Gene PINK1 (Mouse)
PINK1
Sequence
Protein domains of PINK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | PINK1.AA | NKF2 | 156-506 | 60 | 5.1e-276 | 923.26 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 156-506 Range on HMM: 1-365/365 Sequence Identity: 60% (220 aa) YLIGQAIGKGCNAAVYEATMPTLPQHLEKAKHLGLI-GKGPDVVLKGADGEQAPGTPTFPFAIKMMWNISAGSSSEAILSKMSQELVPASRVALAGEYGA |..||.||.|||||||||.||..|||.|..||.||| ..||. .|.....||.||.|.||.|||||||......|.|.|.||.|..||..|.||.||||. YEFGQFIGQGCNAAVYEARMPNSPQHSEGNKHYGLIFNEGPN-ILAEIPPEQKPGQPKFPLAIKMMWNFEHDRDSDAHLNKMMQNEVPPYRNALKGEYGQ VTYRRSRDGPKQLAPHPNIIRVFRAFTSSVPLLPGALADYPDMLPPHYYPEGLGHGRTLFLVMKNYPCTLRQYLEEQ-TPSSRLATMMTLQLLEGVDHLV .||||||..|||.||||||...||||..||..||.|..||||||...|.|||.||..|..||||.|.|||||||..| .||.....||..|.||..|||. MTYRRSRTFPKQPAPHPNIVCMFRAFCDSVRVLPDAHEDYPDMLHQRYWPEGYGHNMTMYLVMKRYRCTLRQYLWMQCHPSYWTRMMMIAQMLEACDHLH QQGIAHRDLKSDNILVEWDSD--GCPWLVISDFGCCLADQHVGLRLPFNSSSVERGGNGSLMAPEVST-AHSGPSAVIDYSKADTWAVGAIAYEIFGLAN |.|.||||.||||||||.|.| .||||||.|||||||..|.|..||..|..|.||||..|||||..| ||.|...|.||.||||||.|||||||||..| QHGVAHRDMKSDNILVEYDFDDGACPWLVIADFGCCLACKHHGWQLPYSSWDVDRGGNACLMAPEIFTGAHPGCNHVHDYEKADTWACGAIAYEIFGQKN PFYG--------QGSAHLESRS--YQEAQLPEMPESVPPEARRLVRSLLQREASKRPSARLAANVL |||. ||..||.|.. |||.|||.||.|.||..|.||..||||..|||||...||||| PFYSSSGGMAREQGEMHLDSCNSDYQEDQLPQMPQSCPPVLRQLVYNLLQRDPSKRPSPQIAANVL |
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| Kinase | PINK1.AA | Pkinase | 265-511 | 20 | 2.4e-20 | 73.05 | Pfam | 55-293 (293) | Show / Hide |
Range on Protein: 265-511 Range on HMM: 55-293/293 Sequence Identity: 20% (59 aa) KQLAPHPNIIRVFRAFTSSVPLLPGALADYPDMLPPHYYPEGLGHGRTLFLVMKNYPC-----TLRQYLE---EQTP--SSRLATMMTLQLLEGVDHLVQ | | ||||.| ...|.. .. . .|| .. | |.. . . | . . .. .|.|.|.... . KRL-NHPNIVRLYDWFED---------------------------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS QGIAHRDLKSDNILVEWDSDGCPWLVISDFGCC-LADQHVGLRLPFNSSSVERGGNGSLMAPEVSTAHSGPSAVIDYSKADTWAVGAIAYEIFGLANPFY .|| |||||..|||. . . .. . |.|||.. ..| . || . | ||||| .. . .|.| |..| | || . ||. MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIR-----GGQYYGPKVDMWSCGCILYEMLCGRPPFP GQ---GSAHLESRSYQEAQLPEMPESVP-----------------------PEARRLVRSLLQREASKRPSARLAANVLHLSLW |. . | . ... |. ... | .|.. .....|.. .|||. |. .|. . GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF |
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| Kinase | PINK1.AA | STE | 341-499 | 19 | 5.9e-15 | 49.34 | In-house | 156-348 (359) | Show / Hide |
Range on Protein: 341-499 Range on HMM: 156-348/359 Sequence Identity: 19% (42 aa) MTLQLLEG-VDHLVQQGIAHRDLKSDNILVEWDSDGCPWLVISDFGCCLADQHVGLRLPFNSSSVERGGNGSL------------------MAPEVSTAH .. |.|.| ..| ...| |||.|..|||. ..|||.| .. . .. | .| . ||||| . ICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANI-Q-S------NN-IIDCIETMQQKRNTFVGTPWMAPEVIQQN SGPSAVIDYS-KADTWAVGAIAYEIFGLANPF--YGQGSAHLESRSY---------------QEAQLPE----------------MPESVPPEARRLVRS ... . .|. |.| | .| . | |. . .| .. . .||. .|... || . .. GQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINK LLQREASKRPSA ||.. .|||.| CLQKDPNKRPTA |
