Gene NRBP2 (Mouse)
NRBP2
Sequence
Protein domains of NRBP2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | NRBP2.AA | NRBP | 44-305 | 67 | 2.6e-166 | 558.83 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 44-305 Range on HMM: 1-261/261 Sequence Identity: 67% (182 aa) QGNMPGIQSTFLAMDTEEGVEVVWNELHFGDRKAFAAHEEKIQTMFEQLALVDHPNIVKLHKYWLDASEARARVIFITEYVSSGSLKQFLKKTKKNHKAM |...|||....|||||||||||||||..|..||.|.|.||||...|..|...||.||||.||||.|..|...||||||||.||||.||||||||||||.| QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNM NARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKIGSVWYRIFSNALPDDLRSPIRAEREELRNLHFFPPEYG--EVNDG-TAVDIFSF |..||||||||||||||.||.|.|||||||||.||||||||||||||.|| ||......|..|||.||.|||.|||| ||.|. |||||.|| NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGCVW--------PDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSF GMCALEMAVLEIQ---ANGDTR-VTEEAIARARHSLSDPNMREFILSCLARDPARRPSAHNLLFHRVLF ||||||||||||| .||... ||||||.||.|||.||..|.||..||..||||||||..||||..|| GMCALEMAVLEIQSGCQNGESEYVTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF |
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| Kinase | NRBP2.AA | WNK | 54-190 | 38 | 5.5e-29 | 90.69 | In-house | 16-148 (261) | Show / Hide |
Range on Protein: 54-190 Range on HMM: 16-148/261 Sequence Identity: 38% (53 aa) FLAMDTEEGVEVVWNELHFGDRKAFAAHEEKIQTMFEQLALVDHPNIVKLHKYWLDASEARARVIFITEYVSSGSLKQFLKKTKKNHKAMNARAWKRWCT . ..||| .||| |.|| |.| . .. | | |||||.. .|| . . .. .|| || || .|| | |. . ..|| YRGLDTETWVEVAWCELQ--DQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKKCIVLVTELMTSGTLKTYLKR----FKKMKPKVLRSWCR QILSALSFLHACSP-PIIHGNLTSDTIFIQ-HNGLIKIG |||. |.||| . | |||| | | ||| .| .||| QILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIG |
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| Kinase | NRBP2.AA | S_TKc | 52-304 | 19 | 2.6e-12 | 3.62 | SMART | 14-231 (231) | Show / Hide |
Range on Protein: 52-304 Range on HMM: 14-231/231 Sequence Identity: 19% (52 aa) STFLAMDTEEGVEVVWNELHFGDRKAFAAHEEKIQTMFEQLALVDHPNIVKLHKYWLDASEARARVIFITEYVSS--GSLKQFLKKTKK--NHKAMNARA . ... ... | .| ... . | .| . .|||||||. .. | .. ...||.. |.|....|| .. ... .. KVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H WKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKIG----SVWYRIFSNALPDDLRSPIRAEREELRNLHFFPPEYGEVNDGT-AVDIFSFGM .... ||..|| ..| ||| | . |.. . |||. . . . ... .|| |. ..|. |.| ARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL------------------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGC CALEMAVLEIQANGDTRVTEEAIARARHSLSDPNMREFILSCLARDPARRPSAHNLLF-------HRVL . ||.. . . .. . | .| ...|| || .||..||.| .| | . ILYEMLCGYPPFP-QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | NRBP2.AA | TKL | 96-190 | 21 | 2.3e-11 | 37.16 | In-house | 83-196 (364) | Show / Hide |
Range on Protein: 96-190 Range on HMM: 83-196/364 Sequence Identity: 21% (28 aa) DHPNIVKLHKYWLDASE---------ARARVIFITEYVSSGS-LKQFLKKTKKNHKAMNARAWK---RWCTQILSALSFLHACS------PPIIHGNLTS .|||||.. | .. . ...||.. || | ... | ||. .| .....||.. ||||| .|.| RHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKS DTIFIQHNGL--------------IKIG . |.. |. .||. KNILVDENWTNVSNYMYNPNADWCCKIC |
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| Kinase | NRBP2.AA | STE | 232-304 | 21 | 7.5e-11 | 34.66 | In-house | 246-359 (359) | Show / Hide |
Range on Protein: 232-304 Range on HMM: 246-359/359 Sequence Identity: 21% (24 aa) GTAVDIFSFGMCALEMAVLEIQ-AN-GDTRVTEEAIAR---------------ARHSLSD----------------------PNMREFILSCLARDPARR .| .|| |.| ...||| . .. ..|. ... .| | |....|| || .|| | DTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKR PSAHNLLF--HRVL |.|. || | . PTASQLLKSEHPFI |
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| Kinase | NRBP2.AA | Pkinase | 92-171 | 24 | 1e-10 | 38.94 | Pfam | 54-131 (293) | Show / Hide |
Range on Protein: 92-171 Range on HMM: 54-131/293 Sequence Identity: 24% (21 aa) LALVDHPNIVKLHKYWLDASEARARVIFITEYVSSG----SLKQFLKKTKKNHKAM--NARAWKRWCTQILSALSFLHACSPPIIH .. ..|||||.|. .. | . .. ...||. | .|. ... ..|... . |....|||..| ..|.. ||| MKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIH |
