NKSDIWSLGCILYELCAL-KHPFQA-----NSWKNLILKICQGPIHPLPAL--------YSCKLQGLVKQMLKRNPSHRPSATTLLCRGSL
 |||.|| |  ..|.. . . |         |.. .| .. ||   | |.          . ..  . ||  ...|. ||. ...  .  .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase NEK3.AA Pkinase_Tyr 47-145 29 1.2e-20 70.53 Pfam 52-156 (270) Show / Hide 
Range on Protein: 47-145
Range on HMM: 52-156/270
Sequence Identity: 29% (31 aa)

KEAVLLAKM-KHPNIVAFKESFE-AEGY--LYIVMEYCDGGDLMQRIKQQ--KGKLFPEDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVFLTHNGKVK
.|| .. .. .||||| .       ..   .||||||. .|||    ...   .. ..  ..|.. .||. | .. . ..  |||.  .|. .|.|..||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

LGDFG
 .|||
ICDFG
Kinase NEK3.AA Pkinase_Tyr 168-196 31 0.477839 4.17 Pfam 182-210 (270) Show / Hide 
Range on Protein: 168-196
Range on HMM: 182-210/270
Sequence Identity: 31% (9 aa)

PPEIWENLPYNNKSDIWSLGCILYELCAL
.|| . .  .. |||.|| |  ..|.. .
APECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase NEK3.AA Pkinase_Tyr 4-17 35 1.570287 2.42 Pfam 1-14 (270) Show / Hide 
Range on Protein: 4-17
Range on HMM: 1-14/270
Sequence Identity: 35% (5 aa)

YTVLRVIGQGSFGR
 | ....|.|.||.
ITFGKKLGEGAFGE