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| Kinase | PINK1.AA | S_TKc | 156-510 | 17 | 8.2e-15 | 40.3 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 156-510
Range on HMM: 1-231/231
Sequence Identity: 17% (66 aa)
YLIGQAIGKGCNAAVYEATMPTLPQHLEKAKHLGLIGKGPDVVLKGADGEQAPGTPTFPFAIKMMWNISAGSSSEAILSKMSQELVPASRVALAGEYGAV
| |.. |||| . || .. .|||.. . |
YEILRKIGKGAFGKVYKCRHKK---------------------------------TGRIVAIKIIK------------------------EHIRREIQIL
TYRRSRDGPKQLAPHPNIIRVFRAFTSSVPLLPGALADYPDMLPPHYYPEGLGHGRTLFLVMKNYPC---TLRQYLEEQTP-------SSRLATMMTLQL
||||.. . .| . |..|| . .|..|.... . . | .. |.
KK-----------HHPNIVKLYDVFQD----------------------------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQI
LEGVDHLVQQGIAHRDLKSDNILVEWDSDGCPWLVISDFGCCLADQHVGLRLPFNSSSVERGGNGSLMAPEVSTAHSGPSAVIDYS--KADTWAVGAIAY
....... ..|| ||||| .|||. . |.||| . | ||||| |. |.| |..| | |
CCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----------GYGKCKCDWWSCGCILY
EIFGLANPFYGQGSAHLESRSYQEAQLPEMPESVPPEARRLVRSLLQREASKRPSARLAAN-----VLHLSL
| . ||. . . .. .|||. ..| .||.. .|||.| | . .| .
EMLCGYPPFP------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | PINK1.AA | CDC2 | 313-385 | 30 | 1.1e-11 | 31.61 | In-house | 75-148 (301) | Show / Hide |
Range on Protein: 313-385 Range on HMM: 75-148/301 Sequence Identity: 30% (24 aa) LFLVMKNYPCTLRQYLEEQTP-----SSRLATMMTLQLLEGVDHLVQQGIAHRDLKSDNILVEWDSDGCPWLVISDFG |..| . . . |..|.... | .. | . |.|.||... |..| ||||| .|||. . . . |.||| LYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN----IKIADFG |
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| Kinase | PINK1.AA | CAMK | 344-385 | 30 | 4.3e-11 | 31.26 | In-house | 187-241 (425) | Show / Hide |
Range on Protein: 344-385 Range on HMM: 187-241/425 Sequence Identity: 30% (17 aa) QLLEGVDHLVQQGIAHRDLKSDNILV-EWDSDGCP-----------W-LVISDFG |....|... ...|.||||| .|||. . ..| .| . . |.||| QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFG |
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| Kinase | PINK1.AA | CMGC | 270-369 | 16 | 4.5e-11 | 31.68 | In-house | 97-217 (513) | Show / Hide |
Range on Protein: 270-369
Range on HMM: 97-217/513
Sequence Identity: 16% (24 aa)
HPNIIRVFRAFTSS-------------VPLLPGALADYPDMLPPHYYPEGLGHGRTLFLVMKNYPCTLRQYLEEQT----------PSSRL---------
|.||.. . |... . | . |.||. ...| ||.... |
HNNIVKLYDIFYHKNSDGNEYEDKHIIS----------------------Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRP
---ATMMT------LQLLEGVD--HLVQQG--IAHRDLKSDNILV
.. |.|.|.. .. ... | ||||| |||.
PHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILI
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| Kinase | PINK1.AA | Ciliate-E2 | 323-385 | 18 | 9.4e-11 | 33.12 | In-house | 120-201 (365) | Show / Hide |
Range on Protein: 323-385 Range on HMM: 120-201/365 Sequence Identity: 18% (17 aa) TLRQYLEEQ------------TPSSRLATMMTLQLLE---------------GVDHLVQQG-IAHRDLKSDNILVEWDSDGCPWLVISDFG .|..|.... .. . . .. |.|. .. .| ... | |||.| .|||. . |.||| DLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFG |
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| Kinase | PINK1.AA | STE-Unique | 341-510 | 22 | 1.4e-10 | 33.19 | In-house | 408-616 (616) | Show / Hide |
Range on Protein: 341-510
Range on HMM: 408-616/616
Sequence Identity: 22% (49 aa)
MTLQLLEGVDHLVQQG--IAHRDLKSDNILVEWDSDG----CPWLVISDFGCCLADQHVGL-------------RLPFN-------------------SS
.|.|.||| ..| |. | |||||..||. ..|| | .|.||| | ... | ..
YTYQILEGLEYLHSQHNPIIHRDLKPHNIFC--MQDGKGRVC-KVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYT
SVERGGNGSLMAPEVSTAHSGPSAVIDYSKADTWAVGAIAYEIFGLANPFYGQGSAHL--ESRSYQEAQLP-----EMPESVPPEARRLVRSLLQREASK
|. |.||| . . .| |.| | |.. .. . |. ... | . . |.| . |.. || . . ...| |. ..
MKYCCGTPCYMCPEVINCRNQINNPYDT-KVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHH
RPSARLAANVLHLSL
|||| . .. |. |
RPSA--HQLLHHFWL
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| Kinase | PINK1.AA | Trio | 344-385 | 38 | 4.8e-10 | 21.27 | In-house | 103-144 (258) | Show / Hide |
Range on Protein: 344-385 Range on HMM: 103-144/258 Sequence Identity: 38% (16 aa) QLLEGVDHLVQQGIAHRDLKSDNILVEWDSDGCPWLVISDFG |.||.|. | ...|.| |.|..|.... . | | . | ||| QMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFG |
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| Kinase | PINK1.AA | Ciliate-E2a | 344-385 | 39 | 1.1e-09 | 24.75 | In-house | 109-154 (275) | Show / Hide |
Range on Protein: 344-385 Range on HMM: 109-154/275 Sequence Identity: 39% (18 aa) QLL-EGVDHLVQQGIAHRDLKSDNILVE-WDSDGC--PWLVISDFG ||| .|. .. |..| ||||| .||| . .... ..|.||| QLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFG |
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| Kinase | PINK1.AA | Ciliate-E2-Unclassified | 323-369 | 22 | 5.5e-08 | 23.81 | In-house | 107-177 (352) | Show / Hide |
Range on Protein: 323-369 Range on HMM: 107-177/352 Sequence Identity: 22% (16 aa) TLRQYLEEQTP------------------SSRLAT-----MMTLQLLEGVDHLVQQG-IAHRDLKSDNILV .|.||.... . . | .. |.|.| ..| ... | |||.| .|||. DLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF |
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| Kinase | PINK1.AA | TyrKc | 156-506 | 16 | 1e-06 | -113.87 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 156-506
Range on HMM: 1-280/280
Sequence Identity: 16% (63 aa)
YLIGQAIGKGCNAAVYEATMPTLPQHLEKAKHLGLIGKGPDVVLKGADGEQAPGTPTFPFAIKMMWNISAGSSSEAILSKMSQELVPASRVALAGEYGAV
|. .| |. ||..|. . |.||. . . | .. |
ITLGKKLGEGAFGEVYKGTWK------------------------------------IQVAVKMLKEDA--------------------REDFMREARIM
TYRRSRDGPKQL-APHPNIIRVFRAFTSS-------VPLL-------PGALADYPDMLPPHYYPEGLGHGRTLFLVMKNYPCTLRQYLEEQTPSSRLATM
..| ||||.| . . |.. ||. |.| || |. . .