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| Kinase | NRBP2.AA | Ciliate-E2-Unclassified | 94-189 | 24 | 4.2e-10 | 31.26 | In-house | 75-188 (352) | Show / Hide |
Range on Protein: 94-189 Range on HMM: 75-188/352 Sequence Identity: 24% (29 aa) LVDHPNIVKLHKYWLDASEARARVIFITEYVSSGSLKQFLKKTKKNH-------------KAMNARAWK-----RWCTQILSALSFLHACSPPIIHGNLT |..||......... . .. .....||. |.|.|..|| ||. | .. | ... |||..|..|| ||| ... LLNHPHPFIVKMFYCFQDK--QNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIK SDTIFIQHNG---LIKI . |... || ||| PENILFDNNGKNYYIKI |
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| Kinase | NRBP2.AA | CAMK | 95-163 | 19 | 7e-10 | 27.28 | In-house | 95-196 (425) | Show / Hide |
Range on Protein: 95-163 Range on HMM: 95-196/425 Sequence Identity: 19% (20 aa) VDHPNIVKLHKYWLD-----------ASEA-----RARVIFIT---EYVSSG----SLKQFLKKTKKN-----------HKAMNARAWKRWCTQILSALS .|||||.||. .. | . . ...... ||.| | | ..... ... .. .. | .|. ||.||. LDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVH FLH ..| YCH |
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| Kinase | NRBP2.AA | TK | 90-190 | 11 | 1.3e-09 | 27.6 | In-house | 93-293 (486) | Show / Hide |
Range on Protein: 90-190 Range on HMM: 93-293/486 Sequence Identity: 11% (23 aa) EQLA--LVDHPNIVKLHKYWLDASE--------ARARVIFITEYVSSGS----LKQFLKKTKKN------------------------------------ ... | .|||||.|. . .. . .. .. ..||.. |. |...|.| ... KMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNS HKAMNARAWKR------------------------------------WCTQILSALSFLHACSP----PIIHGNLTSDTIFIQHNGL-----------IK .. ...... .| || .....||.. ..|..| . . .|. .| PC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK IG |. IA |
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| Kinase | NRBP2.AA | CDC2 | 96-190 | 31 | 1.9e-09 | 24.63 | In-house | 59-145 (301) | Show / Hide |
Range on Protein: 96-190 Range on HMM: 59-145/301 Sequence Identity: 31% (30 aa) DHPNIVKLHKYWLDASEARARVIFITEYVSSGSLKQFLKKTKKNHKAMNARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKIG ||||||||| .. ..||.. ||..... .. | | . | |||....|.|. |.| .| . |.| .| |||. DHPNIVKLHDVIHQ-----NKLYMVFEYLDM-DLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRR--IMHRDLKPQNILIDKKGNIKIA |
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| Kinase | NRBP2.AA | SgK071 | 122-174 | 35 | 2.8e-09 | 28.38 | In-house | 80-130 (283) | Show / Hide |
Range on Protein: 122-174 Range on HMM: 80-130/283 Sequence Identity: 35% (19 aa) EYVSSGSLKQFLKKTKKNHKAMNARAWKRWCTQILSALSFLHACSPPIIHGNL .| . |.. .|.|. .| |.| .||| |.| |. .|| ||| .| DYYKMGDFDRFMKEKRKKKKIMCEEWMQRWCGQMLHAIEYLHHRN--IIHRDL |
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| Kinase | NRBP2.AA | WNK | 232-252 | 52 | 3e-09 | 25.95 | In-house | 182-202 (261) | Show / Hide |
Range on Protein: 232-252 Range on HMM: 182-202/261 Sequence Identity: 52% (11 aa) GTAVDIFSFGMCALEMAVLEI ...||...|||| ||||..|. DESVDVYAFGMCMLEMATSEY |
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| Kinase | NRBP2.AA | TyrKc | 70-304 | 17 | 1.3e-08 | -83.59 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 70-304 Range on HMM: 1-280/280 Sequence Identity: 17% (51 aa) LHFGDR--------------------KAFAAHEEKIQTMFEQ----LALV--DHPNIVKLHKYWLDASEAR---ARVIFITEYVSSGSLKQFLKKTKKNH ...|. | .. . .| . . . .|||||.|. . .. .. . ..||.. |.||..|.|.... ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK- KAMNARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKIGSVWYRIFSNALPDDLRSP---------IRA----EREELRNLHFFPPEYG . . .|.|| . ..|| ..|| | . . .|. .||. | |. . .|. . . . .|| --LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKIS-------DFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI EVNDG---TAVDIFSFGMCALEMAVLEIQANGDT----RVTEEAIARARHS-------L--------SDPNMREFILSCLARDPARRPSAHNLLFHRVL |.| |. |..||| | |. . | . .|.|.. .. . | . ...| ..||. ||. .. |. . --NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | NRBP2.AA | STE | 96-189 | 22 | 1.8e-08 | 26.17 | In-house | 87-188 (359) | Show / Hide |