---------CKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-------------------------------LCMKDLLS
MTLQLLEGVDHLVQQGIAHRDLKSDNILVEWDSDGCPWLV-ISDFGCCLADQHV---GLRLPFNSSSVER----GGNGSL----MAPEVSTAHSGPSAVI
. .| .| ..| .... |||| |.|| . | ||||| . . . | ... ||.. | ||||. .
FCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMAPECI------NYGK
DYSKADTWAVGAIAYEIFGLANPFYGQ-----GSAHLESRSYQEAQLPEMPES--------VPPEARRLVRSLLQREASKRPSARLAANVL
.| | |. | .||| . . | |. . .. .. |.. |.| .. .. ......||. . .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | PINK1.AA | Ciliate-E2 | 429-499 | 18 | 6e-06 | 16.28 | In-house | 272-356 (365) | Show / Hide |
Range on Protein: 429-499 Range on HMM: 272-356/365 Sequence Identity: 18% (17 aa) DYS-KADTWAVGAIAYEIFGLANPFYGQGSAHLESRSYQEAQLPEM---------------PESVPPEARRLVRS----LLQREASKRPS-A .|. |.| |..| | || || .. .. ..|. ......|. | . .||.. .||.. . GYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGW |
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| Kinase | PINK1.AA | CAMK | 432-499 | 18 | 7.7e-05 | 10.75 | In-house | 314-416 (425) | Show / Hide |
Range on Protein: 432-499 Range on HMM: 314-416/425 Sequence Identity: 18% (19 aa) KADTWAVGAIAYEIFGLANPFYGQG------------SAHLESRSYQEAQLPEMPESVPP-----------------------EARRLVRSLLQREASKR |.| |..| | | |||| . . . .... |. ..| |.. |.|..||.. .|| KCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKR PSA ... MTI |
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| Kinase | PINK1.AA | Ciliate-E2-Unclassified | 413-501 | 27 | 0.000438 | 10.09 | In-house | 229-341 (352) | Show / Hide |
Range on Protein: 413-501 Range on HMM: 229-341/352 Sequence Identity: 27% (32 aa) M----APEVSTA--HSGPSAVIDYSKADTWAVGAIAYE-IFGLANPFYGQGSAH----------------LESRSYQE-AQLPEMPE-----SVPPEARR | |||| .....| |.| |..| |.|| .|| |||.. . |.. .| | |..|. ..||| MPQYTAPEVLQGQNYDHSKA----YKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKD LVRSLLQREASKRPSARL ... |||. |.|. |. FINDLLQKMLKKNPNKRI |
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| Kinase | PINK1.AA | Ciliate-E2 | 156-173 | 33 | 0.007804 | 5.54 | In-house | 1-18 (365) | Show / Hide |
Range on Protein: 156-173 Range on HMM: 1-18/365 Sequence Identity: 33% (6 aa) YLIGQAIGKGCNAAVYEA | . . ||.|. . ||.. YKFIKKIGQGNFGSVYKC |
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| Kinase | PINK1.AA | Trio | 472-499 | 28 | 0.010081 | 2.09 | In-house | 222-249 (258) | Show / Hide |
Range on Protein: 472-499 Range on HMM: 222-249/258 Sequence Identity: 28% (8 aa) EMPESVPPEARRLVRSLLQREASKRPSA ... .| .|. ....||. .|||.| CYFCHVSQNAKHFICKVLQEDPWKRPCA |
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| Kinase | PINK1.AA | Ciliate-E2-Unclassified | 156-173 | 38 | 0.01415 | 4.78 | In-house | 1-18 (352) | Show / Hide |
Range on Protein: 156-173 Range on HMM: 1-18/352 Sequence Identity: 38% (7 aa) YLIGQAIGKGCNAAVYEA | |.. ||.|... ||.. YKIIKQIGQGGFGKVYKC |
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