Range on Protein: 96-189 Range on HMM: 87-188/359 Sequence Identity: 22% (25 aa) D-HPNIVKLHKYWLDA---SEARARVIFITEYVSSGSLKQFLK---KTKKNHK-------AMNARAWKRWCTQILSA-LSFLHACSPPIIHGNLTSDTIF . |||||| . . .. .... . . ||.. ||| ...| ...|... .. .. | ||| . |..|| ||| . .. |. HMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANIL IQHNGLIKI . .|. L-----VKL |
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| Kinase | NRBP2.AA | STE-Unique | 235-304 | 27 | 3.1e-08 | 24.75 | In-house | 534-616 (616) | Show / Hide |
Range on Protein: 235-304 Range on HMM: 534-616/616 Sequence Identity: 27% (23 aa) VDIFSFGMCALEMAVLEIQANGDTRVTE--EAIARARHSLS-----------DPNMREFILSCLARDPARRPSAHNLLFHRVL |||.|.|. ..|... .. ... | . . | ...|| .|| |.| |||||.|| | | VDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL |
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| Kinase | NRBP2.AA | WNK | 274-304 | 32 | 1e-05 | 14.39 | In-house | 231-261 (261) | Show / Hide |
Range on Protein: 274-304 Range on HMM: 231-261/261 Sequence Identity: 32% (10 aa) DPNMREFILSCLARDPARRPSAHNLLFHRVL .|. .|.|. |. .. |||. || | . NPEVKEIIEKCIRHNKEERPSIQQLLNHDFF |
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| Kinase | NRBP2.AA | STE-Unique | 122-190 | 29 | 3.1e-05 | 13.89 | In-house | 374-452 (616) | Show / Hide |
Range on Protein: 122-190 Range on HMM: 374-452/616 Sequence Identity: 29% (23 aa) EYVSSGSLKQFLKKTKK-----NHKAMNARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNG-----LIKIG || . |.|.| .| . | . . . .. .||| .| .|| ||||..| .. ||. | .||. EYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKIC |
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| Kinase | NRBP2.AA | Pkinase | 274-304 | 35 | 3.2e-05 | 19.55 | Pfam | 263-293 (293) | Show / Hide |
Range on Protein: 274-304 Range on HMM: 263-293/293 Sequence Identity: 35% (11 aa) DPNMREFILSCLARDPARRPSAHNLLFHRVL ......|| .||..||..||.|. .| | . SEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | NRBP2.AA | TKL | 233-302 | 14 | 0.000362 | 10.92 | In-house | 268-364 (364) | Show / Hide |
Range on Protein: 233-302 Range on HMM: 268-364/364 Sequence Identity: 14% (14 aa) TAVDIFSFGMCALEMAVLEIQAN-GDTRVTE---------EAIARARHSLSDP-----------------NMREFILSCLARDPARRPSAHNLLFHR ...|..|||.. |.. .. . . . . .. .. . | |.. . | . || |||. .| . EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | NRBP2.AA | Pkinase_Tyr | 96-135 | 35 | 0.005127 | 10.84 | Pfam | 62-100 (270) | Show / Hide |
Range on Protein: 96-135 Range on HMM: 62-100/270 Sequence Identity: 35% (14 aa) DHPNIVKLHKYWLDASEARARVIFITEYVSSGSLKQFLKK .|||||.|. .| .| ... ..||. |.|. .|.| HHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLRK |
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| Kinase | NRBP2.AA | TK | 269-302 | 17 | 0.02113 | 3.0 | In-house | 450-486 (486) | Show / Hide |
Range on Protein: 269-302 Range on HMM: 450-486/486 Sequence Identity: 17% (7 aa) RHSLSD-----PNMREFILSCLARDPARRPSAHNLLFHR |. . . . . .....| ..||..||. |. RM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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| Kinase | NRBP2.AA | CAMK | 278-304 | 25 | 0.024551 | 2.53 | In-house | 399-425 (425) | Show / Hide |
Range on Protein: 278-304 Range on HMM: 399-425/425 Sequence Identity: 25% (7 aa) REFILSCLARDPARRPSAHNLLFHRVL . .| ..| .|| .|.... | | . KDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | NRBP2.AA | Ciliate-E2-Unclassified | 273-304 | 22 | 0.211169 | 0.65 | In-house | 317-352 (352) | Show / Hide |
Range on Protein: 273-304 Range on HMM: 317-352/352 Sequence Identity: 22% (8 aa) SDPNMREFIL----SCLARDPARRPSAHNLLFHRVL ..|. .|| ..| .| |... .| | . WSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | NRBP2.AA | Pkinase_Tyr | 275-304 | 23 | 0.52914 | 4.02 | Pfam | 243-270 (270) | Show / Hide |
Range on Protein: 275-304 Range on HMM: 243-270/270 Sequence Identity: 23% (7 aa) PNMREFILSCLARDPARRPSAHNLLFHRVL . . . ...| . ||..||. . |. | DEIYDLMKQCWHYDPEDRPTFSEI--HEQL |
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